Lenthionine

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  • Identifiers

    CAS number
    292-46-6

    Molecular formula
    C2H4S5

    SMILES
    C1SSCSSS1

  • Odor profile

    Fragrance
    Sulfurous 85.53%
    Mushroom 58.31%
    Meaty 53.53%
    Garlic 53.27%
    Onion 47.19%
    Roasted 44.33%
    Alliaceous 39.97%
    Cooked 35.96%
    Savory 32.12%
    Beefy 28.77%

     

    Flavor
    Mushroom 36.97%
    Roasted 29.23%
    Alliaceous 29.16%
    Sulfurous 28.43%
    Meaty 22.83%
    Savory 22.49%
    Alkaline 22.37%
    Fishy 22.22%
    Sulfur 21.75%
    Shrimp 21.65%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    1.1 (strong acid)

    Molecular weight
    188.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 60 - 61 °C

    Boiling point

    • 287.00 °C. @ 760.00 mm Hg

    Flash point

    • 155.07 ˚C est.

  • Synonyms

    • Lenthionine
    • 1,2,3,5,6-Pentathiepane
    • 292-46-6
    • Lenthionin
    • UNII-71G9U1CIRD
    • 71G9U1CIRD
    • 1,2,3,5,6-Pentasulfur-cycloheptane
    • 1,2,3,5,6-Pentathiacycloheptane
    • LENTHIONINE [MI]
    • NSC-291119
    • CHEBI:6408
    • DTXSID20183460
    • NSC 291119
    • MFCD03840531
    • 1,3,5,6-Pentathiepane
    • [1,2,3,5,6]pentathiepane
    • SCHEMBL2675229
    • CHEMBL4288485
    • DTXCID30105951
    • BCP19093
    • NSC291119
    • AKOS006276442
    • FP66538
    • AS-33132
    • CS-0186285
    • NS00121213
    • C08382
    • Q3181449

  • Applications

    Lenthionine (CAS 292-46-6) is a volatile organosulfur compound commonly regarded as an odorant and fragrance ingredient. In the fragrance industry, it can be used as a specialty note providing garlic/onion character to savory profiles; in flavor formulations, it may serve as an aroma-active component contributing garlic/onion notes in processed foods; in cosmetics and personal care, it can function as a fragrance ingredient; in household and cleaning products, it may be used as an odorant or deodorizing/freshening agent; in industrial manufacturing and research contexts, it is sometimes considered as an intermediate or building block in sulfur-containing aroma chemistry; and its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.69
    methanol 11.92
    isopropanol 8.79
    water 0.38
    ethyl acetate 71.41
    n-propanol 11.38
    acetone 77.92
    n-butanol 11.3
    acetonitrile 39.96
    DMF 199.59
    toluene 70.47
    isobutanol 9.06
    1,4-dioxane 167.26
    methyl acetate 81.4
    THF 188.34
    2-butanone 70.32
    n-pentanol 11.9
    sec-butanol 11.01
    n-hexane 3.95
    ethylene glycol 7.0
    NMP 281.73
    cyclohexane 13.14
    DMSO 176.18
    n-butyl acetate 64.18
    n-octanol 21.43
    chloroform 235.18
    n-propyl acetate 59.67
    acetic acid 41.33
    dichloromethane 176.59
    cyclohexanone 148.17
    propylene glycol 6.71
    isopropyl acetate 59.27
    DMAc 190.33
    2-ethoxyethanol 47.4
    isopentanol 11.95
    n-heptane 10.49
    ethyl formate 49.94
    1,2-dichloroethane 108.59
    n-hexanol 17.47
    2-methoxyethanol 55.43
    isobutyl acetate 42.34
    tetrachloromethane 54.88
    n-pentyl acetate 59.23
    transcutol 189.9
    n-heptanol 18.38
    ethylbenzene 39.77
    MIBK 48.42
    2-propoxyethanol 55.04
    tert-butanol 16.64
    MTBE 31.92
    2-butoxyethanol 48.87
    propionic acid 28.93
    o-xylene 61.45
    formic acid 16.92
    diethyl ether 39.38
    m-xylene 52.1
    p-xylene 50.56
    chlorobenzene 126.05
    dimethyl carbonate 62.84
    n-octane 6.12
    formamide 43.99
    cyclopentanone 223.57
    2-pentanone 58.16
    anisole 121.21
    cyclopentyl methyl ether 96.93
    gamma-butyrolactone 224.67
    1-methoxy-2-propanol 45.21
    pyridine 183.79
    3-pentanone 66.45
    furfural 335.15
    n-dodecane 5.87
    diethylene glycol 40.52
    diisopropyl ether 24.31
    tert-amyl alcohol 17.65
    acetylacetone 147.06
    n-hexadecane 7.01
    acetophenone 137.69
    methyl propionate 64.94
    isopentyl acetate 56.4
    trichloroethylene 331.99
    n-nonanol 23.72
    cyclohexanol 23.4
    benzyl alcohol 56.89
    2-ethylhexanol 23.36
    isooctanol 18.52
    dipropyl ether 47.8
    1,2-dichlorobenzene 156.67
    ethyl lactate 34.85
    propylene carbonate 127.52
    n-methylformamide 62.05
    2-pentanol 11.25
    n-pentane 3.99
    1-propoxy-2-propanol 50.08
    1-methoxy-2-propyl acetate 93.83
    2-(2-methoxypropoxy) propanol 75.57
    mesitylene 41.85
    ε-caprolactone 128.1
    p-cymene 41.91
    epichlorohydrin 207.42
    1,1,1-trichloroethane 145.05
    2-aminoethanol 11.05
    morpholine-4-carbaldehyde 278.95
    sulfolane 337.04
    2,2,4-trimethylpentane 4.38
    2-methyltetrahydrofuran 110.28
    n-hexyl acetate 63.69
    isooctane 4.0
    2-(2-butoxyethoxy)ethanol 85.0
    sec-butyl acetate 50.44
    tert-butyl acetate 81.72
    decalin 12.56
    glycerin 17.42
    diglyme 225.71
    acrylic acid 40.38
    isopropyl myristate 41.58
    n-butyric acid 36.83
    acetyl acetate 99.85
    di(2-ethylhexyl) phthalate 41.89
    ethyl propionate 57.9
    nitromethane 162.01
    1,2-diethoxyethane 100.97
    benzonitrile 106.68
    trioctyl phosphate 27.46
    1-bromopropane 40.06
    gamma-valerolactone 276.49
    n-decanol 19.64
    triethyl phosphate 53.45
    4-methyl-2-pentanol 11.21
    propionitrile 31.06
    vinylene carbonate 147.52
    1,1,2-trichlorotrifluoroethane 198.96
    DMS 88.09
    cumene 30.34
    2-octanol 16.11
    2-hexanone 58.72
    octyl acetate 46.38
    limonene 54.27
    1,2-dimethoxyethane 125.69
    ethyl orthosilicate 49.2
    tributyl phosphate 34.06
    diacetone alcohol 69.16
    N,N-dimethylaniline 85.89
    acrylonitrile 57.13
    aniline 63.3
    1,3-propanediol 15.62
    bromobenzene 149.19
    dibromomethane 101.54
    1,1,2,2-tetrachloroethane 239.62
    2-methyl-cyclohexyl acetate 68.92
    tetrabutyl urea 51.6
    diisobutyl methanol 21.87
    2-phenylethanol 59.51
    styrene 59.67
    dioctyl adipate 68.17
    dimethyl sulfate 149.03
    ethyl butyrate 72.58
    methyl lactate 41.04
    butyl lactate 43.51
    diethyl carbonate 57.22
    propanediol butyl ether 39.5
    triethyl orthoformate 66.88
    p-tert-butyltoluene 41.83
    methyl 4-tert-butylbenzoate 106.71
    morpholine 124.09
    tert-butylamine 11.24
    n-dodecanol 17.15
    dimethoxymethane 103.81
    ethylene carbonate 97.26
    cyrene 112.21
    2-ethoxyethyl acetate 100.86
    2-ethylhexyl acetate 55.23
    1,2,4-trichlorobenzene 196.54
    4-methylpyridine 150.14
    dibutyl ether 45.63
    2,6-dimethyl-4-heptanol 21.87
    DEF 101.92
    dimethyl isosorbide 200.07
    tetrachloroethylene 172.64
    eugenol 100.79
    triacetin 119.71
    span 80 68.13
    1,4-butanediol 9.47
    1,1-dichloroethane 81.1
    2-methyl-1-pentanol 13.97
    methyl formate 65.06
    2-methyl-1-butanol 11.48
    n-decane 8.69
    butyronitrile 29.35
    3,7-dimethyl-1-octanol 25.78
    1-chlorooctane 28.26
    1-chlorotetradecane 16.0
    n-nonane 7.63
    undecane 6.9
    tert-butylcyclohexane 9.43
    cyclooctane 8.73
    cyclopentanol 31.17
    tetrahydropyran 88.94
    tert-amyl methyl ether 34.66
    2,5,8-trioxanonane 184.45
    1-hexene 11.14
    2-isopropoxyethanol 38.48
    2,2,2-trifluoroethanol 39.78
    methyl butyrate 72.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction