Methylpyrrolidone

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  • Identifiers

    CAS number
    872-50-4

    Molecular formula
    C5H9NO

    SMILES
    CN1CCCC1=O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Nutty 43.63%
    Burnt 38.47%
    Roasted 37.23%
    Caramellic 36.3%
    Popcorn 35.83%
    Sweet 34.81%
    Fishy 26.96%
    Odorless 25.75%
    Musty 23.51%
    Spicy 22.34%

     

    Flavor
    Bitter 38.8%
    Minty 26.94%
    Fenugreek 21.74%
    Caramel 21.65%
    Roasted 21.48%
    Maple syrup 21.36%
    Nutty 21.26%
    Others 21.18%
    Extremely sweet 21.16%
    Cotton candy 21.15%

     

    Odor impact est.
    Medium

    Odor threshold

    • Odor Threshold Low: 4.0 [mmHg]. Odor Threshold High: 10.0 [mmHg]. Odor thresholds from CSH

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    7.81 (neutral)

    Molecular weight
    99.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • -9 °F (NTP, 1992)
    • -25 °C
    • -24.4 °C
    • -9 °F

    Boiling point

    • 396 °F at 760 mmHg (NTP, 1992)
    • 202 °C at 760 mm Hg
    • 202 °C
    • 396 °F

    Flash point

    • 75.69 ˚C est.
    • 204 °F (NTP, 1992)
    • 96 °C
    • 204 °F (96 °C) (OPEN CUP)
    • 86 °C c.c.
    • 204 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Miscible with water, alcohol, ether, acetone, ethyl acetate, chloroform, benzene
    • Miscible with castor oil
    • Miscible with lower alcohols and ketones
    • Moderately soluble in aliphatic hydrocarbons and dissolves many organic and inorganic compounds.
    • Solubility in water: miscible

  • Synonyms

    • 1-METHYL-2-PYRROLIDINONE
    • 872-50-4
    • N-Methylpyrrolidone
    • N-Methyl-2-pyrrolidone
    • 1-methylpyrrolidin-2-one
    • Methylpyrrolidone
    • N-Methyl-2-pyrrolidinone
    • 1-Methyl-2-pyrrolidone
    • M-Pyrol
    • Methyl pyrrolidone
    • 1-Methylpyrrolidone
    • 1-Methylpyrrolidinone
    • N-Methylpyrrolidinone
    • n-methyl-pyrrolidone
    • 2-Pyrrolidinone, 1-methyl-
    • 1-Methyl-5-pyrrolidinone
    • 1-Methylazacyclopentan-2-one
    • NMP
    • N-methylpyrrolidin-2-one
    • N-Methyl-gamma-butyrolactam
    • N-methyl pyrrolidone
    • pharmasolve
    • 1-methylpyrrolidine-2-one
    • N-methyl pyrrolidinone
    • Methyl-2-pyrrolidinone
    • 2687-44-7
    • 1-methyl-2-pyrrolidon
    • Methylpyrrolidinone
    • Agsolex 1
    • 2-Pyrrolidinone, methyl-
    • N-Methyl-alpha-pyrrolidone
    • N-Methyl-alpha-pyrrolidinone
    • NSC 4594
    • CCRIS 1633
    • Methylpyrrolidone [NF]
    • N-Methylpyrrolid-2-one
    • 51013-18-4
    • DTXSID6020856
    • HSDB 5022
    • UNII-JR9CE63FPM
    • JR9CE63FPM
    • NSC-4594
    • Pyrol M
    • 26138-58-9
    • EINECS 212-828-1
    • MFCD00003193
    • Microposit 2001
    • CHEBI:7307
    • AI3-23116
    • 1-methyl-2-pyrolidinone
    • 1-methyl-pyrrolidin-2-one
    • N-Methyl-.alpha.-pyrrolidone
    • CHEMBL12543
    • DTXCID60856
    • N-Methyl-.gamma.-butyrolactam
    • N-Methyl-.alpha.-pyrrolidinone
    • NSC4594
    • EC 212-828-1
    • N 0131
    • 1-Methyl-2-pyrrolidinone, distilled
    • 1-Methyl-2-pyrrolidinone, HPLC Grade
    • SL 1332
    • M 0418
    • METHYL PYRROLIDONE (II)
    • METHYL PYRROLIDONE [II]
    • METHYLPYRROLIDONE (USP-RS)
    • METHYLPYRROLIDONE [USP-RS]
    • N-METHYLPYRROLIDONE (MART.)
    • N-METHYLPYRROLIDONE [MART.]
    • N-METHYLPYRROLIDONE (USP-RS)
    • N-METHYLPYRROLIDONE [USP-RS]
    • N-Methylpyrrolidon
    • CAS-872-50-4
    • N-METHYLPYRROLIDONE (EP MONOGRAPH)
    • N-METHYLPYRROLIDONE [EP MONOGRAPH]
    • N-methyl-pyrrolidinone
    • N-Methylpyrrolidone; 1-Methylpyrrolidin-2-one
    • Methylpyrrolidone, N-
    • Pyrrolidinone, methyl-
    • N-Methyl-2-pyrrolidon
    • 1-methyl-2-pyrolidone
    • N-methyl-pyrrolidin-2-one
    • 1-Methyl-2-pyrrolidinone, puriss. p.a., >=99.0% (GC)
    • Micropure ultra
    • N-methylpyrolidone
    • N-methypyrrolidone
    • Max-1 peptide
    • N-methylpirrolidone
    • 1methylpyrrolidinone
    • n-methyl pyrrolidon
    • N-methy pyrrolidone
    • N-methyl-pyrolidone
    • N-methyl-pyrrolidon
    • N-methylpyrolidinone
    • 1-methylpyrolidinone
    • n-methylpyrollidinone
    • N-methlypyrrolidinone
    • N-methyl pirrolidone
    • N-methyl pyrollidone
    • N-methyl-pyrollidone
    • N-methylpyrrolidone-
    • 1-methyl pyrrolidone
    • 1-methyl-pyrrolidone
    • methyl-2-pyrrolidone
    • N-methy pyrrolidinone
    • N-methyl pyrolidinone
    • N-methyl-pyrolidinone
    • N-methyl- pyrrolidone
    • N-methylpyrro-lidinone
    • N-methylpyrroli-dinone
    • N-methylpyrrolidin-one
    • 1-methyl-2pyrrolidone
    • 1-methyl2-pyrrolidone
    • 1methyl-2-pyrrolidone
    • 1-methyl pyrrolidinone
    • 1-methyl-pyrrolidinone
    • methylpyrrolidin-2-one
    • N-methy-2-pyrrolidone
    • N-methyl 2-pyrolidone
    • N-methyl-2-pyrolidone
    • PYROL-M
    • 3p1d
    • N-methyl 2-pyrrolidone
    • N-methyl-2-pyrollidone
    • 1-methyl-2-pirrolidone
    • 1-methyl-2-pyroldinone
    • 1-methylpyrrolid-2-one
    • 1methyl-2-pyrrolidinone

  • Applications

    Methylpyrrolidone (CAS 872-50-4) is a polar aprotic solvent widely used across industries. In coatings and inks, it serves as a primary solvent for resins and color carriers; in adhesives, it acts as a solvent and processing aid; in industrial cleaning and paint stripping, it is used for cleaning and degreasing tasks; in electronics and semiconductor manufacturing, it is used in cleaning formulations and in steps involving polymer binders; and in the polymers/plastics sector, it is used to dissolve many polymers and as a solvent for PVDF binders in lithium-ion battery electrode slurries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1373.35
    methanol 2633.33
    isopropanol 738.97
    water 924.15
    ethyl acetate 183.27
    n-propanol 692.14
    acetone 393.49
    n-butanol 535.86
    acetonitrile 620.26
    DMF 924.91
    toluene 69.82
    isobutanol 540.78
    1,4-dioxane 278.88
    methyl acetate 282.36
    THF 292.21
    2-butanone 233.1
    n-pentanol 300.82
    sec-butanol 475.2
    n-hexane 6.07
    ethylene glycol 555.28
    NMP 449.14
    cyclohexane 6.88
    DMSO 453.96
    n-butyl acetate 52.13
    n-octanol 67.68
    chloroform 1070.05
    n-propyl acetate 67.68
    acetic acid 1802.73
    dichloromethane 822.98
    cyclohexanone 205.91
    propylene glycol 508.87
    isopropyl acetate 85.81
    DMAc 586.91
    2-ethoxyethanol 515.0
    isopentanol 394.17
    n-heptane 3.62
    ethyl formate 348.94
    1,2-dichloroethane 249.76
    n-hexanol 119.14
    2-methoxyethanol 1032.57
    isobutyl acetate 41.35
    tetrachloromethane 173.07
    n-pentyl acetate 70.48
    transcutol 542.43
    n-heptanol 92.2
    ethylbenzene 29.07
    MIBK 86.15
    2-propoxyethanol 229.26
    tert-butanol 456.38
    MTBE 145.43
    2-butoxyethanol 212.65
    propionic acid 684.53
    o-xylene 55.95
    formic acid 2118.14
    diethyl ether 124.81
    m-xylene 47.67
    p-xylene 54.32
    chlorobenzene 152.82
    dimethyl carbonate 78.48
    n-octane 2.34
    formamide 2167.5
    cyclopentanone 312.15
    2-pentanone 148.62
    anisole 101.56
    cyclopentyl methyl ether 98.48
    gamma-butyrolactone 444.91
    1-methoxy-2-propanol 486.7
    pyridine 470.47
    3-pentanone 85.65
    furfural 637.22
    n-dodecane 2.34
    diethylene glycol 265.18
    diisopropyl ether 21.62
    tert-amyl alcohol 374.69
    acetylacetone 138.52
    n-hexadecane 2.44
    acetophenone 103.31
    methyl propionate 153.89
    isopentyl acetate 51.87
    trichloroethylene 718.45
    n-nonanol 57.73
    cyclohexanol 188.79
    benzyl alcohol 206.37
    2-ethylhexanol 46.57
    isooctanol 72.58
    dipropyl ether 23.85
    1,2-dichlorobenzene 142.1
    ethyl lactate 67.09
    propylene carbonate 215.86
    n-methylformamide 1094.89
    2-pentanol 231.89
    n-pentane 10.76
    1-propoxy-2-propanol 123.57
    1-methoxy-2-propyl acetate 65.85
    2-(2-methoxypropoxy) propanol 111.85
    mesitylene 24.05
    ε-caprolactone 202.68
    p-cymene 19.76
    epichlorohydrin 428.15
    1,1,1-trichloroethane 295.9
    2-aminoethanol 1017.0
    morpholine-4-carbaldehyde 445.61
    sulfolane 306.2
    2,2,4-trimethylpentane 8.45
    2-methyltetrahydrofuran 219.87
    n-hexyl acetate 82.0
    isooctane 4.58
    2-(2-butoxyethoxy)ethanol 179.48
    sec-butyl acetate 42.15
    tert-butyl acetate 67.17
    decalin 4.62
    glycerin 582.51
    diglyme 297.6
    acrylic acid 725.0
    isopropyl myristate 21.81
    n-butyric acid 644.32
    acetyl acetate 120.56
    di(2-ethylhexyl) phthalate 44.09
    ethyl propionate 51.11
    nitromethane 1489.91
    1,2-diethoxyethane 86.31
    benzonitrile 247.98
    trioctyl phosphate 25.01
    1-bromopropane 114.67
    gamma-valerolactone 470.8
    n-decanol 36.56
    triethyl phosphate 26.95
    4-methyl-2-pentanol 113.12
    propionitrile 346.99
    vinylene carbonate 266.01
    1,1,2-trichlorotrifluoroethane 533.53
    DMS 62.55
    cumene 25.69
    2-octanol 53.97
    2-hexanone 70.36
    octyl acetate 35.07
    limonene 23.3
    1,2-dimethoxyethane 294.12
    ethyl orthosilicate 26.49
    tributyl phosphate 28.71
    diacetone alcohol 159.09
    N,N-dimethylaniline 72.28
    acrylonitrile 557.28
    aniline 274.92
    1,3-propanediol 855.35
    bromobenzene 112.38
    dibromomethane 399.04
    1,1,2,2-tetrachloroethane 457.6
    2-methyl-cyclohexyl acetate 38.64
    tetrabutyl urea 36.6
    diisobutyl methanol 25.36
    2-phenylethanol 127.16
    styrene 44.08
    dioctyl adipate 37.26
    dimethyl sulfate 120.26
    ethyl butyrate 39.23
    methyl lactate 143.14
    butyl lactate 76.19
    diethyl carbonate 30.53
    propanediol butyl ether 188.14
    triethyl orthoformate 31.73
    p-tert-butyltoluene 18.48
    methyl 4-tert-butylbenzoate 93.07
    morpholine 444.22
    tert-butylamine 252.99
    n-dodecanol 23.29
    dimethoxymethane 256.57
    ethylene carbonate 165.36
    cyrene 115.18
    2-ethoxyethyl acetate 109.56
    2-ethylhexyl acetate 34.98
    1,2,4-trichlorobenzene 175.79
    4-methylpyridine 387.37
    dibutyl ether 31.35
    2,6-dimethyl-4-heptanol 25.36
    DEF 225.44
    dimethyl isosorbide 128.44
    tetrachloroethylene 420.1
    eugenol 117.06
    triacetin 83.85
    span 80 102.41
    1,4-butanediol 365.71
    1,1-dichloroethane 361.23
    2-methyl-1-pentanol 227.99
    methyl formate 570.61
    2-methyl-1-butanol 395.99
    n-decane 3.82
    butyronitrile 329.78
    3,7-dimethyl-1-octanol 56.9
    1-chlorooctane 20.69
    1-chlorotetradecane 7.35
    n-nonane 3.35
    undecane 2.86
    tert-butylcyclohexane 5.74
    cyclooctane 2.42
    cyclopentanol 276.36
    tetrahydropyran 147.17
    tert-amyl methyl ether 99.19
    2,5,8-trioxanonane 179.88
    1-hexene 31.24
    2-isopropoxyethanol 247.12
    2,2,2-trifluoroethanol 717.77
    methyl butyrate 92.49

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction