Methoxyacetaldehyde

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  • Identifiers

    CAS number
    10312-83-1

    Molecular formula
    C3H6O2

    SMILES
    COCC=O

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 71.46%
    Sweet 47.56%
    Pungent 45.19%
    Fruity 45.16%
    Alcoholic 43.5%
    Rummy 38.82%
    Sharp 38.28%
    Fresh 37.66%
    Green 37.17%
    Fermented 36.37%

     

    Flavor
    Pungent 60.34%
    Ethereal 53.82%
    Bitter 41.45%
    Musty 39.46%
    Sweet 39.28%
    Nutty 38.03%
    Alcohol 34.49%
    Green 31.14%
    Rum 30.79%
    Ether 30.4%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.4

    pKa est.
    5.99 (weak acid)

    Molecular weight
    74.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    92°C

    Flash point

    • 13.96 ˚C est.

  • Synonyms

    • Methoxyacetaldehyde
    • 2-Methoxyacetaldehyde
    • 10312-83-1
    • Acetaldehyde, methoxy-
    • 5G4O7K64WA
    • DTXSID90145651
    • MALD cpd
    • RefChem:157057
    • DTXCID1068142
    • 233-693-5
    • Methoxyethanal
    • methoxy acetaldehyde
    • 2-methoxyethanal
    • Acetaldehyde, 2-methoxy-
    • MFCD00059176
    • .alpha.-Methoxyacetaldehyde
    • CCRIS 6517
    • EINECS 233-693-5
    • BRN 1738030
    • UNII-5G4O7K64WA
    • methoxyacetaldehye
    • methoxy-acetaldehyde
    • (Methyloxy)acetaldehyde
    • alpha-Methoxyacetaldehyde
    • Acetaldehyde, methoxy-(6CI,7CI,8CI,9CI)
    • SCHEMBL6782
    • O-METHYLGLYCOLALDEHYDE
    • SCHEMBL29356
    • Methoxyacetaldehyde, AldrichCPR
    • SCHEMBL1388136
    • SCHEMBL3091934
    • SCHEMBL3234877
    • SCHEMBL9070434
    • STR06444
    • AKOS010079083
    • AT40266
    • Methoxyacetaldehyde DCM solution (~10%)
    • SY030211
    • DB-007628
    • CS-0108739
    • NS00023205
    • EN300-99260
    • Q27262071
    • 2-Methoxyacetaldehyde,contains DCM inverted exclamation markU20%
    • 10312-83-1

  • Applications

    Methoxyacetaldehyde (CAS 10312-83-1) is primarily used as an organic synthesis intermediate. It serves as a building block in the production of fragrance and flavor compounds, enabling the introduction of a methoxy-aldehyde functionality into target molecules. It is also evaluated for use in pharmaceutical and agrochemical intermediate syntheses, and may be employed in industrial manufacturing as a reactive aldehyde for further transformations (for example in aldol reactions or formylations). Additionally, it can find use in the development of specialty coatings and ink formulations where aldehyde functionality is desired. Its use is subject to appropriate safety measures and local regulatory/formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 139.31
    methanol 349.37
    isopropanol 45.18
    water 184.34
    ethyl acetate 25.84
    n-propanol 70.27
    acetone 43.87
    n-butanol 35.28
    acetonitrile 70.52
    DMF 269.51
    toluene 2.14
    isobutanol 32.4
    1,4-dioxane 60.76
    methyl acetate 57.42
    THF 49.41
    2-butanone 27.45
    n-pentanol 12.84
    sec-butanol 30.93
    n-hexane 0.66
    ethylene glycol 301.55
    NMP 221.09
    cyclohexane 2.38
    DMSO 202.53
    n-butyl acetate 13.85
    n-octanol 9.85
    chloroform 48.17
    n-propyl acetate 11.36
    acetic acid 670.97
    dichloromethane 54.17
    cyclohexanone 40.67
    propylene glycol 141.62
    isopropyl acetate 7.5
    DMAc 172.08
    2-ethoxyethanol 67.6
    isopentanol 15.06
    n-heptane 1.84
    ethyl formate 41.02
    1,2-dichloroethane 26.93
    n-hexanol 18.09
    2-methoxyethanol 220.24
    isobutyl acetate 5.29
    tetrachloromethane 10.74
    n-pentyl acetate 7.04
    transcutol 157.17
    n-heptanol 9.07
    ethylbenzene 1.46
    MIBK 4.6
    2-propoxyethanol 59.89
    tert-butanol 40.27
    MTBE 8.82
    2-butoxyethanol 29.58
    propionic acid 182.7
    o-xylene 3.56
    formic acid 785.26
    diethyl ether 8.21
    m-xylene 2.04
    p-xylene 2.37
    chlorobenzene 8.25
    dimethyl carbonate 18.02
    n-octane 0.56
    formamide 532.37
    cyclopentanone 55.06
    2-pentanone 11.09
    anisole 9.2
    cyclopentyl methyl ether 13.83
    gamma-butyrolactone 105.26
    1-methoxy-2-propanol 78.73
    pyridine 42.95
    3-pentanone 12.26
    furfural 129.27
    n-dodecane 0.6
    diethylene glycol 124.45
    diisopropyl ether 1.59
    tert-amyl alcohol 30.96
    acetylacetone 20.88
    n-hexadecane 0.65
    acetophenone 13.69
    methyl propionate 31.28
    isopentyl acetate 9.83
    trichloroethylene 64.53
    n-nonanol 8.58
    cyclohexanol 32.39
    benzyl alcohol 16.1
    2-ethylhexanol 10.15
    isooctanol 6.61
    dipropyl ether 8.16
    1,2-dichlorobenzene 12.37
    ethyl lactate 20.76
    propylene carbonate 44.37
    n-methylformamide 211.38
    2-pentanol 11.5
    n-pentane 0.98
    1-propoxy-2-propanol 34.06
    1-methoxy-2-propyl acetate 19.69
    2-(2-methoxypropoxy) propanol 44.47
    mesitylene 1.76
    ε-caprolactone 45.16
    p-cymene 4.22
    epichlorohydrin 61.73
    1,1,1-trichloroethane 18.55
    2-aminoethanol 237.37
    morpholine-4-carbaldehyde 174.86
    sulfolane 138.85
    2,2,4-trimethylpentane 0.85
    2-methyltetrahydrofuran 27.94
    n-hexyl acetate 12.36
    isooctane 0.39
    2-(2-butoxyethoxy)ethanol 53.54
    sec-butyl acetate 5.24
    tert-butyl acetate 7.76
    decalin 1.0
    glycerin 265.46
    diglyme 83.24
    acrylic acid 247.87
    isopropyl myristate 5.27
    n-butyric acid 90.31
    acetyl acetate 23.12
    di(2-ethylhexyl) phthalate 12.23
    ethyl propionate 11.27
    nitromethane 440.78
    1,2-diethoxyethane 15.52
    benzonitrile 16.35
    trioctyl phosphate 7.24
    1-bromopropane 6.71
    gamma-valerolactone 100.56
    n-decanol 6.34
    triethyl phosphate 11.92
    4-methyl-2-pentanol 4.25
    propionitrile 33.74
    vinylene carbonate 54.86
    1,1,2-trichlorotrifluoroethane 160.83
    DMS 21.87
    cumene 1.91
    2-octanol 4.45
    2-hexanone 6.69
    octyl acetate 8.48
    limonene 6.77
    1,2-dimethoxyethane 52.47
    ethyl orthosilicate 9.89
    tributyl phosphate 9.44
    diacetone alcohol 23.82
    N,N-dimethylaniline 9.35
    acrylonitrile 73.82
    aniline 19.07
    1,3-propanediol 170.87
    bromobenzene 5.2
    dibromomethane 24.71
    1,1,2,2-tetrachloroethane 45.42
    2-methyl-cyclohexyl acetate 12.63
    tetrabutyl urea 14.83
    diisobutyl methanol 5.22
    2-phenylethanol 15.39
    styrene 2.24
    dioctyl adipate 14.03
    dimethyl sulfate 43.58
    ethyl butyrate 13.37
    methyl lactate 49.48
    butyl lactate 15.45
    diethyl carbonate 12.44
    propanediol butyl ether 38.99
    triethyl orthoformate 11.47
    p-tert-butyltoluene 4.12
    methyl 4-tert-butylbenzoate 21.6
    morpholine 96.25
    tert-butylamine 17.65
    n-dodecanol 5.01
    dimethoxymethane 41.15
    ethylene carbonate 34.89
    cyrene 46.89
    2-ethoxyethyl acetate 15.66
    2-ethylhexyl acetate 7.86
    1,2,4-trichlorobenzene 19.47
    4-methylpyridine 21.27
    dibutyl ether 5.55
    2,6-dimethyl-4-heptanol 5.22
    DEF 41.58
    dimethyl isosorbide 57.34
    tetrachloroethylene 44.0
    eugenol 29.19
    triacetin 27.48
    span 80 40.21
    1,4-butanediol 52.2
    1,1-dichloroethane 16.03
    2-methyl-1-pentanol 8.32
    methyl formate 123.34
    2-methyl-1-butanol 20.74
    n-decane 0.87
    butyronitrile 18.82
    3,7-dimethyl-1-octanol 8.49
    1-chlorooctane 3.43
    1-chlorotetradecane 1.74
    n-nonane 0.78
    undecane 0.7
    tert-butylcyclohexane 0.92
    cyclooctane 0.64
    cyclopentanol 48.01
    tetrahydropyran 22.69
    tert-amyl methyl ether 8.36
    2,5,8-trioxanonane 70.8
    1-hexene 1.82
    2-isopropoxyethanol 28.24
    2,2,2-trifluoroethanol 268.84
    methyl butyrate 17.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction