Methyl di-t-butyl hydroxyhydrocinnamate

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  • Identifiers

    CAS number
    6386-38-5

    Molecular formula
    C18H28O3

    SMILES
    CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCC(=O)OC

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 61.65%
    Fruity 54.32%
    Floral 43.07%
    Dry 41.69%
    Musk 39.92%
    Amber 32.32%
    Spicy 32.13%
    Powdery 30.13%
    Orris 29.9%
    Leathery 29.68%

     

    Flavor
    Woody 42.28%
    Camphor 38.16%
    Herbal 32.34%
    Musty 30.74%
    Bitter 29.57%
    Phenolic 29.56%
    Mild 28.65%
    Green pepper 21.75%
    Thymol 21.55%
    Creosote 21.35%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    7.89 (neutral)

    Molecular weight
    292.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    347°C

    Flash point

    • 150.85 ˚C est.

  • Synonyms

    • 6386-38-5
    • Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
    • methyl di-t-butyl hydroxyhydrocinnamate
    • Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester
    • 35RWF1ITXJ
    • RALOX 35
    • EINECS 228-985-4
    • Methyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate
    • FENOZAN 1
    • Hydrocinnamic acid, 3,5-di-tert-butyl-4-hydroxy-, methyl ester
    • PHENOSAN METHYL ESTER
    • EC 228-985-4
    • methyl 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propionate
    • METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYCINNAMATE
    • methyl (3,5-di-tert-butyl-4-hydroxyphenyl)propionate
    • 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid methyl ester
    • METHYL .BETA.-3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONATE
    • METHYL .BETA.-(4-HYDROXY-3,5-DI-TERT-BUTYLPHENYL)PROPANOATE
    • METHYL .BETA.-(4-HYDROXY-3,5-DI-TERT-BUTYLPHENYL)PROPIONATE
    • METHYL 3,5-DI-TERT-BUTYL-4-HYDROXY-.BETA.-PHENYLPROPIONATE
    • BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-BENZENEPROPANOIC ACID, METHYL ESTER, 3,5-
    • RefChem:817718
    • METHYL DI-T-BUTYL HYDROXYHYDROCINNAMATE [INCI]
    • METHYL BETA-3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONATE
    • METHYL 3,5-DI-TERT-BUTYL-4-HYDROXY-BETA-PHENYLPROPIONATE
    • METHYL BETA-(4-HYDROXY-3,5-DI-TERT-BUTYLPHENYL)PROPANOATE
    • METHYL BETA-(4-HYDROXY-3,5-DI-TERT-BUTYLPHENYL)PROPIONATE
    • 228-985-4
    • methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
    • MFCD00210461
    • Methyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
    • Methyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate
    • Methyl 3-[3,5-di(tert-butyl)-4-hydroxyphenyl]-propanoate
    • methyl 3-[3,5-di(tert-butyl)-4-hydroxyphenyl]propanoate
    • methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate
    • Metilox
    • UNII-35RWF1ITXJ
    • Oprea1_220662
    • SCHEMBL490767
    • SCHEMBL7214169
    • DTXSID7027623
    • CHEBI:183289
    • BB_SC-00207
    • BBL010671
    • MSK161941
    • STK801682
    • AKOS005071308
    • CS-W018869
    • FD70028
    • MSK161941-100A
    • DB-000294
    • M1810
    • NS00010693
    • EN300-6477101
    • 386M385
    • 9R-0039
    • F075968
    • methyl 3-(3,5-di-t-butyl-4-hydroxyphenyl)-propionate
    • methyl 3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate
    • methyl 3-[3,5-di(t-butyl)-4-hydroxyphenyl]propionate
    • Q27256486
    • Z16642804
    • methyl 3-(3,5-ditert-butyl-4-hydroxy-phenyl)propanoate
    • methyl3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
    • methyl 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate
    • Methyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate #
    • 3,5-di-tert-butyl-4-hydroxyhydrocinnamic acid, methyl ester
    • 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid methyl ester
    • methyl beta-(3,5-di-tert.-butyl-4-hydroxyphenyl)-propionate
    • 3-(3,5-di-t-butyl-4-hydroxyphenyl)-propionic acid methyl ester
    • beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid methyl ester
    • beta-(3,5-di-tert-butyl4-hydroxyphenyl)propionic acid methyl ester
    • METHYL-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL) PROPIONATE
    • Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Solution in Acetonitrile, 100ug/mL
    • 6386-38-5

  • Applications

    Methyl di-t-butyl hydroxyhydrocinnamate (CAS 6386-38-5) is typically used as a hindered phenolic antioxidant and stabilizer in a range of formulations. In cosmetics and personal care, it serves as an antioxidant/stabilizer in creams, lotions, and makeup. In polymers and plastics, it functions as a thermal/oxidative stabilizer for polyolefins, polyesters and related resins. In coatings and inks, it helps improve aging resistance and color stability. In adhesives, it acts as an antioxidant stabilizer to enhance longevity. In rubber and elastomer formulations, it retards thermo-oxidative degradation. Where used, its suitability is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 425.85
    methanol 360.99
    isopropanol 426.32
    water 0.6
    ethyl acetate 258.16
    n-propanol 363.8
    acetone 436.33
    n-butanol 305.76
    acetonitrile 183.6
    DMF 736.55
    toluene 240.94
    isobutanol 281.4
    1,4-dioxane 622.06
    methyl acetate 255.41
    THF 1238.76
    2-butanone 377.09
    n-pentanol 278.38
    sec-butanol 323.29
    n-hexane 29.89
    ethylene glycol 66.43
    NMP 482.77
    cyclohexane 37.6
    DMSO 370.83
    n-butyl acetate 234.79
    n-octanol 186.1
    chloroform 819.13
    n-propyl acetate 224.1
    acetic acid 228.42
    dichloromethane 534.19
    cyclohexanone 537.77
    propylene glycol 208.8
    isopropyl acetate 197.55
    DMAc 491.03
    2-ethoxyethanol 327.16
    isopentanol 233.37
    n-heptane 26.02
    ethyl formate 259.4
    1,2-dichloroethane 308.81
    n-hexanol 319.5
    2-methoxyethanol 491.89
    isobutyl acetate 187.02
    tetrachloromethane 84.59
    n-pentyl acetate 197.96
    transcutol 333.48
    n-heptanol 212.42
    ethylbenzene 170.79
    MIBK 195.99
    2-propoxyethanol 443.87
    tert-butanol 429.52
    MTBE 248.45
    2-butoxyethanol 300.37
    propionic acid 200.7
    o-xylene 130.09
    formic acid 80.14
    diethyl ether 202.47
    m-xylene 158.04
    p-xylene 234.85
    chlorobenzene 271.39
    dimethyl carbonate 115.24
    n-octane 20.07
    formamide 124.8
    cyclopentanone 709.65
    2-pentanone 298.28
    anisole 276.28
    cyclopentyl methyl ether 347.01
    gamma-butyrolactone 628.35
    1-methoxy-2-propanol 468.84
    pyridine 494.6
    3-pentanone 188.21
    furfural 477.18
    n-dodecane 16.82
    diethylene glycol 261.79
    diisopropyl ether 72.46
    tert-amyl alcohol 320.7
    acetylacetone 331.12
    n-hexadecane 18.82
    acetophenone 258.98
    methyl propionate 230.81
    isopentyl acetate 226.47
    trichloroethylene 623.45
    n-nonanol 172.83
    cyclohexanol 290.83
    benzyl alcohol 286.7
    2-ethylhexanol 181.35
    isooctanol 169.77
    dipropyl ether 165.92
    1,2-dichlorobenzene 218.52
    ethyl lactate 152.81
    propylene carbonate 390.13
    n-methylformamide 280.71
    2-pentanol 219.19
    n-pentane 23.93
    1-propoxy-2-propanol 336.48
    1-methoxy-2-propyl acetate 261.7
    2-(2-methoxypropoxy) propanol 209.36
    mesitylene 85.07
    ε-caprolactone 428.34
    p-cymene 95.31
    epichlorohydrin 639.38
    1,1,1-trichloroethane 321.43
    2-aminoethanol 174.82
    morpholine-4-carbaldehyde 541.63
    sulfolane 572.41
    2,2,4-trimethylpentane 16.94
    2-methyltetrahydrofuran 555.28
    n-hexyl acetate 251.26
    isooctane 14.25
    2-(2-butoxyethoxy)ethanol 267.67
    sec-butyl acetate 156.7
    tert-butyl acetate 223.36
    decalin 30.28
    glycerin 193.84
    diglyme 394.88
    acrylic acid 149.87
    isopropyl myristate 115.1
    n-butyric acid 309.73
    acetyl acetate 165.71
    di(2-ethylhexyl) phthalate 120.43
    ethyl propionate 181.71
    nitromethane 330.79
    1,2-diethoxyethane 209.58
    benzonitrile 278.52
    trioctyl phosphate 99.38
    1-bromopropane 213.63
    gamma-valerolactone 847.29
    n-decanol 132.82
    triethyl phosphate 92.44
    4-methyl-2-pentanol 134.7
    propionitrile 206.64
    vinylene carbonate 333.0
    1,1,2-trichlorotrifluoroethane 389.79
    DMS 160.23
    cumene 111.46
    2-octanol 167.36
    2-hexanone 259.7
    octyl acetate 157.65
    limonene 114.34
    1,2-dimethoxyethane 534.0
    ethyl orthosilicate 93.61
    tributyl phosphate 97.78
    diacetone alcohol 302.63
    N,N-dimethylaniline 199.66
    acrylonitrile 223.9
    aniline 250.85
    1,3-propanediol 269.7
    bromobenzene 270.26
    dibromomethane 367.95
    1,1,2,2-tetrachloroethane 565.72
    2-methyl-cyclohexyl acetate 190.96
    tetrabutyl urea 139.17
    diisobutyl methanol 96.66
    2-phenylethanol 304.14
    styrene 179.47
    dioctyl adipate 163.47
    dimethyl sulfate 166.13
    ethyl butyrate 186.82
    methyl lactate 168.03
    butyl lactate 179.77
    diethyl carbonate 119.99
    propanediol butyl ether 294.84
    triethyl orthoformate 137.95
    p-tert-butyltoluene 96.31
    methyl 4-tert-butylbenzoate 233.05
    morpholine 729.51
    tert-butylamine 233.24
    n-dodecanol 101.77
    dimethoxymethane 410.69
    ethylene carbonate 272.78
    cyrene 265.19
    2-ethoxyethyl acetate 204.53
    2-ethylhexyl acetate 174.82
    1,2,4-trichlorobenzene 246.35
    4-methylpyridine 522.37
    dibutyl ether 147.0
    2,6-dimethyl-4-heptanol 96.66
    DEF 269.58
    dimethyl isosorbide 364.0
    tetrachloroethylene 290.74
    eugenol 248.33
    triacetin 193.58
    span 80 242.08
    1,4-butanediol 150.37
    1,1-dichloroethane 359.79
    2-methyl-1-pentanol 213.75
    methyl formate 237.2
    2-methyl-1-butanol 229.48
    n-decane 29.28
    butyronitrile 270.77
    3,7-dimethyl-1-octanol 148.03
    1-chlorooctane 110.21
    1-chlorotetradecane 44.94
    n-nonane 27.04
    undecane 21.51
    tert-butylcyclohexane 32.19
    cyclooctane 14.12
    cyclopentanol 378.96
    tetrahydropyran 572.43
    tert-amyl methyl ether 179.14
    2,5,8-trioxanonane 288.98
    1-hexene 127.13
    2-isopropoxyethanol 253.97
    2,2,2-trifluoroethanol 81.34
    methyl butyrate 261.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction