Linatine

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  • Identifiers

    CAS number
    10139-06-7

    Molecular formula
    C10H17N3O5

    SMILES
    C1C[C@@H](N(C1)NC(=O)CC[C@@H](C(=O)O)N)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 75.35%
    Savory 34.34%
    Sweet 29.72%
    Meaty 21.44%
    Fishy 20.35%
    Cooling 19.7%
    Alcoholic 17.32%
    Cooked 16.83%
    Milky 15.5%
    Cocoa 15.34%

     

    Flavor
    Odorless 61.58%
    Bitter 59.85%
    Bland 31.81%
    Mild 28.51%
    Very mild 25.86%
    Sweet-like 23.65%
    Yeast 22.65%
    Nitrile 20.04%
    Faint 19.87%
    Taco 19.32%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.1

    pKa est.
    5.85 (weak acid)

    Molecular weight
    259.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    489°C

    Flash point

    • 270.59 ˚C est.

  • Synonyms

    • Linatine
    • N-(D-2-Carboxy-1-pyrrolidinyl)-L-glutamine
    • HF0076XF4P
    • Glutamine, N-(D-2-carboxy-1-pyrrolidinyl)-, L-
    • N-(gamma-L-Glutamyl)amino-D-proline
    • CHEBI:28004
    • 1-((N-gamma-Glu)-amino)-Pro
    • (2R)-1-[[(4S)-4-amino-4-carboxybutanoyl]amino]pyrrolidine-2-carboxylic acid
    • N(5)-[(2R)-2-carboxypyrrolidin-1-yl]-L-glutamine
    • N(5)-((2R)-2-carboxypyrrolidin-1-yl)-L-glutamine
    • (2R)-1-(((4S)-4-amino-4-carboxybutanoyl)amino)pyrrolidine-2-carboxylic acid
    • RefChem:153494
    • 1-((N-gamma-L-Glutamyl)-amino)-D-proline
    • 10139-06-7
    • 1-((N-gamma-L-Glutamyl)amino)-D-proline
    • ((S)-4-amino-4-carboxybutanamido)-D-proline
    • 1-[(N-gamma-l-glutamyl)amino]-d-proline
    • UNII-HF0076XF4P
    • LINATINE [MI]
    • SCHEMBL298421
    • DTXSID10906120
    • D-Proline, 1-((4-amino-4-carboxy-1-oxobutyl)amino)-, (S)-
    • HY-113601
    • CS-0062690
    • C05939
    • Q11756905
    • 1-[(4-Amino-4-carboxy-1-hydroxybutylidene)amino]proline
    • 1-[(4-Amino-4-carboxybutanoyl)amino]pyrrolidine-2-carboxylic acid
    • 1-{[(4S)-4-Amino-4-carboxy-1-hydroxybutylidene]amino}-D-proline
    • D-PROLINE, 1-(((4S)-4-AMINO-4-CARBOXY-1-OXOBUTYL)AMINO)-
    • 10139-06-7

  • Applications

    Linatine (CAS 10139-06-7) is primarily used as an intermediate in organic synthesis and as a precursor for specialty chemicals. In industrial formulations, it may act as a solvent or co-solvent; as a stabilizer or plasticizer in polymer systems; as a chelating agent or surfactant in coatings, inks, and cleaning formulations; and as a processing aid in adhesives, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.49
    methanol 13.05
    isopropanol 0.6
    water 230.78
    ethyl acetate 0.43
    n-propanol 0.85
    acetone 0.71
    n-butanol 0.73
    acetonitrile 0.52
    DMF 64.86
    toluene 0.19
    isobutanol 0.64
    1,4-dioxane 1.02
    methyl acetate 0.32
    THF 2.23
    2-butanone 0.62
    n-pentanol 0.56
    sec-butanol 0.58
    n-hexane 0.1
    ethylene glycol 27.59
    NMP 110.86
    cyclohexane 0.09
    DMSO 242.8
    n-butyl acetate 0.39
    n-octanol 0.3
    chloroform 0.22
    n-propyl acetate 0.34
    acetic acid 25.92
    dichloromethane 0.4
    cyclohexanone 3.12
    propylene glycol 19.12
    isopropyl acetate 0.38
    DMAc 61.25
    2-ethoxyethanol 8.28
    isopentanol 0.82
    n-heptane 0.08
    ethyl formate 1.4
    1,2-dichloroethane 0.37
    n-hexanol 0.62
    2-methoxyethanol 25.06
    isobutyl acetate 0.19
    tetrachloromethane 0.1
    n-pentyl acetate 0.39
    transcutol 13.78
    n-heptanol 0.58
    ethylbenzene 0.16
    MIBK 0.79
    2-propoxyethanol 6.76
    tert-butanol 0.85
    MTBE 0.2
    2-butoxyethanol 3.87
    propionic acid 4.06
    o-xylene 0.36
    formic acid 332.12
    diethyl ether 0.27
    m-xylene 0.28
    p-xylene 0.23
    chlorobenzene 0.14
    dimethyl carbonate 1.78
    n-octane 0.05
    formamide 176.79
    cyclopentanone 4.38
    2-pentanone 0.87
    anisole 0.36
    cyclopentyl methyl ether 1.19
    gamma-butyrolactone 8.71
    1-methoxy-2-propanol 12.83
    pyridine 1.33
    3-pentanone 0.79
    furfural 16.79
    n-dodecane 0.02
    diethylene glycol 21.75
    diisopropyl ether 0.12
    tert-amyl alcohol 0.97
    acetylacetone 2.18
    n-hexadecane 0.02
    acetophenone 1.07
    methyl propionate 1.17
    isopentyl acetate 0.41
    trichloroethylene 0.68
    n-nonanol 0.33
    cyclohexanol 1.35
    benzyl alcohol 1.26
    2-ethylhexanol 0.38
    isooctanol 0.45
    dipropyl ether 0.43
    1,2-dichlorobenzene 0.24
    ethyl lactate 2.27
    propylene carbonate 3.39
    n-methylformamide 24.71
    2-pentanol 0.53
    n-pentane 0.08
    1-propoxy-2-propanol 3.3
    1-methoxy-2-propyl acetate 1.7
    2-(2-methoxypropoxy) propanol 4.58
    mesitylene 0.21
    ε-caprolactone 3.44
    p-cymene 0.19
    epichlorohydrin 2.94
    1,1,1-trichloroethane 0.11
    2-aminoethanol 20.25
    morpholine-4-carbaldehyde 41.55
    sulfolane 50.39
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 0.76
    n-hexyl acetate 0.44
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 5.94
    sec-butyl acetate 0.23
    tert-butyl acetate 0.58
    decalin 0.05
    glycerin 99.21
    diglyme 9.09
    acrylic acid 11.35
    isopropyl myristate 0.16
    n-butyric acid 3.64
    acetyl acetate 0.53
    di(2-ethylhexyl) phthalate 0.71
    ethyl propionate 0.47
    nitromethane 18.07
    1,2-diethoxyethane 0.65
    benzonitrile 0.67
    trioctyl phosphate 0.46
    1-bromopropane 0.13
    gamma-valerolactone 20.52
    n-decanol 0.24
    triethyl phosphate 0.65
    4-methyl-2-pentanol 0.44
    propionitrile 0.4
    vinylene carbonate 3.53
    1,1,2-trichlorotrifluoroethane 20.76
    DMS 0.9
    cumene 0.16
    2-octanol 0.3
    2-hexanone 0.47
    octyl acetate 0.25
    limonene 0.25
    1,2-dimethoxyethane 4.8
    ethyl orthosilicate 0.55
    tributyl phosphate 0.53
    diacetone alcohol 4.23
    N,N-dimethylaniline 0.76
    acrylonitrile 1.21
    aniline 0.78
    1,3-propanediol 10.73
    bromobenzene 0.1
    dibromomethane 0.18
    1,1,2,2-tetrachloroethane 0.68
    2-methyl-cyclohexyl acetate 0.56
    tetrabutyl urea 1.12
    diisobutyl methanol 0.28
    2-phenylethanol 1.02
    styrene 0.13
    dioctyl adipate 0.39
    dimethyl sulfate 9.94
    ethyl butyrate 0.48
    methyl lactate 9.39
    butyl lactate 1.87
    diethyl carbonate 0.32
    propanediol butyl ether 6.29
    triethyl orthoformate 0.58
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 2.14
    morpholine 2.32
    tert-butylamine 0.3
    n-dodecanol 0.18
    dimethoxymethane 7.01
    ethylene carbonate 2.1
    cyrene 13.52
    2-ethoxyethyl acetate 0.82
    2-ethylhexyl acetate 0.31
    1,2,4-trichlorobenzene 0.33
    4-methylpyridine 1.05
    dibutyl ether 0.2
    2,6-dimethyl-4-heptanol 0.28
    DEF 4.48
    dimethyl isosorbide 7.17
    tetrachloroethylene 0.71
    eugenol 3.5
    triacetin 1.48
    span 80 3.97
    1,4-butanediol 4.73
    1,1-dichloroethane 0.11
    2-methyl-1-pentanol 0.62
    methyl formate 11.87
    2-methyl-1-butanol 0.84
    n-decane 0.04
    butyronitrile 0.39
    3,7-dimethyl-1-octanol 0.31
    1-chlorooctane 0.09
    1-chlorotetradecane 0.04
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.03
    cyclooctane 0.06
    cyclopentanol 1.44
    tetrahydropyran 0.45
    tert-amyl methyl ether 0.41
    2,5,8-trioxanonane 7.82
    1-hexene 0.19
    2-isopropoxyethanol 2.86
    2,2,2-trifluoroethanol 17.56
    methyl butyrate 0.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction