Methionine

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  • Identifiers

    CAS number
    63-68-3

    Molecular formula
    C5H11NO2S

    SMILES
    CSCC[C@@H](C(=O)O)N

  • Odor profile

    Fragrance
    Sulfurous 66.52%
    Meaty 66.22%
    Savory 52.04%
    Roasted 46.35%
    Onion 37.54%
    Cooked 36.59%
    Cheesy 34.4%
    Sweet 31.48%
    Cabbage 29.11%
    Alliaceous 28.17%

     

    Flavor
    Sulfurous 49.96%
    Sulfury 43.72%
    Odorless 32.95%
    Roasted 31.45%
    Onion 30.37%
    Mild 30.35%
    Cooked 30.25%
    Cabbage 26.47%
    Meaty 24.36%
    Tomato 22.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.9

    pKa est.
    5.21 (weak acid)

    Molecular weight
    149.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 536 to 540 °F decomposes 541.4-543.2 °F (NTP, 1992)
    • 283 dec °C
    • 280-282 °C (decomposes, sealed capillary)
    • 284 °C

    Boiling point

    • sublimes at 367 °F (NTP, 1992)
    • 181 °C (decomposes)

    Flash point

    • 140.35 ˚C est.

    Solubility expt.

    • Soluble (NTP, 1992)
    • 56600 mg/L (at 25 °C)
    • Soluble in water but the crystals are somewhat water-repellant at first
    • Soluble in warm dilute alcohol; insoluble in absolute alcohol, ether, petroleum ether, benzene, acetone
    • Slightly soluble in acetic acid
    • In water, 56.6 g/L at 25 °C
    • 56.6 mg/mL

  • Synonyms

    • L-methionine
    • 63-68-3
    • methionine
    • h-Met-oh
    • (S)-2-Amino-4-(methylthio)butanoic acid
    • Cymethion
    • L-(-)-Methionine
    • S-Methionine
    • Liquimeth
    • Neo-methidin
    • L-Methioninum
    • Methilanin
    • (L)-Methionine
    • metionina
    • Acimethin
    • (S)-methionine
    • Methionine (VAN)
    • Methioninum
    • Metionina [DCIT]
    • L-Methionin
    • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
    • L-alpha-Amino-gamma-methylmercaptobutyric acid
    • h-Met-h
    • Methioninum [INN-Latin]
    • L-Homocysteine, S-methyl-
    • met
    • CCRIS 5528
    • CCRIS 5536
    • HSDB 4317
    • L(-)-Amino-gamma-methylthiobutyric acid
    • L-Met
    • L-alpha-Amino-gamma-methylthiobutyric acid
    • L-gamma-Methylthio-alpha-aminobutyric acid
    • (2S)-2-Amino-4-methylsulfanylbutanoic acid
    • L-Methionine-35S
    • METHIONINE, L-
    • 2-Amino-4-methylthiobutanoic acid (S)-
    • UNII-AE28F7PNPL
    • AE28F7PNPL
    • Toxin WAR (Bacillus thuringiensis strain PS205C)
    • 2-Amino-4-(methylthio)butyric acid, (S)-
    • EINECS 200-562-9
    • MFCD00063097
    • NSC 22946
    • Butanoic acid, 2-amino-4-(methylthio)-, (S)-
    • (S)-2-amino-4-(methylthio)butyric acid
    • CHEBI:16643
    • L-a-Amino-g-methylthiobutyric acid
    • carbon-11 methionine
    • S-Methyl-L-homocysteine
    • (S)-(+)-Methionine
    • NSC-22946
    • gamma-Methylthio-alpha-aminobutyric acid
    • L-2-Amino-4-(methylthio)butanoic acid
    • CHEMBL42336
    • 3654-96-4
    • DTXSID5040548
    • L-2-Amino-4methylthiobutyric acid
    • Methionine [USAN:USP:INN:BAN]
    • meritonin
    • METHIONINE (II)
    • METHIONINE [II]
    • Methioninum (INN-Latin)
    • (S)-2-Amino-4-(methylmercapto)butyric acid
    • METHIONINE (MART.)
    • METHIONINE [MART.]
    • Hmet
    • 1006386-95-3
    • METHIONINE (EP MONOGRAPH)
    • METHIONINE [EP MONOGRAPH]
    • METHIONINE (USP MONOGRAPH)
    • METHIONINE [USP MONOGRAPH]
    • Methionine (USAN:USP:INN:BAN)
    • Methionine [USAN:INN]
    • (2S)-2-amino-4-methylsulfanyl-butanoic acid
    • C-11 Methionine
    • 58576-49-1
    • l-2-Amino-4-(methylthio)butyric acid
    • (2S)-2-amino-4-(methylsulfanyl)butanoate
    • C-11 Met
    • L-Lobamine
    • 3h-l-methionine
    • g-Methylthio-a-aminobutyric acid
    • racemic methionine
    • 1wkm
    • Toxin WAR
    • (35S)Methionine
    • Methionine (USP)
    • a-Amino-g-methylmercaptobutyric acid
    • methioninum racemicum
    • 1pg2
    • 1qq9
    • L-Methionine Z (TN)
    • METHIONINE [MI]
    • L-Methionine (JP18)
    • L-Methionine (Standard)
    • METHIONINE [INN]
    • METHIONINE [HSDB]
    • METHIONINE [USAN]
    • Methionine (L-Methionine)
    • METHIONINE [VANDF]
    • Methionine, L- (8CI)
    • bmse000044
    • bmse000915
    • L-METHIONINE [FCC]
    • L-METHIONINE [JAN]
    • SCHEMBL4226
    • G-methylthio-a-aminobutyrate
    • L-Methionine (H-Met-OH)
    • METHIONINE [WHO-DD]
    • 2-Amino-4-methylthiobutanoate
    • L-a-amino-g-methylthiobutyrate
    • L-METHIONINE [USP-RS]
    • GTPL4814
    • A-amino-g-methylmercaptobutyrate
    • IS_METHIONINE-METHYL-D3
    • 2-Amino-4-(methylthio)butyrate
    • DTXCID3020548
    • SCHEMBL15702352
    • HY-N0326R
    • V03AB26
    • Pharmakon1600-01301006
    • alpha-amino-alpha-aminobutyric acid
    • gamma-methylthio-alpha-aminobutyrate
    • HY-N0326
    • L-2-Amino-4-methylthiobutyric acid
    • BDBM50142500
    • MFCD00801344

  • Applications

    Methionine (CAS 63-68-3) is widely used as an essential amino acid supplement in animal nutrition, particularly for poultry, swine, and ruminants, to improve growth performance and feed efficiency. In human nutrition and pharmaceutical contexts, it is used in parenteral nutrition formulations and dietary supplements as a source of essential amino acids. In chemical synthesis and drug development, methionine serves as a sulfur-containing building block for peptides and derivatives, and as a precursor to S-adenosylmethionine (SAM). In industrial and biotech production, methionine is manufactured by fermentation at industrial scale to supply the amino acid market. In cosmetics and personal care, methionine may be used in some formulations as an amino acid conditioning ingredient to support texture and conditioning properties for skin and hair.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.78
    methanol 1.89
    isopropanol 0.53
    water 34.5
    ethyl acetate 0.25
    n-propanol 0.48
    acetone 0.64
    n-butanol 0.4
    acetonitrile 0.21
    DMF 4.08
    toluene 0.14
    isobutanol 0.5
    1,4-dioxane 1.45
    methyl acetate 0.17
    THF 2.46
    2-butanone 0.25
    n-pentanol 0.65
    sec-butanol 0.37
    n-hexane 0.08
    ethylene glycol 11.7
    NMP 30.18
    cyclohexane 0.23
    DMSO 31.48
    n-butyl acetate 0.99
    n-octanol 0.84
    chloroform 0.14
    n-propyl acetate 0.47
    acetic acid 14.0
    dichloromethane 0.23
    cyclohexanone 3.78
    propylene glycol 5.45
    isopropyl acetate 0.44
    DMAc 6.62
    2-ethoxyethanol 5.07
    isopentanol 0.79
    n-heptane 0.24
    ethyl formate 0.56
    1,2-dichloroethane 0.23
    n-hexanol 1.54
    2-methoxyethanol 6.51
    isobutyl acetate 0.47
    tetrachloromethane 0.12
    n-pentyl acetate 0.98
    transcutol 12.79
    n-heptanol 1.67
    ethylbenzene 0.24
    MIBK 0.74
    2-propoxyethanol 6.73
    tert-butanol 1.55
    MTBE 0.23
    2-butoxyethanol 6.16
    propionic acid 2.28
    o-xylene 0.49
    formic acid 31.76
    diethyl ether 0.08
    m-xylene 0.39
    p-xylene 0.42
    chlorobenzene 0.21
    dimethyl carbonate 0.42
    n-octane 0.12
    formamide 16.84
    cyclopentanone 4.06
    2-pentanone 0.4
    anisole 0.48
    cyclopentyl methyl ether 0.98
    gamma-butyrolactone 5.7
    1-methoxy-2-propanol 4.08
    pyridine 0.73
    3-pentanone 0.27
    furfural 9.51
    n-dodecane 0.09
    diethylene glycol 16.5
    diisopropyl ether 0.19
    tert-amyl alcohol 1.18
    acetylacetone 2.09
    n-hexadecane 0.1
    acetophenone 1.59
    methyl propionate 0.29
    isopentyl acetate 1.45
    trichloroethylene 0.45
    n-nonanol 0.93
    cyclohexanol 1.62
    benzyl alcohol 1.64
    2-ethylhexanol 1.38
    isooctanol 1.68
    dipropyl ether 0.52
    1,2-dichlorobenzene 0.5
    ethyl lactate 1.92
    propylene carbonate 3.76
    n-methylformamide 2.16
    2-pentanol 0.32
    n-pentane 0.04
    1-propoxy-2-propanol 4.86
    1-methoxy-2-propyl acetate 2.74
    2-(2-methoxypropoxy) propanol 7.42
    mesitylene 0.58
    ε-caprolactone 4.14
    p-cymene 0.83
    epichlorohydrin 1.58
    1,1,1-trichloroethane 0.17
    2-aminoethanol 7.86
    morpholine-4-carbaldehyde 18.14
    sulfolane 36.36
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 1.11
    n-hexyl acetate 1.16
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 9.51
    sec-butyl acetate 0.41
    tert-butyl acetate 1.14
    decalin 0.22
    glycerin 22.31
    diglyme 11.39
    acrylic acid 4.84
    isopropyl myristate 0.75
    n-butyric acid 2.38
    acetyl acetate 0.73
    di(2-ethylhexyl) phthalate 2.56
    ethyl propionate 0.38
    nitromethane 4.8
    1,2-diethoxyethane 1.01
    benzonitrile 0.86
    trioctyl phosphate 1.85
    1-bromopropane 0.07
    gamma-valerolactone 12.28
    n-decanol 0.78
    triethyl phosphate 1.48
    4-methyl-2-pentanol 0.62
    propionitrile 0.14
    vinylene carbonate 2.76
    1,1,2-trichlorotrifluoroethane 9.8
    DMS 1.32
    cumene 0.43
    2-octanol 0.86
    2-hexanone 0.52
    octyl acetate 1.01
    limonene 1.0
    1,2-dimethoxyethane 2.59
    ethyl orthosilicate 1.43
    tributyl phosphate 1.55
    diacetone alcohol 5.41
    N,N-dimethylaniline 1.04
    acrylonitrile 0.38
    aniline 0.48
    1,3-propanediol 5.92
    bromobenzene 0.18
    dibromomethane 0.15
    1,1,2,2-tetrachloroethane 0.58
    2-methyl-cyclohexyl acetate 2.66
    tetrabutyl urea 2.93
    diisobutyl methanol 1.32
    2-phenylethanol 2.37
    styrene 0.17
    dioctyl adipate 1.72
    dimethyl sulfate 2.55
    ethyl butyrate 0.99
    methyl lactate 2.73
    butyl lactate 3.28
    diethyl carbonate 0.76
    propanediol butyl ether 7.82
    triethyl orthoformate 1.37
    p-tert-butyltoluene 0.86
    methyl 4-tert-butylbenzoate 5.15
    morpholine 1.67
    tert-butylamine 0.58
    n-dodecanol 0.65
    dimethoxymethane 1.04
    ethylene carbonate 1.93
    cyrene 18.56
    2-ethoxyethyl acetate 1.61
    2-ethylhexyl acetate 1.06
    1,2,4-trichlorobenzene 0.76
    4-methylpyridine 0.51
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 1.32
    DEF 1.23
    dimethyl isosorbide 15.48
    tetrachloroethylene 0.67
    eugenol 6.49
    triacetin 3.12
    span 80 9.19
    1,4-butanediol 4.13
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.97
    methyl formate 1.47
    2-methyl-1-butanol 0.56
    n-decane 0.11
    butyronitrile 0.19
    3,7-dimethyl-1-octanol 1.09
    1-chlorooctane 0.25
    1-chlorotetradecane 0.17
    n-nonane 0.1
    undecane 0.1
    tert-butylcyclohexane 0.16
    cyclooctane 0.17
    cyclopentanol 2.47
    tetrahydropyran 0.48
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 13.16
    1-hexene 0.11
    2-isopropoxyethanol 3.32
    2,2,2-trifluoroethanol 5.87
    methyl butyrate 0.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction