Menatetrenone

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  • Identifiers

    CAS number
    863-61-6

    Molecular formula
    C31H40O2

    SMILES
    CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 66.8%
    Fruity 61.12%
    Sweet 48.54%
    Woody 45.38%
    Balsamic 40.26%
    Waxy 39.11%
    Powdery 34.81%
    Fresh 34.75%
    Rose 32.8%
    Tropical 31.92%

     

    Flavor
    Herbal 40.2%
    Woody 33.95%
    Spicy 30.52%
    Balsam 29.83%
    Wood 27.16%
    Balsamic 23.91%
    Spice 22.82%
    Diterpene 21.89%
    Oriental 21.62%
    Low 21.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    7.38 (neutral)

    Molecular weight
    444.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    541°C

    Flash point

    • 213.46 ˚C est.

  • Synonyms

    • menatetrenone
    • Menaquinone-4
    • 863-61-6
    • Menaquinone 4
    • Kaytwo
    • Menaquinone K4
    • vitamin K2(20)
    • Menatetrenona
    • Vitamin MK 4
    • Menatetrenonum
    • Kaytwo n
    • MENATETRANONE
    • 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione
    • DTXSID6048969
    • 2-Methyl-3-trans-tetraprenyl-1,4-naphthoquinone
    • 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone
    • 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoquinone
    • 27Y876D139
    • DTXCID3028895
    • CHEBI:78277
    • 1,4-Naphthalenedione, 2-methyl-3-((2E,6E,10E)3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-
    • vitamin MK-4
    • (E,E,E)-isomer of menatetrenone
    • 2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)-1,4-naphthoquinone
    • 2-methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)naphthalene-1,4-dione
    • 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1,4-naphthoquinone
    • 2-methyl-3-all-trans-tetraprenyl-1,4-naphthoquinone
    • RefChem:810913
    • E0167
    • vitamin K2
    • 11032-49-8
    • Kefton-2
    • Glakay
    • 6041-00-5
    • MK-4
    • MFCD00079646
    • Menaquinone (K2)
    • 2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione
    • MLS000028742
    • C31H40O2
    • 6Z-Vitamin K2
    • SMR000058955
    • Menaquinone 4(Mixture of cis-trans isomers)
    • 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-
    • Vitamin K2(sub 20)
    • Menatetrenone [INN:JAN]
    • MK4
    • Menatetrenonum [INN-Latin]
    • K2(sub 20)
    • Menatetrenona [INN-Spanish]
    • 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetrenyl)-1,4-naphthoquinone
    • Vitamin K2(MK-4);Menaquinone K4
    • Menatetrenone-4
    • E3100
    • Menatetrenone RS
    • menaquinone(4)
    • DKHGMERMDICWDU-GHDNBGIDSA-N
    • UNII-27Y876D139
    • NCGC00183125-01
    • 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]naphthalene-1,4-dione
    • Vitamin K2 (TN)
    • Opera_ID_148
    • 2-Methyl-3-tetraprenyl-1,4-naphthoquinone
    • Vitamin K2 (MK-4)
    • Vitamin K1 Impurity 18
    • Menadione sodium bisulfite;Vitamin K3 sodium bisulfite
    • Menaquinone-4 (Standard)
    • 6Z-Vitamin K2(20)
    • MENATETRENONE [INN]
    • MENATETRENONE [JAN]
    • Vitamin K2 pound MK-7)
    • 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthochinon
    • DSSTox_CID_28895
    • DSSTox_RID_80857
    • Menatetrenone (JP18/INN)
    • DSSTox_GSID_45406
    • MENAQUINONE 4 [MI]
    • 1,4-Naphthalenedione, 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-, (E,E,E)-
    • MENATETRENONE [MART.]
    • SCHEMBL434553
    • MENATETRENONE [WHO-DD]
    • CHEMBL259223
    • MQ-4
    • orb1305653
    • MENAQUINONE-4 [USP-RS]
    • SCHEMBL29362766
    • EX-A5474A
    • HY-B2156R
    • MSK1551
    • GLXC-21940
    • HMS2230J06
    • HMS5084D03
    • Ea-0167
    • HY-B2156
    • Tox21_110567
    • Tox21_113413
    • BDBM50423776
    • MSK160175
    • s5082
    • AKOS025311021
    • AKOS037645019
    • Menaquinone (K2), analytical standard
    • CCG-269176
    • DB12148
    • EBC-616110
    • FM25052
    • 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione
    • NCGC00181325-01
    • NCGC00181325-03
    • AS-17910
    • AS-56161
    • CAS-863-61-6
    • DA-75412
    • CS-0020307
    • M2398
    • NS00069524
    • 2-Methyl-3-geranylgeranyl-1,4-naphthoqui none
    • D00100
    • E-0167
    • 863V616
    • Q192354
    • BRD-K75864342-001-14-2
    • 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]-
    • 2-methyl-3-[(2E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1,4-dihydronaphthalene-1,4-dione
    • Menatetrenone, 2-methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione
    • 863-61-6

  • Applications

    Menatetrenone (CAS 863-61-6) is primarily used as a source of vitamin K2 in nutraceuticals and pharmaceutical formulations, supplying menaquinone-4 in dietary supplement products and medicinal preparations. It is also employed in food processing and fortification to increase vitamin K content in fortified foods. In agriculture, it serves as a feed additive to meet vitamin K requirements for livestock and poultry. In industrial manufacturing, it acts as an intermediate or building block for the synthesis of other menaquinone derivatives and related vitamin K compounds. Researchers may evaluate it in biochemical studies and formulation development under appropriate regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.46
    methanol 1.06
    isopropanol 1.1
    water 0.0
    ethyl acetate 15.74
    n-propanol 3.05
    acetone 7.21
    n-butanol 3.89
    acetonitrile 1.73
    DMF 10.83
    toluene 23.83
    isobutanol 2.72
    1,4-dioxane 19.75
    methyl acetate 10.15
    THF 56.98
    2-butanone 20.23
    n-pentanol 7.25
    sec-butanol 4.24
    n-hexane 3.54
    ethylene glycol 0.05
    NMP 40.46
    cyclohexane 2.33
    DMSO 4.98
    n-butyl acetate 21.19
    n-octanol 4.22
    chloroform 101.11
    n-propyl acetate 20.09
    acetic acid 3.87
    dichloromethane 88.01
    cyclohexanone 40.32
    propylene glycol 0.27
    isopropyl acetate 13.37
    DMAc 53.03
    2-ethoxyethanol 8.36
    isopentanol 5.1
    n-heptane 1.89
    ethyl formate 4.8
    1,2-dichloroethane 36.69
    n-hexanol 6.31
    2-methoxyethanol 3.68
    isobutyl acetate 16.79
    tetrachloromethane 10.99
    n-pentyl acetate 26.37
    transcutol 49.62
    n-heptanol 6.39
    ethylbenzene 22.17
    MIBK 14.15
    2-propoxyethanol 12.84
    tert-butanol 2.43
    MTBE 14.49
    2-butoxyethanol 16.07
    propionic acid 3.95
    o-xylene 15.6
    formic acid 0.6
    diethyl ether 13.11
    m-xylene 15.5
    p-xylene 23.0
    chlorobenzene 30.3
    dimethyl carbonate 5.64
    n-octane 0.87
    formamide 1.19
    cyclopentanone 36.72
    2-pentanone 17.68
    anisole 38.14
    cyclopentyl methyl ether 26.74
    gamma-butyrolactone 29.36
    1-methoxy-2-propanol 5.47
    pyridine 33.79
    3-pentanone 19.67
    furfural 25.65
    n-dodecane 0.46
    diethylene glycol 1.99
    diisopropyl ether 5.34
    tert-amyl alcohol 7.19
    acetylacetone 17.75
    n-hexadecane 0.56
    acetophenone 32.87
    methyl propionate 12.3
    isopentyl acetate 25.0
    trichloroethylene 97.09
    n-nonanol 5.86
    cyclohexanol 6.06
    benzyl alcohol 13.14
    2-ethylhexanol 8.34
    isooctanol 7.39
    dipropyl ether 15.52
    1,2-dichlorobenzene 35.29
    ethyl lactate 5.96
    propylene carbonate 17.63
    n-methylformamide 2.68
    2-pentanol 3.49
    n-pentane 1.25
    1-propoxy-2-propanol 12.17
    1-methoxy-2-propyl acetate 26.15
    2-(2-methoxypropoxy) propanol 23.13
    mesitylene 8.84
    ε-caprolactone 41.26
    p-cymene 9.65
    epichlorohydrin 51.78
    1,1,1-trichloroethane 39.19
    2-aminoethanol 0.38
    morpholine-4-carbaldehyde 29.73
    sulfolane 34.25
    2,2,4-trimethylpentane 2.23
    2-methyltetrahydrofuran 39.93
    n-hexyl acetate 22.98
    isooctane 0.95
    2-(2-butoxyethoxy)ethanol 22.55
    sec-butyl acetate 21.99
    tert-butyl acetate 20.88
    decalin 3.9
    glycerin 0.47
    diglyme 54.34
    acrylic acid 2.95
    isopropyl myristate 9.61
    n-butyric acid 9.17
    acetyl acetate 9.99
    di(2-ethylhexyl) phthalate 11.25
    ethyl propionate 19.92
    nitromethane 8.27
    1,2-diethoxyethane 31.06
    benzonitrile 10.21
    trioctyl phosphate 5.71
    1-bromopropane 27.58
    gamma-valerolactone 50.77
    n-decanol 3.8
    triethyl phosphate 14.11
    4-methyl-2-pentanol 3.58
    propionitrile 3.56
    vinylene carbonate 15.45
    1,1,2-trichlorotrifluoroethane 21.6
    DMS 14.17
    cumene 13.96
    2-octanol 4.68
    2-hexanone 27.26
    octyl acetate 11.29
    limonene 11.78
    1,2-dimethoxyethane 29.37
    ethyl orthosilicate 16.96
    tributyl phosphate 7.45
    diacetone alcohol 13.87
    N,N-dimethylaniline 28.15
    acrylonitrile 3.4
    aniline 11.93
    1,3-propanediol 0.95
    bromobenzene 43.46
    dibromomethane 49.6
    1,1,2,2-tetrachloroethane 77.21
    2-methyl-cyclohexyl acetate 28.58
    tetrabutyl urea 11.51
    diisobutyl methanol 5.58
    2-phenylethanol 15.04
    styrene 21.74
    dioctyl adipate 18.26
    dimethyl sulfate 10.97
    ethyl butyrate 23.19
    methyl lactate 3.32
    butyl lactate 12.56
    diethyl carbonate 13.01
    propanediol butyl ether 6.9
    triethyl orthoformate 23.02
    p-tert-butyltoluene 8.9
    methyl 4-tert-butylbenzoate 32.45
    morpholine 22.31
    tert-butylamine 2.04
    n-dodecanol 2.59
    dimethoxymethane 11.26
    ethylene carbonate 11.6
    cyrene 26.36
    2-ethoxyethyl acetate 34.13
    2-ethylhexyl acetate 25.29
    1,2,4-trichlorobenzene 48.16
    4-methylpyridine 36.42
    dibutyl ether 13.17
    2,6-dimethyl-4-heptanol 5.58
    DEF 22.83
    dimethyl isosorbide 56.55
    tetrachloroethylene 38.44
    eugenol 26.34
    triacetin 26.12
    span 80 17.44
    1,4-butanediol 0.74
    1,1-dichloroethane 26.75
    2-methyl-1-pentanol 13.26
    methyl formate 2.36
    2-methyl-1-butanol 6.59
    n-decane 1.17
    butyronitrile 4.88
    3,7-dimethyl-1-octanol 6.12
    1-chlorooctane 6.1
    1-chlorotetradecane 1.99
    n-nonane 0.95
    undecane 0.68
    tert-butylcyclohexane 3.79
    cyclooctane 1.26
    cyclopentanol 4.37
    tetrahydropyran 28.84
    tert-amyl methyl ether 20.68
    2,5,8-trioxanonane 36.41
    1-hexene 13.37
    2-isopropoxyethanol 10.24
    2,2,2-trifluoroethanol 1.77
    methyl butyrate 24.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction