Methyl Glycyrrhetinate

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  • Identifiers

    CAS number
    1477-44-7

    Molecular formula
    C31H48O4

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)OC

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  • Odor profile

    Fragrance
    Woody 85.29%
    Amber 57.75%
    Cedar 55.48%
    Dry 51.45%
    Musk 42.35%
    Vetiver 37.99%
    Camphoreous 37.6%
    Earthy 37.34%
    Tobacco 36.06%
    Spicy 35.44%

     

    Flavor
    Woody 53.96%
    Camphor 49.61%
    Bitter 49.37%
    Pine 43.1%
    Herbal 35.36%
    Balsam 33.51%
    Earthy 28.69%
    Earth 26.8%
    Spicy 26.71%
    Minty 26.17%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.7

    pKa est.
    6.26 (neutral)

    Molecular weight
    484.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    304°C

    Flash point

    • 249.75 ˚C est.

  • Synonyms

    • Methyl glycyrrhetinate
    • 1477-44-7
    • methyl (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
    • RefChem:1089573
    • 18-beta-Glycyrrhetinic acid methyl ester
    • CHEMBL1271483
    • Methyl 18-beta-glycyrrhetate
    • Methyl 18-beta-glycyrrhetinate
    • Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-, methyl ester
    • SCHEMBL13393872
    • DTXSID90933191
    • BDBM50058817
    • AKOS016036158
    • 18beta-glycyrrhetinic acid methyl ester
    • Methyl 3-hydroxy-11-oxoolean-12-en-29-oate
    • Methyl 3beta-hydroxy-11-oxoolean-12-en-30-oate
    • (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-methyl 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate
    • 1477-44-7

  • Applications

    Methyl Glycyrrhetinate (CAS 1477-44-7) is used primarily as a fragrance ingredient and fixative in perfumery, imparting a characteristic licorice note and helping to stabilize volatile scents in complex formulations. In cosmetics and personal care, it is used to provide licorice-like aroma in products such as creams, lotions, and shampoos. In flavor applications, it may be employed as a licorice flavoring component in confectionery and beverages. In household products, it is used to contribute a pleasant scent in air fresheners, detergents, and surface cleaners. It may also be evaluated as a fragrance additive in other consumer products, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 48.36
    methanol 24.01
    isopropanol 45.56
    water 0.0
    ethyl acetate 19.36
    n-propanol 68.38
    acetone 27.7
    n-butanol 45.28
    acetonitrile 8.39
    DMF 245.29
    toluene 27.44
    isobutanol 36.66
    1,4-dioxane 108.52
    methyl acetate 16.82
    THF 204.74
    2-butanone 33.68
    n-pentanol 28.01
    sec-butanol 25.09
    n-hexane 0.89
    ethylene glycol 3.36
    NMP 106.51
    cyclohexane 1.13
    DMSO 41.01
    n-butyl acetate 15.11
    n-octanol 7.82
    chloroform 66.19
    n-propyl acetate 11.84
    acetic acid 20.69
    dichloromethane 34.05
    cyclohexanone 49.17
    propylene glycol 10.95
    isopropyl acetate 17.09
    DMAc 100.95
    2-ethoxyethanol 54.47
    isopentanol 23.72
    n-heptane 0.63
    ethyl formate 9.75
    1,2-dichloroethane 22.03
    n-hexanol 27.67
    2-methoxyethanol 92.5
    isobutyl acetate 10.76
    tetrachloromethane 7.82
    n-pentyl acetate 18.41
    transcutol 78.71
    n-heptanol 14.52
    ethylbenzene 9.59
    MIBK 17.95
    2-propoxyethanol 114.59
    tert-butanol 21.73
    MTBE 16.13
    2-butoxyethanol 48.3
    propionic acid 17.82
    o-xylene 10.71
    formic acid 7.35
    diethyl ether 34.13
    m-xylene 13.71
    p-xylene 9.11
    chlorobenzene 20.53
    dimethyl carbonate 20.91
    n-octane 0.23
    formamide 11.79
    cyclopentanone 80.28
    2-pentanone 31.24
    anisole 24.99
    cyclopentyl methyl ether 51.61
    gamma-butyrolactone 67.78
    1-methoxy-2-propanol 107.45
    pyridine 78.02
    3-pentanone 23.36
    furfural 51.18
    n-dodecane 0.11
    diethylene glycol 44.58
    diisopropyl ether 5.76
    tert-amyl alcohol 12.94
    acetylacetone 28.04
    n-hexadecane 0.14
    acetophenone 20.43
    methyl propionate 30.36
    isopentyl acetate 15.23
    trichloroethylene 54.9
    n-nonanol 8.88
    cyclohexanol 19.8
    benzyl alcohol 27.87
    2-ethylhexanol 8.8
    isooctanol 10.07
    dipropyl ether 14.17
    1,2-dichlorobenzene 16.28
    ethyl lactate 11.69
    propylene carbonate 22.12
    n-methylformamide 49.08
    2-pentanol 19.21
    n-pentane 1.18
    1-propoxy-2-propanol 61.03
    1-methoxy-2-propyl acetate 38.07
    2-(2-methoxypropoxy) propanol 26.49
    mesitylene 5.81
    ε-caprolactone 42.06
    p-cymene 4.42
    epichlorohydrin 93.95
    1,1,1-trichloroethane 19.14
    2-aminoethanol 20.17
    morpholine-4-carbaldehyde 154.76
    sulfolane 64.62
    2,2,4-trimethylpentane 0.52
    2-methyltetrahydrofuran 58.23
    n-hexyl acetate 19.16
    isooctane 0.47
    2-(2-butoxyethoxy)ethanol 40.96
    sec-butyl acetate 9.42
    tert-butyl acetate 17.68
    decalin 0.78
    glycerin 16.44
    diglyme 71.04
    acrylic acid 16.26
    isopropyl myristate 5.39
    n-butyric acid 29.29
    acetyl acetate 12.5
    di(2-ethylhexyl) phthalate 10.09
    ethyl propionate 12.36
    nitromethane 29.96
    1,2-diethoxyethane 24.07
    benzonitrile 17.91
    trioctyl phosphate 6.42
    1-bromopropane 14.39
    gamma-valerolactone 135.98
    n-decanol 4.57
    triethyl phosphate 7.0
    4-methyl-2-pentanol 9.97
    propionitrile 17.05
    vinylene carbonate 25.86
    1,1,2-trichlorotrifluoroethane 52.43
    DMS 18.14
    cumene 5.05
    2-octanol 6.48
    2-hexanone 17.34
    octyl acetate 8.06
    limonene 5.04
    1,2-dimethoxyethane 69.16
    ethyl orthosilicate 7.67
    tributyl phosphate 5.81
    diacetone alcohol 26.8
    N,N-dimethylaniline 17.85
    acrylonitrile 20.27
    aniline 34.68
    1,3-propanediol 37.17
    bromobenzene 19.19
    dibromomethane 22.41
    1,1,2,2-tetrachloroethane 46.78
    2-methyl-cyclohexyl acetate 12.57
    tetrabutyl urea 9.33
    diisobutyl methanol 4.72
    2-phenylethanol 30.47
    styrene 11.31
    dioctyl adipate 10.61
    dimethyl sulfate 29.38
    ethyl butyrate 11.19
    methyl lactate 23.9
    butyl lactate 20.69
    diethyl carbonate 6.76
    propanediol butyl ether 32.34
    triethyl orthoformate 12.26
    p-tert-butyltoluene 4.75
    methyl 4-tert-butylbenzoate 24.75
    morpholine 178.33
    tert-butylamine 9.98
    n-dodecanol 2.38
    dimethoxymethane 141.22
    ethylene carbonate 20.49
    cyrene 34.74
    2-ethoxyethyl acetate 32.15
    2-ethylhexyl acetate 11.63
    1,2,4-trichlorobenzene 25.02
    4-methylpyridine 60.62
    dibutyl ether 5.41
    2,6-dimethyl-4-heptanol 4.72
    DEF 43.56
    dimethyl isosorbide 48.01
    tetrachloroethylene 29.02
    eugenol 27.36
    triacetin 20.64
    span 80 25.38
    1,4-butanediol 12.42
    1,1-dichloroethane 22.09
    2-methyl-1-pentanol 14.48
    methyl formate 22.92
    2-methyl-1-butanol 22.91
    n-decane 0.34
    butyronitrile 17.02
    3,7-dimethyl-1-octanol 6.36
    1-chlorooctane 2.43
    1-chlorotetradecane 0.57
    n-nonane 0.28
    undecane 0.18
    tert-butylcyclohexane 0.69
    cyclooctane 0.5
    cyclopentanol 31.81
    tetrahydropyran 75.5
    tert-amyl methyl ether 11.57
    2,5,8-trioxanonane 39.12
    1-hexene 4.64
    2-isopropoxyethanol 32.12
    2,2,2-trifluoroethanol 7.82
    methyl butyrate 14.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction