Luteolin

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  • Identifiers

    CAS number
    491-70-3

    Molecular formula
    C15H10O6

    SMILES
    C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 61.96%
    Phenolic 59.01%
    Burnt 37.46%
    Medicinal 24.99%
    Smoky 24.81%
    Spicy 21.11%
    Savory 20.5%
    Bitter 18.96%
    Balsamic 18.66%
    Vanilla 17.69%

     

    Flavor
    Bitter 94.01%
    Odorless 24.46%
    Sweet-like 21.29%
    Very strong 20.7%
    Cedarleaf 20.44%
    Indole 20.42%
    Nitrile 20.3%
    Rotten 19.99%
    Eugenol 19.92%
    Mild 19.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    10.1 (weak base)

    Molecular weight
    286.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    694°C

    Melting point expt.

    • 329.5 °C

    Flash point

    • 238.92 ˚C est.

  • Synonyms

    • luteolin
    • 491-70-3
    • 3',4',5,7-Tetrahydroxyflavone
    • Digitoflavone
    • Luteolol
    • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
    • Flacitran
    • Luteoline
    • Salifazide
    • Yama kariyasu
    • Weld Lake
    • 5,7,3',4'-Tetrahydroxyflavone
    • Cyanidenon-1470
    • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
    • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
    • KUX1ZNC9J2
    • DTXSID4074988
    • CHEBI:15864
    • 3',4',5,7-Tetrahydroxy-Flavone
    • RefChem:6458
    • DTXCID6040668
    • 207-741-0
    • Cyanidenon 1470
    • Bismite
    • MFCD00017309
    • Luteolin (Standard)
    • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
    • CHEMBL151
    • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one
    • FLAVONE, 3',4',5,7-TETRAHYDROXY-
    • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-chromenone
    • 1318-21-4
    • C.I. Natural Yellow 2
    • SMR000326896
    • 7-Tetrahydroxyflavone
    • CCRIS 3790
    • SR-01000779333
    • EINECS 207-741-0
    • UNII-KUX1ZNC9J2
    • BRN 0292084
    • Luteoin
    • Daphneflavonol;
    • Digitoflavone;
    • Lutl
    • Flavopurpol;
    • Luteolin?
    • C.I. 75590
    • 4dew
    • 4dgn
    • 4hkn
    • LU2
    • Prestwick_122
    • DIOSMETIN_met006
    • LUTEOLIN [MI]
    • Prestwick0_000870
    • Prestwick1_000870
    • Prestwick2_000870
    • Prestwick3_000870
    • LUTEOLIN [WHO-DD]
    • BIDD:PXR0059
    • Lopac0_000660
    • Oprea1_849964
    • SCHEMBL20426
    • BSPBio_000919
    • Luteolin, analytical standard
    • MLS000697655
    • MLS000860038
    • MLS002154043
    • MLS006011917
    • BIDD:ER0122
    • SPBio_002840
    • BDBM7459
    • BPBio1_001011
    • GTPL5215
    • MEGxp0_000143
    • orb1310014
    • SCHEMBL29352380
    • SCHEMBL29376494
    • SCHEMBL30045580
    • ACon1_000223
    • cid_5280445
    • HY-N0162R
    • GLXC-06558
    • HMS1570N21
    • HMS2097N21
    • HMS2220C06
    • HMS3356L02
    • HMS3561N09
    • HMS3649N21
    • HMS3656A05
    • HMS3714N21
    • HMS5080H10
    • Luteolin, >=99.0% (TLC)
    • BB_NC-01244
    • HY-N0162
    • MSK40243
    • TNP00073
    • Luteolin, >=98% (TLC), powder
    • BBL027837
    • EBC-11086
    • LMPK12110006
    • s2320
    • SBB066117
    • STK801923
    • AKOS002140588
    • AC-1125
    • CCG-208309
    • CS-4611
    • DB15584
    • FL24959
    • KS-5202
    • Luteolin 100 microg/mL in Acetonitrile
    • SMP2_000042
    • NCGC00016467-01
    • NCGC00016467-02
    • NCGC00016467-03
    • NCGC00016467-04
    • NCGC00016467-05
    • NCGC00016467-06
    • NCGC00016467-07
    • NCGC00016467-08
    • NCGC00016467-12
    • NCGC00016467-21
    • NCGC00142375-01
    • NCGC00142375-02
    • NCGC00142375-03
    • luteolin

  • Applications

    Luteolin (CAS 491-70-3) is a natural flavone with practical applications across several domains: as a cosmetic and personal-care antioxidant and anti-inflammatory ingredient in skin-care formulations; as a bioactive flavonoid investigated in pharmaceutical and nutraceutical research for potential medicinal chemistry applications; as a functional ingredient evaluated in food processing and dietary supplements for antioxidant activity; as an additive explored to act as a stabilizer and antioxidant in polymers and coatings to improve oxidative stability; and as a plant-science research compound used to study flavonoid biosynthesis and plant defense mechanisms.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.38
    methanol 3.18
    isopropanol 6.81
    water 0.01
    ethyl acetate 4.57
    n-propanol 8.55
    acetone 0.21
    n-butanol 9.13
    acetonitrile 0.43
    DMF 34.86
    toluene 0.03
    isobutanol 3.1
    1,4-dioxane 3.3
    methyl acetate 2.54
    THF 31.97
    2-butanone 5.17
    n-pentanol 2.69
    sec-butanol 10.44
    n-hexane 0.0
    ethylene glycol 9.21
    NMP 27.79
    cyclohexane 0.0
    DMSO 327.72
    n-butyl acetate 1.9
    n-octanol 0.39
    chloroform 0.0
    n-propyl acetate 2.29
    acetic acid 3.3
    dichloromethane 0.0
    cyclohexanone 3.63
    propylene glycol 13.47
    isopropyl acetate 2.48
    DMAc 62.33
    2-ethoxyethanol 44.53
    isopentanol 5.22
    n-heptane 0.01
    ethyl formate 1.54
    1,2-dichloroethane 0.0
    n-hexanol 0.98
    2-methoxyethanol 132.75
    isobutyl acetate 0.53
    tetrachloromethane 0.0
    n-pentyl acetate 1.0
    transcutol 75.77
    n-heptanol 0.7
    ethylbenzene 0.03
    MIBK 2.16
    2-propoxyethanol 34.11
    tert-butanol 5.9
    MTBE 1.25
    2-butoxyethanol 10.16
    propionic acid 4.8
    o-xylene 0.04
    formic acid 4.38
    diethyl ether 0.62
    m-xylene 0.04
    p-xylene 0.03
    chlorobenzene 0.01
    dimethyl carbonate 2.38
    n-octane 0.0
    formamide 14.29
    cyclopentanone 10.07
    2-pentanone 4.09
    anisole 0.52
    cyclopentyl methyl ether 2.4
    gamma-butyrolactone 16.85
    1-methoxy-2-propanol 112.19
    pyridine 0.82
    3-pentanone 1.44
    furfural 7.73
    n-dodecane 0.01
    diethylene glycol 41.9
    diisopropyl ether 0.14
    tert-amyl alcohol 7.29
    acetylacetone 5.69
    n-hexadecane 0.01
    acetophenone 1.01
    methyl propionate 6.26
    isopentyl acetate 1.82
    trichloroethylene 0.01
    n-nonanol 0.53
    cyclohexanol 2.17
    benzyl alcohol 1.08
    2-ethylhexanol 0.62
    isooctanol 0.65
    dipropyl ether 1.08
    1,2-dichlorobenzene 0.01
    ethyl lactate 6.33
    propylene carbonate 2.84
    n-methylformamide 13.43
    2-pentanol 4.12
    n-pentane 0.0
    1-propoxy-2-propanol 24.2
    1-methoxy-2-propyl acetate 10.52
    2-(2-methoxypropoxy) propanol 16.41
    mesitylene 0.03
    ε-caprolactone 7.4
    p-cymene 0.08
    epichlorohydrin 6.91
    1,1,1-trichloroethane 0.0
    2-aminoethanol 17.02
    morpholine-4-carbaldehyde 38.3
    sulfolane 51.82
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 6.98
    n-hexyl acetate 1.31
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 23.75
    sec-butyl acetate 1.45
    tert-butyl acetate 3.07
    decalin 0.0
    glycerin 55.79
    diglyme 37.46
    acrylic acid 3.97
    isopropyl myristate 0.74
    n-butyric acid 7.34
    acetyl acetate 0.87
    di(2-ethylhexyl) phthalate 1.09
    ethyl propionate 2.66
    nitromethane 9.73
    1,2-diethoxyethane 5.09
    benzonitrile 0.29
    trioctyl phosphate 0.86
    1-bromopropane 0.01
    gamma-valerolactone 39.2
    n-decanol 0.44
    triethyl phosphate 1.49
    4-methyl-2-pentanol 1.44
    propionitrile 0.85
    vinylene carbonate 1.3
    1,1,2-trichlorotrifluoroethane 10.99
    DMS 1.83
    cumene 0.03
    2-octanol 0.41
    2-hexanone 2.19
    octyl acetate 1.0
    limonene 0.11
    1,2-dimethoxyethane 31.27
    ethyl orthosilicate 1.29
    tributyl phosphate 1.15
    diacetone alcohol 23.73
    N,N-dimethylaniline 0.44
    acrylonitrile 1.44
    aniline 0.34
    1,3-propanediol 44.07
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.02
    2-methyl-cyclohexyl acetate 1.35
    tetrabutyl urea 2.07
    diisobutyl methanol 0.68
    2-phenylethanol 1.01
    styrene 0.02
    dioctyl adipate 1.91
    dimethyl sulfate 7.78
    ethyl butyrate 2.29
    methyl lactate 19.33
    butyl lactate 4.23
    diethyl carbonate 1.14
    propanediol butyl ether 11.01
    triethyl orthoformate 2.57
    p-tert-butyltoluene 0.09
    methyl 4-tert-butylbenzoate 3.18
    morpholine 19.51
    tert-butylamine 0.6
    n-dodecanol 0.33
    dimethoxymethane 20.61
    ethylene carbonate 1.14
    cyrene 13.68
    2-ethoxyethyl acetate 3.62
    2-ethylhexyl acetate 1.01
    1,2,4-trichlorobenzene 0.03
    4-methylpyridine 0.69
    dibutyl ether 0.7
    2,6-dimethyl-4-heptanol 0.68
    DEF 10.88
    dimethyl isosorbide 23.59
    tetrachloroethylene 0.01
    eugenol 4.47
    triacetin 3.66
    span 80 7.3
    1,4-butanediol 6.83
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 2.11
    methyl formate 4.33
    2-methyl-1-butanol 5.46
    n-decane 0.01
    butyronitrile 1.02
    3,7-dimethyl-1-octanol 0.7
    1-chlorooctane 0.04
    1-chlorotetradecane 0.03
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 4.27
    tetrahydropyran 1.36
    tert-amyl methyl ether 2.08
    2,5,8-trioxanonane 27.07
    1-hexene 0.02
    2-isopropoxyethanol 16.9
    2,2,2-trifluoroethanol 1.18
    methyl butyrate 3.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction