Methyl Syringate

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  • Identifiers

    CAS number
    884-35-5

    Molecular formula
    C10H12O5

    SMILES
    COC1=CC(=CC(=C1O)OC)C(=O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 71.86%
    Sweet 63.18%
    Vanilla 61.32%
    Spicy 49.59%
    Balsamic 46.53%
    Powdery 45.35%
    Green 44.75%
    Phenolic 44.66%
    Fruity 41.48%
    Woody 40.62%

     

    Flavor
    Woody 44.3%
    Bitter 39.27%
    Sweet 34.07%
    Smoky 31.16%
    Spice 30.72%
    Vanilla 29.47%
    Powdery 28.9%
    Phenolic 26.2%
    Eugenol 24.46%
    Creamy 24.14%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    6.73 (neutral)

    Molecular weight
    212.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    363°C

    Flash point

    • 138.52 ˚C est.

  • Synonyms

    • Methyl syringate
    • 884-35-5
    • Methyl 4-hydroxy-3,5-dimethoxybenzoate
    • Benzoic acid, 4-hydroxy-3,5-dimethoxy-, methyl ester
    • methyl 4-hydroxy-3,5-dimethoxy-benzoate
    • W5A196MP8A
    • CHEBI:45820
    • DTXSID00237016
    • NSC-16946
    • RefChem:158027
    • DTXCID00159507
    • 429-050-5
    • 618-163-7
    • Methyl 3,5-dimethoxy-4-hydroxybenzoate
    • MFCD00017199
    • Syringic acid methyl ester
    • SBB016976
    • AI3-36426
    • bmse010225
    • NOVOPRIME F 258
    • UNII-W5A196MP8A
    • 4-Hydroxy-3,5-dimethoxybenzoic Acid Methyl Ester
    • SCHEMBL159392
    • Syringic acid monomethyl ester
    • orb1303839
    • CHEMBL1236122
    • Methyl 3,5-dimethoxy-4-hydroxybenzoate; Methyl syringate
    • HMS3886A03
    • NSC611398
    • s4787
    • AKOS002911941
    • CCG-266660
    • CS-W002116
    • DB08589
    • DS-2684
    • EBC-615918
    • FD71054
    • HY-W002116
    • NSC-611398
    • methyl 3,5-dimethoxy-4-hydroxy-benzoate
    • SY032894
    • methyl (4-hydroxy-3,5-dimethoxy)benzoate
    • 530-57-4, Me
    • DB-057070
    • M2806
    • NS00004670
    • ST50307269
    • 3,5-Dimethoxy-4-hydroxybenzoic acid methyl ester
    • 884M355
    • F235488
    • Q27097791
    • 884-35-5

  • Applications

    Methyl Syringate (CAS 884-35-5) is used primarily as a fragrance ingredient and odorant in perfumery and cosmetics, contributing sweet, balsamic notes and serving as an intermediate in scent chemistry. It is also encountered as a fragrance constituent in some household products (air fresheners, cleaners) to impart or enhance aroma. In industrial contexts it may function as a fragrance intermediate for the synthesis of other aroma compounds, with usage depending on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 25.08
    methanol 36.79
    isopropanol 16.76
    water 0.96
    ethyl acetate 54.22
    n-propanol 18.51
    acetone 88.66
    n-butanol 14.47
    acetonitrile 53.49
    DMF 189.92
    toluene 14.02
    isobutanol 12.13
    1,4-dioxane 107.22
    methyl acetate 77.57
    THF 181.22
    2-butanone 54.54
    n-pentanol 11.87
    sec-butanol 15.12
    n-hexane 0.94
    ethylene glycol 25.63
    NMP 250.2
    cyclohexane 2.74
    DMSO 275.0
    n-butyl acetate 29.89
    n-octanol 10.24
    chloroform 64.49
    n-propyl acetate 37.07
    acetic acid 102.87
    dichloromethane 109.88
    cyclohexanone 79.38
    propylene glycol 10.66
    isopropyl acetate 32.0
    DMAc 193.48
    2-ethoxyethanol 64.02
    isopentanol 15.04
    n-heptane 1.98
    ethyl formate 46.87
    1,2-dichloroethane 75.81
    n-hexanol 13.51
    2-methoxyethanol 115.8
    isobutyl acetate 19.92
    tetrachloromethane 13.18
    n-pentyl acetate 20.31
    transcutol 98.27
    n-heptanol 11.57
    ethylbenzene 13.53
    MIBK 24.63
    2-propoxyethanol 49.55
    tert-butanol 40.32
    MTBE 35.44
    2-butoxyethanol 34.25
    propionic acid 39.22
    o-xylene 17.94
    formic acid 92.81
    diethyl ether 29.56
    m-xylene 13.06
    p-xylene 17.48
    chlorobenzene 24.34
    dimethyl carbonate 63.22
    n-octane 1.06
    formamide 236.25
    cyclopentanone 137.27
    2-pentanone 35.58
    anisole 46.08
    cyclopentyl methyl ether 51.45
    gamma-butyrolactone 220.89
    1-methoxy-2-propanol 53.36
    pyridine 86.7
    3-pentanone 36.02
    furfural 196.58
    n-dodecane 0.94
    diethylene glycol 63.97
    diisopropyl ether 9.26
    tert-amyl alcohol 31.25
    acetylacetone 79.27
    n-hexadecane 1.11
    acetophenone 60.2
    methyl propionate 57.57
    isopentyl acetate 30.94
    trichloroethylene 145.78
    n-nonanol 10.4
    cyclohexanol 21.71
    benzyl alcohol 36.11
    2-ethylhexanol 12.54
    isooctanol 11.01
    dipropyl ether 17.13
    1,2-dichlorobenzene 34.83
    ethyl lactate 25.0
    propylene carbonate 81.57
    n-methylformamide 107.37
    2-pentanol 10.1
    n-pentane 1.1
    1-propoxy-2-propanol 29.19
    1-methoxy-2-propyl acetate 47.24
    2-(2-methoxypropoxy) propanol 40.04
    mesitylene 9.46
    ε-caprolactone 79.48
    p-cymene 11.98
    epichlorohydrin 189.01
    1,1,1-trichloroethane 45.55
    2-aminoethanol 27.6
    morpholine-4-carbaldehyde 195.68
    sulfolane 258.97
    2,2,4-trimethylpentane 1.51
    2-methyltetrahydrofuran 89.24
    n-hexyl acetate 26.95
    isooctane 0.72
    2-(2-butoxyethoxy)ethanol 44.06
    sec-butyl acetate 24.06
    tert-butyl acetate 47.84
    decalin 2.6
    glycerin 36.99
    diglyme 117.0
    acrylic acid 55.0
    isopropyl myristate 12.32
    n-butyric acid 38.7
    acetyl acetate 51.87
    di(2-ethylhexyl) phthalate 15.74
    ethyl propionate 35.76
    nitromethane 294.39
    1,2-diethoxyethane 30.85
    benzonitrile 34.56
    trioctyl phosphate 10.67
    1-bromopropane 18.97
    gamma-valerolactone 183.29
    n-decanol 7.87
    triethyl phosphate 28.87
    4-methyl-2-pentanol 8.64
    propionitrile 28.97
    vinylene carbonate 79.95
    1,1,2-trichlorotrifluoroethane 141.69
    DMS 45.57
    cumene 10.78
    2-octanol 7.51
    2-hexanone 27.67
    octyl acetate 15.3
    limonene 15.27
    1,2-dimethoxyethane 111.31
    ethyl orthosilicate 25.13
    tributyl phosphate 13.15
    diacetone alcohol 54.11
    N,N-dimethylaniline 39.32
    acrylonitrile 53.4
    aniline 33.92
    1,3-propanediol 36.48
    bromobenzene 23.32
    dibromomethane 48.57
    1,1,2,2-tetrachloroethane 92.88
    2-methyl-cyclohexyl acetate 33.68
    tetrabutyl urea 20.39
    diisobutyl methanol 9.63
    2-phenylethanol 33.69
    styrene 15.8
    dioctyl adipate 23.85
    dimethyl sulfate 126.39
    ethyl butyrate 31.9
    methyl lactate 41.12
    butyl lactate 16.79
    diethyl carbonate 30.3
    propanediol butyl ether 22.26
    triethyl orthoformate 27.64
    p-tert-butyltoluene 11.6
    methyl 4-tert-butylbenzoate 47.03
    morpholine 113.2
    tert-butylamine 19.21
    n-dodecanol 6.02
    dimethoxymethane 124.36
    ethylene carbonate 60.91
    cyrene 64.74
    2-ethoxyethyl acetate 38.7
    2-ethylhexyl acetate 24.52
    1,2,4-trichlorobenzene 46.22
    4-methylpyridine 59.59
    dibutyl ether 12.27
    2,6-dimethyl-4-heptanol 9.63
    DEF 73.4
    dimethyl isosorbide 92.28
    tetrachloroethylene 79.33
    eugenol 40.4
    triacetin 45.35
    span 80 25.13
    1,4-butanediol 14.43
    1,1-dichloroethane 35.06
    2-methyl-1-pentanol 13.7
    methyl formate 102.56
    2-methyl-1-butanol 13.74
    n-decane 1.54
    butyronitrile 22.26
    3,7-dimethyl-1-octanol 10.96
    1-chlorooctane 7.0
    1-chlorotetradecane 3.21
    n-nonane 1.3
    undecane 1.18
    tert-butylcyclohexane 2.18
    cyclooctane 1.24
    cyclopentanol 32.35
    tetrahydropyran 49.93
    tert-amyl methyl ether 28.67
    2,5,8-trioxanonane 78.16
    1-hexene 4.1
    2-isopropoxyethanol 38.26
    2,2,2-trifluoroethanol 70.79
    methyl butyrate 44.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction