Lauroyl Arginine

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  • Identifiers

    CAS number
    42492-22-8

    Molecular formula
    C18H36N4O3

    SMILES
    CCCCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 45.57%
    Savory 39.21%
    Meaty 36.03%
    Cooling 35.1%
    Fishy 29.58%
    Animal 22.62%
    Mint 21.05%
    Fresh 20.74%
    Herbal 20.36%
    Oily 19.96%

     

    Flavor
    Odorless 43.16%
    Bland 35.0%
    Mild 30.53%
    Bitter 27.2%
    Faint 22.42%
    Slightly waxy 19.9%
    Herbal 19.81%
    Cedarleaf 19.72%
    Sweet-like 19.59%
    Bay oil 19.54%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    7.94 (neutral)

    Molecular weight
    356.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    498°C

    Flash point

    • 224.93 ˚C est.

  • Synonyms

    • lauroyl arginine
    • N-Lauroyl-L-arginine
    • N2-(1-Oxododecyl)-L-arginine
    • EINECS 255-851-2
    • UNII-65091WP61D
    • AMISAFE AL 01
    • AMISAFE AL-01
    • 65091WP61D
    • ARGININE, N2-LAUROYL-
    • DTXSID10195279
    • LAUROYL ARGININE [USP-RS]
    • L-ARGININE, N2-(1-OXODODECYL)-
    • LAUROYL ARGININE (USP-RS)
    • RefChem:152520
    • LAUROYL ARGININE [INCI]
    • DTXCID70117770
    • 42492-22-8
    • (S)-2-Dodecanamido-5-guanidinopentanoic acid
    • (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoic acid
    • N(ALPHA)-LAUROYL-L-ARGININE*
    • Lauroyl L-Arginate
    • lauroylarginine
    • mono-Na-lauroyl-L-arginine
    • N~2~-dodecanoyl-L-arginine
    • SCHEMBL539142
    • mono-Nalpha-lauroyl-L-arginine
    • Nalpha-mono-lauroyl-L-arginine
    • N-(1-OXODODECYL)ARGININE
    • STL524523
    • AKOS027439531
    • BP-13294
    • DB-298178
    • (S)-2-Dodecanamido-5-guanidinopentanoicacid
    • NS00031192
    • H60980
    • Q27263803
    • N~5~-(Diaminomethylidene)-N~2~-dodecanoyl-L-ornithine
    • 42492-22-8

  • Applications

    Lauroyl Arginine (CAS 42492-22-8) is used primarily as a mild surfactant and conditioning-type ingredient in cosmetics and personal care, including shampoos and cleansers, where it helps with foaming, cleansing performance and skin/hair feel. It can serve as an emulsifier and stabilizer in cosmetic formulations, improving compatibility of oils and polymers and enabling smoother dispersion of active ingredients. In household products, it functions as a gentle surfactant and wetting agent for surface cleaners and dishwashing liquids. In industrial manufacturing, it may be used as an intermediate or additive to improve emulsions, wetting, and dispersion in coatings, inks, and adhesives. It is sometimes considered as a specialty excipient or functional aid in pharmaceutical formulations, where it can act as a surfactant or processing aid. In polymer and plastics processing, it can help compatibilize blends and stabilize emulsions during formulation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.33
    methanol 16.45
    isopropanol 1.38
    water 1.47
    ethyl acetate 1.06
    n-propanol 2.42
    acetone 2.34
    n-butanol 1.52
    acetonitrile 0.68
    DMF 19.61
    toluene 0.82
    isobutanol 1.48
    1,4-dioxane 1.7
    methyl acetate 1.11
    THF 7.48
    2-butanone 2.08
    n-pentanol 2.29
    sec-butanol 1.32
    n-hexane 0.17
    ethylene glycol 3.66
    NMP 41.96
    cyclohexane 0.14
    DMSO 80.02
    n-butyl acetate 1.39
    n-octanol 0.75
    chloroform 3.4
    n-propyl acetate 1.74
    acetic acid 22.06
    dichloromethane 3.29
    cyclohexanone 8.28
    propylene glycol 6.22
    isopropyl acetate 1.18
    DMAc 43.75
    2-ethoxyethanol 11.23
    isopentanol 1.52
    n-heptane 0.09
    ethyl formate 2.7
    1,2-dichloroethane 2.31
    n-hexanol 1.35
    2-methoxyethanol 15.16
    isobutyl acetate 1.25
    tetrachloromethane 1.0
    n-pentyl acetate 1.58
    transcutol 20.91
    n-heptanol 1.37
    ethylbenzene 0.77
    MIBK 1.57
    2-propoxyethanol 7.56
    tert-butanol 1.64
    MTBE 0.6
    2-butoxyethanol 6.89
    propionic acid 5.75
    o-xylene 1.02
    formic acid 33.6
    diethyl ether 0.35
    m-xylene 0.77
    p-xylene 1.24
    chlorobenzene 1.09
    dimethyl carbonate 1.87
    n-octane 0.07
    formamide 28.52
    cyclopentanone 11.62
    2-pentanone 1.58
    anisole 1.34
    cyclopentyl methyl ether 2.38
    gamma-butyrolactone 13.24
    1-methoxy-2-propanol 8.6
    pyridine 3.7
    3-pentanone 1.49
    furfural 18.1
    n-dodecane 0.04
    diethylene glycol 9.91
    diisopropyl ether 0.24
    tert-amyl alcohol 2.0
    acetylacetone 4.41
    n-hexadecane 0.05
    acetophenone 3.83
    methyl propionate 1.67
    isopentyl acetate 1.75
    trichloroethylene 5.81
    n-nonanol 0.86
    cyclohexanol 2.35
    benzyl alcohol 3.91
    2-ethylhexanol 0.84
    isooctanol 1.11
    dipropyl ether 0.64
    1,2-dichlorobenzene 1.59
    ethyl lactate 3.68
    propylene carbonate 7.63
    n-methylformamide 10.37
    2-pentanol 0.69
    n-pentane 0.08
    1-propoxy-2-propanol 4.5
    1-methoxy-2-propyl acetate 3.58
    2-(2-methoxypropoxy) propanol 7.09
    mesitylene 0.54
    ε-caprolactone 8.71
    p-cymene 0.57
    epichlorohydrin 8.37
    1,1,1-trichloroethane 1.76
    2-aminoethanol 7.83
    morpholine-4-carbaldehyde 23.33
    sulfolane 46.6
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 2.59
    n-hexyl acetate 1.61
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 8.74
    sec-butyl acetate 1.21
    tert-butyl acetate 1.77
    decalin 0.15
    glycerin 15.64
    diglyme 14.71
    acrylic acid 8.04
    isopropyl myristate 0.6
    n-butyric acid 6.41
    acetyl acetate 1.77
    di(2-ethylhexyl) phthalate 2.13
    ethyl propionate 1.42
    nitromethane 13.06
    1,2-diethoxyethane 1.88
    benzonitrile 2.16
    trioctyl phosphate 1.35
    1-bromopropane 0.72
    gamma-valerolactone 25.51
    n-decanol 0.6
    triethyl phosphate 1.99
    4-methyl-2-pentanol 0.71
    propionitrile 0.71
    vinylene carbonate 6.83
    1,1,2-trichlorotrifluoroethane 26.48
    DMS 2.34
    cumene 0.77
    2-octanol 0.67
    2-hexanone 2.21
    octyl acetate 0.92
    limonene 0.57
    1,2-dimethoxyethane 8.56
    ethyl orthosilicate 1.92
    tributyl phosphate 1.71
    diacetone alcohol 6.0
    N,N-dimethylaniline 2.1
    acrylonitrile 1.53
    aniline 2.31
    1,3-propanediol 7.94
    bromobenzene 0.96
    dibromomethane 1.88
    1,1,2,2-tetrachloroethane 6.29
    2-methyl-cyclohexyl acetate 2.45
    tetrabutyl urea 2.73
    diisobutyl methanol 0.51
    2-phenylethanol 2.62
    styrene 0.77
    dioctyl adipate 1.62
    dimethyl sulfate 8.15
    ethyl butyrate 1.42
    methyl lactate 5.91
    butyl lactate 4.6
    diethyl carbonate 1.17
    propanediol butyl ether 7.84
    triethyl orthoformate 1.86
    p-tert-butyltoluene 0.54
    methyl 4-tert-butylbenzoate 5.36
    morpholine 3.83
    tert-butylamine 0.6
    n-dodecanol 0.42
    dimethoxymethane 4.92
    ethylene carbonate 4.82
    cyrene 13.93
    2-ethoxyethyl acetate 2.88
    2-ethylhexyl acetate 1.31
    1,2,4-trichlorobenzene 2.37
    4-methylpyridine 3.06
    dibutyl ether 0.52
    2,6-dimethyl-4-heptanol 0.51
    DEF 4.25
    dimethyl isosorbide 12.74
    tetrachloroethylene 5.31
    eugenol 6.41
    triacetin 4.37
    span 80 5.49
    1,4-butanediol 4.9
    1,1-dichloroethane 1.22
    2-methyl-1-pentanol 2.27
    methyl formate 6.73
    2-methyl-1-butanol 1.56
    n-decane 0.08
    butyronitrile 0.83
    3,7-dimethyl-1-octanol 0.75
    1-chlorooctane 0.31
    1-chlorotetradecane 0.13
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.13
    cyclooctane 0.08
    cyclopentanol 3.71
    tetrahydropyran 1.31
    tert-amyl methyl ether 0.79
    2,5,8-trioxanonane 10.89
    1-hexene 0.52
    2-isopropoxyethanol 5.9
    2,2,2-trifluoroethanol 11.12
    methyl butyrate 2.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction