Licoflavanone

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  • Identifiers

    CAS number
    119240-82-3

    Molecular formula
    C20H20O5

    SMILES
    CC(=CCC1=C(C=CC(=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 50.52%
    Spicy 47.03%
    Sweet 35.12%
    Odorless 32.17%
    Smoky 26.7%
    Woody 26.39%
    Balsamic 25.24%
    Medicinal 23.47%
    Vanilla 23.24%
    Animal 22.14%

     

    Flavor
    Bitter 90.38%
    Lovage 20.52%
    Cedarleaf 20.33%
    Parsley 20.02%
    Basil 18.64%
    Ripe apricot 18.58%
    Nitrile 18.48%
    Red fruit 18.37%
    Leaves 18.36%
    Heather 18.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    10.27 (weak base)

    Molecular weight
    340.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    683°C

    Flash point

    • 232.13 ˚C est.

  • Synonyms

    • Licoflavanone
    • 119240-82-3
    • 5,7-dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one
    • 5,7-dihydroxy-2-(4-hydroxy-3-(3-methylbut-2-enyl)phenyl)-2,3-dihydrochromen-4-one
    • RefChem:1088455
    • (2S)-abyssinone II
    • CHEMBL457680
    • (S)-4',5,7-Trihydroxy-3'-prenylflavanone
    • 5,7-Dihydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)chroman-4-one
    • 5,7-dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-3,4-dihydro-2H-1-benzopyran-4-one
    • SCHEMBL3364539
    • SCHEMBL29619791
    • SCHEMBL31237322
    • CHEBI:174568
    • BDBM50251004
    • LMPK12140288
    • 4',5,7-trihydroxy-3'-prenylflavanone
    • 119240-82-3

  • Applications

    Licoflavanone (CAS 119240-82-3) is a flavanone that is being evaluated for a range of practical applications across industry. Representative use areas include: serving as an intermediate in pharmaceutical synthesis; evaluated as an antioxidant and stabilizer additive in cosmetics and personal care products; potentially used as an odorant/fragrance ingredient in perfumery; studied as a UV-stabilizing and antioxidant additive in coatings and plastics; and may be considered for household products as a formulation stabilizer. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.4
    methanol 70.84
    isopropanol 39.22
    water 0.09
    ethyl acetate 58.94
    n-propanol 24.43
    acetone 285.39
    n-butanol 21.52
    acetonitrile 96.7
    DMF 580.55
    toluene 3.1
    isobutanol 24.9
    1,4-dioxane 169.01
    methyl acetate 108.8
    THF 534.71
    2-butanone 138.72
    n-pentanol 21.11
    sec-butanol 22.1
    n-hexane 0.07
    ethylene glycol 30.94
    NMP 173.03
    cyclohexane 0.16
    DMSO 1640.72
    n-butyl acetate 28.87
    n-octanol 12.55
    chloroform 22.23
    n-propyl acetate 38.89
    acetic acid 123.16
    dichloromethane 12.66
    cyclohexanone 108.68
    propylene glycol 101.52
    isopropyl acetate 39.83
    DMAc 552.98
    2-ethoxyethanol 138.97
    isopentanol 26.38
    n-heptane 0.17
    ethyl formate 47.0
    1,2-dichloroethane 17.99
    n-hexanol 10.78
    2-methoxyethanol 323.12
    isobutyl acetate 27.19
    tetrachloromethane 1.7
    n-pentyl acetate 21.56
    transcutol 531.06
    n-heptanol 10.3
    ethylbenzene 1.85
    MIBK 48.43
    2-propoxyethanol 151.58
    tert-butanol 77.61
    MTBE 24.04
    2-butoxyethanol 54.49
    propionic acid 58.25
    o-xylene 2.79
    formic acid 50.36
    diethyl ether 11.81
    m-xylene 3.45
    p-xylene 3.56
    chlorobenzene 7.01
    dimethyl carbonate 91.48
    n-octane 0.11
    formamide 127.54
    cyclopentanone 278.96
    2-pentanone 79.0
    anisole 24.92
    cyclopentyl methyl ether 44.4
    gamma-butyrolactone 272.25
    1-methoxy-2-propanol 288.33
    pyridine 41.5
    3-pentanone 52.15
    furfural 138.4
    n-dodecane 0.3
    diethylene glycol 175.1
    diisopropyl ether 4.43
    tert-amyl alcohol 33.51
    acetylacetone 193.86
    n-hexadecane 0.36
    acetophenone 33.23
    methyl propionate 92.65
    isopentyl acetate 31.46
    trichloroethylene 53.95
    n-nonanol 13.06
    cyclohexanol 18.39
    benzyl alcohol 27.18
    2-ethylhexanol 8.24
    isooctanol 10.4
    dipropyl ether 13.08
    1,2-dichlorobenzene 8.56
    ethyl lactate 53.58
    propylene carbonate 74.88
    n-methylformamide 209.27
    2-pentanol 14.28
    n-pentane 0.07
    1-propoxy-2-propanol 104.58
    1-methoxy-2-propyl acetate 88.68
    2-(2-methoxypropoxy) propanol 97.19
    mesitylene 2.52
    ε-caprolactone 79.25
    p-cymene 3.02
    epichlorohydrin 284.6
    1,1,1-trichloroethane 16.91
    2-aminoethanol 53.68
    morpholine-4-carbaldehyde 272.99
    sulfolane 399.23
    2,2,4-trimethylpentane 0.22
    2-methyltetrahydrofuran 77.92
    n-hexyl acetate 34.0
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 135.23
    sec-butyl acetate 24.26
    tert-butyl acetate 53.2
    decalin 0.23
    glycerin 175.23
    diglyme 265.17
    acrylic acid 62.86
    isopropyl myristate 15.23
    n-butyric acid 67.39
    acetyl acetate 50.26
    di(2-ethylhexyl) phthalate 20.13
    ethyl propionate 38.68
    nitromethane 536.7
    1,2-diethoxyethane 81.19
    benzonitrile 25.1
    trioctyl phosphate 14.54
    1-bromopropane 3.54
    gamma-valerolactone 346.56
    n-decanol 9.8
    triethyl phosphate 20.98
    4-methyl-2-pentanol 13.06
    propionitrile 50.67
    vinylene carbonate 65.95
    1,1,2-trichlorotrifluoroethane 193.09
    DMS 58.03
    cumene 1.91
    2-octanol 7.1
    2-hexanone 45.69
    octyl acetate 19.94
    limonene 3.89
    1,2-dimethoxyethane 246.12
    ethyl orthosilicate 18.5
    tributyl phosphate 19.11
    diacetone alcohol 123.74
    N,N-dimethylaniline 15.23
    acrylonitrile 90.1
    aniline 14.55
    1,3-propanediol 88.48
    bromobenzene 5.35
    dibromomethane 5.2
    1,1,2,2-tetrachloroethane 54.54
    2-methyl-cyclohexyl acetate 25.47
    tetrabutyl urea 29.35
    diisobutyl methanol 8.67
    2-phenylethanol 23.18
    styrene 2.42
    dioctyl adipate 30.32
    dimethyl sulfate 174.74
    ethyl butyrate 26.37
    methyl lactate 127.57
    butyl lactate 39.4
    diethyl carbonate 21.63
    propanediol butyl ether 81.91
    triethyl orthoformate 27.87
    p-tert-butyltoluene 3.28
    methyl 4-tert-butylbenzoate 42.59
    morpholine 208.61
    tert-butylamine 13.04
    n-dodecanol 7.1
    dimethoxymethane 339.98
    ethylene carbonate 56.6
    cyrene 85.32
    2-ethoxyethyl acetate 56.0
    2-ethylhexyl acetate 19.66
    1,2,4-trichlorobenzene 15.7
    4-methylpyridine 35.71
    dibutyl ether 15.21
    2,6-dimethyl-4-heptanol 8.67
    DEF 83.93
    dimethyl isosorbide 165.01
    tetrachloroethylene 19.71
    eugenol 46.85
    triacetin 65.69
    span 80 55.08
    1,4-butanediol 36.42
    1,1-dichloroethane 16.22
    2-methyl-1-pentanol 18.28
    methyl formate 184.25
    2-methyl-1-butanol 19.07
    n-decane 0.43
    butyronitrile 31.54
    3,7-dimethyl-1-octanol 14.89
    1-chlorooctane 3.28
    1-chlorotetradecane 1.63
    n-nonane 0.29
    undecane 0.36
    tert-butylcyclohexane 0.27
    cyclooctane 0.09
    cyclopentanol 40.3
    tetrahydropyran 49.29
    tert-amyl methyl ether 17.04
    2,5,8-trioxanonane 191.1
    1-hexene 0.49
    2-isopropoxyethanol 86.01
    2,2,2-trifluoroethanol 43.96
    methyl butyrate 52.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction