Menaquinone 7

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  • Identifiers

    CAS number
    2124-57-4

    Molecular formula
    C46H64O2

    SMILES
    CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 67.88%
    Balsamic 49.26%
    Woody 45.64%
    Fruity 45.53%
    Waxy 44.05%
    Sweet 43.05%
    Oily 36.0%
    Green 32.41%
    Powdery 31.69%
    Rose 30.26%

     

    Flavor
    Balsam 38.93%
    Herbal 34.51%
    Woody 33.65%
    Wood 32.55%
    Balsamic 29.89%
    Spicy 27.92%
    Diterpene 23.97%
    Low 23.33%
    Oriental 22.92%
    Herb 22.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.5

    pKa est.
    -538.88 (strong acid)

    Molecular weight
    649.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 54 °C
    • Yellow crystals from alcohol; MW: 444.65; MP: 35 °C; uv max: 248 nm (E(1%)(1 cm) 439) /Menaquinone 4/
    • Yellow crystals from acetone + alcohol or petroleum ether. MW: 580.88; MP: 50 °C; uv max (petroleum ether): 243, 248, 261, 325-328 nm (E(1%)(1 CM) 304, 320, 290, 292, 53) /Menaquinone 6/

    Boiling point

    • 200 °C at 0.0002 mm Hg (some decomposition)

    Flash point

    • -2665.79 ˚C est.

    Solubility expt.

    • Slightly less soluble than vitamin K1 in the same organic solvents
    • INSOL IN WATER; SOL IN FAT SOLVENTS
    • SOL IN OILS
    • SOL IN FATS

  • Synonyms

    • Menaquinone-7
    • Menaquinone 7
    • 2124-57-4
    • Vitamin K2(35)
    • Menaquinone K7
    • Vitamin MK 7
    • Menakinon 7
    • 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione
    • 8427BML8NY
    • 1,4-Naphthalenedione, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-, (all-E)-
    • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]-3-methylnaphthalene-1,4-dione
    • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
    • CHEBI:44245
    • DTXSID801317474
    • 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-3-methylnaphthalene-1,4-dione
    • RefChem:925473
    • DTXCID90908566
    • MK-7
    • MFCD06200757
    • (all-E)-2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
    • 13425-62-2
    • 2-Methyl-3-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptenyl)-1,4-naphthoquinone
    • Mk7
    • (all-E)-2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosahept-aenyl)-3-methyl-1,4-naphthoquinone
    • Menaquinone 7, Synthetic (90%)
    • Menaquinone K
    • Menlaquinone 7
    • HSDB 1040
    • menaquinone(7)
    • Menaquinone MK-7
    • C46H64O2
    • trans-menaquinone 7
    • Vitamin K2-7
    • Vitamin K2 (MK-7)
    • Menaquinone-7 (Standard)
    • UNII-8427BML8NY
    • MENAQUINONE 7 [MI]
    • MENAQUINONE-7 [DSC]
    • MENAQUINONE 7 [HSDB]
    • SCHEMBL436068
    • CHEMBL1230575
    • MENAQUINONE-7 [USP-RS]
    • MENAQUINONE-7 [WHO-DD]
    • SCHEMBL29359122
    • MSK1597
    • Vitamin K2 Menaquinone-7 (MK-7)
    • AKOS027326821
    • DB13075
    • FM25056
    • HY-112499R
    • 1,4-Naphthalenedione, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosahept-aenyl)-3-methyl-, (all-E)-
    • 1,4-Naphthoquinone, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosahept-aenyl)-3-methyl-, (all-E)-
    • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methyl-naphthalene-1,4-dione
    • AC-36642
    • AS-78195
    • DA-68610
    • SY353428
    • HY-112499
    • CS-0046153
    • NS00072810
    • 124M574
    • Q27120546
    • (All-ee)-2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
    • 1,4-NAPHTHALENEDIONE, 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-HEPTAMETHYL-2,6,10,14,18,22,26-OCTACOSAHEPTAENYL)-3-METHYL-
    • 1,4-NAPHTHOQUINONE, 2-(3,7,11,15,19,23,27-HEPTAMETHYL-2,6,10,14,18,22,26-OCTACOSAHEPTAENYL)-3-METHYL-, (ALL-E)-
    • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl]-3-methylnaphthoquinone #
    • 2124-57-4

  • Applications

    Menaquinone 7, CAS 2124-57-4, is widely used as a vitamin K2 (menaquinone family) in nutrition and pharmaceutical applications. Real-world uses include: 1) dietary supplementation in capsules/tablets or liquids for nutraceutical products; 2) fortification of functional foods and beverages to raise vitamin K2 intake; 3) incorporation as a nutritional additive in animal feeds to support bone health in livestock; 4) evaluation for cosmetic applications as an ingredient containing vitamin K; 5) used as a reference compound or intermediate in research related to synthesis and biological studies of vitamin K2, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.2
    methanol 0.15
    isopropanol 0.16
    water 0.0
    ethyl acetate 5.69
    n-propanol 0.51
    acetone 2.03
    n-butanol 0.59
    acetonitrile 0.39
    DMF 3.06
    toluene 7.25
    isobutanol 0.44
    1,4-dioxane 5.2
    methyl acetate 3.05
    THF 18.53
    2-butanone 5.45
    n-pentanol 1.37
    sec-butanol 0.66
    n-hexane 1.59
    ethylene glycol 0.01
    NMP 18.82
    cyclohexane 0.73
    DMSO 1.48
    n-butyl acetate 6.58
    n-octanol 0.91
    chloroform 33.15
    n-propyl acetate 7.2
    acetic acid 0.93
    dichloromethane 26.57
    cyclohexanone 11.63
    propylene glycol 0.05
    isopropyl acetate 4.67
    DMAc 15.82
    2-ethoxyethanol 1.88
    isopentanol 0.74
    n-heptane 0.87
    ethyl formate 1.54
    1,2-dichloroethane 9.68
    n-hexanol 1.05
    2-methoxyethanol 0.73
    isobutyl acetate 5.31
    tetrachloromethane 3.97
    n-pentyl acetate 8.9
    transcutol 10.1
    n-heptanol 1.28
    ethylbenzene 8.12
    MIBK 4.1
    2-propoxyethanol 2.7
    tert-butanol 0.36
    MTBE 4.0
    2-butoxyethanol 3.73
    propionic acid 1.0
    o-xylene 5.43
    formic acid 0.15
    diethyl ether 3.39
    m-xylene 5.28
    p-xylene 8.19
    chlorobenzene 10.57
    dimethyl carbonate 2.04
    n-octane 0.35
    formamide 0.29
    cyclopentanone 13.62
    2-pentanone 5.38
    anisole 12.62
    cyclopentyl methyl ether 10.85
    gamma-butyrolactone 12.25
    1-methoxy-2-propanol 1.14
    pyridine 10.9
    3-pentanone 6.6
    furfural 10.35
    n-dodecane 0.15
    diethylene glycol 0.35
    diisopropyl ether 1.72
    tert-amyl alcohol 1.33
    acetylacetone 6.34
    n-hexadecane 0.19
    acetophenone 11.66
    methyl propionate 4.45
    isopentyl acetate 7.27
    trichloroethylene 33.27
    n-nonanol 1.37
    cyclohexanol 1.15
    benzyl alcohol 2.96
    2-ethylhexanol 2.0
    isooctanol 1.61
    dipropyl ether 6.66
    1,2-dichlorobenzene 13.74
    ethyl lactate 1.87
    propylene carbonate 6.96
    n-methylformamide 0.74
    2-pentanol 0.6
    n-pentane 0.41
    1-propoxy-2-propanol 3.08
    1-methoxy-2-propyl acetate 8.14
    2-(2-methoxypropoxy) propanol 6.4
    mesitylene 3.16
    ε-caprolactone 15.39
    p-cymene 3.59
    epichlorohydrin 19.32
    1,1,1-trichloroethane 13.32
    2-aminoethanol 0.06
    morpholine-4-carbaldehyde 10.14
    sulfolane 15.17
    2,2,4-trimethylpentane 0.9
    2-methyltetrahydrofuran 14.03
    n-hexyl acetate 7.44
    isooctane 0.35
    2-(2-butoxyethoxy)ethanol 5.24
    sec-butyl acetate 8.24
    tert-butyl acetate 7.32
    decalin 1.68
    glycerin 0.08
    diglyme 15.22
    acrylic acid 0.8
    isopropyl myristate 3.04
    n-butyric acid 2.36
    acetyl acetate 3.89
    di(2-ethylhexyl) phthalate 3.41
    ethyl propionate 8.46
    nitromethane 2.54
    1,2-diethoxyethane 9.33
    benzonitrile 2.52
    trioctyl phosphate 1.59
    1-bromopropane 8.16
    gamma-valerolactone 19.3
    n-decanol 0.83
    triethyl phosphate 6.33
    4-methyl-2-pentanol 0.7
    propionitrile 0.82
    vinylene carbonate 6.49
    1,1,2-trichlorotrifluoroethane 7.5
    DMS 4.47
    cumene 5.28
    2-octanol 1.02
    2-hexanone 8.99
    octyl acetate 3.37
    limonene 4.51
    1,2-dimethoxyethane 7.96
    ethyl orthosilicate 7.41
    tributyl phosphate 2.28
    diacetone alcohol 3.54
    N,N-dimethylaniline 10.55
    acrylonitrile 0.87
    aniline 2.86
    1,3-propanediol 0.15
    bromobenzene 16.79
    dibromomethane 14.48
    1,1,2,2-tetrachloroethane 25.13
    2-methyl-cyclohexyl acetate 11.17
    tetrabutyl urea 3.76
    diisobutyl methanol 1.41
    2-phenylethanol 3.16
    styrene 7.04
    dioctyl adipate 6.02
    dimethyl sulfate 4.71
    ethyl butyrate 9.65
    methyl lactate 0.98
    butyl lactate 3.8
    diethyl carbonate 5.04
    propanediol butyl ether 1.36
    triethyl orthoformate 10.34
    p-tert-butyltoluene 3.43
    methyl 4-tert-butylbenzoate 12.11
    morpholine 5.58
    tert-butylamine 0.32
    n-dodecanol 0.53
    dimethoxymethane 3.34
    ethylene carbonate 4.57
    cyrene 9.43
    2-ethoxyethyl acetate 11.37
    2-ethylhexyl acetate 8.59
    1,2,4-trichlorobenzene 17.53
    4-methylpyridine 10.79
    dibutyl ether 4.58
    2,6-dimethyl-4-heptanol 1.41
    DEF 7.51
    dimethyl isosorbide 20.07
    tetrachloroethylene 12.6
    eugenol 7.25
    triacetin 8.75
    span 80 4.52
    1,4-butanediol 0.13
    1,1-dichloroethane 7.41
    2-methyl-1-pentanol 2.52
    methyl formate 0.78
    2-methyl-1-butanol 1.06
    n-decane 0.43
    butyronitrile 1.05
    3,7-dimethyl-1-octanol 1.41
    1-chlorooctane 2.13
    1-chlorotetradecane 0.61
    n-nonane 0.35
    undecane 0.24
    tert-butylcyclohexane 1.72
    cyclooctane 0.55
    cyclopentanol 1.08
    tetrahydropyran 7.96
    tert-amyl methyl ether 7.24
    2,5,8-trioxanonane 9.42
    1-hexene 5.03
    2-isopropoxyethanol 2.3
    2,2,2-trifluoroethanol 0.51
    methyl butyrate 9.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction