Methyl Cellosolve acetate

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  • Identifiers

    CAS number
    110-49-6

    Molecular formula
    C5H10O3

    SMILES
    CC(=O)OCCOC

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 89.68%
    Sweet 82.63%
    Ethereal 79.62%
    Rummy 53.2%
    Solvent 47.45%
    Winey 44.53%
    Alcoholic 40.4%
    Fermented 38.08%
    Banana 37.7%
    Pungent 35.71%

     

    Flavor
    Fruity 86.92%
    Bitter 69.27%
    Sweet 61.96%
    Ethereal 49.89%
    Green 49.7%
    Banana 48.59%
    Fruit 43.62%
    Pineapple 40.95%
    Apple 39.3%
    Solvent 37.91%

     

    Odor impact est.
    Medium

    Odor threshold

    • Odor Threshold Low: 0.33 [mmHg]. Odor Threshold High: 0.64 [mmHg]. Detection odor threshold from AIHA (mean = 0.33 ppm)

  • Properties

    XLogP3-AA
    0.0

    pKa est.
    6.26 (neutral)

    Molecular weight
    118.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -85 °F (NTP, 1992)
    • -65.1 °C
    • -65 °C
    • -85 °F

    Boiling point

    • 408.4 °F at 760 mmHg (USCG, 1999)
    • 293 °F at 760 mmHg (NTP, 1992)
    • 145 °C
    • 293 °F

    Flash point

    • 44.83 ˚C est.
    • 180 °F (USCG, 1999)
    • 111 °F (NTP, 1992)
    • 111 °F
    • 45 °C (120 °F) (CLOSED CUP)
    • 55.6 °C (Open cup)
    • 45 °C c.c.
    • 120 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Hildebrand solubility parameter(delta) = 18.8 MPa; Coefficient of expansion = 0.00110 °C-1 at 20 °C
    • Miscible with most organic solvents, oils
    • Very soluble in water, ethyl ether, and ethanol; soluble in carbon tetrachloride.
    • Infinitely soluble in water at 25 °C; water infinitely soluble in methyl cellosolve acetate at 25 °C
    • Solubility in water: miscible
    • Miscible

  • Synonyms

    • 2-Methoxyethyl acetate
    • 110-49-6
    • Methyl glycol acetate
    • Ethylene glycol monomethyl ether acetate
    • MeCsac
    • 2-Methoxyethanol acetate
    • Ethanol, 2-methoxy-, acetate
    • Acetic acid 2-methoxyethyl ester
    • Methylglykolacetat
    • METHYL CELLOSOLVE ACETATE
    • Acetyl methyl cellosolve
    • Methylglycolacetate
    • Methylcelosolvacetat
    • Methyl glycol monoacetate
    • Glycol monomethyl ether acetate
    • 2-Methoxyethanol, acetate
    • 2-Metossietilacetato
    • 2-Methoxyaethylacetat
    • EGMEA
    • methoxyethanol acetate
    • Methylcellosolveacetate
    • 2-Methyoxyethylacetate
    • Ethylene glycol methyl ether acetate
    • 2-Methoxy-ethyl acetaat
    • beta-Methoxyethyl acetate
    • Methyl cellosolye acetaat
    • Acetate de methyle glycol
    • Hisolve mc acetate
    • Acetato di metil cellosolve
    • Ethylene glycol acetate monomethyl ether
    • Methylglykolacetat [German]
    • .beta.-Methoxyethyl acetate
    • 2-Methoxyethyle, acetate de
    • Methylcelosolvacetat [Czech]
    • Aethylenglykolmethylaetheracetat
    • CCRIS 5832
    • HSDB 156
    • 2-Methoxyaethylacetat [German]
    • 2-Metossietilacetato [Italian]
    • 2-Methoxy-ethyl acetaat [Dutch]
    • Ethanol, 2-methoxy-, 1-acetate
    • Methyl cellosolye acetaat [Dutch]
    • 2-Methoxyethylester kyseliny octove
    • Acetate de methyle glycol [French]
    • EINECS 203-772-9
    • UN1189
    • Acetato di metil cellosolve [Italian]
    • 2-Methoxyethyle, acetate de [French]
    • Ethylene glycol methyl acetate
    • BRN 1700761
    • Aethylenglykolmethylaetheracetat [German]
    • AI3-11272
    • 2-Methoxyethylester kyseliny octove [Czech]
    • Ethylene glycol monomethyl ether monoacetate
    • Glycol ether em acetate
    • Diethylene glycol methyl ether acetate
    • I62493E04O
    • Acetate de L'ether monomethylique de L'ethylene-glycol
    • DTXSID2025553
    • Acetate de l'ether monomethylique de l'ethylene-glycol [French]
    • Acetic acid, 2-methoxyethyl ester
    • 2-METHOXYETHYL ACETATE [MI]
    • Methylcelosolvacetat (Czech)
    • 1-Acetoxy-2-methoxyethane
    • METHYLGLYKOLACETAT (GERMAN)
    • 2-METHOXYAETHYLACETAT (GERMAN)
    • 2-METOSSIETILACETATO (ITALIAN)
    • 2-METHOXY-ETHYL ACETAAT (DUTCH)
    • METHYL CELLOSOLYE ACETAAT (DUTCH)
    • 35126-86-4
    • ACETATE DE METHYLE GLYCOL (FRENCH)
    • 2-Methoxyethylester kyseliny octove (Czech)
    • ACETATO DI METIL CELLOSOLVE (ITALIAN)
    • 2-METHOXYETHYLE, ACETATE DE (FRENCH)
    • AETHYLENGLYKOLMETHYLAETHERACETAT (GERMAN)
    • Ethanol, methoxy-, acetate
    • ACETATE DE L'ETHER MONOMETHYLIQUE DE L'ETHYLENE-GLYCOL (FRENCH)
    • UNII-I62493E04O
    • 2-Methoxy acetate
    • 2Metossietilacetato
    • 2Methoxyaethylacetat
    • 2Methyoxyethylacetate
    • MFCD00008719
    • 2methoxyethyl acetate
    • 2Methoxyethyl acetaat
    • betaMethoxyethyl acetate
    • 2Methoxyethanol, acetate
    • Glycolmonomethyletheracetate
    • 2Methoxyethyle, acetate de
    • Ethanol, 2methoxy, acetate
    • SCHEMBL24200
    • Acetic acid 2methoxyethyl ester
    • DTXCID205553
    • SCHEMBL8999584
    • 2-METHOXYACETATE ETHANOL
    • CH3C(O)O(CH2)2OCH3
    • 2Methoxyethylester kyseliny octove
    • acetic acid 2-methoxy-ethyl ester
    • Methyl cellosolve acetate (OSHA)
    • 2-Methoxyethyl ester of acetic acid
    • METHOXYETHANOL ACETATE [INCI]
    • 2-Methoxyethyl acetate (ACGIH:OSHA)
    • AKOS006229757
    • FE34353
    • UN 1189
    • DB-040924
    • 2-Methoxyethyl acetate, for HPLC, >=99%
    • 2-Methoxyethyl acetate, reagent grade, 98%
    • ACETIC ACID, (2-METHOXYETHYL) ESTER
    • M0113
    • NS00002059
    • Methyl Cellosolve acetate;1-Acetoxy-2-methoxyethane
    • Q2415195
    • Acetate de l'ether monomethylique de l'ethyleneglycol
    • Ethylene glycol monomethyl ether acetate [UN1189] [Flammable liquid]
    • 203-772-9

  • Applications

    Methyl Cellosolve acetate (CAS 110-49-6) is a glycol ether acetate used primarily as a polar, moderate-volatility solvent and processing aid in industrial formulations. It is commonly employed as a co-solvent for coatings and paints, printing inks, and adhesive formulations to improve flow, leveling, and film formation. It also serves as a cleaning and degreasing solvent for metal parts and electronic components, and as a reactive diluent or processing solvent in polymer and plastics formulations. In some cases it is used as an intermediate in chemical synthesis or formulation adjustments within industrial manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1073.1
    methanol 2085.79
    isopropanol 534.29
    water 389.37
    ethyl acetate 194.24
    n-propanol 492.16
    acetone 390.99
    n-butanol 365.23
    acetonitrile 601.66
    DMF 930.05
    toluene 80.25
    isobutanol 256.06
    1,4-dioxane 865.04
    methyl acetate 296.85
    THF 580.95
    2-butanone 179.85
    n-pentanol 162.06
    sec-butanol 298.44
    n-hexane 17.75
    ethylene glycol 567.23
    NMP 745.03
    cyclohexane 71.8
    DMSO 713.07
    n-butyl acetate 44.65
    n-octanol 67.17
    chloroform 555.04
    n-propyl acetate 63.75
    acetic acid 1527.06
    dichloromethane 637.1
    cyclohexanone 275.11
    propylene glycol 347.32
    isopropyl acetate 66.72
    DMAc 774.66
    2-ethoxyethanol 427.09
    isopentanol 168.7
    n-heptane 15.76
    ethyl formate 269.93
    1,2-dichloroethane 258.91
    n-hexanol 94.76
    2-methoxyethanol 1106.34
    isobutyl acetate 31.84
    tetrachloromethane 93.28
    n-pentyl acetate 36.66
    transcutol 505.72
    n-heptanol 46.74
    ethylbenzene 35.46
    MIBK 39.91
    2-propoxyethanol 226.14
    tert-butanol 417.48
    MTBE 131.34
    2-butoxyethanol 110.78
    propionic acid 498.93
    o-xylene 68.85
    formic acid 1499.85
    diethyl ether 184.82
    m-xylene 44.13
    p-xylene 54.63
    chlorobenzene 105.99
    dimethyl carbonate 77.57
    n-octane 6.69
    formamide 1390.29
    cyclopentanone 271.69
    2-pentanone 95.67
    anisole 109.55
    cyclopentyl methyl ether 161.19
    gamma-butyrolactone 409.84
    1-methoxy-2-propanol 437.83
    pyridine 431.5
    3-pentanone 85.47
    furfural 515.67
    n-dodecane 6.64
    diethylene glycol 306.3
    diisopropyl ether 24.09
    tert-amyl alcohol 253.02
    acetylacetone 111.88
    n-hexadecane 7.07
    acetophenone 88.43
    methyl propionate 159.39
    isopentyl acetate 36.14
    trichloroethylene 416.33
    n-nonanol 60.38
    cyclohexanol 321.54
    benzyl alcohol 148.06
    2-ethylhexanol 48.0
    isooctanol 33.01
    dipropyl ether 56.63
    1,2-dichlorobenzene 96.41
    ethyl lactate 66.35
    propylene carbonate 185.96
    n-methylformamide 739.31
    2-pentanol 131.98
    n-pentane 27.87
    1-propoxy-2-propanol 112.55
    1-methoxy-2-propyl acetate 59.54
    2-(2-methoxypropoxy) propanol 127.02
    mesitylene 23.7
    ε-caprolactone 262.67
    p-cymene 22.11
    epichlorohydrin 379.84
    1,1,1-trichloroethane 180.22
    2-aminoethanol 721.45
    morpholine-4-carbaldehyde 762.92
    sulfolane 350.67
    2,2,4-trimethylpentane 10.35
    2-methyltetrahydrofuran 350.07
    n-hexyl acetate 67.18
    isooctane 4.09
    2-(2-butoxyethoxy)ethanol 162.47
    sec-butyl acetate 35.38
    tert-butyl acetate 51.72
    decalin 15.85
    glycerin 540.95
    diglyme 299.37
    acrylic acid 509.79
    isopropyl myristate 29.59
    n-butyric acid 381.27
    acetyl acetate 125.82
    di(2-ethylhexyl) phthalate 41.6
    ethyl propionate 71.02
    nitromethane 1170.42
    1,2-diethoxyethane 106.31
    benzonitrile 146.37
    trioctyl phosphate 24.96
    1-bromopropane 125.98
    gamma-valerolactone 549.35
    n-decanol 41.81
    triethyl phosphate 39.8
    4-methyl-2-pentanol 47.14
    propionitrile 278.23
    vinylene carbonate 218.19
    1,1,2-trichlorotrifluoroethane 448.88
    DMS 71.73
    cumene 25.93
    2-octanol 30.78
    2-hexanone 52.69
    octyl acetate 41.86
    limonene 37.04
    1,2-dimethoxyethane 518.14
    ethyl orthosilicate 39.66
    tributyl phosphate 32.37
    diacetone alcohol 102.21
    N,N-dimethylaniline 87.99
    acrylonitrile 390.87
    aniline 227.16
    1,3-propanediol 683.21
    bromobenzene 82.06
    dibromomethane 326.78
    1,1,2,2-tetrachloroethane 334.03
    2-methyl-cyclohexyl acetate 47.27
    tetrabutyl urea 52.6
    diisobutyl methanol 24.38
    2-phenylethanol 80.06
    styrene 52.01
    dioctyl adipate 58.35
    dimethyl sulfate 123.83
    ethyl butyrate 52.94
    methyl lactate 137.57
    butyl lactate 46.32
    diethyl carbonate 48.97
    propanediol butyl ether 113.87
    triethyl orthoformate 51.36
    p-tert-butyltoluene 21.15
    methyl 4-tert-butylbenzoate 75.24
    morpholine 1034.43
    tert-butylamine 248.91
    n-dodecanol 32.52
    dimethoxymethane 330.26
    ethylene carbonate 178.07
    cyrene 127.17
    2-ethoxyethyl acetate 64.41
    2-ethylhexyl acetate 29.34
    1,2,4-trichlorobenzene 127.73
    4-methylpyridine 307.59
    dibutyl ether 55.86
    2,6-dimethyl-4-heptanol 24.38
    DEF 281.15
    dimethyl isosorbide 163.68
    tetrachloroethylene 268.32
    eugenol 90.0
    triacetin 95.72
    span 80 108.8
    1,4-butanediol 217.85
    1,1-dichloroethane 233.5
    2-methyl-1-pentanol 101.26
    methyl formate 425.33
    2-methyl-1-butanol 186.77
    n-decane 10.52
    butyronitrile 242.39
    3,7-dimethyl-1-octanol 52.78
    1-chlorooctane 30.73
    1-chlorotetradecane 14.73
    n-nonane 10.19
    undecane 7.84
    tert-butylcyclohexane 12.1
    cyclooctane 14.62
    cyclopentanol 336.85
    tetrahydropyran 455.41
    tert-amyl methyl ether 97.92
    2,5,8-trioxanonane 246.75
    1-hexene 49.81
    2-isopropoxyethanol 172.43
    2,2,2-trifluoroethanol 490.44
    methyl butyrate 106.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction