Madecassic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    18449-41-7

    Molecular formula
    C30H48O6

    SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 63.49%
    Spicy 42.7%
    Balsamic 41.77%
    Amber 36.68%
    Odorless 36.47%
    Cedar 32.57%
    Dry 31.7%
    Herbal 31.26%
    Cooling 29.7%
    Mint 29.33%

     

    Flavor
    Bitter 54.49%
    Herbal 31.32%
    Pine 29.75%
    Woody 28.99%
    Minty 28.9%
    Balsam 28.25%
    Camphor 26.28%
    Sweet 25.87%
    Odorless 25.11%
    Cedarleaf 23.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.4

    pKa est.
    5.27 (weak acid)

    Molecular weight
    504.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    180°C

    Flash point

    • 298.26 ˚C est.

  • Synonyms

    • Madecassic acid
    • Brahmic acid
    • 18449-41-7
    • ORISTRACT MDA
    • DTXSID70939838
    • M7O1N24J82
    • (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
    • CHEBI:73058
    • 2alpha,3beta,6beta,23-Tetrahydroxyurs-12-en-28-oic Acid
    • (2alpha,3beta,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid
    • NSC-88135
    • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-
    • RefChem:41931
    • Callicos CellAwake Mask madecassol
    • DTXCID701775346
    • 606-031-1
    • NSC88135
    • 6beta-hydroxyasiatic acid
    • (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
    • CHEMBL481854
    • Madecassic Acid (97%)
    • SR-05000002181
    • UNII-M7O1N24J82
    • s9502
    • PRAUVHZJPXOEIF-AOLYGAPISA-N
    • NSC 88135
    • MADECASSICACID
    • Madecassic acid (Standard)
    • SCHEMBL153239
    • HY-N0569R
    • MADECASSIC ACID [WHO-DD]
    • 6.BETA.-HYDROXYASIATIC ACID
    • HY-N0569
    • BDBM50244879
    • MFCD00895441
    • MFCD11559128
    • AKOS015896782
    • AC-6055
    • CCG-208587
    • DB14037
    • EBC-618426
    • FM73960
    • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-
    • SY046663
    • CS-0009106
    • NS00071060
    • SR-05000002181-2
    • SR-05000002181-3
    • MADECASSIC ACID (CONSTITUENT OF CENTELLA ASIATICA) [DSC]
    • 2.ALPHA.,3.BETA.,6.BETA.,23-TETRAHYDROXY-URS-12-EN-28-OIC ACID
    • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2|A,3|A,4|A,6|A)-
    • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-,(2.alpha.,3.beta.,4.alpha.,6.beta.)-
    • URS-12-EN-28-OIC ACID, 2.ALPHA.,3.BETA.,6.BETA.,23-TETRAHYDROXY-
    • (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylicacid
    • 6|A-Hydroxyasiatic acid; CID 12073158; Madecassic acid; (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
    • 18449-41-7

  • Applications

    Madecassic acid (CAS 18449-41-7) is a natural triterpenoid constituent of Centella asiatica used mainly in cosmetics and personal care as a skin-conditioning active with anti-inflammatory and antioxidant potential; it is commonly formulated in topical products intended to support skin comfort and has been studied in dermal formulations for wound-healing activity. It also functions as a chemical marker for standardization of Centella asiatica extracts and related products in quality-control workflows. In pharmaceutical and natural-product research contexts, madecassic acid is evaluated for dermal applications and serves as a reference compound in topical formulation research, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.07
    methanol 29.06
    isopropanol 2.73
    water 0.02
    ethyl acetate 1.23
    n-propanol 5.17
    acetone 3.76
    n-butanol 2.44
    acetonitrile 0.78
    DMF 35.07
    toluene 0.81
    isobutanol 1.84
    1,4-dioxane 14.52
    methyl acetate 1.46
    THF 31.13
    2-butanone 2.72
    n-pentanol 1.89
    sec-butanol 1.0
    n-hexane 0.06
    ethylene glycol 2.91
    NMP 18.15
    cyclohexane 0.06
    DMSO 23.98
    n-butyl acetate 1.2
    n-octanol 0.95
    chloroform 2.55
    n-propyl acetate 0.91
    acetic acid 5.36
    dichloromethane 1.89
    cyclohexanone 4.42
    propylene glycol 3.78
    isopropyl acetate 0.96
    DMAc 15.34
    2-ethoxyethanol 11.15
    isopentanol 1.24
    n-heptane 0.05
    ethyl formate 1.51
    1,2-dichloroethane 1.31
    n-hexanol 1.95
    2-methoxyethanol 27.99
    isobutyl acetate 0.64
    tetrachloromethane 0.4
    n-pentyl acetate 2.12
    transcutol 10.73
    n-heptanol 1.96
    ethylbenzene 0.44
    MIBK 1.26
    2-propoxyethanol 18.26
    tert-butanol 1.36
    MTBE 0.77
    2-butoxyethanol 10.06
    propionic acid 1.98
    o-xylene 0.48
    formic acid 7.16
    diethyl ether 1.5
    m-xylene 0.61
    p-xylene 0.47
    chlorobenzene 0.65
    dimethyl carbonate 2.27
    n-octane 0.03
    formamide 7.49
    cyclopentanone 9.93
    2-pentanone 1.97
    anisole 1.49
    cyclopentyl methyl ether 3.31
    gamma-butyrolactone 8.64
    1-methoxy-2-propanol 15.85
    pyridine 6.38
    3-pentanone 1.41
    furfural 7.63
    n-dodecane 0.01
    diethylene glycol 15.24
    diisopropyl ether 0.25
    tert-amyl alcohol 0.75
    acetylacetone 3.06
    n-hexadecane 0.01
    acetophenone 1.78
    methyl propionate 2.12
    isopentyl acetate 1.11
    trichloroethylene 2.97
    n-nonanol 1.01
    cyclohexanol 1.01
    benzyl alcohol 2.76
    2-ethylhexanol 0.64
    isooctanol 1.25
    dipropyl ether 0.95
    1,2-dichlorobenzene 0.59
    ethyl lactate 1.4
    propylene carbonate 2.36
    n-methylformamide 12.61
    2-pentanol 0.71
    n-pentane 0.06
    1-propoxy-2-propanol 7.52
    1-methoxy-2-propyl acetate 3.92
    2-(2-methoxypropoxy) propanol 4.4
    mesitylene 0.32
    ε-caprolactone 3.71
    p-cymene 0.31
    epichlorohydrin 10.93
    1,1,1-trichloroethane 0.56
    2-aminoethanol 8.17
    morpholine-4-carbaldehyde 27.62
    sulfolane 13.6
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 3.8
    n-hexyl acetate 1.94
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 7.55
    sec-butyl acetate 0.51
    tert-butyl acetate 1.18
    decalin 0.04
    glycerin 8.77
    diglyme 13.65
    acrylic acid 2.77
    isopropyl myristate 0.38
    n-butyric acid 2.31
    acetyl acetate 0.94
    di(2-ethylhexyl) phthalate 1.18
    ethyl propionate 0.8
    nitromethane 6.97
    1,2-diethoxyethane 2.28
    benzonitrile 1.18
    trioctyl phosphate 0.75
    1-bromopropane 0.51
    gamma-valerolactone 23.73
    n-decanol 0.46
    triethyl phosphate 0.58
    4-methyl-2-pentanol 0.52
    propionitrile 0.9
    vinylene carbonate 2.88
    1,1,2-trichlorotrifluoroethane 10.58
    DMS 1.76
    cumene 0.31
    2-octanol 0.66
    2-hexanone 1.41
    octyl acetate 0.72
    limonene 0.36
    1,2-dimethoxyethane 11.54
    ethyl orthosilicate 0.63
    tributyl phosphate 0.54
    diacetone alcohol 2.95
    N,N-dimethylaniline 1.34
    acrylonitrile 1.71
    aniline 1.6
    1,3-propanediol 9.41
    bromobenzene 0.5
    dibromomethane 1.03
    1,1,2,2-tetrachloroethane 2.42
    2-methyl-cyclohexyl acetate 1.03
    tetrabutyl urea 1.01
    diisobutyl methanol 0.36
    2-phenylethanol 3.0
    styrene 0.43
    dioctyl adipate 0.87
    dimethyl sulfate 4.1
    ethyl butyrate 0.75
    methyl lactate 3.7
    butyl lactate 2.92
    diethyl carbonate 0.46
    propanediol butyl ether 8.29
    triethyl orthoformate 0.94
    p-tert-butyltoluene 0.32
    methyl 4-tert-butylbenzoate 3.31
    morpholine 19.67
    tert-butylamine 0.4
    n-dodecanol 0.22
    dimethoxymethane 22.18
    ethylene carbonate 2.1
    cyrene 6.81
    2-ethoxyethyl acetate 4.61
    2-ethylhexyl acetate 0.81
    1,2,4-trichlorobenzene 0.97
    4-methylpyridine 3.07
    dibutyl ether 0.38
    2,6-dimethyl-4-heptanol 0.36
    DEF 3.1
    dimethyl isosorbide 7.25
    tetrachloroethylene 2.32
    eugenol 4.49
    triacetin 2.3
    span 80 4.16
    1,4-butanediol 3.16
    1,1-dichloroethane 0.69
    2-methyl-1-pentanol 0.99
    methyl formate 7.09
    2-methyl-1-butanol 1.1
    n-decane 0.03
    butyronitrile 0.8
    3,7-dimethyl-1-octanol 0.57
    1-chlorooctane 0.2
    1-chlorotetradecane 0.04
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.04
    cyclooctane 0.03
    cyclopentanol 2.24
    tetrahydropyran 3.89
    tert-amyl methyl ether 0.6
    2,5,8-trioxanonane 7.16
    1-hexene 0.23
    2-isopropoxyethanol 4.51
    2,2,2-trifluoroethanol 1.77
    methyl butyrate 1.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction