Methyl Glucose Isostearate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    206451-21-0

    Molecular formula
    C25H48O7

    SMILES
    CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)OC)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 50.62%
    Odorless 43.37%
    Fatty 39.15%
    Oily 35.44%
    Milky 25.54%
    Lactonic 23.7%
    Citrus 22.08%
    Fresh 21.78%
    Creamy 21.05%
    Woody 20.52%

     

    Flavor
    Waxy 45.2%
    Fatty 39.69%
    Oily 38.61%
    Mild 37.0%
    Bland 34.03%
    Odorless 26.94%
    Creamy 24.09%
    Slightly waxy 23.19%
    Beer 22.91%
    Faint 22.68%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.1

    pKa est.
    5.63 (weak acid)

    Molecular weight
    460.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    732°C

    Flash point

    • 189.72 ˚C est.

  • Synonyms

    • Isolan IS
    • methyl glucose isostearate
    • 3ZZU89YF2R
    • UNII-3ZZU89YF2R
    • Methyl glucose isostearate [INCI]
    • 206451-21-0
    • RefChem:157880
    • SCHEMBL29440853
    • FQDOYQZLFOUVLE-JUIXOQOVSA-N
    • Q27258264
    • 206451-21-0

  • Applications

    Methyl Glucose Isostearate (CAS 206451-21-0) is a nonionic sugar ester used primarily as an emollient and surfactant in cosmetic and personal care formulations. It provides a slip and skin feel in creams and lotions and can function as a co-emulsifier or cleansing aid in cleaners, shampoos, and shower products. In industrial formulations, it is used as a surfactant and dispersant and as a compatibility aid in coatings, paints, and pigment systems, and it can act as a processing aid or plasticizer in polymer systems. It may also be used as an excipient or emulsifier in pharmaceutical topical formulations, subject to formulation needs and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.53
    methanol 35.44
    isopropanol 8.36
    water 2.32
    ethyl acetate 25.1
    n-propanol 14.3
    acetone 43.04
    n-butanol 10.75
    acetonitrile 10.4
    DMF 83.19
    toluene 8.63
    isobutanol 11.14
    1,4-dioxane 47.47
    methyl acetate 25.5
    THF 104.64
    2-butanone 32.77
    n-pentanol 10.66
    sec-butanol 12.03
    n-hexane 0.57
    ethylene glycol 6.44
    NMP 211.73
    cyclohexane 2.69
    DMSO 251.03
    n-butyl acetate 15.9
    n-octanol 13.54
    chloroform 58.31
    n-propyl acetate 21.45
    acetic acid 115.64
    dichloromethane 62.87
    cyclohexanone 101.76
    propylene glycol 11.34
    isopropyl acetate 24.8
    DMAc 189.01
    2-ethoxyethanol 46.22
    isopentanol 11.66
    n-heptane 0.84
    ethyl formate 23.11
    1,2-dichloroethane 39.46
    n-hexanol 7.93
    2-methoxyethanol 59.55
    isobutyl acetate 15.35
    tetrachloromethane 15.76
    n-pentyl acetate 42.33
    transcutol 191.13
    n-heptanol 14.95
    ethylbenzene 5.64
    MIBK 23.31
    2-propoxyethanol 33.59
    tert-butanol 15.52
    MTBE 14.43
    2-butoxyethanol 55.05
    propionic acid 41.21
    o-xylene 10.91
    formic acid 61.44
    diethyl ether 8.14
    m-xylene 7.96
    p-xylene 8.25
    chlorobenzene 14.47
    dimethyl carbonate 26.36
    n-octane 0.74
    formamide 76.49
    cyclopentanone 118.63
    2-pentanone 27.25
    anisole 14.04
    cyclopentyl methyl ether 41.49
    gamma-butyrolactone 146.33
    1-methoxy-2-propanol 43.98
    pyridine 36.93
    3-pentanone 24.98
    furfural 105.72
    n-dodecane 0.57
    diethylene glycol 28.88
    diisopropyl ether 4.4
    tert-amyl alcohol 18.98
    acetylacetone 67.51
    n-hexadecane 0.66
    acetophenone 30.97
    methyl propionate 30.96
    isopentyl acetate 20.02
    trichloroethylene 93.55
    n-nonanol 13.98
    cyclohexanol 25.91
    benzyl alcohol 19.3
    2-ethylhexanol 7.13
    isooctanol 14.59
    dipropyl ether 7.5
    1,2-dichlorobenzene 19.81
    ethyl lactate 24.89
    propylene carbonate 74.96
    n-methylformamide 44.63
    2-pentanol 7.81
    n-pentane 0.56
    1-propoxy-2-propanol 27.92
    1-methoxy-2-propyl acetate 37.56
    2-(2-methoxypropoxy) propanol 45.82
    mesitylene 5.91
    ε-caprolactone 103.78
    p-cymene 5.53
    epichlorohydrin 102.72
    1,1,1-trichloroethane 41.64
    2-aminoethanol 15.23
    morpholine-4-carbaldehyde 132.56
    sulfolane 332.69
    2,2,4-trimethylpentane 1.08
    2-methyltetrahydrofuran 52.26
    n-hexyl acetate 39.83
    isooctane 0.52
    2-(2-butoxyethoxy)ethanol 62.54
    sec-butyl acetate 17.85
    tert-butyl acetate 37.59
    decalin 1.75
    glycerin 28.44
    diglyme 131.64
    acrylic acid 44.15
    isopropyl myristate 10.7
    n-butyric acid 58.12
    acetyl acetate 34.95
    di(2-ethylhexyl) phthalate 17.68
    ethyl propionate 19.11
    nitromethane 137.77
    1,2-diethoxyethane 30.71
    benzonitrile 17.1
    trioctyl phosphate 14.05
    1-bromopropane 10.96
    gamma-valerolactone 189.59
    n-decanol 8.35
    triethyl phosphate 18.79
    4-methyl-2-pentanol 6.7
    propionitrile 7.82
    vinylene carbonate 64.68
    1,1,2-trichlorotrifluoroethane 147.86
    DMS 33.59
    cumene 5.26
    2-octanol 10.61
    2-hexanone 20.09
    octyl acetate 17.64
    limonene 8.32
    1,2-dimethoxyethane 50.78
    ethyl orthosilicate 17.69
    tributyl phosphate 16.08
    diacetone alcohol 57.18
    N,N-dimethylaniline 13.92
    acrylonitrile 13.61
    aniline 16.44
    1,3-propanediol 22.61
    bromobenzene 13.95
    dibromomethane 29.8
    1,1,2,2-tetrachloroethane 87.75
    2-methyl-cyclohexyl acetate 24.0
    tetrabutyl urea 22.54
    diisobutyl methanol 5.25
    2-phenylethanol 15.89
    styrene 5.67
    dioctyl adipate 25.28
    dimethyl sulfate 82.72
    ethyl butyrate 17.44
    methyl lactate 36.27
    butyl lactate 45.39
    diethyl carbonate 13.42
    propanediol butyl ether 50.45
    triethyl orthoformate 20.24
    p-tert-butyltoluene 5.79
    methyl 4-tert-butylbenzoate 53.35
    morpholine 62.31
    tert-butylamine 6.62
    n-dodecanol 5.2
    dimethoxymethane 45.04
    ethylene carbonate 54.74
    cyrene 63.2
    2-ethoxyethyl acetate 67.66
    2-ethylhexyl acetate 15.71
    1,2,4-trichlorobenzene 30.18
    4-methylpyridine 26.78
    dibutyl ether 10.5
    2,6-dimethyl-4-heptanol 5.25
    DEF 49.94
    dimethyl isosorbide 84.02
    tetrachloroethylene 69.17
    eugenol 44.87
    triacetin 77.0
    span 80 41.57
    1,4-butanediol 11.85
    1,1-dichloroethane 25.15
    2-methyl-1-pentanol 12.61
    methyl formate 39.54
    2-methyl-1-butanol 13.05
    n-decane 1.21
    butyronitrile 7.82
    3,7-dimethyl-1-octanol 11.89
    1-chlorooctane 7.1
    1-chlorotetradecane 2.12
    n-nonane 1.04
    undecane 0.79
    tert-butylcyclohexane 1.22
    cyclooctane 1.13
    cyclopentanol 31.35
    tetrahydropyran 35.33
    tert-amyl methyl ether 16.66
    2,5,8-trioxanonane 78.61
    1-hexene 2.15
    2-isopropoxyethanol 32.07
    2,2,2-trifluoroethanol 77.39
    methyl butyrate 30.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction