Methyl 4-acetoxybenzoate

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  • Identifiers

    CAS number
    24262-66-6

    Molecular formula
    C10H10O4

    SMILES
    CC(=O)OC1=CC=C(C=C1)C(=O)OC

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 56.1%
    Odorless 46.18%
    Floral 41.53%
    Animal 34.72%
    Aromatic 32.9%
    Burnt 32.36%
    Fruity 31.21%
    Grape 28.2%
    Medicinal 27.96%
    Pungent 27.48%

     

    Flavor
    Sweet 75.15%
    Floral 48.46%
    Fruity 43.1%
    Powdery 42.62%
    Balsam 38.04%
    Tobacco 31.32%
    Creamy 31.21%
    Wintergreen 30.87%
    Herbal 30.06%
    Jam 28.09%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    7.12 (neutral)

    Molecular weight
    194.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    282°C

    Flash point

    • 123.53 ˚C est.

  • Synonyms

    • Methyl 4-acetoxybenzoate
    • 24262-66-6
    • methyl 4-acetyloxybenzoate
    • DTXSID70342085
    • RefChem:1089457
    • DTXCID30293165
    • 4-Acetoxybenzoic Acid Methyl Ester
    • Methyl-4-acetoxybenzoate
    • Methyl 4-(acetyloxy)benzoate
    • MFCD00017517
    • Methyl p-acetoxybenzoate
    • 4-acetoxy-benzoic acid methyl ester
    • ACMC-1CKGD
    • AC1LB8WY
    • ZINC00389745
    • Benzoic acid, 4-(acetyloxy)-, methyl ester
    • bmse010008
    • methyl 4-(acetoxy)benzoate
    • Benzoic acid, p-hydroxy-, methyl ester, acetate
    • SCHEMBL4647878
    • SCHEMBL4647885
    • SCHEMBL7405389
    • Methyl 4-(acetyloxy)benzoate #
    • SCHEMBL10367278
    • CHEBI:86900
    • p-(Methoxycarbonyl)phenyl acetate
    • AKOS002951117
    • SY116778
    • DB-046383
    • A1227
    • CS-0315018
    • PARA-ACETOXYBENZOIC ACID METHYL ESTER
    • D88397
    • F329987
    • Q27159284
    • InChI=1/C10H10O4/c1-7(11)14-9-5-3-8(4-6-9)10(12)13-2/h3-6H,1-2H
    • 24262-66-6

  • Applications

    Methyl 4-acetoxybenzoate (CAS number: 24262-66-6) is used as a fragrance ingredient and odorant in perfumery, contributing specific aromatic notes and sometimes functioning as a fixative. It also serves as an intermediate in organic synthesis to access related aromatic esters and fragrance compounds, supporting downstream production in chemical manufacturing. In cosmetics and personal care, it may be incorporated as a fragrance component in creams, lotions, and other products. In household products, it is used as a fragrance additive in detergents, cleaners, and air fresheners to impart a pleasant scent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.61
    methanol 28.2
    isopropanol 20.08
    water 0.48
    ethyl acetate 46.87
    n-propanol 17.26
    acetone 122.08
    n-butanol 17.85
    acetonitrile 51.31
    DMF 366.99
    toluene 14.25
    isobutanol 13.46
    1,4-dioxane 67.81
    methyl acetate 60.22
    THF 160.75
    2-butanone 70.55
    n-pentanol 21.71
    sec-butanol 20.47
    n-hexane 2.54
    ethylene glycol 15.07
    NMP 322.94
    cyclohexane 0.49
    DMSO 455.4
    n-butyl acetate 43.42
    n-octanol 14.33
    chloroform 79.55
    n-propyl acetate 45.3
    acetic acid 65.45
    dichloromethane 117.72
    cyclohexanone 75.85
    propylene glycol 15.41
    isopropyl acetate 37.74
    DMAc 346.28
    2-ethoxyethanol 88.1
    isopentanol 20.51
    n-heptane 1.53
    ethyl formate 37.28
    1,2-dichloroethane 78.83
    n-hexanol 16.99
    2-methoxyethanol 105.07
    isobutyl acetate 29.74
    tetrachloromethane 5.0
    n-pentyl acetate 25.46
    transcutol 233.64
    n-heptanol 10.89
    ethylbenzene 17.54
    MIBK 47.63
    2-propoxyethanol 77.84
    tert-butanol 52.81
    MTBE 48.32
    2-butoxyethanol 36.51
    propionic acid 34.41
    o-xylene 17.25
    formic acid 40.83
    diethyl ether 36.39
    m-xylene 16.59
    p-xylene 23.02
    chlorobenzene 34.19
    dimethyl carbonate 61.22
    n-octane 1.02
    formamide 87.05
    cyclopentanone 148.92
    2-pentanone 59.41
    anisole 81.51
    cyclopentyl methyl ether 57.38
    gamma-butyrolactone 186.84
    1-methoxy-2-propanol 91.92
    pyridine 54.02
    3-pentanone 50.37
    furfural 181.12
    n-dodecane 1.45
    diethylene glycol 78.46
    diisopropyl ether 14.39
    tert-amyl alcohol 44.95
    acetylacetone 116.15
    n-hexadecane 1.67
    acetophenone 81.19
    methyl propionate 60.98
    isopentyl acetate 44.24
    trichloroethylene 159.8
    n-nonanol 14.69
    cyclohexanol 17.33
    benzyl alcohol 48.43
    2-ethylhexanol 16.66
    isooctanol 11.1
    dipropyl ether 28.25
    1,2-dichlorobenzene 44.47
    ethyl lactate 43.28
    propylene carbonate 83.92
    n-methylformamide 99.23
    2-pentanol 16.81
    n-pentane 1.03
    1-propoxy-2-propanol 58.87
    1-methoxy-2-propyl acetate 77.1
    2-(2-methoxypropoxy) propanol 82.83
    mesitylene 12.09
    ε-caprolactone 73.2
    p-cymene 13.39
    epichlorohydrin 188.09
    1,1,1-trichloroethane 47.16
    2-aminoethanol 21.64
    morpholine-4-carbaldehyde 234.84
    sulfolane 310.5
    2,2,4-trimethylpentane 1.94
    2-methyltetrahydrofuran 75.31
    n-hexyl acetate 39.85
    isooctane 1.41
    2-(2-butoxyethoxy)ethanol 85.07
    sec-butyl acetate 35.17
    tert-butyl acetate 65.82
    decalin 2.99
    glycerin 45.96
    diglyme 150.77
    acrylic acid 43.89
    isopropyl myristate 21.88
    n-butyric acid 36.78
    acetyl acetate 40.77
    di(2-ethylhexyl) phthalate 25.79
    ethyl propionate 51.6
    nitromethane 218.77
    1,2-diethoxyethane 62.3
    benzonitrile 49.7
    trioctyl phosphate 17.18
    1-bromopropane 29.26
    gamma-valerolactone 197.94
    n-decanol 12.35
    triethyl phosphate 37.04
    4-methyl-2-pentanol 14.87
    propionitrile 34.65
    vinylene carbonate 79.87
    1,1,2-trichlorotrifluoroethane 128.3
    DMS 66.74
    cumene 15.36
    2-octanol 10.25
    2-hexanone 56.17
    octyl acetate 26.15
    limonene 16.34
    1,2-dimethoxyethane 169.54
    ethyl orthosilicate 32.7
    tributyl phosphate 25.92
    diacetone alcohol 87.0
    N,N-dimethylaniline 65.01
    acrylonitrile 57.27
    aniline 34.81
    1,3-propanediol 33.83
    bromobenzene 30.95
    dibromomethane 56.78
    1,1,2,2-tetrachloroethane 110.5
    2-methyl-cyclohexyl acetate 42.65
    tetrabutyl urea 40.07
    diisobutyl methanol 14.77
    2-phenylethanol 37.66
    styrene 22.19
    dioctyl adipate 38.9
    dimethyl sulfate 172.17
    ethyl butyrate 43.09
    methyl lactate 57.26
    butyl lactate 30.54
    diethyl carbonate 36.32
    propanediol butyl ether 44.53
    triethyl orthoformate 39.27
    p-tert-butyltoluene 14.53
    methyl 4-tert-butylbenzoate 66.88
    morpholine 82.39
    tert-butylamine 24.16
    n-dodecanol 10.29
    dimethoxymethane 157.33
    ethylene carbonate 51.61
    cyrene 93.15
    2-ethoxyethyl acetate 47.69
    2-ethylhexyl acetate 34.26
    1,2,4-trichlorobenzene 55.65
    4-methylpyridine 75.85
    dibutyl ether 25.1
    2,6-dimethyl-4-heptanol 14.77
    DEF 98.36
    dimethyl isosorbide 141.18
    tetrachloroethylene 49.26
    eugenol 66.92
    triacetin 70.61
    span 80 46.79
    1,4-butanediol 19.85
    1,1-dichloroethane 52.16
    2-methyl-1-pentanol 25.86
    methyl formate 92.73
    2-methyl-1-butanol 18.85
    n-decane 2.1
    butyronitrile 31.75
    3,7-dimethyl-1-octanol 18.34
    1-chlorooctane 10.76
    1-chlorotetradecane 5.79
    n-nonane 1.83
    undecane 1.72
    tert-butylcyclohexane 3.72
    cyclooctane 0.46
    cyclopentanol 23.59
    tetrahydropyran 36.79
    tert-amyl methyl ether 48.55
    2,5,8-trioxanonane 130.64
    1-hexene 12.34
    2-isopropoxyethanol 60.81
    2,2,2-trifluoroethanol 44.3
    methyl butyrate 62.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction