Matrine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    519-02-8

    Molecular formula
    C15H24N2O

    SMILES
    C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 47.43%
    Nutty 44.48%
    Animal 37.44%
    Roasted 37.02%
    Popcorn 36.77%
    Sweet 27.84%
    Earthy 25.49%
    Burnt 24.24%
    Spicy 23.76%
    Meaty 22.24%

     

    Flavor
    Bitter 77.4%
    Animal 29.37%
    Alkaline 23.09%
    Cereal 20.8%
    Shrimp 20.36%
    Cedarleaf 19.64%
    Sweet-like 19.41%
    Indole 18.91%
    Very strong 18.83%
    Rotten 18.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    8.3 (weak base)

    Molecular weight
    248.36 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    437°C

    Flash point

    • 188.99 ˚C est.

  • Synonyms

    • Matrine
    • 519-02-8
    • (+)-Matrine
    • Vegard
    • N390W430AC
    • NSC-146051
    • DTXSID00274188
    • NSC-318810
    • (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
    • (1R,2R,9S,17S)-7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-one
    • RefChem:55556
    • DTXCID70820575
    • 2,6-diamino-5-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl)oxy-1H-pyrimidin-4-one
    • 7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-one
    • alpha-Matrine
    • (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
    • MFCD00210527
    • Matrene, (+)-
    • Alpha Matrine
    • C15H24N2O
    • CHEBI:6700
    • .alpha.-Matrine
    • (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
    • NSC 146051
    • BRN 0085851
    • Lupanidine
    • UNII-N390W430AC
    • Matrine CRS
    • Ex Sophporae Radix
    • Matrine (Standard)
    • Matridin-15-one;
    • MATRINE [MI]
    • Matrine ((+)-Matrine)
    • MATRINE [WHO-DD]
    • 5-24-02-00301 (Beilstein Handbook Reference)
    • SCHEMBL177907
    • CHEMBL204860
    • HY-N0164R
    • HMS3884F13
    • HMS6019G05
    • HY-N0164
    • BDBM50249581
    • Matridin-15-one; Vegard; -Matrine
    • MSK000575
    • NSC146051
    • s2322
    • Matridin-15-one;Vegard;alpha-Matrine
    • AKOS007930266
    • CCG-208589
    • CS-1601
    • EBC-466111
    • FM65961
    • KS-5203
    • Matrine 100 microg/mL in Acetonitrile
    • NCGC00346593-01
    • SY016076
    • M2120
    • NS00066991
    • 19M028
    • AA-504/21004001
    • AL-466/21199007
    • AO-228/21245001
    • (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-6-one
    • (4(1)S,7aS,13aR,13bR)-dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(4(1)H)-one
    • (7aS,13aR,13bS,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one
    • 1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)-
    • 519-02-8

  • Applications

    Matrine, an alkaloid from Sophora flavescens (CAS 519-02-8), has real-world applications across several sectors: as a natural pesticide and nematicide in crop protection formulations; as an active ingredient in traditional Chinese medicine preparations and related pharmaceutical products; as a starting material or synthetic intermediate in organic-chemistry research and production of related alkaloids; and as a focus of ongoing research for antimicrobial and antiviral activities within drug discovery and agrochemical development. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 37.65
    methanol 68.08
    isopropanol 25.29
    water 2.11
    ethyl acetate 68.81
    n-propanol 35.95
    acetone 60.89
    n-butanol 35.93
    acetonitrile 38.95
    DMF 108.08
    toluene 61.35
    isobutanol 29.66
    1,4-dioxane 122.04
    methyl acetate 56.69
    THF 111.97
    2-butanone 69.38
    n-pentanol 20.71
    sec-butanol 16.98
    n-hexane 0.4
    ethylene glycol 33.63
    NMP 132.04
    cyclohexane 2.62
    DMSO 134.76
    n-butyl acetate 57.24
    n-octanol 10.11
    chloroform 475.31
    n-propyl acetate 41.38
    acetic acid 188.76
    dichloromethane 371.45
    cyclohexanone 168.91
    propylene glycol 18.5
    isopropyl acetate 47.4
    DMAc 98.92
    2-ethoxyethanol 63.2
    isopentanol 36.87
    n-heptane 0.55
    ethyl formate 99.37
    1,2-dichloroethane 164.52
    n-hexanol 24.04
    2-methoxyethanol 128.88
    isobutyl acetate 32.93
    tetrachloromethane 45.53
    n-pentyl acetate 46.56
    transcutol 242.29
    n-heptanol 17.45
    ethylbenzene 17.0
    MIBK 37.52
    2-propoxyethanol 89.87
    tert-butanol 18.93
    MTBE 9.41
    2-butoxyethanol 67.65
    propionic acid 87.78
    o-xylene 35.02
    formic acid 135.83
    diethyl ether 16.07
    m-xylene 37.76
    p-xylene 24.32
    chlorobenzene 124.1
    dimethyl carbonate 38.61
    n-octane 0.37
    formamide 145.64
    cyclopentanone 176.2
    2-pentanone 52.8
    anisole 33.67
    cyclopentyl methyl ether 39.41
    gamma-butyrolactone 265.45
    1-methoxy-2-propanol 70.09
    pyridine 216.7
    3-pentanone 44.04
    furfural 379.64
    n-dodecane 0.51
    diethylene glycol 110.23
    diisopropyl ether 5.73
    tert-amyl alcohol 13.36
    acetylacetone 89.73
    n-hexadecane 0.64
    acetophenone 58.68
    methyl propionate 56.88
    isopentyl acetate 56.81
    trichloroethylene 507.3
    n-nonanol 11.23
    cyclohexanol 43.03
    benzyl alcohol 70.54
    2-ethylhexanol 17.01
    isooctanol 16.34
    dipropyl ether 8.29
    1,2-dichlorobenzene 119.84
    ethyl lactate 37.05
    propylene carbonate 164.16
    n-methylformamide 119.76
    2-pentanol 15.47
    n-pentane 0.82
    1-propoxy-2-propanol 50.5
    1-methoxy-2-propyl acetate 74.5
    2-(2-methoxypropoxy) propanol 56.64
    mesitylene 20.19
    ε-caprolactone 149.76
    p-cymene 16.32
    epichlorohydrin 266.08
    1,1,1-trichloroethane 112.27
    2-aminoethanol 43.45
    morpholine-4-carbaldehyde 177.67
    sulfolane 222.52
    2,2,4-trimethylpentane 0.85
    2-methyltetrahydrofuran 63.1
    n-hexyl acetate 42.43
    isooctane 0.77
    2-(2-butoxyethoxy)ethanol 81.15
    sec-butyl acetate 29.46
    tert-butyl acetate 36.81
    decalin 1.77
    glycerin 62.93
    diglyme 139.14
    acrylic acid 119.07
    isopropyl myristate 14.86
    n-butyric acid 133.53
    acetyl acetate 79.66
    di(2-ethylhexyl) phthalate 33.9
    ethyl propionate 34.15
    nitromethane 224.2
    1,2-diethoxyethane 42.62
    benzonitrile 127.51
    trioctyl phosphate 19.39
    1-bromopropane 38.24
    gamma-valerolactone 292.16
    n-decanol 8.28
    triethyl phosphate 29.19
    4-methyl-2-pentanol 14.23
    propionitrile 44.4
    vinylene carbonate 210.09
    1,1,2-trichlorotrifluoroethane 264.47
    DMS 54.27
    cumene 13.27
    2-octanol 8.55
    2-hexanone 30.42
    octyl acetate 20.87
    limonene 15.71
    1,2-dimethoxyethane 67.47
    ethyl orthosilicate 24.86
    tributyl phosphate 26.16
    diacetone alcohol 49.96
    N,N-dimethylaniline 21.99
    acrylonitrile 90.44
    aniline 100.62
    1,3-propanediol 80.28
    bromobenzene 113.16
    dibromomethane 163.28
    1,1,2,2-tetrachloroethane 311.71
    2-methyl-cyclohexyl acetate 36.39
    tetrabutyl urea 29.02
    diisobutyl methanol 10.23
    2-phenylethanol 66.55
    styrene 21.07
    dioctyl adipate 29.82
    dimethyl sulfate 64.95
    ethyl butyrate 37.36
    methyl lactate 52.6
    butyl lactate 47.73
    diethyl carbonate 34.09
    propanediol butyl ether 48.05
    triethyl orthoformate 29.9
    p-tert-butyltoluene 13.05
    methyl 4-tert-butylbenzoate 55.73
    morpholine 118.04
    tert-butylamine 8.3
    n-dodecanol 6.42
    dimethoxymethane 63.56
    ethylene carbonate 158.83
    cyrene 70.78
    2-ethoxyethyl acetate 89.52
    2-ethylhexyl acetate 45.06
    1,2,4-trichlorobenzene 157.08
    4-methylpyridine 157.82
    dibutyl ether 8.91
    2,6-dimethyl-4-heptanol 10.23
    DEF 63.88
    dimethyl isosorbide 94.35
    tetrachloroethylene 249.02
    eugenol 61.08
    triacetin 64.2
    span 80 45.75
    1,4-butanediol 28.31
    1,1-dichloroethane 110.04
    2-methyl-1-pentanol 24.17
    methyl formate 104.04
    2-methyl-1-butanol 29.09
    n-decane 0.73
    butyronitrile 49.01
    3,7-dimethyl-1-octanol 14.81
    1-chlorooctane 5.59
    1-chlorotetradecane 2.59
    n-nonane 0.53
    undecane 0.6
    tert-butylcyclohexane 1.27
    cyclooctane 1.0
    cyclopentanol 44.55
    tetrahydropyran 67.17
    tert-amyl methyl ether 9.09
    2,5,8-trioxanonane 93.64
    1-hexene 2.56
    2-isopropoxyethanol 40.55
    2,2,2-trifluoroethanol 119.89
    methyl butyrate 45.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction