Methanediol

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  • Identifiers

    CAS number
    463-57-0

    Molecular formula
    CH4O2

    SMILES
    C(O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 54.81%
    Alcoholic 46.96%
    Ethereal 39.36%
    Fermented 30.16%
    Fruity 28.78%
    Sharp 28.16%
    Pungent 27.13%
    Sweet 22.72%
    Solvent 22.55%
    Winey 20.99%

     

    Flavor
    Bitter 62.24%
    Alcoholic 52.06%
    Odorless 49.99%
    Pungent 43.97%
    Sweet 34.86%
    Alcohol 27.98%
    Musty 27.98%
    Fusel 25.81%
    Ethereal 25.78%
    Very slight 24.04%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    8.59 (weak base)

    Molecular weight
    48.041 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    155°C

    Flash point

    • 101.02 ˚C est.

  • Synonyms

    • Methanediol
    • Methylene glycol
    • dihydroxymethane
    • 463-57-0
    • CHEBI:48397
    • DTXSID50196801
    • 6Z20YM9257
    • RefChem:156911
    • DTXCID50119292
    • 207-339-5
    • formaldehyde hydrate
    • Methandiol
    • Methanediol-
    • UNII-6Z20YM9257
    • EINECS 207-339-5
    • Paraformaldehyde, powder
    • SCHEMBL4597
    • UNII-T0H3L6C7I5
    • SCHEMBL15938
    • SCHEMBL28460
    • SCHEMBL125283
    • SCHEMBL444487
    • SCHEMBL2473800
    • SCHEMBL7597667
    • T0H3L6C7I5
    • SCHEMBL30814232
    • SCHEMBL31478808
    • NS00080778
    • Aldacide; Flo-Mor; Granuform; Paraform; TransFix
    • F543822
    • Q332879
    • Q2365760
    • 463-57-0

  • Applications

    Methanediol (CAS 463-57-0) is mainly used as a reactive feedstock and a source of formaldehyde in the production of formaldehyde-based resins and coatings, including urea-formaldehyde and phenol-formaldehyde adhesives for wood panels and laminates. It functions as an intermediate in hydroxymethylation and crosslinking steps that form resins and binder systems, and it can serve as a building block in specialty organic syntheses for methylene-containing compounds. In industrial manufacturing it may be employed as a processing aid or reactive solvent in tightly controlled formulations, and it is sometimes evaluated for pilot-scale routes to generate formaldehyde-containing derivatives. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 159.49
    methanol 453.99
    isopropanol 66.31
    water 1850.89
    ethyl acetate 6.88
    n-propanol 73.49
    acetone 39.76
    n-butanol 34.97
    acetonitrile 29.27
    DMF 723.22
    toluene 0.53
    isobutanol 32.13
    1,4-dioxane 26.63
    methyl acetate 18.62
    THF 45.9
    2-butanone 14.57
    n-pentanol 15.04
    sec-butanol 29.03
    n-hexane 0.53
    ethylene glycol 724.62
    NMP 277.55
    cyclohexane 0.99
    DMSO 519.66
    n-butyl acetate 6.03
    n-octanol 5.05
    chloroform 4.58
    n-propyl acetate 6.25
    acetic acid 407.87
    dichloromethane 6.21
    cyclohexanone 17.61
    propylene glycol 384.5
    isopropyl acetate 3.26
    DMAc 271.71
    2-ethoxyethanol 87.19
    isopentanol 13.3
    n-heptane 1.17
    ethyl formate 23.17
    1,2-dichloroethane 5.74
    n-hexanol 13.33
    2-methoxyethanol 280.01
    isobutyl acetate 2.88
    tetrachloromethane 2.22
    n-pentyl acetate 3.49
    transcutol 55.78
    n-heptanol 7.02
    ethylbenzene 0.37
    MIBK 3.02
    2-propoxyethanol 59.99
    tert-butanol 42.69
    MTBE 4.79
    2-butoxyethanol 30.79
    propionic acid 145.47
    o-xylene 0.93
    formic acid 997.17
    diethyl ether 4.89
    m-xylene 0.6
    p-xylene 0.61
    chlorobenzene 1.04
    dimethyl carbonate 19.14
    n-octane 0.33
    formamide 766.32
    cyclopentanone 37.32
    2-pentanone 7.31
    anisole 2.46
    cyclopentyl methyl ether 8.81
    gamma-butyrolactone 72.02
    1-methoxy-2-propanol 115.68
    pyridine 13.0
    3-pentanone 6.59
    furfural 69.28
    n-dodecane 0.26
    diethylene glycol 150.78
    diisopropyl ether 1.14
    tert-amyl alcohol 23.01
    acetylacetone 9.36
    n-hexadecane 0.26
    acetophenone 4.97
    methyl propionate 17.29
    isopentyl acetate 3.59
    trichloroethylene 7.62
    n-nonanol 4.33
    cyclohexanol 17.82
    benzyl alcohol 9.02
    2-ethylhexanol 4.41
    isooctanol 4.23
    dipropyl ether 5.55
    1,2-dichlorobenzene 1.54
    ethyl lactate 19.18
    propylene carbonate 23.33
    n-methylformamide 393.17
    2-pentanol 11.39
    n-pentane 0.84
    1-propoxy-2-propanol 33.47
    1-methoxy-2-propyl acetate 9.93
    2-(2-methoxypropoxy) propanol 19.82
    mesitylene 0.58
    ε-caprolactone 21.29
    p-cymene 1.05
    epichlorohydrin 28.06
    1,1,1-trichloroethane 2.18
    2-aminoethanol 495.87
    morpholine-4-carbaldehyde 203.76
    sulfolane 127.08
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 13.52
    n-hexyl acetate 4.34
    isooctane 0.23
    2-(2-butoxyethoxy)ethanol 28.01
    sec-butyl acetate 2.25
    tert-butyl acetate 3.24
    decalin 0.33
    glycerin 622.74
    diglyme 48.66
    acrylic acid 216.24
    isopropyl myristate 1.66
    n-butyric acid 54.96
    acetyl acetate 4.91
    di(2-ethylhexyl) phthalate 4.62
    ethyl propionate 5.58
    nitromethane 255.26
    1,2-diethoxyethane 5.55
    benzonitrile 4.95
    trioctyl phosphate 3.92
    1-bromopropane 1.79
    gamma-valerolactone 77.35
    n-decanol 3.14
    triethyl phosphate 4.78
    4-methyl-2-pentanol 3.87
    propionitrile 15.93
    vinylene carbonate 25.42
    1,1,2-trichlorotrifluoroethane 104.22
    DMS 6.94
    cumene 0.47
    2-octanol 2.96
    2-hexanone 4.24
    octyl acetate 3.27
    limonene 1.78
    1,2-dimethoxyethane 51.45
    ethyl orthosilicate 4.17
    tributyl phosphate 4.1
    diacetone alcohol 15.95
    N,N-dimethylaniline 4.15
    acrylonitrile 36.27
    aniline 6.78
    1,3-propanediol 240.66
    bromobenzene 0.51
    dibromomethane 2.9
    1,1,2,2-tetrachloroethane 8.13
    2-methyl-cyclohexyl acetate 4.12
    tetrabutyl urea 8.39
    diisobutyl methanol 2.43
    2-phenylethanol 6.7
    styrene 0.54
    dioctyl adipate 4.56
    dimethyl sulfate 51.46
    ethyl butyrate 5.45
    methyl lactate 59.39
    butyl lactate 12.04
    diethyl carbonate 4.21
    propanediol butyl ether 41.76
    triethyl orthoformate 5.27
    p-tert-butyltoluene 1.15
    methyl 4-tert-butylbenzoate 9.03
    morpholine 63.54
    tert-butylamine 16.7
    n-dodecanol 2.47
    dimethoxymethane 69.43
    ethylene carbonate 18.57
    cyrene 35.13
    2-ethoxyethyl acetate 5.97
    2-ethylhexyl acetate 2.68
    1,2,4-trichlorobenzene 2.19
    4-methylpyridine 6.69
    dibutyl ether 1.85
    2,6-dimethyl-4-heptanol 2.43
    DEF 34.98
    dimethyl isosorbide 23.69
    tetrachloroethylene 7.9
    eugenol 15.84
    triacetin 9.23
    span 80 25.16
    1,4-butanediol 104.98
    1,1-dichloroethane 2.69
    2-methyl-1-pentanol 5.82
    methyl formate 160.95
    2-methyl-1-butanol 16.5
    n-decane 0.35
    butyronitrile 9.76
    3,7-dimethyl-1-octanol 2.91
    1-chlorooctane 0.86
    1-chlorotetradecane 0.5
    n-nonane 0.34
    undecane 0.28
    tert-butylcyclohexane 0.28
    cyclooctane 0.35
    cyclopentanol 44.78
    tetrahydropyran 10.7
    tert-amyl methyl ether 4.01
    2,5,8-trioxanonane 37.9
    1-hexene 1.05
    2-isopropoxyethanol 29.28
    2,2,2-trifluoroethanol 240.86
    methyl butyrate 9.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction