Methylamine

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  • Identifiers

    CAS number
    74-89-5

    Molecular formula
    CH5N

    SMILES
    CN

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 78.57%
    Cheesy 76.12%
    Ripe 61.72%
    Odorless 32.43%
    Fermented 31.48%
    Oily 29.35%
    Pungent 24.18%
    Alcoholic 24.07%
    Sweaty 22.96%
    Meaty 20.63%

     

    Flavor
    Fishy 35.77%
    Egg 34.93%
    Gasoline 29.52%
    Rotten 28.55%
    Sulfur 28.39%
    Garlic 26.46%
    Decomposing cabbage 26.3%
    Ammoniacal 25.99%
    Ammonia 24.24%
    Pungent 19.64%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.0009 [ppm]. Odor Threshold High: 4.68 [ppm]. Detection odor threshold from AIHA (mean = 4.7 ppm)
    • The odor of methylamine is faint but readily detectable at less than 10 ppm, becomes strong at from 20 to 100 ppm and intolerably ammoniacal at 100 to 500 ppm.
    • Odor recognition in air= 2.10X10-2 ppm (purity not specified)
    • Low: 0.0252 mg/cu m; High: 12.0 mg/cu m

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    8.63 (weak base)

    Molecular weight
    31.057 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -134.5 °F (USCG, 1999)
    • -93.4 °C
    • -93.42 °C
    • -93 °C
    • -39 °C
    • -136 °F

    Boiling point

    • 20.3 °F at 760 mmHg (USCG, 1999)
    • 20.66 °F at 760 mmHg (USCG, 1999)
    • -6.3 °C
    • -6.4 °C
    • BP: -6.3 °C at 760 mm Hg; -19.7 °C at 400 mm Hg; -32.4 °C at 200 mm Hg; -43.7 °C at 100 mm Hg; -73.8 °C at 10 mm Hg
    • -6 °C
    • 48 °C
    • 20.3 °F
    • 21 °F

    Flash point

    • -20.79 ˚C est.
    • 14 °F (Liquid) (NIOSH, 2024)
    • 32 °F (USCG, 1999)
    • The Guide from the Emergency Response Guidebook is for "methylamine, anhydrous." 32 °F
    • -10 °C (14 °F) - closed cup /Methylamine solution 30-50%/
    • 32 °F (closed cup)
    • Flammable gas
    • -10 °C
    • NA (Gas) 14 °F (Liquid)

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
    • 1080000 mg/L (at 25 °C)
    • Very soluble in water
    • 1 volume of water at 12.5 °C dissolves 1154 volumes of gas; at 25 °C dissolves 959 volumes of gas; 10.5 g is contained in 100 mL saturated benzene solution
    • Soluble in ethanol, benzene, and acetone; miscible with ether
    • Solubilities in various solvents at 1 atm and 20 °C.. Table: 255Q [Table#2189]
    • 1080 mg/mL at 25 °C
    • Solubility in water at 25 °C: very good
    • Soluble

  • Synonyms

    • METHYLAMINE
    • Methanamine
    • Aminomethane
    • Monomethylamine
    • 74-89-5
    • Carbinamine
    • Mercurialin
    • N-Methylamine
    • Methylaminen
    • Metilamine
    • Metyloamina
    • Anhydrous Methylamine
    • BSF23SJ79E
    • AI3-15637-X
    • Methylamine, anhydrous
    • DTXSID7025683
    • CHEBI:16830
    • monomethylammonium ion
    • Methylamine (aqueous)
    • Methylamine (anhydrous)
    • methylamine bisulfite
    • RefChem:42734
    • DTXCID305683
    • 200-820-0
    • Methylamine aq
    • Methylamine-d5
    • methyl-amine
    • MeNH2
    • CH3NH2
    • MFCD00008104
    • 3767-37-1
    • monomethyl amine
    • NME
    • Methylamine (33% in EtOH)
    • Methylamine (2.0M in THF)
    • Methylaminen [Dutch]
    • Metilamine [Italian]
    • Metyloamina [Polish]
    • methylamin
    • Methylamine (2.0M in methanol)
    • Methylamine (40% w/w in H2O)
    • METHYL-D3-AMINE (D, 98%)
    • CCRIS 2508
    • HSDB 810
    • CH5N
    • EINECS 200-820-0
    • UN1061
    • UN1235
    • UNII-BSF23SJ79E
    • methaneamine
    • methlamine
    • methlyamine
    • methyamine
    • methylammonia
    • methylarnine
    • metylamine
    • methyl group
    • methylamine-
    • mono-methylamine
    • N-methyl amine
    • methane, amino-
    • mono methyl amine
    • mono-methyl amine
    • 3P8
    • Methylamine anhydrous
    • Secondary-alkyl amine
    • H2NMe
    • NH2Me
    • METHYLAMINE [MI]
    • SCHEMBL632
    • SCHEMBL943
    • METHYLAMINE [HSDB]
    • H2NCH3
    • NH2CH3
    • EC 200-820-0
    • Methylamine (2M in THF)
    • Methylamine, >=99.0%
    • SCHEMBL5446
    • Methylamine, 2M in methanol
    • SCHEMBL24846
    • CH3-NH2
    • Integrase inhibitor, R3{3}
    • UN 1235 (Salt/Mix)
    • CHEMBL43280
    • Methylamine - 50% in water
    • Methylamine, 33% in ethanol
    • SCHEMBL106645
    • SCHEMBL183084
    • SCHEMBL216092
    • SCHEMBL383155
    • SCHEMBL3403275
    • SCHEMBL6915761
    • SCHEMBL7260209
    • SCHEMBL9910737
    • Methylamine, purum, >99.5%
    • SCHEMBL29453922
    • Methylamine, anhydrous, >=98%
    • Methylamine, ca. 2 M in ethanol
    • Methyl Of Gamma-N-Methylasparagine
    • Methylamine, 2M in tetrahydrofuran
    • PAA77955
    • STR00032
    • BDBM50416492
    • BP-11399B
    • STL281863
    • AKOS009031510
    • InChI=1/CH5N/c1-2/h2H2,1H
    • DB01828
    • Methylamine (ca. 9% in Acetonitrile)
    • Methylamine, 40 wt.% aqueous solution
    • UN 1061
    • FM159180
    • M0137
    • M1016
    • M2108
    • M2323
    • M2324
    • M3340
    • M3341
    • NS00004846
    • C00218
    • C22522
    • F049959
    • Methylamine (ca. 40% in Water, ca. 12mol/L)
    • Methylamine, 33 wt.% solution in absolute ethanol
    • Q409304
    • GADODIAMIDE HYDRATE IMPURITY C [EP IMPURITY]
    • 74-89-5

  • Applications

    Methylamine (CAS 74-89-5) is a versatile industrial amine used primarily as a building block in chemical synthesis. It serves as an intermediate for the production of pharmaceutical and agrochemical compounds, enabling the introduction of methylamino groups into APIs and other bioactive molecules. It is a key precursor in the production of methyl isocyanate, which is used to manufacture polyurethanes, coatings, foams, and other polymer materials. It is also employed as a curing agent in specialty epoxy resin formulations and as a reagent for N-alkylation to form higher-order amines in various chemical manufacturing processes. Additionally, methylamine is used as a precursor for certain amine-containing compounds in industrial synthesis. Usage is subject to local regulations and formulation limits, and handling requires appropriate safety controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 119.7
    methanol 329.8
    isopropanol 34.79
    water 66.27
    ethyl acetate 8.25
    n-propanol 66.32
    acetone 12.29
    n-butanol 43.8
    acetonitrile 17.6
    DMF 80.23
    toluene 1.09
    isobutanol 27.06
    1,4-dioxane 16.87
    methyl acetate 13.56
    THF 29.13
    2-butanone 8.62
    n-pentanol 16.85
    sec-butanol 22.94
    n-hexane 0.54
    ethylene glycol 170.06
    NMP 91.07
    cyclohexane 1.25
    DMSO 130.03
    n-butyl acetate 12.36
    n-octanol 5.02
    chloroform 31.8
    n-propyl acetate 5.49
    acetic acid 349.31
    dichloromethane 29.39
    cyclohexanone 19.35
    propylene glycol 95.78
    isopropyl acetate 2.78
    DMAc 31.77
    2-ethoxyethanol 35.51
    isopentanol 14.72
    n-heptane 1.5
    ethyl formate 30.14
    1,2-dichloroethane 13.69
    n-hexanol 20.31
    2-methoxyethanol 120.7
    isobutyl acetate 2.47
    tetrachloromethane 9.72
    n-pentyl acetate 5.59
    transcutol 33.28
    n-heptanol 9.17
    ethylbenzene 0.48
    MIBK 1.58
    2-propoxyethanol 42.71
    tert-butanol 17.93
    MTBE 2.82
    2-butoxyethanol 23.84
    propionic acid 117.04
    o-xylene 0.85
    formic acid 500.54
    diethyl ether 3.94
    m-xylene 0.66
    p-xylene 0.79
    chlorobenzene 6.04
    dimethyl carbonate 5.53
    n-octane 0.43
    formamide 266.16
    cyclopentanone 32.23
    2-pentanone 4.98
    anisole 2.09
    cyclopentyl methyl ether 7.2
    gamma-butyrolactone 71.37
    1-methoxy-2-propanol 40.49
    pyridine 28.3
    3-pentanone 3.76
    furfural 101.11
    n-dodecane 0.25
    diethylene glycol 68.7
    diisopropyl ether 0.6
    tert-amyl alcohol 13.69
    acetylacetone 5.49
    n-hexadecane 0.25
    acetophenone 3.76
    methyl propionate 10.13
    isopentyl acetate 6.46
    trichloroethylene 31.3
    n-nonanol 3.98
    cyclohexanol 21.11
    benzyl alcohol 9.12
    2-ethylhexanol 7.17
    isooctanol 5.06
    dipropyl ether 4.65
    1,2-dichlorobenzene 6.43
    ethyl lactate 10.22
    propylene carbonate 35.08
    n-methylformamide 130.6
    2-pentanol 10.54
    n-pentane 0.92
    1-propoxy-2-propanol 24.0
    1-methoxy-2-propyl acetate 8.64
    2-(2-methoxypropoxy) propanol 9.95
    mesitylene 0.44
    ε-caprolactone 25.05
    p-cymene 1.46
    epichlorohydrin 35.35
    1,1,1-trichloroethane 6.99
    2-aminoethanol 169.34
    morpholine-4-carbaldehyde 57.99
    sulfolane 108.96
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 15.4
    n-hexyl acetate 5.1
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 16.14
    sec-butyl acetate 1.91
    tert-butyl acetate 2.06
    decalin 0.33
    glycerin 160.64
    diglyme 24.46
    acrylic acid 163.18
    isopropyl myristate 1.56
    n-butyric acid 91.87
    acetyl acetate 6.62
    di(2-ethylhexyl) phthalate 5.22
    ethyl propionate 3.76
    nitromethane 137.57
    1,2-diethoxyethane 5.27
    benzonitrile 11.03
    trioctyl phosphate 3.96
    1-bromopropane 5.8
    gamma-valerolactone 52.98
    n-decanol 2.79
    triethyl phosphate 4.79
    4-methyl-2-pentanol 2.77
    propionitrile 14.8
    vinylene carbonate 41.84
    1,1,2-trichlorotrifluoroethane 99.71
    DMS 5.96
    cumene 0.51
    2-octanol 3.56
    2-hexanone 2.96
    octyl acetate 2.93
    limonene 2.37
    1,2-dimethoxyethane 17.61
    ethyl orthosilicate 3.97
    tributyl phosphate 4.68
    diacetone alcohol 7.4
    N,N-dimethylaniline 2.01
    acrylonitrile 33.04
    aniline 12.14
    1,3-propanediol 133.0
    bromobenzene 3.46
    dibromomethane 16.59
    1,1,2,2-tetrachloroethane 23.03
    2-methyl-cyclohexyl acetate 4.93
    tetrabutyl urea 5.6
    diisobutyl methanol 2.56
    2-phenylethanol 10.24
    styrene 0.91
    dioctyl adipate 3.85
    dimethyl sulfate 15.15
    ethyl butyrate 6.83
    methyl lactate 21.34
    butyl lactate 11.27
    diethyl carbonate 5.27
    propanediol butyl ether 20.54
    triethyl orthoformate 5.56
    p-tert-butyltoluene 1.33
    methyl 4-tert-butylbenzoate 6.12
    morpholine 36.55
    tert-butylamine 8.46
    n-dodecanol 2.11
    dimethoxymethane 14.3
    ethylene carbonate 26.88
    cyrene 15.8
    2-ethoxyethyl acetate 7.18
    2-ethylhexyl acetate 5.23
    1,2,4-trichlorobenzene 8.17
    4-methylpyridine 12.31
    dibutyl ether 2.03
    2,6-dimethyl-4-heptanol 2.56
    DEF 15.3
    dimethyl isosorbide 16.55
    tetrachloroethylene 29.04
    eugenol 10.53
    triacetin 6.19
    span 80 15.57
    1,4-butanediol 43.59
    1,1-dichloroethane 7.38
    2-methyl-1-pentanol 7.03
    methyl formate 65.04
    2-methyl-1-butanol 18.95
    n-decane 0.38
    butyronitrile 14.48
    3,7-dimethyl-1-octanol 3.15
    1-chlorooctane 1.41
    1-chlorotetradecane 0.56
    n-nonane 0.39
    undecane 0.29
    tert-butylcyclohexane 0.29
    cyclooctane 0.32
    cyclopentanol 40.51
    tetrahydropyran 11.6
    tert-amyl methyl ether 2.45
    2,5,8-trioxanonane 17.26
    1-hexene 1.5
    2-isopropoxyethanol 11.56
    2,2,2-trifluoroethanol 116.46
    methyl butyrate 7.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction