Levomefolate Calcium

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  • Identifiers

    CAS number
    151533-22-1

    Molecular formula
    C20H23CaN7O6

    SMILES
    CN1[C@H](CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 79.55%
    Savory 34.68%
    Meaty 23.61%
    Cooked 22.04%
    Cooling 21.72%
    Milky 18.46%
    Bitter 17.45%
    Roasted 15.18%
    Burnt 14.52%
    Animal 14.42%

     

    Flavor
    Bitter 81.53%
    Odorless 54.63%
    Bland 29.91%
    Mild 22.43%
    Sweet-like 21.59%
    Very mild 20.85%
    Nitrile 19.32%
    Yeast 18.83%
    Cedarleaf 18.24%
    Bread crust 18.09%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    3.84 (weak acid)

    Molecular weight
    497.5 g/mol

    Flash point

    • 377.02 ˚C est.

  • Synonyms

    • Levomefolate calcium
    • 151533-22-1
    • Calcium levomefolate
    • Levomefolinate calcium
    • Bodyfolin
    • Metafolin
    • Nutrifolin
    • LMCA
    • Extrafolate-S
    • L-methylfolate Calcium
    • Levomefolate (calcium)
    • L-5-Methyltetrahydrofolate calcium
    • L-5-mthf-ca
    • L-methylfolate-calcium
    • Deplin
    • LMC-A
    • UNII-A9R10K3F2F
    • Levomefolate calcium [USAN]
    • CALCIUM L-METHYLFOLATE
    • BAY86-7660
    • BAY 86-7660
    • A9R10K3F2F
    • Calcium L-5-methyltetrahydrofolate
    • L-5-methyl tetrahydrofolic
    • (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid, calcium salt
    • CHEBI:189695
    • L-5-Methyletrahydrofolate calcium
    • NDI 638
    • calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
    • Metafolin (TN)
    • BEYAZ COMPONENT LEVOMEFOLATE CALCIUM
    • SAFYRAL COMPONENT LEVOMEFOLATE CALCIUM
    • (6s)-5-methyltetrahydrofolic acid calcium salt
    • Levomefolate calcium (USAN)
    • Calcium N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
    • L-Glutamic acid, N-[4-[[[(6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)
    • CALCIUML-5-METHYLTETRAHYDROFOLATE
    • CALCIUM LEVOMEFOLATE (MART.)
    • CALCIUM LEVOMEFOLATE [MART.]
    • Denovo
    • calcium (2S)-2-(4-((((6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioate
    • calcium (2S)-2-[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzamido]pentanedioate
    • L-5-MTHF calcium
    • NDI 638 [FDMS]
    • CHEMBL1615371
    • GLXC-20725
    • LEVOMEFOLATE CALCIUM [VANDF]
    • MFCD18642975
    • CALCIUM LEVOMEFOLATE [WHO-DD]
    • AKOS025117256
    • AKOS025402270
    • calcium (6s)-5-methyltetrahydrofolate
    • AC-7457
    • CALCIUM-5-METHYLTETRAHYDROFOLATE
    • CS-1066
    • FM11406
    • GS-6017
    • HY-17383
    • LEVOMEFOLATE CALCIUM [ORANGE BOOK]
    • N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt
    • LEVOMEFOLATE CALCIUM COMPONENT OF BEYAZ
    • D09354
    • CALCIUM L-5-METHYLTETRAHYDROFOLATE [DSC]
    • LEVOMEFOLATE CALCIUM COMPONENT OF SAFYRAL
    • L-5-METHYLTETRAHYDROFOLIC ACID, CALCIUM SALT
    • Q27273818
    • 6(S)-5-METHYLTETRAHYDROFOLIC ACID, CALCIUM SALT [NDI]
    • (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicacid,calciumsalt
    • calcium (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
    • calcium (4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
    • Calcium levomefolate;N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid calcium salt
    • calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
    • L-Glutamic acid, N-(4-((((6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)

  • Applications

    Levomefolate Calcium (CAS 151533-22-1) is a bioavailable folate salt used across pharmaceutical and nutraceutical applications as a source of L-methylfolate. Specifically, it appears in dietary supplements and in some oral or injectable pharmaceutical formulations; it may be incorporated into parenteral nutrition to supply folate, and may be used in fortified foods where permitted by regulation. It is also employed in research and development as a folate source for cell culture media and related biotech studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.3
    methanol 1.3
    isopropanol 0.11
    water 0.12
    ethyl acetate 0.02
    n-propanol 0.24
    acetone 0.13
    n-butanol 0.14
    acetonitrile 0.04
    DMF 3.85
    toluene 0.02
    isobutanol 0.08
    1,4-dioxane 0.23
    methyl acetate 0.05
    THF 0.44
    2-butanone 0.19
    n-pentanol 0.06
    sec-butanol 0.11
    n-hexane 0.0
    ethylene glycol 1.13
    NMP 5.08
    cyclohexane 0.0
    DMSO 5.7
    n-butyl acetate 0.01
    n-octanol 0.02
    chloroform 0.02
    n-propyl acetate 0.02
    acetic acid 0.72
    dichloromethane 0.03
    cyclohexanone 0.29
    propylene glycol 1.21
    isopropyl acetate 0.01
    DMAc 5.52
    2-ethoxyethanol 0.87
    isopentanol 0.06
    n-heptane 0.0
    ethyl formate 0.09
    1,2-dichloroethane 0.03
    n-hexanol 0.02
    2-methoxyethanol 3.57
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.03
    transcutol 1.0
    n-heptanol 0.04
    ethylbenzene 0.01
    MIBK 0.03
    2-propoxyethanol 0.39
    tert-butanol 0.04
    MTBE 0.01
    2-butoxyethanol 0.41
    propionic acid 0.26
    o-xylene 0.01
    formic acid 4.09
    diethyl ether 0.04
    m-xylene 0.01
    p-xylene 0.01
    chlorobenzene 0.01
    dimethyl carbonate 0.07
    n-octane 0.0
    formamide 3.41
    cyclopentanone 0.48
    2-pentanone 0.08
    anisole 0.02
    cyclopentyl methyl ether 0.06
    gamma-butyrolactone 0.41
    1-methoxy-2-propanol 1.03
    pyridine 0.23
    3-pentanone 0.08
    furfural 0.76
    n-dodecane 0.0
    diethylene glycol 0.88
    diisopropyl ether 0.0
    tert-amyl alcohol 0.06
    acetylacetone 0.08
    n-hexadecane 0.0
    acetophenone 0.04
    methyl propionate 0.08
    isopentyl acetate 0.01
    trichloroethylene 0.05
    n-nonanol 0.02
    cyclohexanol 0.07
    benzyl alcohol 0.07
    2-ethylhexanol 0.01
    isooctanol 0.02
    dipropyl ether 0.03
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.08
    propylene carbonate 0.08
    n-methylformamide 1.5
    2-pentanol 0.04
    n-pentane 0.0
    1-propoxy-2-propanol 0.18
    1-methoxy-2-propyl acetate 0.04
    2-(2-methoxypropoxy) propanol 0.31
    mesitylene 0.0
    ε-caprolactone 0.2
    p-cymene 0.0
    epichlorohydrin 0.32
    1,1,1-trichloroethane 0.01
    2-aminoethanol 1.23
    morpholine-4-carbaldehyde 2.58
    sulfolane 1.84
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.11
    n-hexyl acetate 0.03
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.48
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 4.86
    diglyme 0.97
    acrylic acid 0.52
    isopropyl myristate 0.01
    n-butyric acid 0.16
    acetyl acetate 0.01
    di(2-ethylhexyl) phthalate 0.03
    ethyl propionate 0.02
    nitromethane 0.62
    1,2-diethoxyethane 0.07
    benzonitrile 0.03
    trioctyl phosphate 0.02
    1-bromopropane 0.02
    gamma-valerolactone 1.98
    n-decanol 0.02
    triethyl phosphate 0.02
    4-methyl-2-pentanol 0.01
    propionitrile 0.05
    vinylene carbonate 0.11
    1,1,2-trichlorotrifluoroethane 1.22
    DMS 0.03
    cumene 0.0
    2-octanol 0.02
    2-hexanone 0.05
    octyl acetate 0.02
    limonene 0.0
    1,2-dimethoxyethane 0.75
    ethyl orthosilicate 0.02
    tributyl phosphate 0.02
    diacetone alcohol 0.11
    N,N-dimethylaniline 0.02
    acrylonitrile 0.1
    aniline 0.07
    1,3-propanediol 1.23
    bromobenzene 0.0
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.05
    2-methyl-cyclohexyl acetate 0.02
    tetrabutyl urea 0.06
    diisobutyl methanol 0.01
    2-phenylethanol 0.03
    styrene 0.01
    dioctyl adipate 0.02
    dimethyl sulfate 0.27
    ethyl butyrate 0.02
    methyl lactate 0.34
    butyl lactate 0.1
    diethyl carbonate 0.01
    propanediol butyl ether 0.46
    triethyl orthoformate 0.03
    p-tert-butyltoluene 0.0
    methyl 4-tert-butylbenzoate 0.08
    morpholine 0.55
    tert-butylamine 0.01
    n-dodecanol 0.01
    dimethoxymethane 0.68
    ethylene carbonate 0.06
    cyrene 0.58
    2-ethoxyethyl acetate 0.07
    2-ethylhexyl acetate 0.01
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.11
    dibutyl ether 0.02
    2,6-dimethyl-4-heptanol 0.01
    DEF 0.26
    dimethyl isosorbide 0.28
    tetrachloroethylene 0.05
    eugenol 0.15
    triacetin 0.06
    span 80 0.2
    1,4-butanediol 0.28
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.03
    methyl formate 0.63
    2-methyl-1-butanol 0.08
    n-decane 0.0
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.01
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.14
    tetrahydropyran 0.09
    tert-amyl methyl ether 0.02
    2,5,8-trioxanonane 0.68
    1-hexene 0.01
    2-isopropoxyethanol 0.21
    2,2,2-trifluoroethanol 0.4
    methyl butyrate 0.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction