Metribuzin

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  • Identifiers

    CAS number
    21087-64-9

    Molecular formula
    C8H14N4OS

    SMILES
    CC(C)(C)C1=NN=C(N(C1=O)N)SC

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Green 38.41%
    Roasted 33.25%
    Earthy 31.29%
    Nutty 28.78%
    Vegetable 23.71%
    Mint 23.69%
    Meaty 23.36%
    Musty 23.34%
    Burnt 22.14%
    Potato 21.31%

     

    Flavor
    Bitter 38.62%
    Earthy 29.79%
    Roasted 27.29%
    Earth 24.87%
    Burnt 23.34%
    Green 23.33%
    Musty 23.16%
    Green pepper 22.91%
    Carrot 22.71%
    Hazelnut 22.54%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    5.92 (weak acid)

    Molecular weight
    214.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 257 °F (NIOSH, 2024)
    • 126.2 °C
    • 125 °C
    • 257 °F

    Boiling point

    • 132 °C @ 2 Pa

    Flash point

    • 172.12 ˚C est.

    Solubility expt.

    • 0.1 % (NIOSH, 2024)
    • Sol in methanol and ethanol; very slightly soluble in water (1200 ppm).
    • Soluble in ... glycol ether acetate.
    • In dimethylformamide 1780, cyclohexanone 1000, chloroform 850, acetone 820, methanol 450, dichloromethane 340, benzene 220, n-butanol 150, ethanol 190, toluene 87, xylene 90, n-hexane 1 (all in g/l at 20 °C).
    • In water, 1.05X10+3 mg/l @ 20 °C
    • Solubility in water, g/100ml at 0.12 °C:
    • 0.1%

  • Synonyms

    • METRIBUZIN
    • 21087-64-9
    • Lexone
    • Sencor
    • Metribuzine
    • Zenkor
    • Sencorex
    • Senkor
    • Lexone DF
    • Sencor DF
    • 4-Amino-6-tert-butyl-3-methylsulfanyl-4H-[1,2,4]triazin-5-one
    • Lexone 4L
    • Sencor 4F
    • Sencoral
    • Bayer 6159H
    • Bayer 6443H
    • Bay 94337
    • Bayer 94337
    • Sencorex L.F.
    • BAY dic 1468
    • 4-amino-6-(tert-butyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one
    • Caswell No. 033D
    • Metribuzin [BSI:ISO]
    • 1,2,4-Triazin-5(4H)-one, 4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-
    • Metribuzine [ISO-French]
    • DIC 1468
    • 4-Amino-6-tert-butyl-4,5-dihydro-3-methylthio-1,2,4-triazin-5-one
    • BAY 61597
    • NTN 70
    • DTXSID6024204
    • CHEBI:34846
    • HSDB 6844
    • QO836138OV
    • 4-Amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one
    • METRIBUZIN [MI]
    • METRIBUZIN [ISO]
    • 4-Amino-6-tert-butyl-3-(methylthio)-1,2,4-triazin-5-one
    • EINECS 244-209-7
    • METRIBUZIN [HSDB]
    • as-Triazin-5(4H)-one, 4-amino-6-tert-butyl-3-(methylthio)-
    • EPA Pesticide Chemical Code 101101
    • BRN 0746650
    • 3-Methylthio-4-amino-6-tert-butyl-1,2,4-triazin-5-one
    • DTXCID404204
    • 4-Amino-6-tert-butyl-3-(methylthio)-as-triazin-5(4H)-one
    • 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one
    • 4-amino-6-tert-butyl-3-(methylsulfanyl)-4,5-dihydro-1,2,4-triazin-5-one
    • 4-Amino-6-tert-butyl-3-methylthio-as-triazin-5-one
    • 1,2,4-Triazin-5-one, 4-amino-6-tert-butyl-3-(methylthio)-
    • 4-Amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one
    • 4-Amino-6-tert-butyl-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one
    • Metribuzine (ISO-French)
    • 5-26-06-00432 (Beilstein Handbook Reference)
    • 4-amino-6-tert-butyl-3-(methylthio)-1,2,4-triazin-5(4H)-one
    • CAS-21087-64-9
    • Sencorer
    • Sengoral
    • C8H14N4OS
    • 4-Amino-6-tert-butyl-3-methylsulfanyl-4H-(1,2,4)triazin-5-one
    • Bay 94,337
    • Sencor 4L
    • Segal (Salt/Mix)
    • Canopy (Salt/Mix)
    • Lexone 75DF
    • MFCD00055525
    • Salute (Salt/Mix)
    • Sencor 75DF
    • Metribuzin (ACGIH)
    • Bayer 6159
    • SencorlPreview (Salt/Mix)
    • Cambridge id 5373044
    • Oprea1_252886
    • Oprea1_806124
    • SCHEMBL66824
    • BIDD:ER0414
    • UNII-QO836138OV
    • CHEMBL1902519
    • FOXFZRUHNHCZPX-UHFFFAOYSA-
    • BAY 6159 H
    • HMS1582I20
    • BAY 6159
    • Tox21_202006
    • Tox21_300731
    • BBL028065
    • STK830450
    • Metribuzin 500 microg/mL in Acetone
    • AKOS000116775
    • Metribuzin 200 microg/mL in Methanol
    • GS-3125
    • Metribuzin 10 microg/mL in Cyclohexane
    • Metribuzin 10 microg/mL in Acetonitrile
    • NCGC00163856-01
    • NCGC00163856-02
    • NCGC00163856-03
    • NCGC00163856-04
    • NCGC00254637-01
    • NCGC00259555-01
    • Metribuzin 100 microg/mL in Acetonitrile
    • DB-045478
    • HY-116954
    • 3Methylthio4amino6tertbutyl1,2,4triazin5one
    • CS-0066904
    • M3383
    • NS00001636
    • EN300-03840
    • Metribuzin, PESTANAL(R), analytical standard
    • 4Amino6tertbutyl3(methylthio)1,2,4triazin5one
    • 4Amino6tertbutyl3(methylthio)astriazin5(4H)one
    • H10483
    • 1,2,4Triazin5one, 4amino6tertbutyl3(methylthio)
    • 4Amino6tertbutyl3methylthio1,2,4triazin5(4H)one
    • A815132
    • Q421450
    • SR-01000393620
    • SR-01000393620-1
    • 4Amino6tertbutyl4,5dihydro3methylthio1,2,4triazin5one
    • Z56755860
    • 4-amino-6-t-butyl-3-methylthio-1,2,4-triazin-5-one
    • F0111-0053
    • 4-amino-6-t-butyl-3-methylmercapto-1,2,4-triazin-5-one
    • 4-Amino-6-tert-butyl-3-(methylthio)-as-triazin-S(4H)-one
    • 4-amino-6-tert.-butyl-3-methylthio-1,2,4-triazin-5-one
    • Triazin-5(4H)-one, 4-amino-6-tert-butyl-3-(methylthio)-
    • 3-methylthio-4-amino-6-tert.-butyl-1,2,4-triazin-5(4H)-one
    • 4-amino-6-tert-butyl-3-(methylthio)-s-triazin-5-(4H)-one
    • 4-amino-6-tert.-butyl-3-methylthio-1,2,4-triazin-5(4H)-one
    • 4-azanyl-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one
    • 4Amino6(1,1dimethylethyl)3(methylthio)1,2,4triazin5(4H)one

  • Applications

    Metribuzin (CAS 21087-64-9) is a selective triazinone herbicide used in crop protection to control broadleaf weeds and some grasses in crops such as sugar beet, potato, soybean, and tomato. It is typically applied pre-emergence or early post-emergence and can provide residual soil activity. It is commonly formulated as an agricultural herbicide product and is frequently used in tank mixtures with other herbicides to broaden the spectrum and improve control. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 115.77
    methanol 204.0
    isopropanol 63.29
    water 53.27
    ethyl acetate 42.6
    n-propanol 79.98
    acetone 93.81
    n-butanol 60.05
    acetonitrile 61.29
    DMF 171.13
    toluene 9.43
    isobutanol 53.02
    1,4-dioxane 80.53
    methyl acetate 72.12
    THF 116.06
    2-butanone 70.44
    n-pentanol 38.99
    sec-butanol 55.85
    n-hexane 1.17
    ethylene glycol 119.13
    NMP 208.75
    cyclohexane 2.84
    DMSO 133.6
    n-butyl acetate 36.62
    n-octanol 17.09
    chloroform 140.81
    n-propyl acetate 28.7
    acetic acid 424.21
    dichloromethane 90.88
    cyclohexanone 114.46
    propylene glycol 107.69
    isopropyl acetate 23.4
    DMAc 144.94
    2-ethoxyethanol 93.29
    isopentanol 41.23
    n-heptane 1.44
    ethyl formate 95.04
    1,2-dichloroethane 63.45
    n-hexanol 47.56
    2-methoxyethanol 221.32
    isobutyl acetate 17.84
    tetrachloromethane 23.13
    n-pentyl acetate 27.95
    transcutol 104.95
    n-heptanol 29.39
    ethylbenzene 6.05
    MIBK 22.35
    2-propoxyethanol 107.99
    tert-butanol 53.7
    MTBE 18.21
    2-butoxyethanol 68.64
    propionic acid 144.78
    o-xylene 8.46
    formic acid 465.08
    diethyl ether 16.33
    m-xylene 7.39
    p-xylene 10.66
    chlorobenzene 34.84
    dimethyl carbonate 31.13
    n-octane 0.82
    formamide 356.64
    cyclopentanone 130.66
    2-pentanone 38.13
    anisole 17.52
    cyclopentyl methyl ether 31.2
    gamma-butyrolactone 204.47
    1-methoxy-2-propanol 104.75
    pyridine 82.32
    3-pentanone 32.28
    furfural 222.62
    n-dodecane 0.65
    diethylene glycol 138.26
    diisopropyl ether 4.26
    tert-amyl alcohol 52.8
    acetylacetone 54.97
    n-hexadecane 0.71
    acetophenone 36.14
    methyl propionate 44.7
    isopentyl acetate 33.05
    trichloroethylene 184.16
    n-nonanol 14.93
    cyclohexanol 54.37
    benzyl alcohol 44.09
    2-ethylhexanol 22.39
    isooctanol 21.09
    dipropyl ether 9.07
    1,2-dichlorobenzene 39.27
    ethyl lactate 39.19
    propylene carbonate 128.23
    n-methylformamide 182.21
    2-pentanol 28.68
    n-pentane 1.59
    1-propoxy-2-propanol 56.86
    1-methoxy-2-propyl acetate 42.34
    2-(2-methoxypropoxy) propanol 44.67
    mesitylene 5.13
    ε-caprolactone 106.7
    p-cymene 8.1
    epichlorohydrin 147.79
    1,1,1-trichloroethane 58.49
    2-aminoethanol 144.89
    morpholine-4-carbaldehyde 162.43
    sulfolane 210.15
    2,2,4-trimethylpentane 1.52
    2-methyltetrahydrofuran 66.58
    n-hexyl acetate 31.26
    isooctane 0.88
    2-(2-butoxyethoxy)ethanol 59.71
    sec-butyl acetate 15.52
    tert-butyl acetate 24.69
    decalin 1.59
    glycerin 186.37
    diglyme 87.86
    acrylic acid 185.02
    isopropyl myristate 9.34
    n-butyric acid 144.23
    acetyl acetate 41.89
    di(2-ethylhexyl) phthalate 24.08
    ethyl propionate 22.5
    nitromethane 363.01
    1,2-diethoxyethane 19.89
    benzonitrile 43.97
    trioctyl phosphate 16.59
    1-bromopropane 19.6
    gamma-valerolactone 210.1
    n-decanol 10.75
    triethyl phosphate 18.94
    4-methyl-2-pentanol 16.19
    propionitrile 42.64
    vinylene carbonate 128.22
    1,1,2-trichlorotrifluoroethane 223.11
    DMS 34.12
    cumene 5.9
    2-octanol 16.3
    2-hexanone 26.79
    octyl acetate 15.49
    limonene 11.2
    1,2-dimethoxyethane 82.4
    ethyl orthosilicate 16.45
    tributyl phosphate 17.14
    diacetone alcohol 55.24
    N,N-dimethylaniline 15.58
    acrylonitrile 73.55
    aniline 34.93
    1,3-propanediol 154.49
    bromobenzene 23.3
    dibromomethane 50.25
    1,1,2,2-tetrachloroethane 143.65
    2-methyl-cyclohexyl acetate 28.97
    tetrabutyl urea 22.61
    diisobutyl methanol 10.26
    2-phenylethanol 48.66
    styrene 6.92
    dioctyl adipate 18.14
    dimethyl sulfate 61.28
    ethyl butyrate 22.22
    methyl lactate 65.43
    butyl lactate 39.65
    diethyl carbonate 19.03
    propanediol butyl ether 63.97
    triethyl orthoformate 18.42
    p-tert-butyltoluene 7.67
    methyl 4-tert-butylbenzoate 36.65
    morpholine 108.55
    tert-butylamine 25.93
    n-dodecanol 7.78
    dimethoxymethane 66.39
    ethylene carbonate 92.63
    cyrene 79.6
    2-ethoxyethyl acetate 38.18
    2-ethylhexyl acetate 25.38
    1,2,4-trichlorobenzene 56.04
    4-methylpyridine 55.36
    dibutyl ether 6.7
    2,6-dimethyl-4-heptanol 10.26
    DEF 50.6
    dimethyl isosorbide 75.63
    tetrachloroethylene 115.38
    eugenol 50.27
    triacetin 36.09
    span 80 45.97
    1,4-butanediol 70.72
    1,1-dichloroethane 51.44
    2-methyl-1-pentanol 32.21
    methyl formate 170.03
    2-methyl-1-butanol 43.06
    n-decane 0.97
    butyronitrile 38.68
    3,7-dimethyl-1-octanol 14.7
    1-chlorooctane 5.59
    1-chlorotetradecane 2.36
    n-nonane 0.86
    undecane 0.78
    tert-butylcyclohexane 1.4
    cyclooctane 0.91
    cyclopentanol 79.5
    tetrahydropyran 47.42
    tert-amyl methyl ether 16.66
    2,5,8-trioxanonane 58.22
    1-hexene 4.57
    2-isopropoxyethanol 48.16
    2,2,2-trifluoroethanol 218.94
    methyl butyrate 38.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction