Methylserine

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  • Identifiers

    CAS number
    2480-26-4

    Molecular formula
    C4H9NO3

    SMILES
    CN[C@@H](CO)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 61.0%
    Sweet 44.75%
    Savory 29.03%
    Meaty 22.19%
    Fishy 19.91%
    Bitter 18.84%
    Milky 16.89%
    Cheesy 16.22%
    Alcoholic 15.91%
    Cooked 15.7%

     

    Flavor
    Odorless 73.44%
    Mild 33.15%
    Bland 26.54%
    Very mild 26.08%
    Sweet-like 24.26%
    Yeast 23.36%
    Sour 22.39%
    Acidic 22.26%
    Faint 20.33%
    Stinky 19.68%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.9

    pKa est.
    6.44 (neutral)

    Molecular weight
    119.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    288°C

    Flash point

    • 159.38 ˚C est.

  • Synonyms

    • N-Methyl-L-serine
    • 2480-26-4
    • methylserine
    • N-Methylserine
    • Aquaserine
    • Serine, N-methyl-, L-
    • L-Serine, N-methyl
    • N-Methyl-(S)-serine
    • (S)-3-Hydroxy-2-methylaminopropionic acid
    • B6423FC3I2
    • DTXSID10179498
    • RefChem:818694
    • METHYLSERINE [INCI]
    • DTXCID40101989
    • H-N-Me-Ser-OH
    • N-Me-Ser-OH
    • (S)-3-Hydroxy-2-(methylamino)propanoic acid
    • (2S)-3-Hydroxy-2-(methylamino)propanoic acid
    • MFCD00037756
    • (2S)-3-hydroxy-2-(methylazaniumyl)propanoate
    • H-N-Me-Ser-OH.HCl
    • H-Meser-OH
    • L-Serine, N-methyl-
    • UNII-B6423FC3I2
    • methyl-l-serine
    • L-Serine,N-methyl-
    • H-MeSer-OH HCl
    • SCHEMBL163350
    • CHEBI:172327
    • AKOS006275623
    • CS-W013588
    • HY-W012872
    • N-Methyl-L-serine, >=98% (TLC)
    • DA-74239
    • MS-22753
    • PD196863
    • SY066216
    • F10793
    • F450576
    • (2S)-3-HYDROXY-2-(METHYLAMMONIO)PROPANOATE
    • Q27274419
    • 2480-26-4

  • Applications

    Methylserine (CAS 2480-26-4) is mainly used as an intermediate in organic synthesis and in the preparation of amino acid derivatives, typically serving as an intermediate for pharmaceuticals and peptide-like compounds; it also functions as a building block for peptides and peptidomimetics in pharmaceutical research. It can also be used as a chiral starting point for asymmetric synthesis and is considered a reagent in medicinal chemistry and materials science research. In polymer and materials contexts, methylserine may serve as a functional building block or linker for new polymer systems. These applications are primarily in pharmaceutical synthesis, organic synthesis, and materials research, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.22
    methanol 11.34
    isopropanol 0.28
    water 363.87
    ethyl acetate 0.25
    n-propanol 0.74
    acetone 0.39
    n-butanol 0.53
    acetonitrile 0.35
    DMF 21.4
    toluene 0.05
    isobutanol 0.57
    1,4-dioxane 1.03
    methyl acetate 0.27
    THF 1.92
    2-butanone 0.32
    n-pentanol 0.36
    sec-butanol 0.41
    n-hexane 0.04
    ethylene glycol 48.16
    NMP 98.57
    cyclohexane 0.08
    DMSO 102.91
    n-butyl acetate 0.45
    n-octanol 0.56
    chloroform 0.1
    n-propyl acetate 0.21
    acetic acid 24.46
    dichloromethane 0.18
    cyclohexanone 2.28
    propylene glycol 15.9
    isopropyl acetate 0.22
    DMAc 22.59
    2-ethoxyethanol 5.16
    isopentanol 0.65
    n-heptane 0.14
    ethyl formate 0.77
    1,2-dichloroethane 0.24
    n-hexanol 0.94
    2-methoxyethanol 15.58
    isobutyl acetate 0.16
    tetrachloromethane 0.12
    n-pentyl acetate 0.43
    transcutol 13.24
    n-heptanol 0.96
    ethylbenzene 0.06
    MIBK 0.52
    2-propoxyethanol 5.36
    tert-butanol 0.89
    MTBE 0.18
    2-butoxyethanol 3.64
    propionic acid 5.06
    o-xylene 0.18
    formic acid 250.92
    diethyl ether 0.1
    m-xylene 0.15
    p-xylene 0.09
    chlorobenzene 0.08
    dimethyl carbonate 0.57
    n-octane 0.06
    formamide 104.15
    cyclopentanone 2.78
    2-pentanone 0.36
    anisole 0.2
    cyclopentyl methyl ether 0.85
    gamma-butyrolactone 7.0
    1-methoxy-2-propanol 5.77
    pyridine 0.4
    3-pentanone 0.35
    furfural 10.93
    n-dodecane 0.03
    diethylene glycol 20.72
    diisopropyl ether 0.1
    tert-amyl alcohol 1.26
    acetylacetone 1.17
    n-hexadecane 0.04
    acetophenone 0.65
    methyl propionate 0.51
    isopentyl acetate 0.53
    trichloroethylene 0.34
    n-nonanol 0.57
    cyclohexanol 1.28
    benzyl alcohol 0.64
    2-ethylhexanol 0.75
    isooctanol 0.84
    dipropyl ether 0.36
    1,2-dichlorobenzene 0.2
    ethyl lactate 1.61
    propylene carbonate 2.85
    n-methylformamide 11.93
    2-pentanol 0.29
    n-pentane 0.04
    1-propoxy-2-propanol 3.22
    1-methoxy-2-propyl acetate 1.4
    2-(2-methoxypropoxy) propanol 6.16
    mesitylene 0.21
    ε-caprolactone 3.14
    p-cymene 0.3
    epichlorohydrin 1.9
    1,1,1-trichloroethane 0.1
    2-aminoethanol 26.05
    morpholine-4-carbaldehyde 31.36
    sulfolane 52.59
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 0.93
    n-hexyl acetate 0.65
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 6.78
    sec-butyl acetate 0.17
    tert-butyl acetate 0.58
    decalin 0.07
    glycerin 79.4
    diglyme 10.04
    acrylic acid 11.49
    isopropyl myristate 0.32
    n-butyric acid 2.87
    acetyl acetate 0.35
    di(2-ethylhexyl) phthalate 1.29
    ethyl propionate 0.28
    nitromethane 9.59
    1,2-diethoxyethane 0.57
    benzonitrile 0.33
    trioctyl phosphate 0.97
    1-bromopropane 0.07
    gamma-valerolactone 12.12
    n-decanol 0.43
    triethyl phosphate 0.88
    4-methyl-2-pentanol 0.43
    propionitrile 0.24
    vinylene carbonate 2.42
    1,1,2-trichlorotrifluoroethane 14.4
    DMS 0.82
    cumene 0.12
    2-octanol 0.44
    2-hexanone 0.27
    octyl acetate 0.49
    limonene 0.49
    1,2-dimethoxyethane 2.65
    ethyl orthosilicate 0.73
    tributyl phosphate 0.99
    diacetone alcohol 3.97
    N,N-dimethylaniline 0.51
    acrylonitrile 0.57
    aniline 0.32
    1,3-propanediol 11.83
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.43
    2-methyl-cyclohexyl acetate 0.94
    tetrabutyl urea 1.89
    diisobutyl methanol 0.63
    2-phenylethanol 0.92
    styrene 0.04
    dioctyl adipate 0.81
    dimethyl sulfate 4.81
    ethyl butyrate 0.52
    methyl lactate 4.74
    butyl lactate 1.83
    diethyl carbonate 0.35
    propanediol butyl ether 6.03
    triethyl orthoformate 0.65
    p-tert-butyltoluene 0.31
    methyl 4-tert-butylbenzoate 2.95
    morpholine 1.86
    tert-butylamine 0.36
    n-dodecanol 0.33
    dimethoxymethane 1.88
    ethylene carbonate 1.41
    cyrene 14.51
    2-ethoxyethyl acetate 0.81
    2-ethylhexyl acetate 0.44
    1,2,4-trichlorobenzene 0.3
    4-methylpyridine 0.32
    dibutyl ether 0.21
    2,6-dimethyl-4-heptanol 0.63
    DEF 2.37
    dimethyl isosorbide 10.03
    tetrachloroethylene 0.58
    eugenol 3.9
    triacetin 1.66
    span 80 6.02
    1,4-butanediol 4.94
    1,1-dichloroethane 0.06
    2-methyl-1-pentanol 0.53
    methyl formate 5.19
    2-methyl-1-butanol 0.72
    n-decane 0.05
    butyronitrile 0.21
    3,7-dimethyl-1-octanol 0.62
    1-chlorooctane 0.13
    1-chlorotetradecane 0.07
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.06
    cyclooctane 0.06
    cyclopentanol 1.95
    tetrahydropyran 0.32
    tert-amyl methyl ether 0.35
    2,5,8-trioxanonane 9.87
    1-hexene 0.06
    2-isopropoxyethanol 2.08
    2,2,2-trifluoroethanol 18.3
    methyl butyrate 0.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction