Maleic Hydrazide

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  • Identifiers

    CAS number
    123-33-1

    Molecular formula
    C4H4N2O2

    SMILES
    C1=CC(=O)NNC1=O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Odorless 62.55%
    Burnt 42.01%
    Nutty 32.09%
    Pungent 23.2%
    Caramellic 22.78%
    Bitter 21.96%
    Roasted 21.31%
    Musty 17.8%
    Popcorn 17.61%
    Cooked 16.79%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.8

    Molecular weight
    112.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • greater than 572 °F (decomposes) (NTP, 1992)
    • 298-300 °C

    Boiling point

    • Decomposes (NTP, 1992)

    Flash point est.
    225.36 ˚C

    Flash point expt.

    • 572 °F (300 °C) (Closed cup)

    Solubility expt.

    • less than 0.1 mg/mL at 68 °F (NTP, 1992)
    • Solubility at 25 °C: water 0.6%, ethanol 0.1%, DMF 2.4% /Technical maleic hydrazide/
    • Solubility in water at 25 °C, 300,000 mg/L at 20 °C and 340,000 mg/L at 25 °C /Maleic hydrazide potassium salt/
    • Solubility in water at 25 °C, 200 g/kg /Maleic hydrazide sodium salt/
    • Slightly sol in hot alcohol, more sol in hot water
    • SOL IN AQ ALKALI & CERTAIN ORG BASES
    • Sol @ 25 °C in acetone, 1000 ppm; water, 6000 ppm; dimethylformamide, 20400 ppm; dimethyl sulfoxide, 90000 ppm; xylene <1000 ppm
    • In water, 4,507 mg/L at 25 °C

  • Synonyms

    • MALEIC HYDRAZIDE
    • 123-33-1
    • Pyridazine-3,6-diol
    • 3,6-Dihydroxypyridazine
    • 3,6-Pyridazinediol
    • 1,2-Dihydropyridazine-3,6-dione
    • 3,6-Pyridazinedione, 1,2-dihydro-
    • Maleic acid hydrazide
    • Stuntman
    • Vondalhyde
    • 1,2-Dihydro-3,6-pyridazinedione
    • Antergon
    • Antyrost
    • Malazide
    • Malzid
    • Regulox
    • Retard
    • Vondrax
    • Maleic hydrazine
    • Sprout/off
    • Sucker-Stuff
    • De-sprout
    • Sprout-Stop
    • Super-de-sprout
    • De-cut
    • Maintain 3
    • Super sucker-stuff
    • Burtolin
    • Fazor
    • Mazide
    • Regulox 36
    • Super de-sprout
    • N,N-Maleoylhydrazine
    • Royal mh-30
    • 3,6-Dioxopyridazine
    • Royal slo-gro
    • Drexel-super P
    • Regulox W
    • Super sprout stop
    • 6-Hydroxy-3(2H)-pyridazinone
    • Fair PS
    • Unriprim
    • Malein 30
    • Fair-2
    • Regulox 50 W
    • Fair plus
    • Super sucker-stuff hc
    • Fair 30
    • Hydrazide maleique
    • 3(2H)-Pyridazinone, 6-hydroxy-
    • Maleinsaeurehydrazid
    • MG-T
    • Rcra waste number U148
    • MH 36 BAYER
    • Caswell No. 352
    • Maleic acid cyclic hydrazide
    • MH 30
    • MH-40
    • 116595-47-2
    • 6-Hydroxy-2H-pyridazin-3-one
    • ENT 18,870
    • Hydrazid kyseliny maleinove
    • 1,2-Dihydro-3,6-pyradizinedione
    • Maleinsaeurehydrazid [German]
    • Maleic hydrazide [BSI:ISO]
    • CCRIS 1879
    • Malepin
    • Sorbatran
    • HSDB 1162
    • Hydrazide maleique [ISO-French]
    • 1,2,3,6-Tetrahydro-3,6-dioxopyridazine
    • Hydrazid kyseliny maleinove [Czech]
    • EINECS 204-619-9
    • TQ7L3FCV66
    • NSC 13892
    • EPA Pesticide Chemical Code 051501
    • DTXSID9020792
    • CHEBI:81771
    • AI3-18870
    • Maleic acid, hydrazide
    • Maleic cyclic hydrazide
    • NSC-13892
    • Maleic acid, cyclic hydrazide
    • DTXCID10792
    • MALEIC HYDRAZIDE [MI]
    • 1,2,3,6-tetrahydropyridazine-3,6-dione
    • MALEIC HYDRAZIDE [ISO]
    • MALEIC HYDRAZIDE [HSDB]
    • MALEIC HYDRAZIDE [IARC]
    • KMH
    • MAH
    • CHEMBL1489913
    • 1,6-pyridazinedione
    • 1,6-dione
    • 3, 1,2-dihydro-
    • WLN: T6VMMVJ
    • Maleinsaeurehydrazid (German)
    • 6-Hydroxy-2H-pyridazin-2-one
    • MALEIC HYDRAZIDE (IARC)
    • Hydrazide maleique (ISO-French)
    • 1,2-dihydropyridazine-3,6-dione; 6-hydroxy-3-pyridazinone
    • maleichydrazide
    • Hydrazide, Maleic
    • 1,3,6-Tetrahydro-3,6-dioxopyridazine
    • CAS-123-33-1
    • Acid Hydrazide, Maleic
    • Hydrazide, Maleic Acid
    • RCRA waste no. U148
    • UNII-TQ7L3FCV66
    • maleinhydrazid
    • Sproutstop
    • Suckerstuff
    • Superdesprout
    • Desprout
    • Decut
    • Super desprout
    • Yadi
    • Royal slogro
    • Drexelsuper P
    • Fair-plus
    • Super suckerstuff
    • Fair2
    • 3,6Pyridazinediol
    • N,NMaleoylhydrazine
    • 3,6Dioxopyridazine
    • MFCD00006665
    • Super suckerstuff HC
    • Royal MH30

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.98
    methanol 18.3
    isopropanol 3.6
    water 13.58
    ethyl acetate 0.85
    n-propanol 3.77
    acetone 3.42
    n-butanol 2.49
    acetonitrile 3.54
    DMF 38.03
    toluene 0.16
    isobutanol 2.15
    1,4-dioxane 3.1
    methyl acetate 2.7
    THF 4.11
    2-butanone 2.68
    n-pentanol 2.12
    sec-butanol 2.89
    n-hexane 0.11
    ethylene glycol 4.24
    NMP 24.45
    cyclohexane 0.06
    DMSO 52.09
    n-butyl acetate 0.97
    n-octanol 0.71
    chloroform 0.54
    n-propyl acetate 0.87
    acetic acid 7.08
    dichloromethane 1.12
    cyclohexanone 1.96
    propylene glycol 2.7
    isopropyl acetate 0.57
    DMAc 47.09
    2-ethoxyethanol 8.66
    isopentanol 2.17
    n-heptane 0.15
    ethyl formate 3.59
    1,2-dichloroethane 0.96
    n-hexanol 1.13
    2-methoxyethanol 14.72
    isobutyl acetate 0.35
    tetrachloromethane 0.22
    n-pentyl acetate 0.94
    transcutol 12.22
    n-heptanol 1.03
    ethylbenzene 0.23
    MIBK 0.77
    2-propoxyethanol 4.45
    tert-butanol 3.56
    MTBE 1.39
    2-butoxyethanol 3.96
    propionic acid 3.26
    o-xylene 0.31
    formic acid 15.14
    diethyl ether 1.03
    m-xylene 0.17
    p-xylene 0.38
    chlorobenzene 0.16
    dimethyl carbonate 1.4
    n-octane 0.07
    formamide 35.5
    cyclopentanone 3.22
    2-pentanone 1.22
    anisole 1.05
    cyclopentyl methyl ether 0.86
    gamma-butyrolactone 5.95
    1-methoxy-2-propanol 6.33
    pyridine 2.69
    3-pentanone 0.97
    furfural 9.67
    n-dodecane 0.05
    diethylene glycol 6.39
    diisopropyl ether 0.23
    tert-amyl alcohol 3.46
    acetylacetone 1.34
    n-hexadecane 0.05
    acetophenone 1.53
    methyl propionate 1.39
    isopentyl acetate 0.97
    trichloroethylene 0.96
    n-nonanol 0.77
    cyclohexanol 0.89
    benzyl alcohol 1.52
    2-ethylhexanol 0.7
    isooctanol 0.84
    dipropyl ether 0.86
    1,2-dichlorobenzene 0.25
    ethyl lactate 1.56
    propylene carbonate 2.28
    n-methylformamide 18.1
    2-pentanol 1.18
    n-pentane 0.1
    1-propoxy-2-propanol 2.83
    1-methoxy-2-propyl acetate 1.31
    2-(2-methoxypropoxy) propanol 4.91
    mesitylene 0.17
    ε-caprolactone 2.56
    p-cymene 0.31
    epichlorohydrin 4.27
    1,1,1-trichloroethane 0.33
    2-aminoethanol 6.63
    morpholine-4-carbaldehyde 16.37
    sulfolane 11.43
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 2.08
    n-hexyl acetate 0.94
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 5.2
    sec-butyl acetate 0.48
    tert-butyl acetate 0.7
    decalin 0.05
    glycerin 5.79
    diglyme 12.12
    acrylic acid 3.98
    isopropyl myristate 0.44
    n-butyric acid 2.43
    acetyl acetate 0.61
    di(2-ethylhexyl) phthalate 1.03
    ethyl propionate 0.81
    nitromethane 15.83
    1,2-diethoxyethane 2.1
    benzonitrile 1.08
    trioctyl phosphate 0.63
    1-bromopropane 0.48
    gamma-valerolactone 8.77
    n-decanol 0.58
    triethyl phosphate 1.04
    4-methyl-2-pentanol 0.72
    propionitrile 1.89
    vinylene carbonate 2.39
    1,1,2-trichlorotrifluoroethane 4.98
    DMS 1.01
    cumene 0.25
    2-octanol 0.62
    2-hexanone 1.27
    octyl acetate 0.63
    limonene 0.36
    1,2-dimethoxyethane 12.7
    ethyl orthosilicate 0.98
    tributyl phosphate 0.8
    diacetone alcohol 2.22
    N,N-dimethylaniline 1.48
    acrylonitrile 3.34
    aniline 0.82
    1,3-propanediol 6.29
    bromobenzene 0.1
    dibromomethane 0.59
    1,1,2,2-tetrachloroethane 0.91
    2-methyl-cyclohexyl acetate 0.87
    tetrabutyl urea 1.65
    diisobutyl methanol 0.61
    2-phenylethanol 1.14
    styrene 0.25
    dioctyl adipate 0.88
    dimethyl sulfate 4.12
    ethyl butyrate 1.02
    methyl lactate 2.61
    butyl lactate 1.75
    diethyl carbonate 0.98
    propanediol butyl ether 3.38
    triethyl orthoformate 1.2
    p-tert-butyltoluene 0.29
    methyl 4-tert-butylbenzoate 2.16
    morpholine 5.27
    tert-butylamine 1.56
    n-dodecanol 0.44
    dimethoxymethane 6.53
    ethylene carbonate 1.63
    cyrene 4.74
    2-ethoxyethyl acetate 1.64
    2-ethylhexyl acetate 0.73
    1,2,4-trichlorobenzene 0.39
    4-methylpyridine 2.05
    dibutyl ether 0.69
    2,6-dimethyl-4-heptanol 0.61
    DEF 4.98
    dimethyl isosorbide 5.93
    tetrachloroethylene 0.76
    eugenol 3.03
    triacetin 1.53
    span 80 2.31
    1,4-butanediol 3.58
    1,1-dichloroethane 0.41
    2-methyl-1-pentanol 1.9
    methyl formate 10.49
    2-methyl-1-butanol 2.18
    n-decane 0.08
    butyronitrile 1.76
    3,7-dimethyl-1-octanol 0.71
    1-chlorooctane 0.2
    1-chlorotetradecane 0.1
    n-nonane 0.07
    undecane 0.06
    tert-butylcyclohexane 0.06
    cyclooctane 0.03
    cyclopentanol 1.4
    tetrahydropyran 1.14
    tert-amyl methyl ether 1.32
    2,5,8-trioxanonane 8.97
    1-hexene 0.35
    2-isopropoxyethanol 3.73
    2,2,2-trifluoroethanol 4.96
    methyl butyrate 1.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction