Methyl morpholine oxide

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  • Identifiers

    CAS number
    7529-22-8

    Molecular formula
    C5H11NO2

    SMILES
    C[N+]1(CCOCC1)[O-]

    Safety labels

    Flammable
    Flammable

    Oxidizer
    Oxidizer

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Sweet 37.45%
    Fishy 30.71%
    Odorless 26.77%
    Solvent 25.26%
    Musty 25.19%
    Mint 25.12%
    Nutty 23.58%
    Oily 20.3%
    Alcoholic 19.71%
    Woody 19.18%

     

    Flavor
    Sulfurous 40.71%
    Roasted 38.91%
    Meaty 28.81%
    Onion 26.41%
    Sulfury 25.81%
    Chicken 25.17%
    Bouillon 23.51%
    Vegetable 23.5%
    Alkaline 22.74%
    Fishy 22.7%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    3.9 (weak acid)

    Molecular weight
    117.15 g/mol

    Flash point

    • -380.24 ˚C est.

  • Synonyms

    • 7529-22-8
    • 4-Methylmorpholine 4-oxide
    • N-Methylmorpholine oxide
    • N-Methylmorpholine N-oxide
    • Morpholine, 4-methyl-, 4-oxide
    • Methyl morpholine oxide
    • 4-Methylmorpholine-4-oxide
    • 4-Methylmorpholine Oxide
    • 4-methylmorpholine-N-oxide
    • N-Methylmorpholine 4-oxide
    • NSC 73198
    • NSC 82153
    • EINECS 231-391-8
    • DTXSID3029287
    • NSC-73198
    • NSC-82153
    • 4-methylmorpholine 4-oxide, monohydrate
    • DTXCID509287
    • CHEBI:52093
    • EC 231-391-8
    • N-METHYLMORPHOLINE N-OXIDE [MI]
    • NMethylmorpholine oxide
    • 4Methylmorpholine4oxide
    • NMethylmorpholine Noxide
    • 4Methylmorpholine Noxide
    • RefChem:817860
    • Morpholine, 4methyl, 4oxide
    • METHYL MORPHOLINE OXIDE [INCI]
    • 4-methyl-4-oxidomorpholin-4-ium
    • N-Methylmorpholine-N-oxide
    • NMO
    • NMMO
    • 4-methyl-4-oxido-morpholin-4-ium
    • MFCD00005947
    • 4-methylmorpholin-4-ium-4-olate
    • ARC64PKJ0F
    • N-Methyl morpholine N-oxide
    • NSC73198
    • Morpholine, 4-oxide
    • 4-MethylmorpholineN-oxide
    • UNII-ARC64PKJ0F
    • 4-methyl morpholine N-oxide
    • 4-methyl-morpholine-N-oxide
    • n-methylmorpholineoxide
    • methylmorpholine N-oxide
    • methylmorpholine-N-oxide
    • 4-Methylmorpholine-oxide
    • N-methylmorpholin-N-oxid
    • 4methylmorpholine N-oxide
    • 4methylmorpholine-N oxide
    • 4methylmorpholine-N-oxide
    • N-methyl morpholine oxide
    • N-methyl morpholine-oxide
    • N-methyl-morpholine oxide
    • 4-methyl morpholine oxide
    • N-methylmopholine N-oxide
    • N-methylmorphline N-oxide
    • N-methylmorpholin-N-oxide
    • N-methymorpholine N-oxide
    • 4-methylmopholine N-oxide
    • 4-methylmorpholin-N-oxide
    • 4-Methylmorpholine4-oxide
    • 4-methymorpholine N-oxide
    • 4-methylmorpholin-4-oxide
    • N-methyimorpholine N-oxide
    • 4-methylmorpholine N oxide
    • 4-methylmorpholine-N oxide
    • N-methyl morpholin-N-oxide
    • 4-methy-morpholine-N-oxide
    • 4-methyl morpholin N-oxide
    • 4-methylnnorpholine N-oxide
    • SCHEMBL1845
    • N-methyl morpholine-N-oxide
    • N-methyl-morpholine N-oxide
    • N-methyl-morpholine-N-oxide
    • 4-methyl morpholine-N-oxide
    • 4-methyl-morpholine N-oxide
    • 4-methylmorpholine-N- oxide
    • NCIOpen2_000398
    • NCIOpen2_000960
    • 4-methyl morpholine-4-oxide
    • 4-methyl-morpholine 4-oxide
    • 4-methyl-morpholine-4-oxide
    • 4-Methylmorpholine 4-oxide, 50%aqueous solution
    • 4-methyl-morpholine-N- oxide
    • 4-Methylmorpholine N-oxideNMO
    • orb1310427
    • SCHEMBL3757453
    • CHEMBL3184330
    • LFTLOKWAGJYHHR-UHFFFAOYSA-
    • N-Methyl morpholine-N-oxide; NMO
    • 4-Methylmorpholine N-oxide, 97%
    • NSC82153
    • Tox21_200479
    • c1367
    • AKOS009159059
    • FM11086
    • FM16244
    • NCGC00248649-01
    • NCGC00258033-01
    • 4-Methyl-4-oxo-1,4lambda~5~-oxazinane
    • BP-30197
    • PD055432
    • 4-Methyl-1,4.lambda.~5~-oxazinan-4-ol
    • CAS-7529-22-8
    • CS-0016218
    • M0981
    • M2192
    • NS00009028
    • EN300-37514
    • D71257
    • F225495
    • F600966
    • Q416248
    • F0001-6019
    • N-Methylmorpholine N-oxide - 50% w/w aqueous solution
    • Z381542114
    • 4-methylmorpholine n-oxide (50% in water, ca. 4.8mol/l)
    • InChI=1/C5H11NO2/c1-6(7)2-4-8-5-3-6/h2-5H2,1H3
    • 7529-22-8

  • Applications

    Methyl morpholine oxide (CAS 7529-22-8) is primarily used as a solvent and processing aid in cellulose dissolution for Lyocell and other regenerated cellulose products, and it also serves as a polar solvent in coatings, inks, and polymer formulations. It is commonly employed as an intermediate or reagent in the synthesis of morpholine-containing compounds for pharmaceuticals and specialty chemicals. In addition, it may be used as a solvent or formulation component in cleaning products and other industrial formulations, with application limits governed by local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 172.88
    methanol 512.81
    isopropanol 63.52
    water 607.81
    ethyl acetate 50.68
    n-propanol 76.61
    acetone 78.44
    n-butanol 40.36
    acetonitrile 155.18
    DMF 262.85
    toluene 11.07
    isobutanol 37.81
    1,4-dioxane 103.08
    methyl acetate 88.49
    THF 76.45
    2-butanone 47.49
    n-pentanol 14.75
    sec-butanol 37.52
    n-hexane 1.52
    ethylene glycol 252.75
    NMP 234.08
    cyclohexane 4.95
    DMSO 157.62
    n-butyl acetate 11.89
    n-octanol 9.82
    chloroform 269.8
    n-propyl acetate 12.45
    acetic acid 532.04
    dichloromethane 238.43
    cyclohexanone 52.37
    propylene glycol 119.84
    isopropyl acetate 14.7
    DMAc 218.89
    2-ethoxyethanol 78.03
    isopentanol 18.0
    n-heptane 2.07
    ethyl formate 75.48
    1,2-dichloroethane 72.18
    n-hexanol 14.93
    2-methoxyethanol 264.9
    isobutyl acetate 5.85
    tetrachloromethane 51.29
    n-pentyl acetate 9.46
    transcutol 151.18
    n-heptanol 9.59
    ethylbenzene 4.67
    MIBK 7.65
    2-propoxyethanol 60.39
    tert-butanol 40.17
    MTBE 11.43
    2-butoxyethanol 30.59
    propionic acid 195.8
    o-xylene 13.33
    formic acid 1048.15
    diethyl ether 19.57
    m-xylene 8.11
    p-xylene 8.02
    chlorobenzene 29.85
    dimethyl carbonate 28.11
    n-octane 0.87
    formamide 816.97
    cyclopentanone 73.67
    2-pentanone 19.25
    anisole 18.03
    cyclopentyl methyl ether 21.11
    gamma-butyrolactone 151.05
    1-methoxy-2-propanol 100.24
    pyridine 95.52
    3-pentanone 25.05
    furfural 202.59
    n-dodecane 0.85
    diethylene glycol 110.18
    diisopropyl ether 2.79
    tert-amyl alcohol 27.5
    acetylacetone 32.21
    n-hexadecane 0.91
    acetophenone 22.89
    methyl propionate 56.17
    isopentyl acetate 8.78
    trichloroethylene 187.84
    n-nonanol 9.48
    cyclohexanol 32.89
    benzyl alcohol 27.67
    2-ethylhexanol 7.75
    isooctanol 6.6
    dipropyl ether 8.16
    1,2-dichlorobenzene 34.36
    ethyl lactate 20.56
    propylene carbonate 65.2
    n-methylformamide 298.16
    2-pentanol 14.45
    n-pentane 2.35
    1-propoxy-2-propanol 30.16
    1-methoxy-2-propyl acetate 22.52
    2-(2-methoxypropoxy) propanol 38.47
    mesitylene 4.6
    ε-caprolactone 62.77
    p-cymene 5.55
    epichlorohydrin 105.36
    1,1,1-trichloroethane 63.08
    2-aminoethanol 230.75
    morpholine-4-carbaldehyde 196.68
    sulfolane 124.76
    2,2,4-trimethylpentane 1.29
    2-methyltetrahydrofuran 44.78
    n-hexyl acetate 13.9
    isooctane 0.51
    2-(2-butoxyethoxy)ethanol 47.16
    sec-butyl acetate 6.53
    tert-butyl acetate 9.92
    decalin 1.59
    glycerin 239.63
    diglyme 83.11
    acrylic acid 262.53
    isopropyl myristate 5.43
    n-butyric acid 98.29
    acetyl acetate 44.88
    di(2-ethylhexyl) phthalate 11.55
    ethyl propionate 16.85
    nitromethane 527.74
    1,2-diethoxyethane 16.87
    benzonitrile 31.98
    trioctyl phosphate 6.01
    1-bromopropane 23.87
    gamma-valerolactone 140.95
    n-decanol 6.84
    triethyl phosphate 11.49
    4-methyl-2-pentanol 5.86
    propionitrile 66.51
    vinylene carbonate 85.79
    1,1,2-trichlorotrifluoroethane 209.71
    DMS 24.51
    cumene 4.07
    2-octanol 4.72
    2-hexanone 7.95
    octyl acetate 8.68
    limonene 7.58
    1,2-dimethoxyethane 62.4
    ethyl orthosilicate 10.03
    tributyl phosphate 8.17
    diacetone alcohol 23.05
    N,N-dimethylaniline 14.65
    acrylonitrile 123.71
    aniline 51.19
    1,3-propanediol 159.31
    bromobenzene 22.19
    dibromomethane 110.87
    1,1,2,2-tetrachloroethane 122.65
    2-methyl-cyclohexyl acetate 11.3
    tetrabutyl urea 11.87
    diisobutyl methanol 4.24
    2-phenylethanol 20.52
    styrene 6.86
    dioctyl adipate 12.45
    dimethyl sulfate 55.67
    ethyl butyrate 12.54
    methyl lactate 64.36
    butyl lactate 14.48
    diethyl carbonate 12.4
    propanediol butyl ether 32.63
    triethyl orthoformate 11.39
    p-tert-butyltoluene 5.19
    methyl 4-tert-butylbenzoate 24.53
    morpholine 126.66
    tert-butylamine 20.89
    n-dodecanol 5.19
    dimethoxymethane 63.08
    ethylene carbonate 56.17
    cyrene 40.98
    2-ethoxyethyl acetate 22.49
    2-ethylhexyl acetate 7.52
    1,2,4-trichlorobenzene 48.71
    4-methylpyridine 54.84
    dibutyl ether 6.28
    2,6-dimethyl-4-heptanol 4.24
    DEF 55.08
    dimethyl isosorbide 47.93
    tetrachloroethylene 128.45
    eugenol 30.32
    triacetin 30.98
    span 80 30.91
    1,4-butanediol 43.6
    1,1-dichloroethane 70.22
    2-methyl-1-pentanol 9.18
    methyl formate 171.49
    2-methyl-1-butanol 22.79
    n-decane 1.33
    butyronitrile 37.26
    3,7-dimethyl-1-octanol 8.54
    1-chlorooctane 4.7
    1-chlorotetradecane 2.21
    n-nonane 1.21
    undecane 1.01
    tert-butylcyclohexane 1.26
    cyclooctane 1.58
    cyclopentanol 52.47
    tetrahydropyran 40.56
    tert-amyl methyl ether 10.89
    2,5,8-trioxanonane 67.47
    1-hexene 4.01
    2-isopropoxyethanol 28.96
    2,2,2-trifluoroethanol 340.32
    methyl butyrate 20.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction