Launobine

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  • Identifiers

    CAS number
    20497-21-6

    Molecular formula
    C18H17NO4

    SMILES
    COC1=C(C2=C(C[C@H]3C4=C2C5=C(C=C4CCN3)OCO5)C=C1)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 40.63%
    Phenolic 34.33%
    Spicy 32.24%
    Vanilla 30.28%
    Animal 26.04%
    Sweet 25.23%
    Smoky 23.78%
    Powdery 22.35%
    Burnt 20.23%
    Balsamic 20.17%

     

    Flavor
    Bitter 96.05%
    Bland 20.24%
    Sweet-like 19.37%
    Cedarleaf 18.89%
    Very strong 17.84%
    Indole 17.84%
    Cereal 17.83%
    Parsley 17.65%
    Alkaline 17.57%
    Lovage 16.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.77 (neutral)

    Molecular weight
    311.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    708°C

    Flash point

    • 236.46 ˚C est.

  • Synonyms

    • Launobine
    • 20497-21-6
    • (+)-Launobine
    • (12S)-17-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol
    • (+)-Launobine;
    • (S)-11-methoxy-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinolin-12-ol
    • CHEMBL516862
    • orb1696600
    • SCHEMBL28948970
    • DTXSID10942669
    • CHEBI:174971
    • AKOS040752437
    • H50835
    • AM-721/20651040
    • 11-Methoxy-6,7,7a,8-tetrahydro-2H,5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol
    • (7aS)-11-Methoxy-6,7,7a,8-tetrahydro-2H,5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol
    • 17-Methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol
    • 20497-21-6

  • Applications

    Launobine (CAS 20497-21-6) is typically evaluated for use as a fragrance component or odorant in perfumery and cosmetic formulations, where it can contribute a distinctive note and act as a fragrance ingredient; it may also function as a solvent or processing aid in coatings, inks, and household cleaners, supporting resin solubility and formulation uniformity. In polymer and plastics formulations, it may serve as a plasticizer or processing additive to influence processing characteristics. It is sometimes used as an intermediate in chemical synthesis for specialty formulations. Additionally, it may appear in cosmetics and personal care products as a fragrance modifier and in household cleaning products for scent and solvent roles; its use is subject to regulatory constraints and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.12
    methanol 3.26
    isopropanol 1.64
    water 0.09
    ethyl acetate 7.24
    n-propanol 1.8
    acetone 7.49
    n-butanol 2.27
    acetonitrile 3.31
    DMF 29.74
    toluene 1.56
    isobutanol 1.61
    1,4-dioxane 10.09
    methyl acetate 6.05
    THF 16.17
    2-butanone 5.98
    n-pentanol 2.01
    sec-butanol 0.92
    n-hexane 0.03
    ethylene glycol 5.59
    NMP 30.58
    cyclohexane 0.15
    DMSO 32.23
    n-butyl acetate 8.71
    n-octanol 2.85
    chloroform 11.88
    n-propyl acetate 7.57
    acetic acid 23.2
    dichloromethane 12.97
    cyclohexanone 19.58
    propylene glycol 1.81
    isopropyl acetate 7.25
    DMAc 37.06
    2-ethoxyethanol 12.3
    isopentanol 3.39
    n-heptane 0.15
    ethyl formate 9.0
    1,2-dichloroethane 9.17
    n-hexanol 3.54
    2-methoxyethanol 22.81
    isobutyl acetate 6.55
    tetrachloromethane 2.13
    n-pentyl acetate 9.8
    transcutol 35.25
    n-heptanol 4.66
    ethylbenzene 1.11
    MIBK 6.4
    2-propoxyethanol 22.5
    tert-butanol 2.6
    MTBE 1.1
    2-butoxyethanol 17.96
    propionic acid 6.16
    o-xylene 1.64
    formic acid 21.59
    diethyl ether 1.66
    m-xylene 1.74
    p-xylene 1.68
    chlorobenzene 4.29
    dimethyl carbonate 14.11
    n-octane 0.12
    formamide 28.81
    cyclopentanone 21.62
    2-pentanone 6.54
    anisole 3.83
    cyclopentyl methyl ether 5.18
    gamma-butyrolactone 28.9
    1-methoxy-2-propanol 14.19
    pyridine 11.99
    3-pentanone 4.61
    furfural 40.19
    n-dodecane 0.18
    diethylene glycol 32.03
    diisopropyl ether 0.95
    tert-amyl alcohol 1.43
    acetylacetone 16.43
    n-hexadecane 0.22
    acetophenone 9.58
    methyl propionate 7.57
    isopentyl acetate 9.96
    trichloroethylene 23.83
    n-nonanol 3.6
    cyclohexanol 3.29
    benzyl alcohol 7.35
    2-ethylhexanol 3.32
    isooctanol 4.51
    dipropyl ether 2.72
    1,2-dichlorobenzene 6.23
    ethyl lactate 9.09
    propylene carbonate 18.91
    n-methylformamide 14.59
    2-pentanol 1.24
    n-pentane 0.05
    1-propoxy-2-propanol 12.22
    1-methoxy-2-propyl acetate 17.26
    2-(2-methoxypropoxy) propanol 15.73
    mesitylene 1.36
    ε-caprolactone 18.74
    p-cymene 2.5
    epichlorohydrin 25.48
    1,1,1-trichloroethane 5.25
    2-aminoethanol 4.45
    morpholine-4-carbaldehyde 41.43
    sulfolane 41.4
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 4.96
    n-hexyl acetate 8.69
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 19.47
    sec-butyl acetate 5.29
    tert-butyl acetate 7.71
    decalin 0.18
    glycerin 14.64
    diglyme 36.87
    acrylic acid 11.69
    isopropyl myristate 4.67
    n-butyric acid 11.4
    acetyl acetate 11.68
    di(2-ethylhexyl) phthalate 7.84
    ethyl propionate 6.28
    nitromethane 35.99
    1,2-diethoxyethane 8.79
    benzonitrile 9.63
    trioctyl phosphate 6.07
    1-bromopropane 1.77
    gamma-valerolactone 46.26
    n-decanol 2.76
    triethyl phosphate 7.76
    4-methyl-2-pentanol 1.86
    propionitrile 3.64
    vinylene carbonate 24.03
    1,1,2-trichlorotrifluoroethane 46.9
    DMS 12.76
    cumene 1.2
    2-octanol 2.34
    2-hexanone 5.53
    octyl acetate 5.89
    limonene 2.68
    1,2-dimethoxyethane 18.19
    ethyl orthosilicate 6.79
    tributyl phosphate 6.36
    diacetone alcohol 12.81
    N,N-dimethylaniline 3.97
    acrylonitrile 8.48
    aniline 5.09
    1,3-propanediol 9.77
    bromobenzene 3.71
    dibromomethane 5.23
    1,1,2,2-tetrachloroethane 16.16
    2-methyl-cyclohexyl acetate 9.61
    tetrabutyl urea 9.14
    diisobutyl methanol 2.47
    2-phenylethanol 10.49
    styrene 1.32
    dioctyl adipate 8.36
    dimethyl sulfate 25.91
    ethyl butyrate 7.81
    methyl lactate 14.52
    butyl lactate 10.97
    diethyl carbonate 7.83
    propanediol butyl ether 10.6
    triethyl orthoformate 7.83
    p-tert-butyltoluene 2.19
    methyl 4-tert-butylbenzoate 15.04
    morpholine 11.24
    tert-butylamine 0.97
    n-dodecanol 2.13
    dimethoxymethane 21.05
    ethylene carbonate 19.56
    cyrene 22.25
    2-ethoxyethyl acetate 17.81
    2-ethylhexyl acetate 7.56
    1,2,4-trichlorobenzene 8.94
    4-methylpyridine 9.16
    dibutyl ether 2.71
    2,6-dimethyl-4-heptanol 2.47
    DEF 12.48
    dimethyl isosorbide 27.64
    tetrachloroethylene 14.36
    eugenol 16.44
    triacetin 14.82
    span 80 11.42
    1,4-butanediol 3.83
    1,1-dichloroethane 3.79
    2-methyl-1-pentanol 2.58
    methyl formate 15.17
    2-methyl-1-butanol 2.0
    n-decane 0.26
    butyronitrile 3.65
    3,7-dimethyl-1-octanol 3.43
    1-chlorooctane 1.44
    1-chlorotetradecane 0.8
    n-nonane 0.17
    undecane 0.22
    tert-butylcyclohexane 0.13
    cyclooctane 0.09
    cyclopentanol 3.29
    tetrahydropyran 4.29
    tert-amyl methyl ether 1.23
    2,5,8-trioxanonane 28.84
    1-hexene 0.21
    2-isopropoxyethanol 9.01
    2,2,2-trifluoroethanol 16.86
    methyl butyrate 8.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction