(+-)-Mevalonolactone

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  • Identifiers

    CAS number
    674-26-0

    Molecular formula
    C6H10O3

    SMILES
    CC1(CCOC(=O)C1)O

    Safety labels

  • Odor profile

    Fragrance
    Sweet 47.5%
    Coconut 40.01%
    Creamy 38.87%
    Woody 37.3%
    Coumarinic 34.25%
    Floral 33.88%
    Lactonic 33.78%
    Fruity 33.18%
    Nutty 32.98%
    Herbal 32.07%

     

    Flavor
    Sweet 66.56%
    Herbal 44.55%
    Tobacco 38.8%
    Fruity 37.54%
    Caramel 31.99%
    Minty 30.49%
    Woody 29.94%
    Fatty 29.71%
    Coumarin 29.07%
    Coconut 28.17%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.3

    pKa est.
    8.43 (weak base)

    Molecular weight
    130.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    293°C

    Flash point

    • 92.43 ˚C est.

  • Synonyms

    • 674-26-0
    • DL-Mevalonic acid lactone
    • 1RJ06DC41B
    • (+-)-Mevalonolactone
    • RefChem:818792
    • GlyTouCan:G04468UB
    • Mevalonolactone, (+-)-
    • G04468UB
    • DL-Mevalonolactone
    • 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
    • 4-hydroxy-4-methyloxan-2-one
    • D,L-Mevalonic Acid Lactone
    • (+/-)-Mevalonolactone
    • Mevalolactone
    • MFCD00006648
    • Mevalonolactone, (+/-)-
    • 4-hydroxy-4-methyl-tetrahydropyran-2-one
    • Mevalonic lactone
    • 503-48-0
    • Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one
    • NSC-90804
    • beta-Hydroxy-beta-methyl-delta-valerolactone
    • DL-Mevalolactone
    • 2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-
    • 2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (.+/-.)-
    • (+/-)-Mevalonolactone;Mevalolactone
    • D,L-Mevalonic Acid Lactone (>90%)
    • (1)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one
    • NSC 90804
    • UNII-1RJ06DC41B
    • EINECS 211-615-0
    • MVSL
    • (RS)-Mevalonolactone
    • Prestwick3_000750
    • SCHEMBL880
    • MEVALONOLACTONE, DL-
    • BSPBio_000740
    • Mevalonic acid .delta.-lactone
    • BPBio1_000814
    • orb1308872
    • ()-Mevalonolactone;Mevalolactone
    • CHEMBL4758470
    • CHEBI:95115
    • DTXSID00964572
    • HMS2097E22
    • HMS3714E22
    • NSC90804
    • LMFA07040003
    • AKOS015906454
    • CCG-214600
    • EBC-616076
    • FM25990
    • Tetrahydro-4-hydroxy-4-methyl-2-pyrone
    • 4-Hydroxy-4-methyltetrahydropyran-2-one
    • MSK165642-1000B
    • NCGC00179453-01
    • AS-65830
    • SY032939
    • DB-044755
    • DB-055030
    • HY-107855
    • (+/-)-Mevalonolactone, ~97% (titration)
    • AB00513915
    • CS-0030738
    • D0587
    • NS00014877
    • ST51038127
    • (+/-)-3-Hydroxy-3-methyl delta-valerolactone
    • C76125
    • (+/-)-Mevalonolactone, purum, >=96.0% (T)
    • 674M260
    • F226574
    • SR-01000872630
    • (+/-)-beta-Hydroxy-beta-methyl-delta-valerolactone
    • .beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone
    • 4-hydroxy-4-methyl-3H-4,5,6-trihydropyran-2-one
    • SR-01000872630-1
    • BRD-A05674712-001-06-0
    • Q27166894
    • 009D7F12-69C6-4BBF-A66D-12BA84648C72
    • DL-Mevalonic acid lactone Solution in Acetone, 1000ug/mL
    • 2H-PYRAN-2-ONE, TETRAHYDRO-4-HYDROXY-4-METHYL-, (+/-)-
    • 674-26-0

  • Applications

    (+-)-Mevalonolactone (CAS 674-26-0) is a versatile building block in organic synthesis, widely used as a precursor to isoprenoid and terpenoid derivatives and to steroid-like frameworks. It is commonly evaluated for fragrance and flavor chemistry as a precursor to aroma compounds, and in pharmaceutical manufacturing as an intermediate in the synthesis of terpenoid- and steroid-based structures. In polymer and biomaterials research, it can serve as a monomer or functionalized building block for lactone-based polyesters via ring-opening strategies. In cosmetics and personal care, it is used as a chiral building block for fragrance ingredients and related formulations. Its use is subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 338.14
    methanol 684.88
    isopropanol 258.67
    water 253.24
    ethyl acetate 83.12
    n-propanol 183.2
    acetone 294.85
    n-butanol 131.54
    acetonitrile 179.19
    DMF 779.1
    toluene 8.25
    isobutanol 114.19
    1,4-dioxane 212.53
    methyl acetate 116.05
    THF 294.71
    2-butanone 103.55
    n-pentanol 69.07
    sec-butanol 128.38
    n-hexane 1.93
    ethylene glycol 378.15
    NMP 332.47
    cyclohexane 2.09
    DMSO 399.7
    n-butyl acetate 27.86
    n-octanol 46.21
    chloroform 72.99
    n-propyl acetate 40.38
    acetic acid 607.13
    dichloromethane 55.09
    cyclohexanone 89.67
    propylene glycol 431.37
    isopropyl acetate 44.34
    DMAc 483.56
    2-ethoxyethanol 218.5
    isopentanol 86.76
    n-heptane 2.04
    ethyl formate 93.69
    1,2-dichloroethane 30.32
    n-hexanol 61.04
    2-methoxyethanol 565.85
    isobutyl acetate 25.77
    tetrachloromethane 9.83
    n-pentyl acetate 25.09
    transcutol 419.35
    n-heptanol 34.75
    ethylbenzene 5.93
    MIBK 52.83
    2-propoxyethanol 190.93
    tert-butanol 239.09
    MTBE 46.44
    2-butoxyethanol 94.5
    propionic acid 232.47
    o-xylene 11.55
    formic acid 624.54
    diethyl ether 46.27
    m-xylene 13.78
    p-xylene 9.37
    chlorobenzene 14.07
    dimethyl carbonate 78.14
    n-octane 1.04
    formamide 510.42
    cyclopentanone 155.24
    2-pentanone 79.54
    anisole 37.85
    cyclopentyl methyl ether 69.75
    gamma-butyrolactone 216.8
    1-methoxy-2-propanol 369.12
    pyridine 54.99
    3-pentanone 51.05
    furfural 193.05
    n-dodecane 1.5
    diethylene glycol 295.06
    diisopropyl ether 12.3
    tert-amyl alcohol 120.96
    acetylacetone 110.94
    n-hexadecane 1.62
    acetophenone 44.2
    methyl propionate 100.8
    isopentyl acetate 25.56
    trichloroethylene 65.1
    n-nonanol 37.86
    cyclohexanol 73.9
    benzyl alcohol 52.19
    2-ethylhexanol 25.32
    isooctanol 25.04
    dipropyl ether 20.26
    1,2-dichlorobenzene 17.73
    ethyl lactate 64.69
    propylene carbonate 112.97
    n-methylformamide 387.87
    2-pentanol 72.33
    n-pentane 2.55
    1-propoxy-2-propanol 109.31
    1-methoxy-2-propyl acetate 62.51
    2-(2-methoxypropoxy) propanol 113.94
    mesitylene 10.24
    ε-caprolactone 93.35
    p-cymene 7.94
    epichlorohydrin 150.0
    1,1,1-trichloroethane 30.12
    2-aminoethanol 400.18
    morpholine-4-carbaldehyde 339.58
    sulfolane 212.01
    2,2,4-trimethylpentane 1.99
    2-methyltetrahydrofuran 108.6
    n-hexyl acetate 49.79
    isooctane 1.91
    2-(2-butoxyethoxy)ethanol 147.66
    sec-butyl acetate 25.34
    tert-butyl acetate 48.58
    decalin 1.86
    glycerin 581.31
    diglyme 214.96
    acrylic acid 249.43
    isopropyl myristate 19.2
    n-butyric acid 164.75
    acetyl acetate 63.5
    di(2-ethylhexyl) phthalate 29.35
    ethyl propionate 45.56
    nitromethane 577.71
    1,2-diethoxyethane 48.31
    benzonitrile 41.54
    trioctyl phosphate 21.55
    1-bromopropane 12.39
    gamma-valerolactone 245.04
    n-decanol 27.03
    triethyl phosphate 20.35
    4-methyl-2-pentanol 42.87
    propionitrile 90.25
    vinylene carbonate 105.02
    1,1,2-trichlorotrifluoroethane 217.99
    DMS 47.21
    cumene 7.15
    2-octanol 22.29
    2-hexanone 42.56
    octyl acetate 29.03
    limonene 10.57
    1,2-dimethoxyethane 212.45
    ethyl orthosilicate 18.04
    tributyl phosphate 25.71
    diacetone alcohol 130.96
    N,N-dimethylaniline 31.9
    acrylonitrile 130.02
    aniline 41.24
    1,3-propanediol 368.47
    bromobenzene 8.61
    dibromomethane 25.81
    1,1,2,2-tetrachloroethane 61.92
    2-methyl-cyclohexyl acetate 25.97
    tetrabutyl urea 36.95
    diisobutyl methanol 16.8
    2-phenylethanol 45.47
    styrene 6.3
    dioctyl adipate 34.25
    dimethyl sulfate 119.16
    ethyl butyrate 26.52
    methyl lactate 150.0
    butyl lactate 43.23
    diethyl carbonate 21.65
    propanediol butyl ether 142.47
    triethyl orthoformate 22.28
    p-tert-butyltoluene 8.52
    methyl 4-tert-butylbenzoate 57.9
    morpholine 259.8
    tert-butylamine 81.39
    n-dodecanol 19.33
    dimethoxymethane 258.69
    ethylene carbonate 82.41
    cyrene 113.46
    2-ethoxyethyl acetate 45.15
    2-ethylhexyl acetate 18.43
    1,2,4-trichlorobenzene 26.14
    4-methylpyridine 56.68
    dibutyl ether 19.57
    2,6-dimethyl-4-heptanol 16.8
    DEF 121.75
    dimethyl isosorbide 132.1
    tetrachloroethylene 36.96
    eugenol 69.25
    triacetin 67.28
    span 80 91.81
    1,4-butanediol 135.52
    1,1-dichloroethane 36.08
    2-methyl-1-pentanol 49.33
    methyl formate 276.55
    2-methyl-1-butanol 79.61
    n-decane 2.28
    butyronitrile 67.83
    3,7-dimethyl-1-octanol 35.25
    1-chlorooctane 10.34
    1-chlorotetradecane 4.52
    n-nonane 1.98
    undecane 1.8
    tert-butylcyclohexane 2.23
    cyclooctane 1.06
    cyclopentanol 123.51
    tetrahydropyran 83.93
    tert-amyl methyl ether 37.9
    2,5,8-trioxanonane 173.76
    1-hexene 6.6
    2-isopropoxyethanol 109.97
    2,2,2-trifluoroethanol 238.93
    methyl butyrate 57.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction