Methoxymethyl salicylate

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  • Identifiers

    CAS number
    575-82-6

    Molecular formula
    C9H10O4

    SMILES
    COCOC(=O)C1=CC=CC=C1O

  • Odor profile

    Fragrance
    Floral 64.69%
    Green 61.41%
    Sweet 60.79%
    Herbal 51.14%
    Balsamic 43.41%
    Phenolic 36.56%
    Fruity 35.92%
    Aromatic 33.35%
    Spicy 32.53%
    Fresh 31.95%

     

    Flavor
    Floral 44.3%
    Sweet 42.81%
    Bitter 40.03%
    Balsam 39.34%
    Fruity 38.62%
    Wintergreen 37.76%
    Herbal 34.69%
    Powdery 30.51%
    Grape 28.46%
    Faint 26.31%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    7.6 (neutral)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    245°C

    Flash point

    • 131.28 ˚C est.

  • Synonyms

    • Methoxymethyl salicylate
    • mesotan
    • methoxymethyl 2-hydroxybenzoate
    • 575-82-6
    • Ericin
    • MEZOTAN
    • SALIMETHYL
    • SALMESTER
    • JLO907D86Z
    • EINECS 209-393-5
    • Benzoic acid, 2-hydroxy-, methoxymethyl ester
    • DTXSID10206112
    • METHANOL, METHOXY-, SALICYLATE
    • SALICYLIC ACID, METHOXYMETHYL ESTER
    • UNII-JLO907D86Z
    • Salicylsauremethoxymethylester
    • DTXCID10128603
    • NTIBMIIYTKPBNR-UHFFFAOYSA-N
    • NS00033752
    • Q27281568
    • 209-393-5

  • Applications

    Methoxymethyl salicylate (CAS 575-82-6) is primarily used as a fragrance ingredient and odorant in perfumery, where it contributes specific aroma notes and can act as a mild fixative to help extend fragrance longevity. In cosmetics and personal care, it is commonly formulated as a fragrance component in products such as lotions, creams, and hair care items. In household products, it serves as a fragrance additive in cleaners and air fresheners to impart stable aroma profiles. It is also employed as an intermediate in fragrance chemistry for the synthesis of related aroma compounds, enabling development of new scent materials. In industrial manufacturing settings, its role is typically as a fragrance-related additive within scent-formulation blends, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 341.0
    methanol 440.46
    isopropanol 277.51
    water 1.34
    ethyl acetate 129.88
    n-propanol 219.23
    acetone 344.93
    n-butanol 186.43
    acetonitrile 167.3
    DMF 1244.98
    toluene 25.42
    isobutanol 143.11
    1,4-dioxane 303.47
    methyl acetate 175.83
    THF 553.62
    2-butanone 196.39
    n-pentanol 106.11
    sec-butanol 171.83
    n-hexane 1.33
    ethylene glycol 227.47
    NMP 496.47
    cyclohexane 3.38
    DMSO 1136.7
    n-butyl acetate 64.58
    n-octanol 34.17
    chloroform 142.04
    n-propyl acetate 78.58
    acetic acid 365.34
    dichloromethane 152.66
    cyclohexanone 191.47
    propylene glycol 261.19
    isopropyl acetate 68.87
    DMAc 602.54
    2-ethoxyethanol 253.41
    isopentanol 149.36
    n-heptane 1.75
    ethyl formate 121.08
    1,2-dichloroethane 154.12
    n-hexanol 78.85
    2-methoxyethanol 683.22
    isobutyl acetate 44.02
    tetrachloromethane 13.54
    n-pentyl acetate 30.51
    transcutol 347.8
    n-heptanol 36.38
    ethylbenzene 16.67
    MIBK 91.16
    2-propoxyethanol 178.45
    tert-butanol 408.85
    MTBE 98.71
    2-butoxyethanol 94.66
    propionic acid 178.85
    o-xylene 24.22
    formic acid 262.62
    diethyl ether 74.98
    m-xylene 26.43
    p-xylene 21.2
    chlorobenzene 45.81
    dimethyl carbonate 121.34
    n-octane 0.8
    formamide 502.21
    cyclopentanone 319.49
    2-pentanone 148.32
    anisole 82.49
    cyclopentyl methyl ether 133.36
    gamma-butyrolactone 369.9
    1-methoxy-2-propanol 414.74
    pyridine 151.1
    3-pentanone 84.06
    furfural 290.77
    n-dodecane 1.3
    diethylene glycol 258.9
    diisopropyl ether 16.78
    tert-amyl alcohol 227.03
    acetylacetone 182.18
    n-hexadecane 1.5
    acetophenone 85.77
    methyl propionate 155.03
    isopentyl acetate 55.19
    trichloroethylene 275.9
    n-nonanol 30.09
    cyclohexanol 130.3
    benzyl alcohol 96.01
    2-ethylhexanol 38.42
    isooctanol 29.87
    dipropyl ether 27.27
    1,2-dichlorobenzene 48.02
    ethyl lactate 78.56
    propylene carbonate 165.86
    n-methylformamide 468.07
    2-pentanol 103.41
    n-pentane 1.63
    1-propoxy-2-propanol 107.8
    1-methoxy-2-propyl acetate 87.79
    2-(2-methoxypropoxy) propanol 96.78
    mesitylene 16.59
    ε-caprolactone 154.04
    p-cymene 14.93
    epichlorohydrin 391.49
    1,1,1-trichloroethane 86.3
    2-aminoethanol 309.57
    morpholine-4-carbaldehyde 367.93
    sulfolane 494.03
    2,2,4-trimethylpentane 3.1
    2-methyltetrahydrofuran 230.01
    n-hexyl acetate 51.87
    isooctane 2.3
    2-(2-butoxyethoxy)ethanol 123.98
    sec-butyl acetate 46.44
    tert-butyl acetate 90.97
    decalin 3.55
    glycerin 385.52
    diglyme 245.25
    acrylic acid 195.83
    isopropyl myristate 20.84
    n-butyric acid 177.39
    acetyl acetate 81.47
    di(2-ethylhexyl) phthalate 30.58
    ethyl propionate 70.8
    nitromethane 569.89
    1,2-diethoxyethane 55.54
    benzonitrile 82.52
    trioctyl phosphate 23.62
    1-bromopropane 45.64
    gamma-valerolactone 331.41
    n-decanol 22.85
    triethyl phosphate 34.67
    4-methyl-2-pentanol 55.56
    propionitrile 116.84
    vinylene carbonate 142.87
    1,1,2-trichlorotrifluoroethane 360.56
    DMS 65.8
    cumene 14.46
    2-octanol 21.19
    2-hexanone 79.54
    octyl acetate 28.54
    limonene 21.82
    1,2-dimethoxyethane 317.82
    ethyl orthosilicate 29.87
    tributyl phosphate 26.41
    diacetone alcohol 200.34
    N,N-dimethylaniline 58.78
    acrylonitrile 181.06
    aniline 100.31
    1,3-propanediol 370.68
    bromobenzene 33.59
    dibromomethane 81.5
    1,1,2,2-tetrachloroethane 215.6
    2-methyl-cyclohexyl acetate 45.57
    tetrabutyl urea 40.68
    diisobutyl methanol 24.4
    2-phenylethanol 70.16
    styrene 22.05
    dioctyl adipate 39.18
    dimethyl sulfate 214.48
    ethyl butyrate 49.95
    methyl lactate 165.75
    butyl lactate 46.07
    diethyl carbonate 41.3
    propanediol butyl ether 109.8
    triethyl orthoformate 36.97
    p-tert-butyltoluene 15.32
    methyl 4-tert-butylbenzoate 69.24
    morpholine 409.54
    tert-butylamine 136.79
    n-dodecanol 17.36
    dimethoxymethane 372.14
    ethylene carbonate 112.48
    cyrene 133.43
    2-ethoxyethyl acetate 53.42
    2-ethylhexyl acetate 38.37
    1,2,4-trichlorobenzene 68.36
    4-methylpyridine 140.75
    dibutyl ether 20.37
    2,6-dimethyl-4-heptanol 24.4
    DEF 201.03
    dimethyl isosorbide 137.78
    tetrachloroethylene 116.05
    eugenol 77.0
    triacetin 62.43
    span 80 71.69
    1,4-butanediol 115.3
    1,1-dichloroethane 104.15
    2-methyl-1-pentanol 86.38
    methyl formate 328.35
    2-methyl-1-butanol 129.66
    n-decane 1.82
    butyronitrile 111.85
    3,7-dimethyl-1-octanol 36.14
    1-chlorooctane 11.81
    1-chlorotetradecane 5.51
    n-nonane 1.48
    undecane 1.51
    tert-butylcyclohexane 3.37
    cyclooctane 1.22
    cyclopentanol 177.7
    tetrahydropyran 164.33
    tert-amyl methyl ether 75.5
    2,5,8-trioxanonane 158.55
    1-hexene 9.85
    2-isopropoxyethanol 139.0
    2,2,2-trifluoroethanol 153.68
    methyl butyrate 102.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction