Lactobionic Acid

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  • Identifiers

    CAS number
    96-82-2

    Molecular formula
    C12H22O12

    SMILES
    C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](C(=O)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 75.3%
    Sweet 45.51%
    Caramellic 22.65%
    Alcoholic 19.57%
    Savory 18.42%
    Milky 17.66%
    Buttery 17.43%
    Clean 17.09%
    Bitter 16.28%
    Cooling 16.18%

     

    Flavor
    Odorless 67.32%
    Sweet 51.91%
    Sweet-like 33.98%
    Bitter 32.02%
    Very mild 28.3%
    Bland 25.98%
    Very slight 21.51%
    Cauliflower 20.08%
    Yeast 19.68%
    Mild 19.67%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.0

    pKa est.
    2.23 (strong acid)

    Molecular weight
    358.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3101°C

    Flash point

    • 311.83 ˚C est.

  • Synonyms

    • LACTOBIONIC ACID
    • 96-82-2
    • 4-O-beta-D-Galactopyranosyl-D-gluconic acid
    • 4-(beta-D-Galactosido)-D-gluconic acid
    • DTXSID3048861
    • 65R938S4DV
    • DTXCID6028787
    • CHEBI:55481
    • RefChem:798371
    • GlyTouCan:G18874TB
    • G18874TB
    • D-GLUCONIC ACID, 4-O-BETA-D-GALACTOPYRANOSYL-
    • 202-538-3
    • MFCD00078147
    • D-Gluconic acid, 4-O-b-D-galactopyranosyl-
    • (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoic acid
    • (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-hexanoic acid
    • C12H22O12
    • D-Gluconic acid, 4-O-.beta.-D-galactopyranosyl-
    • (2R,3R,4R,5R)-2,3,5,6-Tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanoic acid
    • UNII-65R938S4DV
    • maltobionic-acid
    • CAS-96-82-2
    • NCGC00016356-01
    • Prestwick_560
    • EINECS 202-538-3
    • Lactobionic acid CRS
    • NSC15850
    • Lactobionic acid, purum
    • 4-O-B-D-galactopyranosyl-D-gluconic acid
    • Lactobionic acid, 97%
    • 110638-68-1
    • 4-O-|A-D-Galactopyranosyl-D-gluconic acid
    • Prestwick0_000452
    • Prestwick1_000452
    • Prestwick2_000452
    • Prestwick3_000452
    • SCHEMBL24870
    • BSPBio_000524
    • LACTOBIONIC ACID [II]
    • LACTOBIONIC ACID [MI]
    • SPBio_002463
    • BPBio1_000578
    • orb1299253
    • CHEMBL3039602
    • LACTOBIONIC ACID [MART.]
    • LACTOBIONIC ACID [USP-RS]
    • LACTOBIONIC ACID [WHO-DD]
    • HMS1569K06
    • HMS2096K06
    • HY-N7059
    • Methyl (R)-(-)-2-Chloromandelate
    • Tox21_113353
    • MSK160860
    • s4964
    • AKOS015896798
    • AKOS015924795
    • LACTOBIONIC ACID [EP IMPURITY]
    • Tox21_113353_1
    • CCG-214227
    • CS-W011829
    • EBC-616365
    • LACTOBIONIC ACID [EP MONOGRAPH]
    • Lactobionic acid, cell impermeant agent
    • OL03220
    • NCGC00179532-01
    • NCGC00179532-03
    • (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexanoic acid
    • 4-O-beta-galactopyranosyl-d-gluconic acid
    • AS-16070
    • DA-54763
    • SY035643
    • 4-O-ss-D-galactopyranosyl-D-gluconic acid
    • Lactobionic acid (*Calcium salt*) (VAN)
    • L0005
    • Lactobionic acid, (*Calcium salt (2:1)*)
    • NS00014344
    • C22921
    • D70310
    • 078L147
    • F493706
    • Q6138969
    • BRD-K01624185-001-05-7
    • D0229170-C0EC-40FC-A777-BF34018EED2A
    • Lactobionic acid, European Pharmacopoeia (EP) Reference Standard
    • 2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-hexanoic acid
    • 96-82-2

  • Applications

    Lactobionic Acid (CAS 96-82-2), a polyhydroxy acid derived from lactose, is commonly used in cosmetics as a mild exfoliant and humectant, providing gentle AHA-like exfoliation with moisturizing benefits; in pharmaceuticals it serves as an excipient and stabilizer in topical formulations; in cleaning and household products it acts as a chelating agent to sequester metal ions and improve formulation stability; in polymers and bio-based materials it is explored as a functional monomer or crosslinking component for hydrogels and sustainable polymers; in coatings and inks it can function as a processing aid and stabilizer, helping control pH and metal ion content during formulation; its actual use is formulation- and regulation-dependent and is often evaluated for these roles in relevant industries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.34
    methanol 2.24
    isopropanol 0.14
    water 421.56
    ethyl acetate 0.1
    n-propanol 0.22
    acetone 0.22
    n-butanol 0.14
    acetonitrile 0.11
    DMF 38.63
    toluene 0.11
    isobutanol 0.11
    1,4-dioxane 0.77
    methyl acetate 0.1
    THF 0.43
    2-butanone 0.13
    n-pentanol 0.08
    sec-butanol 0.15
    n-hexane 0.03
    ethylene glycol 31.54
    NMP 38.93
    cyclohexane 0.2
    DMSO 138.62
    n-butyl acetate 0.08
    n-octanol 0.18
    chloroform 0.02
    n-propyl acetate 0.05
    acetic acid 4.14
    dichloromethane 0.03
    cyclohexanone 0.51
    propylene glycol 8.71
    isopropyl acetate 0.07
    DMAc 19.96
    2-ethoxyethanol 2.38
    isopentanol 0.09
    n-heptane 0.15
    ethyl formate 0.13
    1,2-dichloroethane 0.07
    n-hexanol 0.21
    2-methoxyethanol 8.81
    isobutyl acetate 0.02
    tetrachloromethane 0.03
    n-pentyl acetate 0.09
    transcutol 4.08
    n-heptanol 0.28
    ethylbenzene 0.06
    MIBK 0.1
    2-propoxyethanol 2.23
    tert-butanol 0.23
    MTBE 0.06
    2-butoxyethanol 1.29
    propionic acid 0.78
    o-xylene 0.23
    formic acid 101.16
    diethyl ether 0.09
    m-xylene 0.13
    p-xylene 0.05
    chlorobenzene 0.02
    dimethyl carbonate 1.16
    n-octane 0.06
    formamide 58.71
    cyclopentanone 0.65
    2-pentanone 0.15
    anisole 0.1
    cyclopentyl methyl ether 0.48
    gamma-butyrolactone 1.11
    1-methoxy-2-propanol 4.61
    pyridine 0.4
    3-pentanone 0.22
    furfural 1.9
    n-dodecane 0.03
    diethylene glycol 11.6
    diisopropyl ether 0.05
    tert-amyl alcohol 0.24
    acetylacetone 0.51
    n-hexadecane 0.03
    acetophenone 0.22
    methyl propionate 0.4
    isopentyl acetate 0.06
    trichloroethylene 0.08
    n-nonanol 0.19
    cyclohexanol 0.55
    benzyl alcohol 0.27
    2-ethylhexanol 0.13
    isooctanol 0.15
    dipropyl ether 0.26
    1,2-dichlorobenzene 0.03
    ethyl lactate 0.61
    propylene carbonate 0.37
    n-methylformamide 8.06
    2-pentanol 0.13
    n-pentane 0.05
    1-propoxy-2-propanol 1.3
    1-methoxy-2-propyl acetate 0.56
    2-(2-methoxypropoxy) propanol 1.5
    mesitylene 0.12
    ε-caprolactone 0.55
    p-cymene 0.1
    epichlorohydrin 0.3
    1,1,1-trichloroethane 0.02
    2-aminoethanol 10.4
    morpholine-4-carbaldehyde 19.2
    sulfolane 14.09
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.19
    n-hexyl acetate 0.11
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.12
    sec-butyl acetate 0.03
    tert-butyl acetate 0.13
    decalin 0.04
    glycerin 71.26
    diglyme 3.28
    acrylic acid 2.6
    isopropyl myristate 0.06
    n-butyric acid 0.36
    acetyl acetate 0.13
    di(2-ethylhexyl) phthalate 0.12
    ethyl propionate 0.09
    nitromethane 3.27
    1,2-diethoxyethane 0.26
    benzonitrile 0.07
    trioctyl phosphate 0.13
    1-bromopropane 0.03
    gamma-valerolactone 2.93
    n-decanol 0.15
    triethyl phosphate 0.21
    4-methyl-2-pentanol 0.08
    propionitrile 0.07
    vinylene carbonate 0.39
    1,1,2-trichlorotrifluoroethane 5.03
    DMS 0.31
    cumene 0.05
    2-octanol 0.14
    2-hexanone 0.05
    octyl acetate 0.09
    limonene 0.17
    1,2-dimethoxyethane 1.12
    ethyl orthosilicate 0.18
    tributyl phosphate 0.09
    diacetone alcohol 1.05
    N,N-dimethylaniline 0.26
    acrylonitrile 0.21
    aniline 0.3
    1,3-propanediol 3.68
    bromobenzene 0.02
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.13
    2-methyl-cyclohexyl acetate 0.11
    tetrabutyl urea 0.33
    diisobutyl methanol 0.12
    2-phenylethanol 0.28
    styrene 0.04
    dioctyl adipate 0.12
    dimethyl sulfate 6.49
    ethyl butyrate 0.11
    methyl lactate 4.41
    butyl lactate 0.4
    diethyl carbonate 0.09
    propanediol butyl ether 2.1
    triethyl orthoformate 0.21
    p-tert-butyltoluene 0.12
    methyl 4-tert-butylbenzoate 0.67
    morpholine 1.39
    tert-butylamine 0.11
    n-dodecanol 0.12
    dimethoxymethane 3.6
    ethylene carbonate 0.26
    cyrene 4.2
    2-ethoxyethyl acetate 0.23
    2-ethylhexyl acetate 0.05
    1,2,4-trichlorobenzene 0.05
    4-methylpyridine 0.18
    dibutyl ether 0.08
    2,6-dimethyl-4-heptanol 0.12
    DEF 1.58
    dimethyl isosorbide 2.13
    tetrachloroethylene 0.17
    eugenol 0.77
    triacetin 0.4
    span 80 1.56
    1,4-butanediol 1.53
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.06
    methyl formate 3.0
    2-methyl-1-butanol 0.12
    n-decane 0.05
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.08
    1-chlorooctane 0.05
    1-chlorotetradecane 0.03
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.02
    cyclooctane 0.15
    cyclopentanol 0.52
    tetrahydropyran 0.22
    tert-amyl methyl ether 0.14
    2,5,8-trioxanonane 3.45
    1-hexene 0.03
    2-isopropoxyethanol 0.75
    2,2,2-trifluoroethanol 6.07
    methyl butyrate 0.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction