Maslinic Acid

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  • Identifiers

    CAS number
    4373-41-5

    Molecular formula
    C30H48O4

    SMILES
    C[C@@]12CC[C@@H]3[C@@]([C@H]1CC=C4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)(C[C@H]([C@@H](C3(C)C)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 83.77%
    Amber 55.41%
    Dry 50.02%
    Cedar 49.85%
    Balsamic 46.15%
    Spicy 39.98%
    Musk 39.86%
    Sandalwood 36.67%
    Camphoreous 36.3%
    Pine 32.55%

     

    Flavor
    Woody 62.85%
    Camphor 48.16%
    Pine 46.33%
    Balsam 42.48%
    Sweet 41.93%
    Herbal 39.25%
    Bitter 34.08%
    Spicy 33.22%
    Earthy 32.52%
    Dry 29.94%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    5.92 (weak acid)

    Molecular weight
    472.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    204°C

    Melting point expt.

    • 249 - 250 °C

    Flash point

    • 270.82 ˚C est.

    Solubility expt.

    • Solubility of 0.3 mg/mL in a 1:2 solution of Ethanol:Buffered Water (pH 7.2) at 25 °C
    • In ethanol: 0.5 mg/mL; in DMSO: 20 mg/mL; in dimethyl formamide: 15 mg/mL
    • Sparingly soluble in aqueous buffers

  • Synonyms

    • Maslinic acid
    • 4373-41-5
    • Crategolic acid
    • Crataegolic acid
    • Maslic acid
    • Masilinic acid
    • 2alpha-hydroxyoleanolic acid
    • (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
    • E233J88OHQ
    • 2alpha,3beta-dihydroxyurs-12-en-29-oic acid
    • CHEBI:66682
    • DTXSID30905074
    • 2-hydroxyoleanolic acid
    • Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
    • RefChem:41765
    • (2alpha, 3beta)-2,3-dihydroxyolean-12-en-28-oic acid
    • (2beta, 3alpha)-2,3-dihydroxyolean-12-en-28-oic acid
    • (2alpha, 3beta)-2,3-dihydroxy-olean-12-en-28-oic acid
    • DTXCID101334176
    • olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha, 3beta)-
    • 610-137-3
    • MFCD00049293
    • CHEMBL201515
    • (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
    • 2alpha,3beta-dihydroxyolean-12-en-28-oic acid
    • Maslinicacid
    • Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2.alpha.,3.beta.)-
    • (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid
    • UNII-E233J88OHQ
    • maslinatic acid
    • Maslinic-acid
    • HSDB 8099
    • Maslinic acid (Standard)
    • alpha-hydroxyoleanolic acid
    • 2alpha-Hydroxyoleanoic Acid
    • SCHEMBL570425
    • 2alpha-hydroxyl oleanolic acid
    • orb1303769
    • HY-N0629R
    • HMS3886H14
    • Maslinic acid, analytical standard
    • Maslinic acid, >=98% (HPLC)
    • EX-A6799
    • HY-N0629
    • MSK40239
    • BDBM50175892
    • s9040
    • 2.ALPHA.-HYDROXYOLEANOLIC ACID
    • AKOS015951204
    • CCG-269468
    • Crategolic acid;2-Hydroxyoleanolic acid
    • CS-3801
    • EBC-616568
    • FC42668
    • LMPR0106180014
    • EMD-1176098
    • NCGC00390255-05
    • NCGC00390255-06
    • AC-33937
    • AS-56463
    • SY075653
    • 2alpha,3beta-dihydroxyolean-12-en-28-acid
    • C16939
    • 2alpha,3beta-dihydroxy-12-oleanen-28-oic acid
    • 2alpha,3beta-dihydroxy-olean-12-en-28-oic acid
    • 373M415
    • Q1907191
    • (2alpha,3beta)- 2,3-dihydroxy-Olean-12-en-28-oate
    • (2alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid
    • (2.alpha.,3.beta.)-2,3-dihydroxy-Olean-12-en-28-oate
    • (2alpha,3beta)- 2,3-dihydroxy-Olean-12-en-28-oic acid
    • (2.alpha.,3.beta.)-2,3-dihydroxy-Olean-12-en-28-oic acid
    • 4373-41-5

  • Applications

    Maslinic acid (CAS 4373-41-5) is a pentacyclic triterpenoid acid derived from olives. In industrial contexts, it is regarded as a natural bioactive with antioxidant properties and is commonly used as an active ingredient in cosmetics and personal care formulations for skin protection and care. It is also investigated in pharmaceutical research for anti-inflammatory and anti-proliferative activities, serving as a lead compound in pharmacological studies and the development of bioactive agents. The compound is often evaluated for use as a nutraceutical or functional ingredient derived from olive sources. Additionally, maslinic acid can act as a starting material or building block for the synthesis of other triterpenoid derivatives, enabling semi-synthetic exploration. Subject to formulation limits and local regulations, it may be used in these contexts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.7
    methanol 10.33
    isopropanol 6.86
    water 0.0
    ethyl acetate 4.77
    n-propanol 14.7
    acetone 5.42
    n-butanol 10.55
    acetonitrile 1.27
    DMF 75.99
    toluene 5.74
    isobutanol 7.83
    1,4-dioxane 38.64
    methyl acetate 4.11
    THF 92.56
    2-butanone 8.75
    n-pentanol 8.24
    sec-butanol 5.65
    n-hexane 0.3
    ethylene glycol 1.13
    NMP 41.53
    cyclohexane 0.27
    DMSO 14.3
    n-butyl acetate 5.35
    n-octanol 3.52
    chloroform 12.82
    n-propyl acetate 3.46
    acetic acid 4.83
    dichloromethane 6.97
    cyclohexanone 13.46
    propylene glycol 3.59
    isopropyl acetate 4.67
    DMAc 38.01
    2-ethoxyethanol 20.21
    isopentanol 6.35
    n-heptane 0.27
    ethyl formate 2.66
    1,2-dichloroethane 4.41
    n-hexanol 9.55
    2-methoxyethanol 34.79
    isobutyl acetate 3.3
    tetrachloromethane 1.45
    n-pentyl acetate 8.44
    transcutol 38.84
    n-heptanol 7.28
    ethylbenzene 2.75
    MIBK 5.6
    2-propoxyethanol 51.21
    tert-butanol 4.46
    MTBE 5.48
    2-butoxyethanol 26.43
    propionic acid 4.14
    o-xylene 2.94
    formic acid 2.85
    diethyl ether 7.84
    m-xylene 3.96
    p-xylene 2.46
    chlorobenzene 4.06
    dimethyl carbonate 5.86
    n-octane 0.11
    formamide 3.89
    cyclopentanone 25.86
    2-pentanone 8.15
    anisole 8.16
    cyclopentyl methyl ether 18.31
    gamma-butyrolactone 20.78
    1-methoxy-2-propanol 39.79
    pyridine 22.63
    3-pentanone 5.75
    furfural 15.81
    n-dodecane 0.04
    diethylene glycol 19.01
    diisopropyl ether 1.74
    tert-amyl alcohol 4.12
    acetylacetone 8.6
    n-hexadecane 0.05
    acetophenone 6.67
    methyl propionate 7.98
    isopentyl acetate 5.85
    trichloroethylene 12.32
    n-nonanol 3.93
    cyclohexanol 4.85
    benzyl alcohol 9.15
    2-ethylhexanol 3.56
    isooctanol 5.15
    dipropyl ether 5.56
    1,2-dichlorobenzene 3.5
    ethyl lactate 3.84
    propylene carbonate 6.45
    n-methylformamide 13.45
    2-pentanol 4.53
    n-pentane 0.3
    1-propoxy-2-propanol 28.79
    1-methoxy-2-propyl acetate 16.28
    2-(2-methoxypropoxy) propanol 13.86
    mesitylene 1.92
    ε-caprolactone 12.76
    p-cymene 1.82
    epichlorohydrin 29.46
    1,1,1-trichloroethane 3.05
    2-aminoethanol 6.51
    morpholine-4-carbaldehyde 63.02
    sulfolane 25.1
    2,2,4-trimethylpentane 0.21
    2-methyltetrahydrofuran 19.86
    n-hexyl acetate 8.38
    isooctane 0.19
    2-(2-butoxyethoxy)ethanol 22.81
    sec-butyl acetate 2.85
    tert-butyl acetate 5.94
    decalin 0.28
    glycerin 6.68
    diglyme 37.42
    acrylic acid 4.06
    isopropyl myristate 2.01
    n-butyric acid 7.35
    acetyl acetate 2.97
    di(2-ethylhexyl) phthalate 4.13
    ethyl propionate 3.57
    nitromethane 7.16
    1,2-diethoxyethane 9.94
    benzonitrile 4.1
    trioctyl phosphate 2.78
    1-bromopropane 2.77
    gamma-valerolactone 48.47
    n-decanol 1.92
    triethyl phosphate 2.53
    4-methyl-2-pentanol 3.05
    propionitrile 2.69
    vinylene carbonate 7.08
    1,1,2-trichlorotrifluoroethane 18.52
    DMS 6.4
    cumene 1.78
    2-octanol 3.04
    2-hexanone 5.4
    octyl acetate 3.3
    limonene 2.13
    1,2-dimethoxyethane 24.99
    ethyl orthosilicate 3.0
    tributyl phosphate 2.13
    diacetone alcohol 9.88
    N,N-dimethylaniline 6.7
    acrylonitrile 3.65
    aniline 7.99
    1,3-propanediol 10.64
    bromobenzene 3.66
    dibromomethane 4.28
    1,1,2,2-tetrachloroethane 10.66
    2-methyl-cyclohexyl acetate 4.76
    tetrabutyl urea 3.66
    diisobutyl methanol 2.01
    2-phenylethanol 11.28
    styrene 2.79
    dioctyl adipate 3.94
    dimethyl sulfate 9.65
    ethyl butyrate 3.71
    methyl lactate 8.28
    butyl lactate 9.47
    diethyl carbonate 2.04
    propanediol butyl ether 18.25
    triethyl orthoformate 4.74
    p-tert-butyltoluene 1.99
    methyl 4-tert-butylbenzoate 11.7
    morpholine 64.74
    tert-butylamine 1.96
    n-dodecanol 0.91
    dimethoxymethane 51.14
    ethylene carbonate 5.4
    cyrene 16.49
    2-ethoxyethyl acetate 14.45
    2-ethylhexyl acetate 4.55
    1,2,4-trichlorobenzene 5.69
    4-methylpyridine 14.3
    dibutyl ether 1.96
    2,6-dimethyl-4-heptanol 2.01
    DEF 12.7
    dimethyl isosorbide 24.44
    tetrachloroethylene 7.38
    eugenol 13.15
    triacetin 7.94
    span 80 13.48
    1,4-butanediol 3.65
    1,1-dichloroethane 3.5
    2-methyl-1-pentanol 4.8
    methyl formate 6.62
    2-methyl-1-butanol 6.54
    n-decane 0.13
    butyronitrile 3.0
    3,7-dimethyl-1-octanol 2.79
    1-chlorooctane 0.89
    1-chlorotetradecane 0.18
    n-nonane 0.11
    undecane 0.07
    tert-butylcyclohexane 0.28
    cyclooctane 0.17
    cyclopentanol 8.06
    tetrahydropyran 20.88
    tert-amyl methyl ether 4.47
    2,5,8-trioxanonane 19.54
    1-hexene 1.33
    2-isopropoxyethanol 12.15
    2,2,2-trifluoroethanol 1.76
    methyl butyrate 4.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction