Lidocaine hydrochloride monohydrate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6108-05-0

    Molecular formula
    C14H25ClN2O2

    SMILES
    CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.O.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 39.0%
    Fishy 38.04%
    Savory 30.76%
    Cheesy 29.87%
    Cooling 29.08%
    Animal 28.84%
    Meaty 27.45%
    Ripe 26.4%
    Sweet 21.96%
    Cooked 20.58%

     

    Flavor
    Odorless 32.66%
    Mild 29.32%
    Bitter 27.82%
    Bland 24.49%
    Roasted 21.14%
    Green pepper 19.72%
    Syrup 19.66%
    Nitrile 19.45%
    Cedarleaf 19.44%
    Creosote 19.32%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.95 (neutral)

    Molecular weight
    288.81 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    309°C

    Flash point

    • 168.73 ˚C est.

    Solubility expt.

    • 40.1 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Lidocaine hydrochloride monohydrate
    • Dolicaine
    • Zingo TM
    • Lidocaine HCl hydrate
    • DTXSID80209953
    • Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride, monohydrate
    • Lidocaine hydrochloride [USP:BAN:JAN]
    • Diethylaminoacet-2,6-xylidide hydrochloride monohydrate
    • LIDOCAINE HYDROCHLORIDE MONOHYDRATE [WHO-DD]
    • 2',6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE, HYDRATE
    • Lidocaine hydrochloride (USP:BAN:JAN)
    • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride monohydrate
    • N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride--water (1/1)
    • RefChem:799105
    • DTXCID30132444
    • 6108-05-0
    • 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate
    • Lidocaine (hydrochloride hydrate)
    • Dalcaine
    • Lidocaine (hydrochloride)
    • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride
    • 2-(Diethylamino)-2',6'-acetoxylidide monohydrochloride monohydrate
    • C14H25ClN2O2
    • UNII-V13007Z41A
    • Lidocaine Hydrochloride Monohydrate; Lidocaine hydrochloride monohydrate; CCI 1873A
    • Xylocaine hydrochloride monohydrate
    • Lidocaine (TN)
    • MFCD00150329
    • Zingo (TN)
    • Lidocaine hydrochloride RS
    • Lidocaine hydrochloride CRS
    • SCHEMBL29128
    • MLS001076361
    • orb1309620
    • orb3025398
    • CHEMBL1200409
    • HY-B0185B
    • LIDOCAINE HYDROCHLORIDE [MI]
    • 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide Hydrochloride Monohydrate
    • AKOS015995687
    • EBC-618588
    • FD24891
    • KS-5057
    • LIDOCAINE HYDROCHLORIDE [VANDF]
    • LIDOCAINE HYDROCHLORIDE [USP-RS]
    • LIDOCAINE HYDROCHLORIDE [WHO-IP]
    • Lidocaine hydrochloride monohydrate, solid
    • SMR000653485
    • DB-053787
    • LIDOCAINE HYDROCHLORIDE [GREEN BOOK]
    • CS-0021579
    • LIDOCAINE HYDROCHLORIDE [EP IMPURITY]
    • LIDOCAINE HYDROCHLORIDE [ORANGE BOOK]
    • NS00076418
    • D08127
    • EMBOLEX COMPONENT LIDOCAINE HYDROCHLORIDE
    • H11982
    • HBN-1 COMPONENT LIDOCAINE HYDROCHLORIDE
    • LIDOCAINE HYDROCHLORIDE [USP MONOGRAPH]
    • LIDOCAINI HYDROCHLORIDUM [WHO-IP LATIN]
    • DUOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
    • F448728
    • IONTOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
    • LIDOCAINE HYDROCHLORIDE MONOHYDRATE [MART.]
    • OCTOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
    • Q27128594
    • LIDOCAINE HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH]
    • LIGNOSPAN FORTE COMPONENT LIDOCAINE HYDROCHLORIDE
    • LIDOSITE TOPICAL SYSTEM KIT COMPONENT LIDOCAINE HYDROCHLORIDE
    • [2-(2,6-dimethylanilino)-2-oxo-ethyl]-diethyl-ammonium;chloride;hydrate
    • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride
    • Lidocaine hydrochloride, British Pharmacopoeia (BP) Reference Standard
    • Lidocaine hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • Lidocaine hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • Lidocaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    • N-(2,6-Dimethylphenyl)-N~2~,N~2~-diethylglycinamide--hydrogen chloride--water (1/1/1)
    • 6108-05-0

  • Applications

    Lidocaine hydrochloride monohydrate, CAS 6108-05-0, is primarily used in pharmaceuticals as a local anesthetic in topical formulations and dental anesthesia, with the salt form enhancing water solubility and formulation stability; typical applications include gels, creams, and sprays for local numbness, as well as injectable preparations for minor procedures, and in veterinary medicine for local anesthesia during procedures or examinations; it is also used as a chemical intermediate or reference salt in pharmaceutical synthesis, where its salt form facilitates handling and solubility in research and development settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.45
    methanol 55.42
    isopropanol 23.81
    water 2.25
    ethyl acetate 26.87
    n-propanol 28.78
    acetone 31.44
    n-butanol 25.93
    acetonitrile 13.84
    DMF 121.7
    toluene 10.34
    isobutanol 23.92
    1,4-dioxane 48.91
    methyl acetate 27.51
    THF 49.38
    2-butanone 28.32
    n-pentanol 23.77
    sec-butanol 21.78
    n-hexane 3.48
    ethylene glycol 24.09
    NMP 101.25
    cyclohexane 3.39
    DMSO 85.77
    n-butyl acetate 52.18
    n-octanol 15.26
    chloroform 168.44
    n-propyl acetate 21.51
    acetic acid 76.56
    dichloromethane 124.95
    cyclohexanone 57.39
    propylene glycol 22.17
    isopropyl acetate 25.6
    DMAc 168.58
    2-ethoxyethanol 42.4
    isopentanol 30.97
    n-heptane 1.85
    ethyl formate 26.65
    1,2-dichloroethane 84.05
    n-hexanol 41.03
    2-methoxyethanol 61.92
    isobutyl acetate 23.53
    tetrachloromethane 25.5
    n-pentyl acetate 24.63
    transcutol 145.17
    n-heptanol 20.64
    ethylbenzene 10.79
    MIBK 25.55
    2-propoxyethanol 78.3
    tert-butanol 37.0
    MTBE 32.53
    2-butoxyethanol 46.32
    propionic acid 38.05
    o-xylene 15.04
    formic acid 53.51
    diethyl ether 20.64
    m-xylene 13.31
    p-xylene 15.84
    chlorobenzene 33.95
    dimethyl carbonate 22.06
    n-octane 1.37
    formamide 46.13
    cyclopentanone 58.43
    2-pentanone 22.85
    anisole 21.7
    cyclopentyl methyl ether 26.33
    gamma-butyrolactone 68.12
    1-methoxy-2-propanol 42.85
    pyridine 34.31
    3-pentanone 27.52
    furfural 78.79
    n-dodecane 1.4
    diethylene glycol 83.84
    diisopropyl ether 10.62
    tert-amyl alcohol 34.74
    acetylacetone 40.61
    n-hexadecane 1.56
    acetophenone 27.67
    methyl propionate 26.18
    isopentyl acetate 59.93
    trichloroethylene 157.75
    n-nonanol 16.11
    cyclohexanol 26.1
    benzyl alcohol 24.32
    2-ethylhexanol 27.28
    isooctanol 18.7
    dipropyl ether 17.62
    1,2-dichlorobenzene 49.75
    ethyl lactate 23.79
    propylene carbonate 50.98
    n-methylformamide 39.99
    2-pentanol 18.39
    n-pentane 2.35
    1-propoxy-2-propanol 51.47
    1-methoxy-2-propyl acetate 60.59
    2-(2-methoxypropoxy) propanol 57.2
    mesitylene 11.28
    ε-caprolactone 56.56
    p-cymene 15.56
    epichlorohydrin 76.9
    1,1,1-trichloroethane 72.34
    2-aminoethanol 31.44
    morpholine-4-carbaldehyde 97.8
    sulfolane 111.07
    2,2,4-trimethylpentane 3.87
    2-methyltetrahydrofuran 35.27
    n-hexyl acetate 31.44
    isooctane 2.37
    2-(2-butoxyethoxy)ethanol 65.9
    sec-butyl acetate 19.88
    tert-butyl acetate 36.94
    decalin 4.35
    glycerin 48.65
    diglyme 98.92
    acrylic acid 43.93
    isopropyl myristate 15.96
    n-butyric acid 50.84
    acetyl acetate 33.12
    di(2-ethylhexyl) phthalate 29.18
    ethyl propionate 21.05
    nitromethane 71.22
    1,2-diethoxyethane 41.89
    benzonitrile 26.04
    trioctyl phosphate 19.73
    1-bromopropane 30.84
    gamma-valerolactone 85.01
    n-decanol 12.68
    triethyl phosphate 33.13
    4-methyl-2-pentanol 18.61
    propionitrile 17.75
    vinylene carbonate 52.82
    1,1,2-trichlorotrifluoroethane 120.25
    DMS 46.76
    cumene 12.57
    2-octanol 13.03
    2-hexanone 23.27
    octyl acetate 19.71
    limonene 18.97
    1,2-dimethoxyethane 59.4
    ethyl orthosilicate 32.22
    tributyl phosphate 27.08
    diacetone alcohol 44.1
    N,N-dimethylaniline 24.58
    acrylonitrile 24.15
    aniline 21.95
    1,3-propanediol 44.05
    bromobenzene 32.08
    dibromomethane 75.05
    1,1,2,2-tetrachloroethane 158.97
    2-methyl-cyclohexyl acetate 39.44
    tetrabutyl urea 34.15
    diisobutyl methanol 18.78
    2-phenylethanol 37.02
    styrene 10.72
    dioctyl adipate 27.27
    dimethyl sulfate 56.77
    ethyl butyrate 31.91
    methyl lactate 30.19
    butyl lactate 33.07
    diethyl carbonate 30.46
    propanediol butyl ether 35.44
    triethyl orthoformate 33.14
    p-tert-butyltoluene 16.12
    methyl 4-tert-butylbenzoate 46.09
    morpholine 49.39
    tert-butylamine 24.1
    n-dodecanol 10.18
    dimethoxymethane 45.61
    ethylene carbonate 45.15
    cyrene 47.45
    2-ethoxyethyl acetate 38.82
    2-ethylhexyl acetate 48.92
    1,2,4-trichlorobenzene 55.02
    4-methylpyridine 31.69
    dibutyl ether 15.86
    2,6-dimethyl-4-heptanol 18.78
    DEF 41.92
    dimethyl isosorbide 90.21
    tetrachloroethylene 108.94
    eugenol 52.2
    triacetin 36.6
    span 80 41.77
    1,4-butanediol 24.34
    1,1-dichloroethane 57.62
    2-methyl-1-pentanol 28.7
    methyl formate 34.98
    2-methyl-1-butanol 28.42
    n-decane 2.07
    butyronitrile 18.53
    3,7-dimethyl-1-octanol 20.36
    1-chlorooctane 10.43
    1-chlorotetradecane 5.31
    n-nonane 1.72
    undecane 1.66
    tert-butylcyclohexane 4.73
    cyclooctane 1.5
    cyclopentanol 25.72
    tetrahydropyran 32.1
    tert-amyl methyl ether 29.0
    2,5,8-trioxanonane 82.01
    1-hexene 10.3
    2-isopropoxyethanol 33.06
    2,2,2-trifluoroethanol 55.6
    methyl butyrate 28.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction