L-Phenylalanyl-L-phenylalanine

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  • Identifiers

    CAS number
    2577-40-4

    Molecular formula
    C18H20N2O3

    SMILES
    C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 42.0%
    Savory 30.87%
    Sweet 27.79%
    Bitter 25.32%
    Fruity 23.8%
    Spicy 22.56%
    Cocoa 22.4%
    Cooked 22.36%
    Balsamic 21.59%
    Cooling 20.96%

     

    Flavor
    Bitter 54.34%
    Odorless 51.06%
    Mild 30.89%
    Bland 24.42%
    Nitrile 20.65%
    Sweet-like 20.37%
    Yeast 19.28%
    Heather 18.71%
    Butyric 18.66%
    Cedarleaf 18.55%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -0.8

    pKa est.
    5.28 (weak acid)

    Molecular weight
    312.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    538°C

    Flash point

    • 248.01 ˚C est.

  • Synonyms

    • 2577-40-4
    • L-Phenylalanyl-L-phenylalanine
    • Phe-Phe
    • (2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
    • CHEBI:72723
    • DTXSID80948633
    • 89TM36C65S
    • (2S)-2-(((2S)-2-amino-3-phenylpropanoyl)amino)-3-phenylpropanoic acid
    • (2S)-2-{[(2S)-2-amino-3-phenylpropanoyl]amino}-3-phenylpropanoic acid
    • RefChem:1088253
    • DTXCID601511266
    • H-PHE-PHE-OH
    • MFCD00063154
    • (S)-2-((S)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid
    • Phenylalanyl-phenylalanine
    • CHEMBL55868
    • Phe-Phe-OH
    • L-Phe-L-Phe
    • 3-Phenyl-N-(3-phenyl-L-alanyl)-L-alanine
    • Di-L-phenylalanine
    • L,L-Diphenylalanine
    • L-Phe-L-Phe-OH
    • H-L-Phe-L-Phe-OH
    • (Phenylalanyl)phenylalanine
    • SCHEMBL825577
    • orb1299276
    • L-Phenylalanine, L-phenylalanyl-
    • FF
    • L-Phenylalanine, N-L-phenylalanyl-
    • BDBM50169134
    • s6093
    • 2-(2-Amino-3-phenyl-propionylamino)-3-phenyl-propionic acid
    • AKOS015919869
    • CS-W007970
    • FP48776
    • HY-W007970
    • s12216
    • AS-18242
    • BP-41248
    • SY110509
    • NS00045604
    • P2580
    • F077081
    • L-Phenylalanyl-L-phenylalanine (H-L-Phe-L-Phe-OH)
    • Q27140102
    • (2S)-2-[[(2S)-2-azaniumyl-3-phenyl-propanoyl]amino]-3-phenyl-propanoate
    • (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionic acid
    • I(S)-2-((S)-2-Amino-3-phenyl-propionylaIImino)-3-phenyl-propionic acid
    • 2577-40-4

  • Applications

    L-Phenylalanyl-L-phenylalanine (CAS 2577-40-4) is a dipeptide primarily used as a building block in peptide synthesis for pharmaceuticals and research. In pharmaceutical and biopharmaceutical manufacturing, it typically serves as an intermediate or foundational component for peptide-based APIs and other complex biomolecules. In analytical and biochemical settings, this dipeptide is used as a reference standard or substrate for chromatography and enzymatic assays, aiding method development and quantitation of peptides. Owing to its phenylalanine-derived aromatic moiety, it may be evaluated for potential applications in cosmetics and personal care as a fragrance precursor or to influence formulation stability and texture. It may also be used as a core-building block in industrial peptide synthesis workflows, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.07
    methanol 17.9
    isopropanol 1.11
    water 2.97
    ethyl acetate 2.35
    n-propanol 1.67
    acetone 3.96
    n-butanol 1.02
    acetonitrile 1.37
    DMF 85.3
    toluene 0.5
    isobutanol 0.79
    1,4-dioxane 3.04
    methyl acetate 1.66
    THF 9.75
    2-butanone 2.22
    n-pentanol 1.03
    sec-butanol 0.89
    n-hexane 0.05
    ethylene glycol 12.4
    NMP 62.23
    cyclohexane 0.03
    DMSO 123.08
    n-butyl acetate 1.42
    n-octanol 0.33
    chloroform 0.88
    n-propyl acetate 1.23
    acetic acid 25.61
    dichloromethane 1.36
    cyclohexanone 4.75
    propylene glycol 8.34
    isopropyl acetate 1.78
    DMAc 148.83
    2-ethoxyethanol 19.6
    isopentanol 1.08
    n-heptane 0.08
    ethyl formate 3.51
    1,2-dichloroethane 1.51
    n-hexanol 1.12
    2-methoxyethanol 40.11
    isobutyl acetate 0.56
    tetrachloromethane 0.22
    n-pentyl acetate 0.75
    transcutol 25.14
    n-heptanol 1.03
    ethylbenzene 0.5
    MIBK 1.52
    2-propoxyethanol 15.31
    tert-butanol 1.55
    MTBE 0.54
    2-butoxyethanol 7.39
    propionic acid 5.53
    o-xylene 0.66
    formic acid 83.89
    diethyl ether 0.58
    m-xylene 0.49
    p-xylene 0.62
    chlorobenzene 0.59
    dimethyl carbonate 9.31
    n-octane 0.04
    formamide 124.42
    cyclopentanone 12.28
    2-pentanone 2.03
    anisole 1.94
    cyclopentyl methyl ether 2.23
    gamma-butyrolactone 20.93
    1-methoxy-2-propanol 18.83
    pyridine 4.3
    3-pentanone 1.99
    furfural 25.35
    n-dodecane 0.03
    diethylene glycol 29.02
    diisopropyl ether 0.27
    tert-amyl alcohol 1.31
    acetylacetone 8.88
    n-hexadecane 0.03
    acetophenone 3.96
    methyl propionate 4.45
    isopentyl acetate 1.55
    trichloroethylene 3.61
    n-nonanol 0.44
    cyclohexanol 0.95
    benzyl alcohol 3.42
    2-ethylhexanol 0.75
    isooctanol 0.88
    dipropyl ether 1.28
    1,2-dichlorobenzene 1.04
    ethyl lactate 4.7
    propylene carbonate 8.03
    n-methylformamide 31.49
    2-pentanol 0.63
    n-pentane 0.03
    1-propoxy-2-propanol 7.24
    1-methoxy-2-propyl acetate 6.74
    2-(2-methoxypropoxy) propanol 8.07
    mesitylene 0.35
    ε-caprolactone 5.91
    p-cymene 0.48
    epichlorohydrin 12.23
    1,1,1-trichloroethane 0.51
    2-aminoethanol 13.9
    morpholine-4-carbaldehyde 47.62
    sulfolane 49.93
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 2.01
    n-hexyl acetate 0.75
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 10.92
    sec-butyl acetate 0.9
    tert-butyl acetate 2.22
    decalin 0.06
    glycerin 36.39
    diglyme 22.7
    acrylic acid 11.07
    isopropyl myristate 0.44
    n-butyric acid 5.64
    acetyl acetate 3.26
    di(2-ethylhexyl) phthalate 1.42
    ethyl propionate 2.11
    nitromethane 44.67
    1,2-diethoxyethane 2.65
    benzonitrile 1.54
    trioctyl phosphate 0.82
    1-bromopropane 0.26
    gamma-valerolactone 30.92
    n-decanol 0.39
    triethyl phosphate 2.32
    4-methyl-2-pentanol 0.62
    propionitrile 0.91
    vinylene carbonate 7.15
    1,1,2-trichlorotrifluoroethane 31.1
    DMS 3.2
    cumene 0.43
    2-octanol 0.37
    2-hexanone 1.15
    octyl acetate 0.63
    limonene 0.51
    1,2-dimethoxyethane 15.99
    ethyl orthosilicate 2.11
    tributyl phosphate 0.98
    diacetone alcohol 8.12
    N,N-dimethylaniline 2.4
    acrylonitrile 2.93
    aniline 2.0
    1,3-propanediol 12.64
    bromobenzene 0.46
    dibromomethane 0.51
    1,1,2,2-tetrachloroethane 3.47
    2-methyl-cyclohexyl acetate 1.91
    tetrabutyl urea 2.15
    diisobutyl methanol 0.66
    2-phenylethanol 2.95
    styrene 0.52
    dioctyl adipate 1.18
    dimethyl sulfate 27.0
    ethyl butyrate 2.0
    methyl lactate 16.11
    butyl lactate 2.98
    diethyl carbonate 1.88
    propanediol butyl ether 5.35
    triethyl orthoformate 2.4
    p-tert-butyltoluene 0.46
    methyl 4-tert-butylbenzoate 5.55
    morpholine 5.41
    tert-butylamine 0.44
    n-dodecanol 0.31
    dimethoxymethane 23.54
    ethylene carbonate 5.05
    cyrene 15.03
    2-ethoxyethyl acetate 2.37
    2-ethylhexyl acetate 1.03
    1,2,4-trichlorobenzene 1.68
    4-methylpyridine 2.62
    dibutyl ether 0.4
    2,6-dimethyl-4-heptanol 0.66
    DEF 9.64
    dimethyl isosorbide 16.65
    tetrachloroethylene 3.02
    eugenol 7.16
    triacetin 3.58
    span 80 5.13
    1,4-butanediol 5.59
    1,1-dichloroethane 0.38
    2-methyl-1-pentanol 1.2
    methyl formate 20.66
    2-methyl-1-butanol 1.02
    n-decane 0.04
    butyronitrile 0.76
    3,7-dimethyl-1-octanol 0.46
    1-chlorooctane 0.14
    1-chlorotetradecane 0.08
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.05
    cyclooctane 0.03
    cyclopentanol 1.65
    tetrahydropyran 0.93
    tert-amyl methyl ether 0.75
    2,5,8-trioxanonane 18.17
    1-hexene 0.21
    2-isopropoxyethanol 7.49
    2,2,2-trifluoroethanol 15.99
    methyl butyrate 2.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction