L-(-)-Ornithine

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  • Identifiers

    CAS number
    70-26-8

    Molecular formula
    C5H12N2O2

    SMILES
    C(C[C@@H](C(=O)O)N)CN

    Safety labels

  • Odor profile

    Fragrance
    Odorless 64.03%
    Fishy 50.66%
    Savory 30.2%
    Meaty 24.73%
    Cheesy 24.28%
    Ripe 20.78%
    Cooling 19.78%
    Sweet 18.82%
    Animal 18.56%
    Green 16.78%

     

    Flavor
    Odorless 61.52%
    Mild 35.53%
    Bland 27.04%
    Sulfury 26.98%
    Faint 24.58%
    Sulfurous 23.39%
    Sweet-like 21.75%
    Yeast 20.78%
    Bloody 19.86%
    Glue 19.83%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.4

    pKa est.
    4.91 (weak acid)

    Molecular weight
    132.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    298°C

    Melting point expt.

    • 140 °C

    Flash point

    • 151.92 ˚C est.

    Solubility expt.

    • Appreciable
    • 620 mg/mL

  • Synonyms

    • L-ornithine
    • ornithine
    • 70-26-8
    • (S)-2,5-Diaminopentanoic acid
    • (S)-2,5-diaminovaleric acid
    • (S)-Ornithine
    • (2S)-2,5-diaminopentanoic acid
    • Ornitina
    • (S)-alpha,delta-Diaminovaleric acid
    • (+)-S-Ornithine
    • Ornithinum
    • (S)-2,5-Diaminopentanoate
    • L-(-)-Ornithine
    • NSC-758894
    • E524N2IXA3
    • CHEBI:15729
    • DTXSID00883219
    • CHEBI:18257
    • DTXSID00860383
    • RefChem:856923
    • 2,5 Diaminopentanoic Acid
    • A05BA06
    • DTXCID40197342
    • DTXCID201022768
    • (2S)-2,5-diaminopentanoate;hydron
    • 200-731-7
    • 2,5-Diaminopentanoate
    • 2,5-Diaminovaleric acid
    • Ornithine [INN]
    • L-Norvaline, 5-amino-
    • Ornithinum [Latin]
    • Ornitina [Spanish]
    • Ornithine (VAN)
    • Pentanoic acid, 2,5-diamino-, (S)-
    • ORNITHINE, L-
    • MFCD00242584
    • L-Ornithine, HCl
    • BRN 1722298
    • Ornithine, (L)-Isomer
    • 25104-12-5
    • 5-amino-L-Norvaline
    • Ornithine (INN)
    • L( )-Ornithine
    • L(-)-Ornithine
    • ORN
    • EINECS 200-731-7
    • UNII-E524N2IXA3
    • levo-ornithine
    • 1hqg
    • 1lah
    • 3jdw
    • ()-Ornithine
    • L-Ornithine (9CI)
    • 5-diaminopentanoic acid
    • H-Orn-OH, HCl salt
    • ORNITHINE [MI]
    • (S)-a,d-Diaminovalerate
    • Ornithine, L- (8CI)
    • bmse000162
    • ORNITHINE [MART.]
    • ORNITHINE [WHO-DD]
    • SCHEMBL8579
    • GTPL725
    • (S)-a,d-Diaminovaleric acid
    • 4-04-00-02644 (Beilstein Handbook Reference)
    • Pentanoic acid, 2,5-diamino
    • CHEMBL446143
    • orb1310337
    • pentanoic acid, 2,5-diamino-
    • SCHEMBL9227620
    • alpha, delta-diaminovaleric acid
    • MSK8341
    • Pharmakon1600-01504524
    • HY-B1352
    • (R,S)-2,5-Diamino-pentanoic acid
    • BDBM50487430
    • EBC-26067
    • L-Ornithine;2,5-Diaminovaleric acid
    • NSC758894
    • s4857
    • AKOS006239312
    • CS-4817
    • DB00129
    • NSC 758894
    • SMP2_000009
    • NCGC00263569-01
    • AC-13803
    • AS-80993
    • BP-14192
    • DA-75080
    • SY256915
    • (S)-2
    • NS00068568
    • S4653
    • EN300-96942
    • A11694
    • C00077
    • D08302
    • LYSINE ACETATE IMPURITY E [EP IMPURITY]
    • 070O268
    • Q410198
    • 8AB10027-4D34-488A-9F55-E86692CA2853
    • L-Ornithine; Arginine EP Impurity C; Lysine Acetate EP Impurity E
    • 70-26-8

  • Applications

    L-(-)-Ornithine (CAS 70-26-8) is a versatile chiral building block used in pharmaceutical manufacture, serving as an intermediate for arginine derivatives, peptidomimetics, and other amino acid–based compounds. It is commonly formulated as a dietary supplement ingredient in nutraceuticals, providing a source of amino nitrogen. In cosmetics and personal care, it is employed as a conditioning amino acid in skin and hair care formulations. In agriculture and animal nutrition, it can be used as a feed additive to supply amino nitrogen and support nitrogen metabolism. In industrial manufacturing, it acts as a precursor for specialty polymers and other chemical syntheses that require a chiral amino acid building block. It is also used in fermentation and bioprocess workflows as a substrate or intermediate for microbial production of ornithine and downstream derivatives such as citrulline or arginine.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.13
    methanol 0.51
    isopropanol 0.09
    water 71.78
    ethyl acetate 0.11
    n-propanol 0.09
    acetone 0.09
    n-butanol 0.09
    acetonitrile 0.09
    DMF 2.11
    toluene 0.05
    isobutanol 0.1
    1,4-dioxane 0.47
    methyl acetate 0.06
    THF 0.43
    2-butanone 0.07
    n-pentanol 0.09
    sec-butanol 0.08
    n-hexane 0.05
    ethylene glycol 6.41
    NMP 16.08
    cyclohexane 0.11
    DMSO 12.86
    n-butyl acetate 0.16
    n-octanol 0.1
    chloroform 0.06
    n-propyl acetate 0.08
    acetic acid 4.79
    dichloromethane 0.09
    cyclohexanone 0.76
    propylene glycol 2.29
    isopropyl acetate 0.12
    DMAc 4.01
    2-ethoxyethanol 0.94
    isopentanol 0.13
    n-heptane 0.1
    ethyl formate 0.2
    1,2-dichloroethane 0.08
    n-hexanol 0.24
    2-methoxyethanol 1.92
    isobutyl acetate 0.06
    tetrachloromethane 0.07
    n-pentyl acetate 0.12
    transcutol 1.98
    n-heptanol 0.22
    ethylbenzene 0.06
    MIBK 0.11
    2-propoxyethanol 1.4
    tert-butanol 0.17
    MTBE 0.05
    2-butoxyethanol 0.98
    propionic acid 0.87
    o-xylene 0.17
    formic acid 39.81
    diethyl ether 0.04
    m-xylene 0.11
    p-xylene 0.1
    chlorobenzene 0.06
    dimethyl carbonate 0.22
    n-octane 0.04
    formamide 11.08
    cyclopentanone 0.74
    2-pentanone 0.1
    anisole 0.08
    cyclopentyl methyl ether 0.32
    gamma-butyrolactone 1.53
    1-methoxy-2-propanol 1.04
    pyridine 0.25
    3-pentanone 0.12
    furfural 3.55
    n-dodecane 0.02
    diethylene glycol 6.29
    diisopropyl ether 0.06
    tert-amyl alcohol 0.18
    acetylacetone 0.42
    n-hexadecane 0.02
    acetophenone 0.27
    methyl propionate 0.16
    isopentyl acetate 0.19
    trichloroethylene 0.13
    n-nonanol 0.11
    cyclohexanol 0.41
    benzyl alcohol 0.26
    2-ethylhexanol 0.24
    isooctanol 0.22
    dipropyl ether 0.16
    1,2-dichlorobenzene 0.14
    ethyl lactate 0.51
    propylene carbonate 1.15
    n-methylformamide 1.05
    2-pentanol 0.08
    n-pentane 0.03
    1-propoxy-2-propanol 0.83
    1-methoxy-2-propyl acetate 0.52
    2-(2-methoxypropoxy) propanol 1.29
    mesitylene 0.15
    ε-caprolactone 0.99
    p-cymene 0.18
    epichlorohydrin 0.38
    1,1,1-trichloroethane 0.04
    2-aminoethanol 2.6
    morpholine-4-carbaldehyde 7.99
    sulfolane 12.27
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 0.25
    n-hexyl acetate 0.14
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 1.56
    sec-butyl acetate 0.08
    tert-butyl acetate 0.2
    decalin 0.07
    glycerin 16.33
    diglyme 2.06
    acrylic acid 2.29
    isopropyl myristate 0.09
    n-butyric acid 0.84
    acetyl acetate 0.26
    di(2-ethylhexyl) phthalate 0.43
    ethyl propionate 0.11
    nitromethane 1.61
    1,2-diethoxyethane 0.16
    benzonitrile 0.18
    trioctyl phosphate 0.28
    1-bromopropane 0.03
    gamma-valerolactone 2.85
    n-decanol 0.1
    triethyl phosphate 0.35
    4-methyl-2-pentanol 0.11
    propionitrile 0.05
    vinylene carbonate 0.98
    1,1,2-trichlorotrifluoroethane 4.44
    DMS 0.35
    cumene 0.1
    2-octanol 0.12
    2-hexanone 0.07
    octyl acetate 0.13
    limonene 0.23
    1,2-dimethoxyethane 0.6
    ethyl orthosilicate 0.34
    tributyl phosphate 0.25
    diacetone alcohol 0.83
    N,N-dimethylaniline 0.21
    acrylonitrile 0.14
    aniline 0.17
    1,3-propanediol 1.56
    bromobenzene 0.05
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.18
    2-methyl-cyclohexyl acetate 0.37
    tetrabutyl urea 0.48
    diisobutyl methanol 0.21
    2-phenylethanol 0.42
    styrene 0.04
    dioctyl adipate 0.2
    dimethyl sulfate 1.45
    ethyl butyrate 0.2
    methyl lactate 1.27
    butyl lactate 0.54
    diethyl carbonate 0.16
    propanediol butyl ether 1.33
    triethyl orthoformate 0.3
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 0.84
    morpholine 0.53
    tert-butylamine 0.08
    n-dodecanol 0.09
    dimethoxymethane 0.34
    ethylene carbonate 0.68
    cyrene 5.15
    2-ethoxyethyl acetate 0.24
    2-ethylhexyl acetate 0.16
    1,2,4-trichlorobenzene 0.18
    4-methylpyridine 0.17
    dibutyl ether 0.06
    2,6-dimethyl-4-heptanol 0.21
    DEF 0.61
    dimethyl isosorbide 2.99
    tetrachloroethylene 0.26
    eugenol 1.16
    triacetin 0.53
    span 80 1.8
    1,4-butanediol 0.92
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.14
    methyl formate 0.64
    2-methyl-1-butanol 0.13
    n-decane 0.03
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.11
    1-chlorooctane 0.04
    1-chlorotetradecane 0.03
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.04
    cyclooctane 0.08
    cyclopentanol 0.55
    tetrahydropyran 0.14
    tert-amyl methyl ether 0.08
    2,5,8-trioxanonane 2.52
    1-hexene 0.04
    2-isopropoxyethanol 0.5
    2,2,2-trifluoroethanol 4.39
    methyl butyrate 0.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction