Lotusine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6871-67-6

    Molecular formula
    C19H24NO3+

    SMILES
    C[N+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC=C(C=C3)O)OC)O)C

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 60.32%
    Spicy 51.84%
    Sweet 51.74%
    Smoky 39.26%
    Woody 38.0%
    Animal 33.02%
    Balsamic 32.77%
    Leathery 31.46%
    Vanilla 31.17%
    Medicinal 30.23%

     

    Flavor
    Bitter 56.6%
    Sweet 35.24%
    Fruity 31.58%
    Woody 29.21%
    Mild 22.5%
    Spicy 22.21%
    Phenolic 20.95%
    Eugenol 20.69%
    Flat 20.48%
    Orange blossom 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    9.45 (weak base)

    Molecular weight
    314.4 g/mol

    Flash point

    • 91.44 ˚C est.

  • Synonyms

    • Lotusine
    • RefChem:924938
    • 6871-67-6
    • (1R)-1,2,3,4-Tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethylisoquinolinium
    • (-)-Lotusine
    • (1R)-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium-6-ol
    • D-(-)-Lotusine
    • (1R)-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-ium
    • Lotusine, (-)-
    • 4V8U3YU3QP
    • orb1299132
    • SCHEMBL29444547
    • CHEBI:81190
    • DTXSID501317849
    • HY-N4309
    • AKOS037515015
    • AC-34435
    • DA-65060
    • CS-0032713
    • C17567
    • E80653
    • Q27155136
    • Isoquinolinium, 1,2,3,4-tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-, (1R)
    • Isoquinolinium, 1,2,3,4-tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-, (1R)-
    • Isoquinolinium, 1,2,3,4-tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-, (R)-
    • 6871-67-6

  • Applications

    Lotusine may function as an odorant and fragrance ingredient in perfumery, and may be used in cosmetics/personal care as a scent additive; it can be evaluated for household products to impart aroma; it may serve as an intermediate in fragrance synthesis in industrial manufacturing; it may also be considered for flavor/fragrance formulations and for coatings/inks to introduce aroma, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 129.59
    methanol 214.79
    isopropanol 100.28
    water 0.3
    ethyl acetate 160.04
    n-propanol 148.24
    acetone 100.16
    n-butanol 116.85
    acetonitrile 72.07
    DMF 152.15
    toluene 25.09
    isobutanol 64.14
    1,4-dioxane 268.83
    methyl acetate 137.82
    THF 341.24
    2-butanone 127.63
    n-pentanol 54.08
    sec-butanol 55.06
    n-hexane 0.28
    ethylene glycol 50.49
    NMP 27.69
    cyclohexane 1.53
    DMSO 250.14
    n-butyl acetate 39.93
    n-octanol 15.37
    chloroform 247.84
    n-propyl acetate 52.04
    acetic acid 152.92
    dichloromethane 160.18
    cyclohexanone 101.3
    propylene glycol 85.29
    isopropyl acetate 68.57
    DMAc 186.26
    2-ethoxyethanol 267.78
    isopentanol 67.67
    n-heptane 0.93
    ethyl formate 90.94
    1,2-dichloroethane 102.2
    n-hexanol 41.8
    2-methoxyethanol 567.66
    isobutyl acetate 33.49
    tetrachloromethane 15.47
    n-pentyl acetate 30.45
    transcutol 416.0
    n-heptanol 23.76
    ethylbenzene 8.7
    MIBK 51.09
    2-propoxyethanol 193.38
    tert-butanol 100.62
    MTBE 44.24
    2-butoxyethanol 86.98
    propionic acid 84.89
    o-xylene 13.54
    formic acid 101.41
    diethyl ether 57.28
    m-xylene 16.58
    p-xylene 11.48
    chlorobenzene 34.45
    dimethyl carbonate 68.77
    n-octane 0.61
    formamide 211.59
    cyclopentanone 120.74
    2-pentanone 88.63
    anisole 42.48
    cyclopentyl methyl ether 65.18
    gamma-butyrolactone 136.83
    1-methoxy-2-propanol 292.88
    pyridine 119.95
    3-pentanone 57.5
    furfural 150.37
    n-dodecane 0.59
    diethylene glycol 194.54
    diisopropyl ether 10.38
    tert-amyl alcohol 54.63
    acetylacetone 118.54
    n-hexadecane 0.7
    acetophenone 42.97
    methyl propionate 114.32
    isopentyl acetate 39.66
    trichloroethylene 248.45
    n-nonanol 16.59
    cyclohexanol 44.37
    benzyl alcohol 61.03
    2-ethylhexanol 17.08
    isooctanol 20.3
    dipropyl ether 20.68
    1,2-dichlorobenzene 32.09
    ethyl lactate 43.36
    propylene carbonate 65.4
    n-methylformamide 149.93
    2-pentanol 41.31
    n-pentane 0.51
    1-propoxy-2-propanol 89.05
    1-methoxy-2-propyl acetate 88.49
    2-(2-methoxypropoxy) propanol 63.86
    mesitylene 9.29
    ε-caprolactone 79.28
    p-cymene 8.56
    epichlorohydrin 258.15
    1,1,1-trichloroethane 71.19
    2-aminoethanol 119.68
    morpholine-4-carbaldehyde 153.04
    sulfolane 108.67
    2,2,4-trimethylpentane 0.74
    2-methyltetrahydrofuran 84.07
    n-hexyl acetate 31.16
    isooctane 0.69
    2-(2-butoxyethoxy)ethanol 109.46
    sec-butyl acetate 34.06
    tert-butyl acetate 64.74
    decalin 0.93
    glycerin 146.85
    diglyme 238.89
    acrylic acid 80.08
    isopropyl myristate 13.04
    n-butyric acid 142.83
    acetyl acetate 85.14
    di(2-ethylhexyl) phthalate 18.82
    ethyl propionate 43.7
    nitromethane 303.59
    1,2-diethoxyethane 84.5
    benzonitrile 46.42
    trioctyl phosphate 12.93
    1-bromopropane 26.4
    gamma-valerolactone 228.65
    n-decanol 11.83
    triethyl phosphate 21.17
    4-methyl-2-pentanol 23.74
    propionitrile 73.09
    vinylene carbonate 80.47
    1,1,2-trichlorotrifluoroethane 214.98
    DMS 45.62
    cumene 6.58
    2-octanol 11.97
    2-hexanone 38.12
    octyl acetate 17.2
    limonene 9.8
    1,2-dimethoxyethane 261.15
    ethyl orthosilicate 21.8
    tributyl phosphate 14.93
    diacetone alcohol 95.14
    N,N-dimethylaniline 22.75
    acrylonitrile 100.51
    aniline 63.7
    1,3-propanediol 236.82
    bromobenzene 30.35
    dibromomethane 66.89
    1,1,2,2-tetrachloroethane 183.39
    2-methyl-cyclohexyl acetate 29.48
    tetrabutyl urea 19.03
    diisobutyl methanol 12.87
    2-phenylethanol 49.41
    styrene 11.64
    dioctyl adipate 22.95
    dimethyl sulfate 81.64
    ethyl butyrate 32.37
    methyl lactate 77.95
    butyl lactate 32.81
    diethyl carbonate 27.77
    propanediol butyl ether 64.03
    triethyl orthoformate 30.97
    p-tert-butyltoluene 8.93
    methyl 4-tert-butylbenzoate 43.02
    morpholine 330.03
    tert-butylamine 26.76
    n-dodecanol 8.2
    dimethoxymethane 256.36
    ethylene carbonate 72.75
    cyrene 62.0
    2-ethoxyethyl acetate 77.1
    2-ethylhexyl acetate 26.22
    1,2,4-trichlorobenzene 42.92
    4-methylpyridine 82.08
    dibutyl ether 14.64
    2,6-dimethyl-4-heptanol 12.87
    DEF 72.44
    dimethyl isosorbide 100.57
    tetrachloroethylene 101.39
    eugenol 48.68
    triacetin 52.78
    span 80 41.62
    1,4-butanediol 65.85
    1,1-dichloroethane 76.27
    2-methyl-1-pentanol 35.79
    methyl formate 115.75
    2-methyl-1-butanol 50.11
    n-decane 1.04
    butyronitrile 59.68
    3,7-dimethyl-1-octanol 17.41
    1-chlorooctane 5.81
    1-chlorotetradecane 2.37
    n-nonane 0.81
    undecane 0.77
    tert-butylcyclohexane 0.89
    cyclooctane 0.65
    cyclopentanol 45.7
    tetrahydropyran 134.1
    tert-amyl methyl ether 26.62
    2,5,8-trioxanonane 143.64
    1-hexene 2.1
    2-isopropoxyethanol 118.59
    2,2,2-trifluoroethanol 61.29
    methyl butyrate 55.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction