Lactamide

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  • Identifiers

    CAS number
    2043-43-8

    Molecular formula
    C3H7NO2

    SMILES
    CC(C(=O)N)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 49.19%
    Sweet 41.68%
    Buttery 32.85%
    Caramellic 27.36%
    Savory 24.82%
    Milky 22.16%
    Nutty 21.81%
    Creamy 21.17%
    Fishy 20.87%
    Burnt 18.27%

     

    Flavor
    Odorless 65.11%
    Sour 32.37%
    Acidic 29.18%
    Very mild 24.61%
    Milky 23.52%
    Buttery 23.35%
    Sweet-like 21.76%
    Caramellic 21.66%
    Acetoin 20.8%
    Soy 20.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    7.12 (neutral)

    Molecular weight
    89.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    279°C

    Flash point

    • 115.18 ˚C est.

  • Synonyms

    • Lactamide
    • 2-Hydroxypropanamide
    • 2043-43-8
    • Propanamide, 2-hydroxy-
    • 2-Hydroxypropionamide
    • DL-Lactamide
    • Lactic amide
    • Lactic acid amide
    • alpha-Hydroxypropionamide
    • 4JZP7XJN3O
    • NSC-9903
    • NSC-61454
    • CHEBI:75144
    • DTXSID90862816
    • RefChem:798348
    • DTXCID20811534
    • 218-049-3
    • 65144-02-7
    • .alpha.-Hydroxypropionamide
    • MFCD00008017
    • (+/-)-lactamide
    • 2-hydroxy-propionamide
    • Propanamide,2-hydroxy-
    • DL-Lactic acid amide
    • UNII-4JZP7XJN3O
    • (R)-(+)-2-Hydroxypropionamide
    • D,L-lactamide
    • 2-Hydroxypropionam
    • NSC 9903
    • EINECS 218-049-3
    • iminopropylene glycol
    • NSC 61454
    • 2-hydroxy-propanamide
    • alpha-hydroxypropanamide
    • 2-Hydroxypropanamide #
    • DL-Lactamide, 97%
    • MeCH(OH)CONH2
    • LACTAMIDE, DL-
    • CH3CH(OH)CONH2
    • SCHEMBL27579
    • SCHEMBL95564
    • SCHEMBL177670
    • SCHEMBL1259836
    • SCHEMBL27814777
    • SCHEMBL29360331
    • NSC9903
    • BB_SC-07034
    • NSC61454
    • BBL012097
    • STK045828
    • AKOS000491583
    • AKOS016352359
    • SB44655
    • SB44681
    • SB83792
    • AS-57860
    • SY051724
    • L0001
    • NS00014861
    • EN300-72519
    • D91225
    • F341750
    • Q6468911
    • Z57206008
    • 2043-43-8

  • Applications

    Lactamide (CAS 2043-43-8) is primarily used as an intermediate in organic synthesis and as a polar solvent or co-solvent in a range of industrial formulations, including coatings, inks, and cleaners. It can serve as a processing aid or plasticizer in polymers and plastics. In cosmetics and personal care, it may function as a humectant or conditioning agent. It also appears as an additive in household cleaning formulations to support formulation stability and moisture retention, and may be pursued as a precursor for more specialized amide derivatives in chemical manufacture.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.55
    methanol 11.78
    isopropanol 1.66
    water 725.28
    ethyl acetate 0.53
    n-propanol 2.31
    acetone 0.96
    n-butanol 2.4
    acetonitrile 1.37
    DMF 17.45
    toluene 0.21
    isobutanol 2.02
    1,4-dioxane 1.74
    methyl acetate 0.64
    THF 2.29
    2-butanone 0.92
    n-pentanol 1.2
    sec-butanol 2.09
    n-hexane 0.29
    ethylene glycol 23.01
    NMP 28.03
    cyclohexane 0.38
    DMSO 16.04
    n-butyl acetate 0.31
    n-octanol 0.68
    chloroform 0.43
    n-propyl acetate 0.29
    acetic acid 23.56
    dichloromethane 0.53
    cyclohexanone 2.13
    propylene glycol 13.63
    isopropyl acetate 0.4
    DMAc 16.32
    2-ethoxyethanol 4.73
    isopentanol 2.17
    n-heptane 0.31
    ethyl formate 2.37
    1,2-dichloroethane 0.39
    n-hexanol 0.96
    2-methoxyethanol 12.27
    isobutyl acetate 0.19
    tetrachloromethane 0.48
    n-pentyl acetate 0.55
    transcutol 6.99
    n-heptanol 1.17
    ethylbenzene 0.19
    MIBK 0.66
    2-propoxyethanol 3.09
    tert-butanol 2.57
    MTBE 0.75
    2-butoxyethanol 3.83
    propionic acid 5.07
    o-xylene 0.47
    formic acid 124.52
    diethyl ether 0.49
    m-xylene 0.29
    p-xylene 0.31
    chlorobenzene 0.19
    dimethyl carbonate 0.92
    n-octane 0.17
    formamide 57.27
    cyclopentanone 2.98
    2-pentanone 0.78
    anisole 0.39
    cyclopentyl methyl ether 1.17
    gamma-butyrolactone 4.22
    1-methoxy-2-propanol 5.43
    pyridine 1.07
    3-pentanone 0.73
    furfural 7.72
    n-dodecane 0.08
    diethylene glycol 9.5
    diisopropyl ether 0.26
    tert-amyl alcohol 3.29
    acetylacetone 1.09
    n-hexadecane 0.08
    acetophenone 0.69
    methyl propionate 0.8
    isopentyl acetate 0.38
    trichloroethylene 0.6
    n-nonanol 0.65
    cyclohexanol 2.29
    benzyl alcohol 1.03
    2-ethylhexanol 0.67
    isooctanol 0.98
    dipropyl ether 0.41
    1,2-dichlorobenzene 0.27
    ethyl lactate 1.1
    propylene carbonate 2.29
    n-methylformamide 11.58
    2-pentanol 1.22
    n-pentane 0.26
    1-propoxy-2-propanol 1.89
    1-methoxy-2-propyl acetate 0.72
    2-(2-methoxypropoxy) propanol 4.08
    mesitylene 0.3
    ε-caprolactone 2.41
    p-cymene 0.28
    epichlorohydrin 1.63
    1,1,1-trichloroethane 0.27
    2-aminoethanol 18.92
    morpholine-4-carbaldehyde 15.01
    sulfolane 13.02
    2,2,4-trimethylpentane 0.22
    2-methyltetrahydrofuran 1.59
    n-hexyl acetate 0.59
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 4.57
    sec-butyl acetate 0.23
    tert-butyl acetate 0.58
    decalin 0.16
    glycerin 42.28
    diglyme 6.3
    acrylic acid 8.13
    isopropyl myristate 0.27
    n-butyric acid 4.24
    acetyl acetate 0.63
    di(2-ethylhexyl) phthalate 0.99
    ethyl propionate 0.35
    nitromethane 10.67
    1,2-diethoxyethane 0.61
    benzonitrile 0.6
    trioctyl phosphate 0.64
    1-bromopropane 0.24
    gamma-valerolactone 7.06
    n-decanol 0.51
    triethyl phosphate 0.54
    4-methyl-2-pentanol 0.87
    propionitrile 0.76
    vinylene carbonate 2.07
    1,1,2-trichlorotrifluoroethane 6.88
    DMS 0.6
    cumene 0.24
    2-octanol 0.64
    2-hexanone 0.43
    octyl acetate 0.42
    limonene 0.42
    1,2-dimethoxyethane 3.25
    ethyl orthosilicate 0.56
    tributyl phosphate 0.62
    diacetone alcohol 2.56
    N,N-dimethylaniline 0.73
    acrylonitrile 1.25
    aniline 0.82
    1,3-propanediol 12.41
    bromobenzene 0.13
    dibromomethane 0.35
    1,1,2,2-tetrachloroethane 0.66
    2-methyl-cyclohexyl acetate 0.52
    tetrabutyl urea 1.13
    diisobutyl methanol 0.52
    2-phenylethanol 0.8
    styrene 0.17
    dioctyl adipate 0.56
    dimethyl sulfate 2.74
    ethyl butyrate 0.38
    methyl lactate 3.54
    butyl lactate 1.56
    diethyl carbonate 0.28
    propanediol butyl ether 5.08
    triethyl orthoformate 0.51
    p-tert-butyltoluene 0.29
    methyl 4-tert-butylbenzoate 1.89
    morpholine 2.81
    tert-butylamine 1.23
    n-dodecanol 0.39
    dimethoxymethane 2.54
    ethylene carbonate 1.46
    cyrene 6.03
    2-ethoxyethyl acetate 0.82
    2-ethylhexyl acetate 0.3
    1,2,4-trichlorobenzene 0.34
    4-methylpyridine 1.0
    dibutyl ether 0.32
    2,6-dimethyl-4-heptanol 0.52
    DEF 3.06
    dimethyl isosorbide 4.22
    tetrachloroethylene 0.98
    eugenol 2.66
    triacetin 1.15
    span 80 3.52
    1,4-butanediol 5.22
    1,1-dichloroethane 0.21
    2-methyl-1-pentanol 1.39
    methyl formate 7.05
    2-methyl-1-butanol 2.62
    n-decane 0.12
    butyronitrile 0.97
    3,7-dimethyl-1-octanol 0.62
    1-chlorooctane 0.18
    1-chlorotetradecane 0.1
    n-nonane 0.13
    undecane 0.09
    tert-butylcyclohexane 0.13
    cyclooctane 0.23
    cyclopentanol 3.12
    tetrahydropyran 0.9
    tert-amyl methyl ether 0.99
    2,5,8-trioxanonane 6.29
    1-hexene 0.32
    2-isopropoxyethanol 2.19
    2,2,2-trifluoroethanol 15.29
    methyl butyrate 0.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction