L-Proline, 5-hydroxy-, dihydroxymethylsilyl ester

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  • Identifiers

    CAS number
    105883-44-1

    Molecular formula
    C6H11NO5Si

    SMILES
    C1CC(N[C@@H]1C(=O)[O+]=[Si-]C(O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 62.73%
    Sweet 34.18%
    Savory 21.38%
    Nutty 20.75%
    Meaty 16.85%
    Bitter 16.06%
    Roasted 15.83%
    Buttery 15.78%
    Milky 15.62%
    Cooling 15.34%

     

    Flavor
    Bitter 59.16%
    Odorless 55.38%
    Very mild 29.61%
    Bland 28.23%
    Sweet-like 25.09%
    Yeast 20.58%
    Mild 19.8%
    Nitrile 19.3%
    Formyl 18.95%
    Rotten 18.69%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.52 (neutral)

    Molecular weight
    205.24 g/mol

    Flash point

    • 183.31 ˚C est.

  • Synonyms

    • JVLZSXQOFXSRCV-WUCPZUCCSA-N
    • DTXSID801021825
    • L-Proline, 5-hydroxy-, dihydroxymethylsilyl ester
    • 105883-44-1
    • 105883-44-1

  • Applications

    L-Proline, 5-hydroxy-, dihydroxymethylsilyl ester (CAS 105883-44-1) is a protected amino acid derivative based on L-proline with a dihydroxymethylsilyl group that enables silane coupling and integration into polymeric materials. Real-world applications include: (1) serving as a chiral building block and precursor for pharmaceutical and agrochemical synthesis; (2) a protected amino acid derivative used in solid-phase or solution-phase peptide synthesis; (3) a precursor for silicon-containing polymers and silane-modified coatings, paints, and adhesives to improve surface adhesion and crosslinking; (4) used in research as a scaffold for proline-based organocatalysis to develop enantioselective transformations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.42
    methanol 24.72
    isopropanol 3.46
    water 200.97
    ethyl acetate 0.87
    n-propanol 2.73
    acetone 3.04
    n-butanol 2.42
    acetonitrile 1.27
    DMF 125.63
    toluene 0.63
    isobutanol 1.5
    1,4-dioxane 4.42
    methyl acetate 0.83
    THF 6.25
    2-butanone 0.87
    n-pentanol 2.15
    sec-butanol 2.06
    n-hexane 0.19
    ethylene glycol 75.65
    NMP 95.16
    cyclohexane 1.03
    DMSO 194.33
    n-butyl acetate 1.69
    n-octanol 2.52
    chloroform 0.37
    n-propyl acetate 1.17
    acetic acid 28.06
    dichloromethane 0.66
    cyclohexanone 5.04
    propylene glycol 31.14
    isopropyl acetate 1.12
    DMAc 71.46
    2-ethoxyethanol 30.15
    isopentanol 2.6
    n-heptane 0.88
    ethyl formate 2.6
    1,2-dichloroethane 0.74
    n-hexanol 3.36
    2-methoxyethanol 59.31
    isobutyl acetate 0.7
    tetrachloromethane 0.19
    n-pentyl acetate 1.75
    transcutol 31.99
    n-heptanol 3.49
    ethylbenzene 0.69
    MIBK 1.65
    2-propoxyethanol 18.65
    tert-butanol 6.02
    MTBE 0.97
    2-butoxyethanol 14.72
    propionic acid 4.48
    o-xylene 1.37
    formic acid 193.97
    diethyl ether 0.73
    m-xylene 1.13
    p-xylene 0.86
    chlorobenzene 0.38
    dimethyl carbonate 3.69
    n-octane 0.46
    formamide 157.41
    cyclopentanone 5.87
    2-pentanone 1.29
    anisole 1.69
    cyclopentyl methyl ether 3.21
    gamma-butyrolactone 10.17
    1-methoxy-2-propanol 30.36
    pyridine 3.02
    3-pentanone 0.94
    furfural 20.36
    n-dodecane 0.28
    diethylene glycol 54.84
    diisopropyl ether 0.61
    tert-amyl alcohol 3.96
    acetylacetone 4.46
    n-hexadecane 0.3
    acetophenone 4.04
    methyl propionate 1.67
    isopentyl acetate 1.69
    trichloroethylene 1.0
    n-nonanol 2.55
    cyclohexanol 4.87
    benzyl alcohol 4.72
    2-ethylhexanol 2.12
    isooctanol 2.67
    dipropyl ether 2.07
    1,2-dichlorobenzene 0.69
    ethyl lactate 7.17
    propylene carbonate 6.0
    n-methylformamide 39.3
    2-pentanol 1.86
    n-pentane 0.26
    1-propoxy-2-propanol 11.96
    1-methoxy-2-propyl acetate 4.9
    2-(2-methoxypropoxy) propanol 15.87
    mesitylene 1.21
    ε-caprolactone 5.98
    p-cymene 1.34
    epichlorohydrin 4.27
    1,1,1-trichloroethane 0.25
    2-aminoethanol 48.29
    morpholine-4-carbaldehyde 57.52
    sulfolane 45.29
    2,2,4-trimethylpentane 0.19
    2-methyltetrahydrofuran 2.54
    n-hexyl acetate 2.08
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 19.77
    sec-butyl acetate 0.8
    tert-butyl acetate 2.1
    decalin 0.35
    glycerin 103.75
    diglyme 29.03
    acrylic acid 11.04
    isopropyl myristate 1.23
    n-butyric acid 4.68
    acetyl acetate 1.37
    di(2-ethylhexyl) phthalate 3.12
    ethyl propionate 1.14
    nitromethane 21.47
    1,2-diethoxyethane 2.89
    benzonitrile 2.08
    trioctyl phosphate 2.5
    1-bromopropane 0.29
    gamma-valerolactone 20.87
    n-decanol 2.12
    triethyl phosphate 2.53
    4-methyl-2-pentanol 1.62
    propionitrile 0.75
    vinylene carbonate 5.6
    1,1,2-trichlorotrifluoroethane 23.63
    DMS 2.13
    cumene 0.72
    2-octanol 2.04
    2-hexanone 1.07
    octyl acetate 1.83
    limonene 1.8
    1,2-dimethoxyethane 16.73
    ethyl orthosilicate 2.34
    tributyl phosphate 2.06
    diacetone alcohol 10.61
    N,N-dimethylaniline 3.62
    acrylonitrile 2.15
    aniline 1.88
    1,3-propanediol 29.87
    bromobenzene 0.31
    dibromomethane 0.4
    1,1,2,2-tetrachloroethane 1.37
    2-methyl-cyclohexyl acetate 2.78
    tetrabutyl urea 5.0
    diisobutyl methanol 2.06
    2-phenylethanol 5.03
    styrene 0.59
    dioctyl adipate 2.62
    dimethyl sulfate 12.77
    ethyl butyrate 2.03
    methyl lactate 14.47
    butyl lactate 6.05
    diethyl carbonate 1.68
    propanediol butyl ether 19.14
    triethyl orthoformate 2.79
    p-tert-butyltoluene 1.38
    methyl 4-tert-butylbenzoate 8.2
    morpholine 8.65
    tert-butylamine 2.12
    n-dodecanol 1.78
    dimethoxymethane 15.79
    ethylene carbonate 3.73
    cyrene 29.23
    2-ethoxyethyl acetate 3.04
    2-ethylhexyl acetate 1.25
    1,2,4-trichlorobenzene 0.95
    4-methylpyridine 2.38
    dibutyl ether 1.15
    2,6-dimethyl-4-heptanol 2.06
    DEF 8.63
    dimethyl isosorbide 19.78
    tetrachloroethylene 1.21
    eugenol 12.46
    triacetin 5.12
    span 80 14.32
    1,4-butanediol 18.32
    1,1-dichloroethane 0.23
    2-methyl-1-pentanol 1.85
    methyl formate 18.55
    2-methyl-1-butanol 1.99
    n-decane 0.42
    butyronitrile 0.91
    3,7-dimethyl-1-octanol 2.19
    1-chlorooctane 0.66
    1-chlorotetradecane 0.4
    n-nonane 0.42
    undecane 0.33
    tert-butylcyclohexane 0.19
    cyclooctane 0.71
    cyclopentanol 5.22
    tetrahydropyran 1.91
    tert-amyl methyl ether 1.4
    2,5,8-trioxanonane 27.61
    1-hexene 0.32
    2-isopropoxyethanol 12.16
    2,2,2-trifluoroethanol 17.38
    methyl butyrate 2.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction