Mangiferin

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  • Identifiers

    CAS number
    4773-96-0

    Molecular formula
    C19H18O11

    SMILES
    C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 79.3%
    Phenolic 33.72%
    Burnt 24.82%
    Vanilla 21.23%
    Smoky 19.96%
    Savory 19.4%
    Bitter 18.78%
    Milky 17.19%
    Balsamic 15.41%
    Caramellic 15.09%

     

    Flavor
    Bitter 79.99%
    Odorless 39.2%
    Bland 29.94%
    Sweet-like 26.45%
    Mild 20.5%
    Very mild 20.12%
    Cedarleaf 19.97%
    Eugenol 19.44%
    Nitrile 19.16%
    Very slight 19.13%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -0.4

    pKa est.
    7.91 (neutral)

    Molecular weight
    422.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3722°C

    Flash point

    • 347.75 ˚C est.

  • Synonyms

    • Mangiferin
    • 4773-96-0
    • Chinonin
    • Alpizarin
    • Hedysarid
    • Alpizarine
    • Chinomin
    • 1M84LD0UMD
    • 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
    • CHEBI:6682
    • 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
    • DTXSID60197263
    • NSC-248870
    • 9H-Xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-
    • 1,3,6,7-tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)xanthen-9-one
    • RefChem:42324
    • DTXCID70119754
    • Aphloiol
    • Mangiferin Mangifera indica
    • Xanthone-c-glucoside
    • MFCD00075656
    • 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy-
    • (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-2-yl)-D-glucitol
    • 1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one
    • C19H18O11
    • 9H-Xanthen-9-one, 2-.beta.-D-glucopyranosyl-1,3,6,7-tetrahydroxy-
    • Chinoinin
    • Shamimin
    • 9H-Xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy- (9CI)
    • 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]xanthen-9-one
    • UNII-1M84LD0UMD
    • cid_5358385
    • Mangiferol
    • NSC248870
    • Mangiferin CRS
    • HZI
    • Mangiferin, 98%
    • Mangiferin - 90%
    • NSC 248870
    • Mangiferin (Standard)
    • MANGIFERIN [USP-RS]
    • MANGIFERIN [WHO-DD]
    • SCHEMBL556844
    • Mangiferin (Many other names)
    • Mangiferin, analytical standard
    • CHEMBL464825
    • orb1304623
    • SCHEMBL29360104
    • SCHEMBL29398476
    • BCBcMAP01_000240
    • GTPL13843
    • HY-N0290R
    • WLZ4637
    • GLXC-03051
    • HY-N0290
    • BDBM50248691
    • MSK158066
    • s3808
    • STL564509
    • AKOS015896788
    • CCG-268909
    • CS-4663
    • EBC-445042
    • MT08923
    • SMP1_000290
    • 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one
    • AC-34484
    • AS-15337
    • DA-75300
    • FM158983
    • M2886
    • NS00074224
    • 2beta-glucosyl-1,3,6,7-tratrahydroxyxanthone
    • 1,3,6,7-Tetrahydroxyxanthone-C2-?-D-glucoside
    • 773M960
    • AN-668/21203018
    • 1,3,6,7-tetrahydroxyxanthone-C-2-beta-D-glucoside
    • Q1074417
    • c2-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone
    • 2beta-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthen-9-one
    • Mangiferin, European Pharmacopoeia (EP) Reference Standard
    • 2-?-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
    • 9H-Xanthen-9-one, 2-|A-D-glucopyranosyl-1,3,6,7-tetrahydroxy-
    • 4773-96-0

  • Applications

    Mangiferin (CAS 4773-96-0) is a natural xanthone glycoside commonly considered as an antioxidant and has potential as a photostabilizer in cosmetics and personal care formulations. In coatings, inks, and polymer applications, it is used as an antioxidant/UV-stabilizing additive for polymers, coatings, and printing inks. In food processing and nutraceuticals, it is evaluated as a natural antioxidant. In pharmaceutical development, mangiferin is investigated as a scaffold or intermediate for pharmaceutical synthesis. In agriculture, it is studied for antimicrobial properties with potential use in agrochemical formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.43
    methanol 30.18
    isopropanol 2.64
    water 1.22
    ethyl acetate 0.28
    n-propanol 5.83
    acetone 1.14
    n-butanol 1.55
    acetonitrile 0.29
    DMF 51.81
    toluene 0.05
    isobutanol 1.07
    1,4-dioxane 2.75
    methyl acetate 0.52
    THF 5.03
    2-butanone 1.24
    n-pentanol 0.71
    sec-butanol 1.73
    n-hexane 0.02
    ethylene glycol 60.96
    NMP 46.97
    cyclohexane 0.04
    DMSO 123.34
    n-butyl acetate 0.19
    n-octanol 0.53
    chloroform 0.01
    n-propyl acetate 0.2
    acetic acid 11.94
    dichloromethane 0.02
    cyclohexanone 1.6
    propylene glycol 39.82
    isopropyl acetate 0.16
    DMAc 36.89
    2-ethoxyethanol 18.63
    isopentanol 0.5
    n-heptane 0.05
    ethyl formate 0.65
    1,2-dichloroethane 0.05
    n-hexanol 0.53
    2-methoxyethanol 77.62
    isobutyl acetate 0.05
    tetrachloromethane 0.01
    n-pentyl acetate 0.29
    transcutol 10.79
    n-heptanol 0.78
    ethylbenzene 0.03
    MIBK 0.2
    2-propoxyethanol 9.72
    tert-butanol 0.89
    MTBE 0.14
    2-butoxyethanol 5.24
    propionic acid 3.62
    o-xylene 0.05
    formic acid 84.96
    diethyl ether 0.4
    m-xylene 0.04
    p-xylene 0.03
    chlorobenzene 0.01
    dimethyl carbonate 1.27
    n-octane 0.03
    formamide 84.39
    cyclopentanone 3.48
    2-pentanone 0.58
    anisole 0.11
    cyclopentyl methyl ether 0.79
    gamma-butyrolactone 5.05
    1-methoxy-2-propanol 32.36
    pyridine 1.03
    3-pentanone 0.5
    furfural 3.87
    n-dodecane 0.02
    diethylene glycol 29.21
    diisopropyl ether 0.05
    tert-amyl alcohol 0.8
    acetylacetone 0.77
    n-hexadecane 0.02
    acetophenone 0.22
    methyl propionate 1.07
    isopentyl acetate 0.13
    trichloroethylene 0.05
    n-nonanol 0.57
    cyclohexanol 0.82
    benzyl alcohol 0.41
    2-ethylhexanol 0.18
    isooctanol 0.36
    dipropyl ether 0.48
    1,2-dichlorobenzene 0.01
    ethyl lactate 1.58
    propylene carbonate 0.74
    n-methylformamide 27.29
    2-pentanol 0.57
    n-pentane 0.03
    1-propoxy-2-propanol 4.45
    1-methoxy-2-propyl acetate 1.03
    2-(2-methoxypropoxy) propanol 3.43
    mesitylene 0.02
    ε-caprolactone 1.71
    p-cymene 0.03
    epichlorohydrin 1.5
    1,1,1-trichloroethane 0.01
    2-aminoethanol 51.83
    morpholine-4-carbaldehyde 33.42
    sulfolane 20.58
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.09
    n-hexyl acetate 0.32
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 5.94
    sec-butyl acetate 0.08
    tert-butyl acetate 0.19
    decalin 0.01
    glycerin 108.06
    diglyme 8.34
    acrylic acid 6.02
    isopropyl myristate 0.11
    n-butyric acid 1.45
    acetyl acetate 0.12
    di(2-ethylhexyl) phthalate 0.23
    ethyl propionate 0.23
    nitromethane 9.72
    1,2-diethoxyethane 0.65
    benzonitrile 0.09
    trioctyl phosphate 0.26
    1-bromopropane 0.04
    gamma-valerolactone 16.0
    n-decanol 0.38
    triethyl phosphate 0.24
    4-methyl-2-pentanol 0.17
    propionitrile 0.33
    vinylene carbonate 0.63
    1,1,2-trichlorotrifluoroethane 8.08
    DMS 0.37
    cumene 0.02
    2-octanol 0.34
    2-hexanone 0.27
    octyl acetate 0.24
    limonene 0.07
    1,2-dimethoxyethane 7.14
    ethyl orthosilicate 0.2
    tributyl phosphate 0.19
    diacetone alcohol 2.33
    N,N-dimethylaniline 0.16
    acrylonitrile 0.7
    aniline 0.27
    1,3-propanediol 29.48
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.07
    2-methyl-cyclohexyl acetate 0.17
    tetrabutyl urea 0.59
    diisobutyl methanol 0.1
    2-phenylethanol 0.33
    styrene 0.02
    dioctyl adipate 0.3
    dimethyl sulfate 3.83
    ethyl butyrate 0.24
    methyl lactate 8.89
    butyl lactate 1.23
    diethyl carbonate 0.14
    propanediol butyl ether 6.69
    triethyl orthoformate 0.34
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.79
    morpholine 8.74
    tert-butylamine 0.21
    n-dodecanol 0.24
    dimethoxymethane 12.29
    ethylene carbonate 0.47
    cyrene 6.32
    2-ethoxyethyl acetate 0.66
    2-ethylhexyl acetate 0.09
    1,2,4-trichlorobenzene 0.02
    4-methylpyridine 0.31
    dibutyl ether 0.21
    2,6-dimethyl-4-heptanol 0.1
    DEF 2.97
    dimethyl isosorbide 3.73
    tetrachloroethylene 0.09
    eugenol 1.35
    triacetin 0.75
    span 80 3.14
    1,4-butanediol 7.01
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.25
    methyl formate 9.09
    2-methyl-1-butanol 0.66
    n-decane 0.03
    butyronitrile 0.18
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.07
    1-chlorotetradecane 0.02
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.0
    cyclooctane 0.02
    cyclopentanol 2.04
    tetrahydropyran 1.06
    tert-amyl methyl ether 0.23
    2,5,8-trioxanonane 6.59
    1-hexene 0.05
    2-isopropoxyethanol 3.48
    2,2,2-trifluoroethanol 4.97
    methyl butyrate 0.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction