L-Lysine, dihydroxymethylsilyl ester

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  • Identifiers

    CAS number
    190270-74-7

    Molecular formula
    C7H16N2O4Si

    SMILES
    C(CCN)C[C@@H](C(=O)O[Si]C(O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 61.57%
    Savory 34.14%
    Fishy 32.06%
    Meaty 26.81%
    Cooling 23.38%
    Sweet 20.41%
    Cheesy 20.06%
    Oily 17.82%
    Alcoholic 17.28%
    Ripe 16.98%

     

    Flavor
    Odorless 64.78%
    Mild 34.3%
    Bland 33.75%
    Sweet-like 25.75%
    Bitter 23.79%
    Faint 23.11%
    Yeast 20.29%
    Bay oil 19.84%
    Very slight 19.74%
    Bouillon 19.67%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.05 (neutral)

    Molecular weight
    220.3 g/mol

    Flash point

    • 160.58 ˚C est.

  • Synonyms

    • DTXSID701021822
    • L-Lysine, dihydroxymethylsilyl ester
    • 190270-74-7
    • 190270-74-7

  • Applications

    L-Lysine, dihydroxymethylsilyl ester (CAS 190270-74-7) is a protected carboxyl derivative of lysine commonly used as a building block in peptide synthesis and combinatorial chemistry. It serves as a monomer or functional unit in the synthesis of lysine-containing polymers and hydrogels and other biodegradable polymers designed for biomedical and industrial applications. With the dihydroxymethylsilyl group enabling surface modification and crosslinking, it can function as a functional additive in coatings, inks, and adhesives. It is also considered a precursor for pharmaceutical and biotech manufacturing involving lysine-containing peptides or peptidomimetics, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.14
    methanol 1.42
    isopropanol 0.05
    water 144.92
    ethyl acetate 0.08
    n-propanol 0.08
    acetone 0.14
    n-butanol 0.05
    acetonitrile 0.07
    DMF 4.13
    toluene 0.08
    isobutanol 0.06
    1,4-dioxane 0.19
    methyl acetate 0.06
    THF 0.37
    2-butanone 0.06
    n-pentanol 0.07
    sec-butanol 0.05
    n-hexane 0.02
    ethylene glycol 17.54
    NMP 25.43
    cyclohexane 0.11
    DMSO 46.56
    n-butyl acetate 0.17
    n-octanol 0.08
    chloroform 0.05
    n-propyl acetate 0.1
    acetic acid 15.19
    dichloromethane 0.07
    cyclohexanone 0.58
    propylene glycol 4.18
    isopropyl acetate 0.09
    DMAc 5.46
    2-ethoxyethanol 1.82
    isopentanol 0.07
    n-heptane 0.07
    ethyl formate 0.26
    1,2-dichloroethane 0.07
    n-hexanol 0.18
    2-methoxyethanol 3.53
    isobutyl acetate 0.06
    tetrachloromethane 0.05
    n-pentyl acetate 0.13
    transcutol 3.97
    n-heptanol 0.19
    ethylbenzene 0.06
    MIBK 0.11
    2-propoxyethanol 1.88
    tert-butanol 0.17
    MTBE 0.04
    2-butoxyethanol 1.23
    propionic acid 1.14
    o-xylene 0.18
    formic acid 136.38
    diethyl ether 0.02
    m-xylene 0.13
    p-xylene 0.09
    chlorobenzene 0.06
    dimethyl carbonate 0.59
    n-octane 0.03
    formamide 53.0
    cyclopentanone 0.91
    2-pentanone 0.08
    anisole 0.12
    cyclopentyl methyl ether 0.26
    gamma-butyrolactone 2.07
    1-methoxy-2-propanol 1.46
    pyridine 0.27
    3-pentanone 0.09
    furfural 6.24
    n-dodecane 0.01
    diethylene glycol 14.11
    diisopropyl ether 0.03
    tert-amyl alcohol 0.15
    acetylacetone 0.67
    n-hexadecane 0.02
    acetophenone 0.46
    methyl propionate 0.16
    isopentyl acetate 0.19
    trichloroethylene 0.16
    n-nonanol 0.09
    cyclohexanol 0.28
    benzyl alcohol 0.44
    2-ethylhexanol 0.16
    isooctanol 0.17
    dipropyl ether 0.13
    1,2-dichlorobenzene 0.12
    ethyl lactate 1.05
    propylene carbonate 1.52
    n-methylformamide 2.56
    2-pentanol 0.04
    n-pentane 0.02
    1-propoxy-2-propanol 1.09
    1-methoxy-2-propyl acetate 0.81
    2-(2-methoxypropoxy) propanol 1.99
    mesitylene 0.16
    ε-caprolactone 0.76
    p-cymene 0.17
    epichlorohydrin 0.36
    1,1,1-trichloroethane 0.03
    2-aminoethanol 5.67
    morpholine-4-carbaldehyde 9.89
    sulfolane 26.29
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.14
    n-hexyl acetate 0.13
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.23
    sec-butyl acetate 0.07
    tert-butyl acetate 0.23
    decalin 0.04
    glycerin 40.14
    diglyme 3.42
    acrylic acid 4.45
    isopropyl myristate 0.08
    n-butyric acid 0.78
    acetyl acetate 0.34
    di(2-ethylhexyl) phthalate 0.43
    ethyl propionate 0.12
    nitromethane 5.04
    1,2-diethoxyethane 0.16
    benzonitrile 0.19
    trioctyl phosphate 0.28
    1-bromopropane 0.02
    gamma-valerolactone 3.4
    n-decanol 0.08
    triethyl phosphate 0.48
    4-methyl-2-pentanol 0.06
    propionitrile 0.04
    vinylene carbonate 1.34
    1,1,2-trichlorotrifluoroethane 8.88
    DMS 0.41
    cumene 0.07
    2-octanol 0.09
    2-hexanone 0.07
    octyl acetate 0.12
    limonene 0.2
    1,2-dimethoxyethane 0.84
    ethyl orthosilicate 0.41
    tributyl phosphate 0.26
    diacetone alcohol 1.25
    N,N-dimethylaniline 0.28
    acrylonitrile 0.17
    aniline 0.24
    1,3-propanediol 2.26
    bromobenzene 0.05
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.2
    2-methyl-cyclohexyl acetate 0.4
    tetrabutyl urea 0.54
    diisobutyl methanol 0.16
    2-phenylethanol 0.59
    styrene 0.05
    dioctyl adipate 0.24
    dimethyl sulfate 4.17
    ethyl butyrate 0.22
    methyl lactate 2.85
    butyl lactate 0.76
    diethyl carbonate 0.23
    propanediol butyl ether 2.02
    triethyl orthoformate 0.38
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 1.29
    morpholine 0.28
    tert-butylamine 0.07
    n-dodecanol 0.07
    dimethoxymethane 0.67
    ethylene carbonate 0.74
    cyrene 8.35
    2-ethoxyethyl acetate 0.3
    2-ethylhexyl acetate 0.15
    1,2,4-trichlorobenzene 0.19
    4-methylpyridine 0.16
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.16
    DEF 0.45
    dimethyl isosorbide 4.85
    tetrachloroethylene 0.3
    eugenol 1.94
    triacetin 0.81
    span 80 2.3
    1,4-butanediol 1.49
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.09
    methyl formate 1.95
    2-methyl-1-butanol 0.07
    n-decane 0.02
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.09
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.08
    cyclopentanol 0.39
    tetrahydropyran 0.08
    tert-amyl methyl ether 0.06
    2,5,8-trioxanonane 4.09
    1-hexene 0.02
    2-isopropoxyethanol 0.73
    2,2,2-trifluoroethanol 11.04
    methyl butyrate 0.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction