Levocarnitine fumarate

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  • Identifiers

    CAS number
    220349-64-4

    Molecular formula
    C18H36N2O10

    SMILES
    C[N+](C)(C)C[C@@H](CC(=O)O)O.C[N+](C)(C)C[C@@H](CC(=O)O)O.C(CC(=O)[O-])C(=O)[O-]

    Safety labels

  • Odor profile

    Fragrance
    Fruity 43.1%
    Cheesy 40.73%
    Odorless 34.54%
    Sour 32.58%
    Fatty 30.45%
    Sweaty 26.85%
    Dairy 25.76%
    Milky 23.08%
    Creamy 22.25%
    Oily 21.11%

     

    Flavor
    Odorless 39.4%
    Mild 32.13%
    Bland 28.51%
    Stinky 21.15%
    Green 20.99%
    Sulfury 20.89%
    Yeasty 20.33%
    Acrid 19.85%
    Sulfurous 19.5%
    Catty 19.34%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.16 (weak acid)

    Molecular weight
    440.5 g/mol

    Flash point

    • -85.68 ˚C est.

  • Synonyms

    • Levocarnitine fumarate
    • 8Q37GK439O
    • 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, (2R)-, (2E)-2-butenedioate (2:1)
    • 220349-64-4
    • RefChem:1088438
    • L-Carnitine fumarate
    • Carnitine Fumarate
    • UNII-8Q37GK439O
    • LEVOCARNITINE HEMIFUMARATE
    • LEVOCARNITINE FUMARATE [WHO-DD]
    • Q27270880
    • 220349-64-4

  • Applications

    Levocarnitine fumarate (CAS 220349-64-4) is the fumarate salt of L-carnitine and is principally used as a source of carnitine in pharmaceutical and medical nutrition applications. In pharmaceuticals, it serves as an active ingredient or carnitine supplement to support replacement therapy in carnitine-deficient individuals and to aid fatty acid and energy metabolism. In the nutraceuticals and dietary supplement space, it is formulated in products for athletes to support energy metabolism and overall metabolic function. In clinical nutrition, it may be used in enteral or parenteral nutrition formulations when carnitine supplementation is indicated. In animal nutrition, it is studied and used as a feed additive to improve energy utilization and growth performance. This usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 27.27
    methanol 117.46
    isopropanol 2.64
    water 633.46
    ethyl acetate 0.61
    n-propanol 10.26
    acetone 0.21
    n-butanol 3.44
    acetonitrile 0.95
    DMF 9.34
    toluene 0.1
    isobutanol 2.32
    1,4-dioxane 2.82
    methyl acetate 0.92
    THF 3.93
    2-butanone 0.33
    n-pentanol 1.04
    sec-butanol 2.09
    n-hexane 0.07
    ethylene glycol 197.36
    NMP 77.28
    cyclohexane 0.12
    DMSO 6.5
    n-butyl acetate 1.56
    n-octanol 1.78
    chloroform 0.98
    n-propyl acetate 0.64
    acetic acid 167.64
    dichloromethane 1.23
    cyclohexanone 2.36
    propylene glycol 99.41
    isopropyl acetate 0.28
    DMAc 11.74
    2-ethoxyethanol 10.78
    isopentanol 0.76
    n-heptane 0.22
    ethyl formate 3.03
    1,2-dichloroethane 0.48
    n-hexanol 3.69
    2-methoxyethanol 60.19
    isobutyl acetate 0.44
    tetrachloromethane 0.47
    n-pentyl acetate 0.99
    transcutol 22.16
    n-heptanol 3.14
    ethylbenzene 0.13
    MIBK 0.17
    2-propoxyethanol 26.68
    tert-butanol 1.32
    MTBE 0.15
    2-butoxyethanol 13.96
    propionic acid 35.29
    o-xylene 0.26
    formic acid 806.58
    diethyl ether 0.23
    m-xylene 0.2
    p-xylene 0.18
    chlorobenzene 0.25
    dimethyl carbonate 1.82
    n-octane 0.07
    formamide 229.6
    cyclopentanone 3.4
    2-pentanone 0.23
    anisole 0.44
    cyclopentyl methyl ether 1.2
    gamma-butyrolactone 18.4
    1-methoxy-2-propanol 13.89
    pyridine 1.54
    3-pentanone 0.29
    furfural 22.9
    n-dodecane 0.06
    diethylene glycol 67.44
    diisopropyl ether 0.06
    tert-amyl alcohol 1.52
    acetylacetone 0.51
    n-hexadecane 0.06
    acetophenone 1.17
    methyl propionate 1.66
    isopentyl acetate 1.2
    trichloroethylene 1.07
    n-nonanol 1.65
    cyclohexanol 2.82
    benzyl alcohol 1.64
    2-ethylhexanol 1.67
    isooctanol 1.69
    dipropyl ether 0.73
    1,2-dichlorobenzene 0.6
    ethyl lactate 5.44
    propylene carbonate 10.29
    n-methylformamide 30.97
    2-pentanol 0.69
    n-pentane 0.07
    1-propoxy-2-propanol 11.51
    1-methoxy-2-propyl acetate 3.8
    2-(2-methoxypropoxy) propanol 12.29
    mesitylene 0.19
    ε-caprolactone 8.04
    p-cymene 0.6
    epichlorohydrin 4.04
    1,1,1-trichloroethane 0.23
    2-aminoethanol 177.57
    morpholine-4-carbaldehyde 49.17
    sulfolane 37.85
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 1.64
    n-hexyl acetate 1.72
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 15.86
    sec-butyl acetate 0.32
    tert-butyl acetate 0.41
    decalin 0.1
    glycerin 272.57
    diglyme 13.12
    acrylic acid 66.39
    isopropyl myristate 0.55
    n-butyric acid 12.85
    acetyl acetate 0.79
    di(2-ethylhexyl) phthalate 3.14
    ethyl propionate 0.75
    nitromethane 23.45
    1,2-diethoxyethane 0.8
    benzonitrile 0.94
    trioctyl phosphate 2.22
    1-bromopropane 0.19
    gamma-valerolactone 18.37
    n-decanol 1.16
    triethyl phosphate 2.49
    4-methyl-2-pentanol 0.33
    propionitrile 0.86
    vinylene carbonate 12.03
    1,1,2-trichlorotrifluoroethane 41.17
    DMS 2.82
    cumene 0.22
    2-octanol 0.99
    2-hexanone 0.26
    octyl acetate 1.19
    limonene 0.75
    1,2-dimethoxyethane 3.13
    ethyl orthosilicate 2.09
    tributyl phosphate 2.35
    diacetone alcohol 2.23
    N,N-dimethylaniline 0.86
    acrylonitrile 2.39
    aniline 1.05
    1,3-propanediol 62.46
    bromobenzene 0.14
    dibromomethane 0.6
    1,1,2,2-tetrachloroethane 1.18
    2-methyl-cyclohexyl acetate 2.88
    tetrabutyl urea 3.23
    diisobutyl methanol 0.67
    2-phenylethanol 3.27
    styrene 0.1
    dioctyl adipate 1.81
    dimethyl sulfate 5.97
    ethyl butyrate 1.37
    methyl lactate 13.75
    butyl lactate 6.48
    diethyl carbonate 1.46
    propanediol butyl ether 19.0
    triethyl orthoformate 1.91
    p-tert-butyltoluene 0.64
    methyl 4-tert-butylbenzoate 5.39
    morpholine 8.53
    tert-butylamine 0.58
    n-dodecanol 0.81
    dimethoxymethane 2.89
    ethylene carbonate 6.76
    cyrene 26.26
    2-ethoxyethyl acetate 1.88
    2-ethylhexyl acetate 1.2
    1,2,4-trichlorobenzene 1.02
    4-methylpyridine 0.7
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 0.67
    DEF 1.92
    dimethyl isosorbide 22.0
    tetrachloroethylene 1.66
    eugenol 9.06
    triacetin 4.63
    span 80 16.98
    1,4-butanediol 12.42
    1,1-dichloroethane 0.16
    2-methyl-1-pentanol 0.5
    methyl formate 13.5
    2-methyl-1-butanol 1.41
    n-decane 0.09
    butyronitrile 0.58
    3,7-dimethyl-1-octanol 1.04
    1-chlorooctane 0.27
    1-chlorotetradecane 0.14
    n-nonane 0.08
    undecane 0.07
    tert-butylcyclohexane 0.09
    cyclooctane 0.07
    cyclopentanol 5.71
    tetrahydropyran 0.98
    tert-amyl methyl ether 0.29
    2,5,8-trioxanonane 13.3
    1-hexene 0.13
    2-isopropoxyethanol 3.06
    2,2,2-trifluoroethanol 79.6
    methyl butyrate 1.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction