Lansoprazole

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  • Identifiers

    CAS number
    103577-45-3

    Molecular formula
    C16H14F3N3O2S

    SMILES
    CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 49.67%
    Meaty 31.88%
    Savory 30.88%
    Roasted 29.73%
    Cooked 28.64%
    Fatty 24.38%
    Fruity 23.55%
    Grape 21.84%
    Milky 21.51%
    Burnt 19.69%

     

    Flavor
    Bitter 78.28%
    Odorless 38.35%
    Bland 27.37%
    Roasted 23.22%
    Sweet-like 20.04%
    Bread crust 19.22%
    Scallion 19.14%
    Nitrile 18.83%
    Roasted peanuts 18.73%
    Taco 18.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    4.09 (weak acid)

    Molecular weight
    369.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    583°C

    Melting point expt.

    • 178-182 °C
    • 178 to 182 °C (decomposes)
    • MP: approx 166 °C with decomposition. Stable when exposed to light for up to two months. The compound degrades in aqueous solution, the rate of degradation increasing with decreasing pH. At 25 °C the half-lives are approx 0.5 and 18 hrs at pH 5.0 and pH 7.0, respectively.
    • 178 - 182 °C

    Flash point

    • 246.54 ˚C est.

    Solubility expt.

    • >55.4 [ug/mL] (The mean of the results at pH 7.4)
    • 0.97 mg/L
    • Freely soluble in dimethylformamide; soluble in ethyl acetate, dichloromethane and acetonitrile; very slightly soluble in ether, and practically insoluble in hexane and water.

  • Synonyms

    • lansoprazole
    • 103577-45-3
    • Prevacid
    • Limpidex
    • Agopton
    • Lanzor
    • Bamalite
    • Lansoprazol
    • Monolitum
    • Takepron
    • Ogastro
    • Prevacid SoluTab
    • Lanzopral
    • Opiren
    • Zoton
    • Lanproton
    • Lansopep
    • Lasoprol
    • Mesactol
    • Aprazol
    • Blason
    • Ketian
    • Lancid
    • Lanston
    • Lanz
    • lanzoprazole
    • Lansoprazolum
    • Prosogan
    • Suprecid
    • Compraz
    • Ilsatec
    • Lansox
    • Zoprol
    • Dakar
    • Ogast
    • Promp
    • AG-1749
    • Prevacid Iv
    • PrevOnco
    • Lanzol-30
    • AG 1749
    • Prevacid 24HR
    • Prevacid I.V.
    • Ogastoro
    • A-65006
    • Lansoprazol [INN-Spanish]
    • Lansoprazolum [INN-Latin]
    • Lanzol
    • Lanzul
    • Lanzo
    • CHEBI:6375
    • HSDB 7204
    • UNII-0K5C5T2QPG
    • 0K5C5T2QPG
    • MFCD00866873
    • NSC-758638
    • 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
    • BRN 4333393
    • Prezal
    • A 65006
    • 1261394-42-6
    • DTXSID4023200
    • Pro Ulco
    • 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
    • R-(+)-LANSOPRAZOLE
    • TAK-390MR
    • (+/-)-LANSOPRAZOLE
    • 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
    • 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
    • MLS000069705
    • DTXCID703200
    • Lansoprazole [USAN:USP:INN:BAN]
    • PREVPAC COMPONENT LANSOPRAZOLE
    • 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-
    • 1H-Benzimidazole, 2-[(S)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-
    • NSC 758638
    • NCGC00015615-02
    • SMR000058469
    • CAS-103577-45-3
    • Lansoprazol (INN-Spanish)
    • Lansoprazolum (INN-Latin)
    • MLS-0003247.0001
    • Prevacid NapraPAC
    • 1H-Benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-
    • 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
    • 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
    • 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
    • 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole
    • LANSOPRAZOLE (MART.)
    • LANSOPRAZOLE [MART.]
    • LANSOPRAZOLE (USP-RS)
    • LANSOPRAZOLE [USP-RS]
    • TAK 390MR
    • Lansoprazoles
    • Lansophed
    • LANSOPRAZOLE (EP MONOGRAPH)
    • LANSOPRAZOLE [EP MONOGRAPH]
    • Lansoprazole (USAN:USP:INN:BAN)
    • LANSOPRAZOLE (USP MONOGRAPH)
    • LANSOPRAZOLE [USP MONOGRAPH]
    • Prevacid (TN)
    • 2-(((3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-2-YL)METHYL)SULFINYL)-1H-BENZIMIDAZOLE
    • 2-({3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl} sulphinylbenzimidazole;2-({3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl} sulphinylbenzimidazole
    • SR-01000000169
    • Lanfast
    • Lapraz
    • LansoprazoleDR
    • Lansoprazole DR
    • 2-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl}-1H-benzimidazole
    • ABT-006
    • equate lansoprazole
    • Lansoprazole24 HR
    • Prevacid 24 Hr
    • safeway acid reducer
    • Sunmark Lansoprazole
    • Topcare Lansoprazole
    • Equaline Lansoprazole
    • CG-4801
    • Dg Health Lansoprazole
    • Basic Care Lansoprazole
    • Good Sense Lansoprazole
    • Spectrum_001580
    • Up and Up Lansoprazole
    • caring mill lansoprazole
    • CPD000058469
    • Lansoprazole (Standard)
    • Health Mart Lansoprazole
    • Prevacid Delayed Release

  • Applications

    In the pharmaceutical industry, Lansoprazole is used as an active pharmaceutical ingredient (API) in proton pump inhibitor formulations. In research and development, it serves as a lead compound and reference for structure-activity relationship (SAR) studies of acid-suppressing agents. In formulation development, it is used to design dosage forms with delayed-release profiles, such as enteric-coated capsules, to protect the drug from gastric acid and support stability studies. In analytical laboratories, Lansoprazole may be used as a reference standard or analytical target in assay methods and quality-control testing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 114.68
    methanol 430.64
    isopropanol 19.17
    water 0.26
    ethyl acetate 19.69
    n-propanol 36.83
    acetone 61.65
    n-butanol 24.89
    acetonitrile 52.48
    DMF 153.14
    toluene 1.49
    isobutanol 31.23
    1,4-dioxane 42.23
    methyl acetate 58.25
    THF 114.72
    2-butanone 23.62
    n-pentanol 11.15
    sec-butanol 20.6
    n-hexane 0.22
    ethylene glycol 36.88
    NMP 90.59
    cyclohexane 0.34
    DMSO 189.67
    n-butyl acetate 10.63
    n-octanol 4.48
    chloroform 20.13
    n-propyl acetate 17.64
    acetic acid 84.52
    dichloromethane 39.81
    cyclohexanone 26.2
    propylene glycol 20.96
    isopropyl acetate 8.85
    DMAc 137.97
    2-ethoxyethanol 76.01
    isopentanol 18.2
    n-heptane 0.41
    ethyl formate 32.12
    1,2-dichloroethane 21.87
    n-hexanol 9.06
    2-methoxyethanol 215.35
    isobutyl acetate 4.32
    tetrachloromethane 1.35
    n-pentyl acetate 9.89
    transcutol 99.06
    n-heptanol 6.33
    ethylbenzene 1.35
    MIBK 6.91
    2-propoxyethanol 47.98
    tert-butanol 13.03
    MTBE 7.14
    2-butoxyethanol 27.88
    propionic acid 30.41
    o-xylene 1.38
    formic acid 132.69
    diethyl ether 14.04
    m-xylene 0.92
    p-xylene 1.63
    chlorobenzene 2.49
    dimethyl carbonate 29.0
    n-octane 0.23
    formamide 237.34
    cyclopentanone 48.4
    2-pentanone 16.32
    anisole 9.66
    cyclopentyl methyl ether 12.96
    gamma-butyrolactone 73.12
    1-methoxy-2-propanol 65.87
    pyridine 29.26
    3-pentanone 12.91
    furfural 64.65
    n-dodecane 0.21
    diethylene glycol 66.81
    diisopropyl ether 1.85
    tert-amyl alcohol 15.21
    acetylacetone 26.04
    n-hexadecane 0.23
    acetophenone 13.22
    methyl propionate 28.83
    isopentyl acetate 7.62
    trichloroethylene 31.84
    n-nonanol 4.71
    cyclohexanol 10.62
    benzyl alcohol 13.1
    2-ethylhexanol 4.75
    isooctanol 4.83
    dipropyl ether 6.99
    1,2-dichlorobenzene 3.08
    ethyl lactate 17.49
    propylene carbonate 26.75
    n-methylformamide 130.62
    2-pentanol 9.07
    n-pentane 0.36
    1-propoxy-2-propanol 23.38
    1-methoxy-2-propyl acetate 17.26
    2-(2-methoxypropoxy) propanol 30.59
    mesitylene 0.54
    ε-caprolactone 30.66
    p-cymene 1.47
    epichlorohydrin 96.66
    1,1,1-trichloroethane 5.89
    2-aminoethanol 55.46
    morpholine-4-carbaldehyde 108.16
    sulfolane 74.96
    2,2,4-trimethylpentane 0.21
    2-methyltetrahydrofuran 32.37
    n-hexyl acetate 10.34
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 39.56
    sec-butyl acetate 6.81
    tert-butyl acetate 6.71
    decalin 0.18
    glycerin 43.14
    diglyme 77.51
    acrylic acid 36.58
    isopropyl myristate 3.95
    n-butyric acid 24.5
    acetyl acetate 13.79
    di(2-ethylhexyl) phthalate 8.59
    ethyl propionate 15.55
    nitromethane 179.84
    1,2-diethoxyethane 20.25
    benzonitrile 10.51
    trioctyl phosphate 5.06
    1-bromopropane 7.37
    gamma-valerolactone 86.97
    n-decanol 3.7
    triethyl phosphate 7.05
    4-methyl-2-pentanol 4.21
    propionitrile 25.94
    vinylene carbonate 27.54
    1,1,2-trichlorotrifluoroethane 62.65
    DMS 18.29
    cumene 0.95
    2-octanol 3.49
    2-hexanone 12.41
    octyl acetate 6.8
    limonene 1.95
    1,2-dimethoxyethane 100.82
    ethyl orthosilicate 6.21
    tributyl phosphate 5.99
    diacetone alcohol 15.34
    N,N-dimethylaniline 6.09
    acrylonitrile 42.04
    aniline 7.18
    1,3-propanediol 62.09
    bromobenzene 1.76
    dibromomethane 15.29
    1,1,2,2-tetrachloroethane 22.46
    2-methyl-cyclohexyl acetate 7.92
    tetrabutyl urea 10.95
    diisobutyl methanol 2.28
    2-phenylethanol 11.82
    styrene 1.6
    dioctyl adipate 9.96
    dimethyl sulfate 39.66
    ethyl butyrate 10.65
    methyl lactate 32.26
    butyl lactate 14.27
    diethyl carbonate 9.75
    propanediol butyl ether 22.31
    triethyl orthoformate 9.05
    p-tert-butyltoluene 1.12
    methyl 4-tert-butylbenzoate 14.05
    morpholine 63.1
    tert-butylamine 4.99
    n-dodecanol 2.8
    dimethoxymethane 112.42
    ethylene carbonate 22.98
    cyrene 32.85
    2-ethoxyethyl acetate 22.59
    2-ethylhexyl acetate 5.97
    1,2,4-trichlorobenzene 4.92
    4-methylpyridine 16.3
    dibutyl ether 4.71
    2,6-dimethyl-4-heptanol 2.28
    DEF 31.39
    dimethyl isosorbide 41.88
    tetrachloroethylene 13.29
    eugenol 21.75
    triacetin 20.07
    span 80 18.07
    1,4-butanediol 19.49
    1,1-dichloroethane 10.39
    2-methyl-1-pentanol 10.57
    methyl formate 103.87
    2-methyl-1-butanol 23.35
    n-decane 0.33
    butyronitrile 18.28
    3,7-dimethyl-1-octanol 3.84
    1-chlorooctane 1.52
    1-chlorotetradecane 0.73
    n-nonane 0.28
    undecane 0.26
    tert-butylcyclohexane 0.13
    cyclooctane 0.11
    cyclopentanol 19.69
    tetrahydropyran 18.57
    tert-amyl methyl ether 7.48
    2,5,8-trioxanonane 57.97
    1-hexene 1.41
    2-isopropoxyethanol 29.45
    2,2,2-trifluoroethanol 32.26
    methyl butyrate 22.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction