L-Methionylglycine

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  • Identifiers

    CAS number
    14486-03-4

    Molecular formula
    C7H14N2O3S

    SMILES
    CSCC[C@@H](C(=O)NCC(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 60.93%
    Savory 53.31%
    Odorless 38.85%
    Sulfurous 38.39%
    Roasted 38.29%
    Cooked 35.08%
    Cheesy 26.27%
    Fishy 25.47%
    Beefy 25.32%
    Sweet 24.38%

     

    Flavor
    Odorless 47.15%
    Mild 31.99%
    Bland 28.72%
    Sulfury 28.57%
    Roasted 28.14%
    Cooked 27.76%
    Sulfurous 27.22%
    Bitter 23.96%
    Faint 21.35%
    Sweet-like 21.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.0

    pKa est.
    5.92 (weak acid)

    Molecular weight
    206.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    386°C

    Flash point

    • 200.4 ˚C est.

    Solubility expt.

    • Slightly soluble in water
    • Practically insoluble (in ethanol)

  • Synonyms

    • L-Methionylglycine
    • 14486-03-4
    • Met-Gly
    • (S)-2-(2-amino-4-(methylthio)butanamido)acetic acid
    • H-Met-Gly-OH
    • Methionylglycine
    • Glycine, L-methionyl-
    • N-L-Methionylglycine
    • L-Methionyl-glycine
    • L-Met-Gly
    • UNII-T872MM2E20
    • CHEBI:73611
    • T872MM2E20
    • N-METHIONYLGLYCINE
    • EINECS 238-487-9
    • Glycine, N-L-methionyl-
    • NSC 88865
    • METHIONYLGLYCINE, L-
    • CHEMBL90972
    • FEMA NO. 4692
    • DTXSID401020087
    • NSC-88865
    • J81.776G
    • 2-[(2S)-2-amino-4-(methylsulfanyl)butanamido]acetic acid
    • 2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]acetic acid
    • 2-[[(2S)-2-Azaniumyl-4-methylsulfanylbutanoyl]amino]acetate
    • MFCD00021730
    • SCHEMBL538055
    • DTXCID101477928
    • BDBM50407420
    • AKOS010405233
    • AKOS015854100
    • CS-W015315
    • HY-W014599
    • L-Methionylglycine (H-L-Met-Gly-OH)
    • DA-64216
    • DS-14534
    • FM108125
    • M0250
    • NS00054161
    • EN300-881949
    • Q27141928
    • Z760081498
    • {[(2S)-2-amino-4-(methylthio)butanoyl]amino}acetic acid
    • M-G

  • Applications

    L-Methionylglycine is a dipeptide commonly used as an intermediate and building block in peptide synthesis for pharmaceutical and biotech applications. It serves as a research reagent and analytical standard for chromatography-based assays (LC–MS/HPLC) and proteomics work. It can function as a substrate or reagent in enzymatic assays involving peptidases and studies of proteolysis. It also acts as a precursor for peptide-based materials and medicinal chemistry derivatives, supporting the discovery and development of peptide-related compounds. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.53
    methanol 2.68
    isopropanol 0.3
    water 147.48
    ethyl acetate 0.35
    n-propanol 0.37
    acetone 1.05
    n-butanol 0.31
    acetonitrile 0.33
    DMF 31.12
    toluene 0.26
    isobutanol 0.36
    1,4-dioxane 1.14
    methyl acetate 0.23
    THF 2.85
    2-butanone 0.41
    n-pentanol 0.39
    sec-butanol 0.29
    n-hexane 0.1
    ethylene glycol 15.56
    NMP 100.5
    cyclohexane 0.33
    DMSO 125.58
    n-butyl acetate 0.77
    n-octanol 0.25
    chloroform 0.13
    n-propyl acetate 0.5
    acetic acid 31.06
    dichloromethane 0.2
    cyclohexanone 4.03
    propylene glycol 6.29
    isopropyl acetate 0.49
    DMAc 33.79
    2-ethoxyethanol 5.98
    isopentanol 0.53
    n-heptane 0.19
    ethyl formate 1.01
    1,2-dichloroethane 0.24
    n-hexanol 0.68
    2-methoxyethanol 9.61
    isobutyl acetate 0.36
    tetrachloromethane 0.11
    n-pentyl acetate 0.47
    transcutol 13.88
    n-heptanol 0.53
    ethylbenzene 0.25
    MIBK 0.69
    2-propoxyethanol 5.24
    tert-butanol 1.1
    MTBE 0.26
    2-butoxyethanol 3.14
    propionic acid 2.98
    o-xylene 0.58
    formic acid 129.8
    diethyl ether 0.13
    m-xylene 0.44
    p-xylene 0.42
    chlorobenzene 0.19
    dimethyl carbonate 1.2
    n-octane 0.08
    formamide 67.32
    cyclopentanone 5.82
    2-pentanone 0.53
    anisole 0.52
    cyclopentyl methyl ether 1.4
    gamma-butyrolactone 9.39
    1-methoxy-2-propanol 4.78
    pyridine 1.08
    3-pentanone 0.53
    furfural 18.96
    n-dodecane 0.04
    diethylene glycol 19.08
    diisopropyl ether 0.17
    tert-amyl alcohol 0.96
    acetylacetone 3.32
    n-hexadecane 0.04
    acetophenone 1.63
    methyl propionate 0.59
    isopentyl acetate 1.04
    trichloroethylene 0.44
    n-nonanol 0.3
    cyclohexanol 1.38
    benzyl alcohol 1.39
    2-ethylhexanol 0.6
    isooctanol 0.55
    dipropyl ether 0.53
    1,2-dichlorobenzene 0.38
    ethyl lactate 2.36
    propylene carbonate 5.99
    n-methylformamide 8.2
    2-pentanol 0.24
    n-pentane 0.07
    1-propoxy-2-propanol 3.27
    1-methoxy-2-propyl acetate 2.74
    2-(2-methoxypropoxy) propanol 5.86
    mesitylene 0.49
    ε-caprolactone 4.43
    p-cymene 0.48
    epichlorohydrin 1.73
    1,1,1-trichloroethane 0.14
    2-aminoethanol 9.07
    morpholine-4-carbaldehyde 39.95
    sulfolane 69.69
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 1.12
    n-hexyl acetate 0.51
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 6.36
    sec-butyl acetate 0.38
    tert-butyl acetate 1.1
    decalin 0.15
    glycerin 42.86
    diglyme 10.67
    acrylic acid 7.94
    isopropyl myristate 0.32
    n-butyric acid 3.02
    acetyl acetate 1.12
    di(2-ethylhexyl) phthalate 1.27
    ethyl propionate 0.52
    nitromethane 14.75
    1,2-diethoxyethane 0.79
    benzonitrile 0.78
    trioctyl phosphate 0.74
    1-bromopropane 0.09
    gamma-valerolactone 19.69
    n-decanol 0.26
    triethyl phosphate 1.55
    4-methyl-2-pentanol 0.36
    propionitrile 0.22
    vinylene carbonate 4.66
    1,1,2-trichlorotrifluoroethane 13.76
    DMS 1.3
    cumene 0.29
    2-octanol 0.29
    2-hexanone 0.49
    octyl acetate 0.44
    limonene 0.62
    1,2-dimethoxyethane 4.45
    ethyl orthosilicate 1.31
    tributyl phosphate 0.89
    diacetone alcohol 5.12
    N,N-dimethylaniline 1.18
    acrylonitrile 0.61
    aniline 0.68
    1,3-propanediol 5.43
    bromobenzene 0.15
    dibromomethane 0.14
    1,1,2,2-tetrachloroethane 0.54
    2-methyl-cyclohexyl acetate 1.58
    tetrabutyl urea 1.93
    diisobutyl methanol 0.61
    2-phenylethanol 1.39
    styrene 0.2
    dioctyl adipate 0.91
    dimethyl sulfate 8.47
    ethyl butyrate 0.97
    methyl lactate 4.99
    butyl lactate 2.09
    diethyl carbonate 0.85
    propanediol butyl ether 4.73
    triethyl orthoformate 1.29
    p-tert-butyltoluene 0.49
    methyl 4-tert-butylbenzoate 3.4
    morpholine 1.71
    tert-butylamine 0.43
    n-dodecanol 0.23
    dimethoxymethane 2.62
    ethylene carbonate 2.96
    cyrene 19.77
    2-ethoxyethyl acetate 1.08
    2-ethylhexyl acetate 0.73
    1,2,4-trichlorobenzene 0.56
    4-methylpyridine 0.84
    dibutyl ether 0.21
    2,6-dimethyl-4-heptanol 0.61
    DEF 2.98
    dimethyl isosorbide 13.92
    tetrachloroethylene 0.62
    eugenol 4.72
    triacetin 2.35
    span 80 5.32
    1,4-butanediol 3.38
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.6
    methyl formate 5.26
    2-methyl-1-butanol 0.47
    n-decane 0.06
    butyronitrile 0.23
    3,7-dimethyl-1-octanol 0.36
    1-chlorooctane 0.09
    1-chlorotetradecane 0.07
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.09
    cyclooctane 0.19
    cyclopentanol 1.93
    tetrahydropyran 0.54
    tert-amyl methyl ether 0.39
    2,5,8-trioxanonane 11.97
    1-hexene 0.14
    2-isopropoxyethanol 2.86
    2,2,2-trifluoroethanol 13.24
    methyl butyrate 0.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction