Methyl cellulose

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  • Identifiers

    CAS number
    9004-67-5

    Molecular formula
    C20H38O11

    SMILES
    COCC1[C@H](C(C(C(O1)OC)OC)OC)O[C@H]2C(C(C(C(O2)COC)OC)OC)OC

  • Odor profile

    Fragrance
    Odorless 59.0%
    Alcoholic 31.38%
    Ethereal 25.41%
    Fruity 23.68%
    Buttery 20.15%
    Malty 20.03%
    Sweet 18.22%
    Cooling 16.86%
    Mint 16.38%
    Milky 16.0%

     

    Flavor
    Sweet 41.11%
    Bitter 36.79%
    Fatty 34.12%
    Vegetable 25.59%
    Sweet-like 24.74%
    Odorless 24.25%
    Green 23.18%
    Earthy 22.97%
    Cauliflower 22.47%
    Fruity 22.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    2.33 (strong acid)

    Molecular weight
    454.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    496°C

    Melting point expt.

    • 290 to 305 °C /Film/

    Flash point

    • 112.97 ˚C est.

    Solubility expt.

    • Swelling in water, producing a clear to opalescent, viscous, colloidal solution.; Insoluble in ethanol, ether and chloroform.; Soluble in glacial acetic acid
    • Sol in cold water
    • Insoluble in alcohol, ether, chloroform, and in water warmer that 50.5 °C; soluble in glacial acetic acid; unaffected by oils and greases.
    • INSOL IN HOT WATER & MOST ORGANIC SOLVENTS
    • INSOL IN ALCOHOL, ETHER & CHLOROFORM; SOL IN GLACIAL ACETIC ACID
    • SOL IN MIXTURE OF EQUAL PARTS OF ALCOHOL & CHLOROFORM; INSOL IN SATURATED SALT SOLN

  • Synonyms

    • METHYL CELLULOSE
    • Methylcellulose
    • 9004-67-5
    • MFCD00081763
    • (5R)-2,3,4-Trimethoxy-6-(methoxymethyl)-5-[(2S)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane
    • Metilcellulosa
    • Adulsin
    • Bagolax
    • Bulkaloid
    • Cellapret
    • Cellogel
    • Cellogran
    • Cellothyl
    • Cellumeth
    • Cethylose
    • Cethytin
    • Cologel
    • Hydrolose
    • Mellose
    • Methulose
    • Napolone
    • Syncelose
    • Tylose
    • Viscol
    • Nicel
    • Methocel A
    • Bufapto methalose
    • Celacol M
    • Culminal MC
    • Methocel MC
    • Celacol MM
    • Celacol WA
    • Edisol M
    • Methocel CHG
    • Avicel SG
    • Tylose MF
    • Tylose SL
    • Celacol MMPR
    • Tylose SAP
    • Tylose TWA
    • Viscontran L52
    • Methocel 10
    • Methocel 15
    • Methyl cellulose-A
    • Mapolose M25
    • Metolose 60SH
    • Tylose A4S
    • USP methylcellulose
    • Benecel M 0
    • Celacol M20
    • Culminal K 42
    • Culminal MC 25S
    • Culminal MC 40
    • Culminal MC 60S
    • Mapolose 60SHS0
    • Methocel 181
    • Methocel 400
    • Methocel 400CPS
    • Methocel MC 25
    • Metolose SM 15
    • Tylose MH20
    • Tylose MH50
    • Benecel M 02
    • Benecel MO 42
    • Celacol M 20P
    • Celacol M450
    • Celacol MM 10P
    • Mapolose 60SH50
    • Methocel 4000
    • Methocel MC4000
    • Methocel SM 100
    • Metolose SM 100
    • MMTs-BTR
    • Tylose MH300
    • Tylose MH300P
    • Daicel 170
    • Methyl cellulose ether
    • Tylose 444
    • Methocel 4000CPS
    • Methocel A 4000
    • Cesca MC 25S
    • Celacol M 2500
    • Culminal MC 2000
    • Methocel MC 8000
    • Metilcellulosa [DCIT]
    • Metolose 60SH400
    • Metolose MC 8000
    • Metolose SM 4000
    • Tylose MH1000
    • Tylose MH2000
    • Tylose MH4000
    • Tylose SL 100
    • Tylose SL 400
    • Tylose SL 600
    • Cellulose, methyl ether
    • Cesca MC 400
    • Culminal MC 3000P
    • EMP-H
    • Methocel 4000 CPS
    • Benecel MC 4000PS
    • Culminal MC 3000PR
    • UNII-BI55GG2WLI
    • UNII-ME8KD9K6LP
    • Cesca C 8556
    • BI55GG2WLI
    • ME8KD9K6LP
    • Methylcellulose (1/2%)
    • Walsroder MC 20000S
    • UNII-MRJ667KA5E
    • UNII-NPU9M2E6L8
    • UNII-O0GN6F9B2Y
    • MRJ667KA5E
    • NPU9M2E6L8
    • O0GN6F9B2Y
    • UNII-4GFU244C4J
    • UNII-Z944H5SN0H
    • Metilcelulosa [INN-Spanish]
    • Methylcellulosum [INN-Latin]
    • Methylcellulose (4000 cps)
    • UNII-P0NTE48364
    • FEMA No. 2696
    • 4GFU244C4J
    • CCRIS 3945
    • Z944H5SN0H
    • Hi-SM 4000
    • MC 4000 cP
    • Methylcellulose (4000 mpa.s)
    • FEMA 2696

  • Applications

    Methyl cellulose (CAS 9004-67-5) is primarily used as a thickener and rheology modifier, with binder and film-forming roles in a range of formulations. In cosmetics and personal care, it helps adjust viscosity and stabilize emulsions in creams and lotions; in paints, coatings, and inks, it acts as a viscosity modifier and binder for coatings and printed materials; in construction and building materials, it serves as a water-retaining thickener and binder in mortars, tile adhesives, and related systems; in household and cleaning products, it increases viscosity and stabilizes cleaning formulations; in pharmaceuticals, methyl cellulose is used as a binder in tablets and as a thickening/stabilizing excipient in suspensions and gels. Applications vary with regional regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 40.66
    methanol 73.47
    isopropanol 18.13
    water 38.12
    ethyl acetate 68.99
    n-propanol 31.48
    acetone 41.89
    n-butanol 22.56
    acetonitrile 37.71
    DMF 92.1
    toluene 10.36
    isobutanol 19.89
    1,4-dioxane 62.21
    methyl acetate 64.55
    THF 60.06
    2-butanone 32.82
    n-pentanol 16.03
    sec-butanol 19.74
    n-hexane 0.94
    ethylene glycol 61.13
    NMP 268.03
    cyclohexane 5.03
    DMSO 190.6
    n-butyl acetate 25.38
    n-octanol 9.34
    chloroform 197.35
    n-propyl acetate 24.22
    acetic acid 443.08
    dichloromethane 217.15
    cyclohexanone 89.92
    propylene glycol 33.97
    isopropyl acetate 31.07
    DMAc 152.31
    2-ethoxyethanol 71.87
    isopentanol 15.18
    n-heptane 1.74
    ethyl formate 70.41
    1,2-dichloroethane 100.19
    n-hexanol 14.01
    2-methoxyethanol 113.46
    isobutyl acetate 12.73
    tetrachloromethane 48.85
    n-pentyl acetate 21.55
    transcutol 90.58
    n-heptanol 12.56
    ethylbenzene 5.79
    MIBK 13.24
    2-propoxyethanol 53.72
    tert-butanol 15.04
    MTBE 9.04
    2-butoxyethanol 45.34
    propionic acid 135.2
    o-xylene 12.87
    formic acid 398.74
    diethyl ether 13.85
    m-xylene 7.37
    p-xylene 8.1
    chlorobenzene 33.09
    dimethyl carbonate 61.14
    n-octane 0.92
    formamide 312.27
    cyclopentanone 90.26
    2-pentanone 24.41
    anisole 11.85
    cyclopentyl methyl ether 30.08
    gamma-butyrolactone 229.17
    1-methoxy-2-propanol 61.13
    pyridine 63.06
    3-pentanone 27.96
    furfural 226.53
    n-dodecane 0.74
    diethylene glycol 91.09
    diisopropyl ether 4.03
    tert-amyl alcohol 20.39
    acetylacetone 64.88
    n-hexadecane 0.82
    acetophenone 29.45
    methyl propionate 65.69
    isopentyl acetate 19.95
    trichloroethylene 242.15
    n-nonanol 9.51
    cyclohexanol 39.09
    benzyl alcohol 29.84
    2-ethylhexanol 10.25
    isooctanol 10.28
    dipropyl ether 9.87
    1,2-dichlorobenzene 45.51
    ethyl lactate 37.87
    propylene carbonate 145.46
    n-methylformamide 111.99
    2-pentanol 12.3
    n-pentane 1.46
    1-propoxy-2-propanol 32.57
    1-methoxy-2-propyl acetate 46.34
    2-(2-methoxypropoxy) propanol 37.27
    mesitylene 5.24
    ε-caprolactone 125.21
    p-cymene 8.41
    epichlorohydrin 150.96
    1,1,1-trichloroethane 78.13
    2-aminoethanol 61.79
    morpholine-4-carbaldehyde 169.18
    sulfolane 323.45
    2,2,4-trimethylpentane 1.6
    2-methyltetrahydrofuran 43.88
    n-hexyl acetate 20.17
    isooctane 0.55
    2-(2-butoxyethoxy)ethanol 41.34
    sec-butyl acetate 14.78
    tert-butyl acetate 21.82
    decalin 2.22
    glycerin 98.8
    diglyme 77.54
    acrylic acid 187.89
    isopropyl myristate 7.28
    n-butyric acid 126.68
    acetyl acetate 98.92
    di(2-ethylhexyl) phthalate 18.59
    ethyl propionate 28.04
    nitromethane 360.78
    1,2-diethoxyethane 19.1
    benzonitrile 31.82
    trioctyl phosphate 12.87
    1-bromopropane 24.71
    gamma-valerolactone 185.74
    n-decanol 6.65
    triethyl phosphate 28.98
    4-methyl-2-pentanol 6.77
    propionitrile 23.6
    vinylene carbonate 162.56
    1,1,2-trichlorotrifluoroethane 309.87
    DMS 42.04
    cumene 5.07
    2-octanol 6.63
    2-hexanone 13.43
    octyl acetate 12.23
    limonene 12.22
    1,2-dimethoxyethane 44.55
    ethyl orthosilicate 22.43
    tributyl phosphate 15.19
    diacetone alcohol 37.39
    N,N-dimethylaniline 12.67
    acrylonitrile 46.51
    aniline 30.09
    1,3-propanediol 74.28
    bromobenzene 29.59
    dibromomethane 107.88
    1,1,2,2-tetrachloroethane 179.98
    2-methyl-cyclohexyl acetate 23.46
    tetrabutyl urea 20.12
    diisobutyl methanol 5.66
    2-phenylethanol 24.71
    styrene 6.8
    dioctyl adipate 19.28
    dimethyl sulfate 147.79
    ethyl butyrate 26.03
    methyl lactate 83.53
    butyl lactate 29.62
    diethyl carbonate 25.08
    propanediol butyl ether 35.67
    triethyl orthoformate 22.26
    p-tert-butyltoluene 7.46
    methyl 4-tert-butylbenzoate 41.48
    morpholine 75.07
    tert-butylamine 7.17
    n-dodecanol 4.86
    dimethoxymethane 52.68
    ethylene carbonate 123.02
    cyrene 80.71
    2-ethoxyethyl acetate 40.63
    2-ethylhexyl acetate 17.72
    1,2,4-trichlorobenzene 67.26
    4-methylpyridine 41.3
    dibutyl ether 6.1
    2,6-dimethyl-4-heptanol 5.66
    DEF 56.72
    dimethyl isosorbide 69.34
    tetrachloroethylene 176.22
    eugenol 35.5
    triacetin 51.89
    span 80 32.95
    1,4-butanediol 35.96
    1,1-dichloroethane 58.67
    2-methyl-1-pentanol 14.6
    methyl formate 110.77
    2-methyl-1-butanol 20.01
    n-decane 1.19
    butyronitrile 17.82
    3,7-dimethyl-1-octanol 8.08
    1-chlorooctane 5.76
    1-chlorotetradecane 2.37
    n-nonane 1.05
    undecane 0.9
    tert-butylcyclohexane 1.3
    cyclooctane 1.88
    cyclopentanol 47.88
    tetrahydropyran 32.6
    tert-amyl methyl ether 12.56
    2,5,8-trioxanonane 55.24
    1-hexene 2.76
    2-isopropoxyethanol 34.94
    2,2,2-trifluoroethanol 360.16
    methyl butyrate 34.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction