Lactide

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  • Identifiers

    CAS number
    95-96-5

    Molecular formula
    C6H8O4

    SMILES
    CC1C(=O)OC(C(=O)O1)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Caramellic 80.91%
    Sweet 65.64%
    Burnt 58.95%
    Buttery 50.81%
    Nutty 39.68%
    Roasted 37.45%
    Coffee 35.56%
    Creamy 32.7%
    Fruity 32.17%
    Coumarinic 29.24%

     

    Flavor
    Sweet 78.52%
    Caramel 66.41%
    Fruity 46.55%
    Tobacco 38.19%
    Sugar 37.25%
    Buttery 36.55%
    Maple 35.24%
    Bread 34.73%
    Creamy 34.53%
    Candy 32.5%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    5.5 (weak acid)

    Molecular weight
    144.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    242°C

    Flash point

    • 75.95 ˚C est.

  • Synonyms

    • 95-96-5
    • LACTIDE
    • Dilactide
    • p-Dioxane-2,5-dione, 3,6-dimethyl-
    • RefChem:57699
    • 202-468-3
    • 3,6-Dimethyl-1,4-dioxane-2,5-dione
    • DL-Lactide
    • DL-Dilactide
    • 33135-50-1
    • 1,4-Dioxane-2,5-dione, 3,6-dimethyl-
    • 3,6-Dimethyl-2,5-dioxo-1,4-dioxane
    • Lactic acid, bimol. cyclic ester
    • MFCD00011685
    • LACTIDE, DL-
    • Propanoic acid, 2-hydroxy-, bimol. cyclic ester
    • 7EH08MWO6M
    • DTXSID7041253
    • NSC-403080
    • Purasorb DL; dl-Dilactide; rac-Lactide
    • EINECS 202-468-3
    • UNII-7EH08MWO6M
    • NSC 403080
    • lactid
    • rac-lactide
    • AI3-05059
    • DIMETHYLGLYCOLIDE
    • D,L-LACTIDE
    • (3S,6S)-(-)-3,6-Dimethyl-1,4-dioxane-2,5-dione
    • EC 202-468-3
    • 3,5-dioxo-1,4-dioxane
    • SCHEMBL15034
    • 1,5-dione, 3,6-dimethyl-
    • p-Dioxane-2, 3,6-dimethyl-
    • CHEMBL3185272
    • DTXCID5021253
    • CHEBI:177651
    • IBA13550
    • Propanoic acid, bimol. cyclic ester
    • Tox21_302164
    • NSC403080
    • SBB007949
    • AKOS005206744
    • FL62737
    • CAS-95-96-5
    • NCGC00255679-01
    • AS-17933
    • SY062065
    • 3,6-DIMETHYL-P-DIOXANE-2,5-DIONE
    • DB-070627
    • DB-080384
    • Resomer(R) R 202 H, Poly(D,L-lactide)
    • L0091
    • NS00007003
    • ST50823895
    • 2,5-DIMETHYL-3,6-DIOXO-1,4-DIOXANE
    • D81885
    • EN300-1180042
    • F339951
    • Q421313
    • DL-Dilactide, 3,6-Dimethyl-1,4-dioxane-2,5-dione
    • 95-96-5

  • Applications

    Lactide (CAS 95-96-5) is the cyclic di-ester of lactic acid and is used as a monomer to produce polylactic acid (PLA) and copolymers; typical applications include PLA plastics for packaging and biodegradable films, PLA-based materials for 3D printing filaments, bio-based resins for coatings and adhesives, and PLA-derived materials for medical and pharmaceutical uses such as drug-delivery systems and implantable devices; it may be considered for biodegradable agricultural mulch films.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.47
    methanol 179.88
    isopropanol 47.08
    water 22.44
    ethyl acetate 414.92
    n-propanol 38.77
    acetone 936.3
    n-butanol 35.95
    acetonitrile 657.35
    DMF 1234.68
    toluene 66.54
    isobutanol 34.61
    1,4-dioxane 479.76
    methyl acetate 494.7
    THF 330.41
    2-butanone 383.59
    n-pentanol 44.82
    sec-butanol 48.24
    n-hexane 15.14
    ethylene glycol 62.44
    NMP 805.58
    cyclohexane 16.68
    DMSO 1630.12
    n-butyl acetate 162.36
    n-octanol 46.78
    chloroform 554.33
    n-propyl acetate 219.67
    acetic acid 323.68
    dichloromethane 852.66
    cyclohexanone 377.1
    propylene glycol 32.11
    isopropyl acetate 208.54
    DMAc 1014.78
    2-ethoxyethanol 227.88
    isopentanol 42.56
    n-heptane 10.8
    ethyl formate 361.19
    1,2-dichloroethane 594.88
    n-hexanol 37.37
    2-methoxyethanol 320.74
    isobutyl acetate 88.8
    tetrachloromethane 90.11
    n-pentyl acetate 111.98
    transcutol 318.86
    n-heptanol 29.51
    ethylbenzene 69.14
    MIBK 137.05
    2-propoxyethanol 144.36
    tert-butanol 106.87
    MTBE 163.94
    2-butoxyethanol 87.03
    propionic acid 176.25
    o-xylene 91.73
    formic acid 241.09
    diethyl ether 163.85
    m-xylene 63.46
    p-xylene 116.55
    chlorobenzene 195.77
    dimethyl carbonate 255.33
    n-octane 8.1
    formamide 512.21
    cyclopentanone 529.52
    2-pentanone 267.9
    anisole 207.5
    cyclopentyl methyl ether 145.17
    gamma-butyrolactone 787.34
    1-methoxy-2-propanol 185.83
    pyridine 318.95
    3-pentanone 282.92
    furfural 799.66
    n-dodecane 7.88
    diethylene glycol 174.88
    diisopropyl ether 60.8
    tert-amyl alcohol 98.24
    acetylacetone 592.67
    n-hexadecane 9.21
    acetophenone 271.31
    methyl propionate 349.63
    isopentyl acetate 122.09
    trichloroethylene 963.39
    n-nonanol 42.35
    cyclohexanol 56.6
    benzyl alcohol 131.45
    2-ethylhexanol 36.39
    isooctanol 27.71
    dipropyl ether 75.01
    1,2-dichlorobenzene 272.07
    ethyl lactate 121.35
    propylene carbonate 367.91
    n-methylformamide 588.18
    2-pentanol 36.84
    n-pentane 10.51
    1-propoxy-2-propanol 100.09
    1-methoxy-2-propyl acetate 181.29
    2-(2-methoxypropoxy) propanol 115.28
    mesitylene 57.12
    ε-caprolactone 340.8
    p-cymene 43.71
    epichlorohydrin 660.04
    1,1,1-trichloroethane 382.81
    2-aminoethanol 53.84
    morpholine-4-carbaldehyde 802.33
    sulfolane 1028.24
    2,2,4-trimethylpentane 12.13
    2-methyltetrahydrofuran 228.22
    n-hexyl acetate 140.97
    isooctane 6.9
    2-(2-butoxyethoxy)ethanol 130.68
    sec-butyl acetate 125.28
    tert-butyl acetate 196.91
    decalin 17.47
    glycerin 97.18
    diglyme 388.45
    acrylic acid 227.58
    isopropyl myristate 60.19
    n-butyric acid 166.73
    acetyl acetate 351.42
    di(2-ethylhexyl) phthalate 58.25
    ethyl propionate 220.46
    nitromethane 1506.37
    1,2-diethoxyethane 175.66
    benzonitrile 243.25
    trioctyl phosphate 44.72
    1-bromopropane 152.48
    gamma-valerolactone 723.06
    n-decanol 33.18
    triethyl phosphate 99.87
    4-methyl-2-pentanol 30.87
    propionitrile 232.42
    vinylene carbonate 418.05
    1,1,2-trichlorotrifluoroethane 447.41
    DMS 239.55
    cumene 54.14
    2-octanol 30.38
    2-hexanone 179.24
    octyl acetate 76.4
    limonene 55.54
    1,2-dimethoxyethane 566.69
    ethyl orthosilicate 80.15
    tributyl phosphate 65.17
    diacetone alcohol 179.62
    N,N-dimethylaniline 158.17
    acrylonitrile 430.96
    aniline 105.25
    1,3-propanediol 81.81
    bromobenzene 206.78
    dibromomethane 425.98
    1,1,2,2-tetrachloroethane 671.59
    2-methyl-cyclohexyl acetate 95.54
    tetrabutyl urea 93.38
    diisobutyl methanol 34.68
    2-phenylethanol 91.78
    styrene 89.18
    dioctyl adipate 95.45
    dimethyl sulfate 595.15
    ethyl butyrate 147.42
    methyl lactate 173.76
    butyl lactate 82.49
    diethyl carbonate 129.51
    propanediol butyl ether 82.86
    triethyl orthoformate 101.63
    p-tert-butyltoluene 43.19
    methyl 4-tert-butylbenzoate 160.14
    morpholine 309.98
    tert-butylamine 61.77
    n-dodecanol 26.83
    dimethoxymethane 516.39
    ethylene carbonate 330.0
    cyrene 150.08
    2-ethoxyethyl acetate 181.6
    2-ethylhexyl acetate 97.83
    1,2,4-trichlorobenzene 295.23
    4-methylpyridine 311.68
    dibutyl ether 71.35
    2,6-dimethyl-4-heptanol 34.68
    DEF 479.66
    dimethyl isosorbide 234.91
    tetrachloroethylene 478.42
    eugenol 140.54
    triacetin 212.21
    span 80 76.37
    1,4-butanediol 54.74
    1,1-dichloroethane 361.85
    2-methyl-1-pentanol 48.88
    methyl formate 660.14
    2-methyl-1-butanol 40.18
    n-decane 12.03
    butyronitrile 159.39
    3,7-dimethyl-1-octanol 47.88
    1-chlorooctane 44.32
    1-chlorotetradecane 21.36
    n-nonane 11.61
    undecane 9.45
    tert-butylcyclohexane 14.78
    cyclooctane 8.67
    cyclopentanol 72.66
    tetrahydropyran 156.66
    tert-amyl methyl ether 138.35
    2,5,8-trioxanonane 249.48
    1-hexene 39.59
    2-isopropoxyethanol 139.39
    2,2,2-trifluoroethanol 275.66
    methyl butyrate 289.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction