Methyl methoxyacetate

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  • Identifiers

    CAS number
    6290-49-9

    Molecular formula
    C4H8O3

    SMILES
    COCC(=O)OC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 82.09%
    Ethereal 71.5%
    Sweet 55.75%
    Caramellic 47.35%
    Rummy 45.15%
    Winey 39.64%
    Nutty 35.75%
    Fermented 35.46%
    Buttery 35.22%
    Sharp 32.25%

     

    Flavor
    Fruity 87.04%
    Sweet 67.5%
    Green 52.5%
    Apple 45.5%
    Pineapple 42.76%
    Bitter 42.31%
    Floral 38.79%
    Fruit 35.67%
    Banana 33.99%
    Tropical 33.35%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    6.1 (neutral)

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    124°C

    Flash point

    • 32.15 ˚C est.

  • Synonyms

    • Methyl methoxyacetate
    • 6290-49-9
    • Methyl 2-methoxyacetate
    • Methoxyacetic acid, methyl ester
    • Acetic acid, 2-methoxy-, methyl ester
    • N960NQ69LF
    • NSC-6701
    • NSC-61447
    • DTXSID3074608
    • RefChem:817859
    • DTXCID7043586
    • methyl ester of methoxyacetic acid
    • 228-539-9
    • Methy methoxy acetate
    • Acetic acid, methoxy-, methyl ester
    • Methoxyacetic acid methyl ester
    • CBC 108569
    • MFCD00008451
    • methoxy acetic acid methyl ester
    • 115171-85-2
    • Methyl-2-methoxyacetate
    • NSC 6701
    • EINECS 228-539-9
    • NSC 61447
    • BRN 1742944
    • AI3-22758
    • methyl metoxyacetate
    • Methoxyacetic Acid Methyl Ester; Methyl 2-Methoxyacetate; Methyl Methoxyacetate; Methyl alpha-Methoxyacetate; NSC 61447; NSC 6701
    • methyl methoxylacetate
    • Methyl methoxyacetate 99%
    • Methyl methoxyacetate, 99%
    • UNII-N960NQ69LF
    • SCHEMBL29374
    • 4-03-00-00578 (Beilstein Handbook Reference)
    • SCHEMBL597016
    • SCHEMBL2259365
    • SCHEMBL6093074
    • Methoxy-acetic acid methyl ester
    • CHEBI:34841
    • QRMHDGWGLNLHMN-UHFFFAOYSA-
    • ACETICACID,METHOXY-,METHYL
    • NSC6701
    • NSC61447
    • METHYL .ALPHA.-METHOXYACETATE
    • AKOS008905286
    • AS-10783
    • M0863
    • NS00021269
    • EN300-84757
    • F53343
    • F358440
    • Q27116293
    • F0001-1705
    • InChI=1/C4H8O3/c1-6-3-4(5)7-2/h3H2,1-2H3
    • 6290-49-9

  • Applications

    Methyl methoxyacetate (CAS 6290-49-9) is principally used as an organic synthesis intermediate for producing other chemicals, notably building blocks for fragrance and flavor ingredients, as well as precursors for pharmaceutical and agrochemical products. It is also employed as a solvent or co-solvent in coatings, inks, adhesives, and specialty cleaners. The polar ester can serve as a processing aid or formulation component in polymer and plastics manufacture. It may be evaluated as a precursor in various specialty chemical syntheses under local regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 302.41
    methanol 592.3
    isopropanol 174.15
    water 229.41
    ethyl acetate 88.92
    n-propanol 185.58
    acetone 176.64
    n-butanol 114.89
    acetonitrile 209.74
    DMF 622.17
    toluene 9.4
    isobutanol 120.33
    1,4-dioxane 216.55
    methyl acetate 155.05
    THF 174.41
    2-butanone 107.71
    n-pentanol 56.53
    sec-butanol 143.53
    n-hexane 3.68
    ethylene glycol 434.51
    NMP 444.22
    cyclohexane 9.1
    DMSO 595.23
    n-butyl acetate 31.1
    n-octanol 37.46
    chloroform 213.73
    n-propyl acetate 37.65
    acetic acid 1041.17
    dichloromethane 244.09
    cyclohexanone 126.05
    propylene glycol 301.04
    isopropyl acetate 33.65
    DMAc 395.3
    2-ethoxyethanol 221.13
    isopentanol 66.06
    n-heptane 4.85
    ethyl formate 140.38
    1,2-dichloroethane 120.62
    n-hexanol 45.23
    2-methoxyethanol 581.4
    isobutyl acetate 19.1
    tetrachloromethane 42.86
    n-pentyl acetate 26.87
    transcutol 216.12
    n-heptanol 33.12
    ethylbenzene 8.7
    MIBK 26.39
    2-propoxyethanol 124.47
    tert-butanol 184.39
    MTBE 57.09
    2-butoxyethanol 80.14
    propionic acid 339.56
    o-xylene 17.01
    formic acid 842.15
    diethyl ether 43.71
    m-xylene 9.72
    p-xylene 14.41
    chlorobenzene 34.15
    dimethyl carbonate 51.08
    n-octane 2.64
    formamide 705.42
    cyclopentanone 171.45
    2-pentanone 54.36
    anisole 36.38
    cyclopentyl methyl ether 58.42
    gamma-butyrolactone 279.58
    1-methoxy-2-propanol 288.22
    pyridine 117.49
    3-pentanone 51.03
    furfural 305.72
    n-dodecane 2.5
    diethylene glycol 221.03
    diisopropyl ether 9.69
    tert-amyl alcohol 164.3
    acetylacetone 82.96
    n-hexadecane 2.65
    acetophenone 50.48
    methyl propionate 99.89
    isopentyl acetate 27.46
    trichloroethylene 255.25
    n-nonanol 31.44
    cyclohexanol 114.29
    benzyl alcohol 63.58
    2-ethylhexanol 28.01
    isooctanol 26.96
    dipropyl ether 18.92
    1,2-dichlorobenzene 49.61
    ethyl lactate 63.43
    propylene carbonate 131.67
    n-methylformamide 440.99
    2-pentanol 59.96
    n-pentane 4.94
    1-propoxy-2-propanol 73.72
    1-methoxy-2-propyl acetate 45.04
    2-(2-methoxypropoxy) propanol 87.48
    mesitylene 8.66
    ε-caprolactone 139.55
    p-cymene 12.87
    epichlorohydrin 218.88
    1,1,1-trichloroethane 85.83
    2-aminoethanol 435.53
    morpholine-4-carbaldehyde 366.33
    sulfolane 397.29
    2,2,4-trimethylpentane 5.16
    2-methyltetrahydrofuran 123.14
    n-hexyl acetate 43.44
    isooctane 2.43
    2-(2-butoxyethoxy)ethanol 103.79
    sec-butyl acetate 20.73
    tert-butyl acetate 34.97
    decalin 5.52
    glycerin 574.81
    diglyme 181.2
    acrylic acid 407.3
    isopropyl myristate 16.69
    n-butyric acid 235.32
    acetyl acetate 61.91
    di(2-ethylhexyl) phthalate 28.59
    ethyl propionate 38.31
    nitromethane 869.75
    1,2-diethoxyethane 35.43
    benzonitrile 62.62
    trioctyl phosphate 21.16
    1-bromopropane 36.45
    gamma-valerolactone 269.19
    n-decanol 22.73
    triethyl phosphate 29.04
    4-methyl-2-pentanol 26.36
    propionitrile 110.12
    vinylene carbonate 143.49
    1,1,2-trichlorotrifluoroethane 411.42
    DMS 48.21
    cumene 10.28
    2-octanol 23.45
    2-hexanone 29.87
    octyl acetate 26.17
    limonene 21.09
    1,2-dimethoxyethane 199.12
    ethyl orthosilicate 24.37
    tributyl phosphate 23.4
    diacetone alcohol 91.91
    N,N-dimethylaniline 38.24
    acrylonitrile 198.75
    aniline 57.27
    1,3-propanediol 360.12
    bromobenzene 24.22
    dibromomethane 122.21
    1,1,2,2-tetrachloroethane 213.3
    2-methyl-cyclohexyl acetate 34.06
    tetrabutyl urea 34.27
    diisobutyl methanol 17.44
    2-phenylethanol 48.56
    styrene 10.8
    dioctyl adipate 33.42
    dimethyl sulfate 129.32
    ethyl butyrate 29.47
    methyl lactate 135.37
    butyl lactate 43.28
    diethyl carbonate 27.09
    propanediol butyl ether 103.74
    triethyl orthoformate 26.73
    p-tert-butyltoluene 13.07
    methyl 4-tert-butylbenzoate 63.71
    morpholine 270.78
    tert-butylamine 84.63
    n-dodecanol 17.15
    dimethoxymethane 149.0
    ethylene carbonate 98.28
    cyrene 114.89
    2-ethoxyethyl acetate 41.79
    2-ethylhexyl acetate 21.93
    1,2,4-trichlorobenzene 74.2
    4-methylpyridine 76.68
    dibutyl ether 17.85
    2,6-dimethyl-4-heptanol 17.44
    DEF 140.46
    dimethyl isosorbide 107.96
    tetrachloroethylene 173.84
    eugenol 76.15
    triacetin 67.97
    span 80 81.15
    1,4-butanediol 139.27
    1,1-dichloroethane 93.95
    2-methyl-1-pentanol 42.22
    methyl formate 294.75
    2-methyl-1-butanol 84.1
    n-decane 3.8
    butyronitrile 81.24
    3,7-dimethyl-1-octanol 30.24
    1-chlorooctane 15.23
    1-chlorotetradecane 6.7
    n-nonane 3.68
    undecane 2.93
    tert-butylcyclohexane 5.23
    cyclooctane 3.3
    cyclopentanol 160.87
    tetrahydropyran 93.96
    tert-amyl methyl ether 49.24
    2,5,8-trioxanonane 138.33
    1-hexene 10.81
    2-isopropoxyethanol 101.01
    2,2,2-trifluoroethanol 429.11
    methyl butyrate 64.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction