L-Homoserine

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  • Identifiers

    CAS number
    672-15-1

    Molecular formula
    C4H9NO3

    SMILES
    C(CO)[C@@H](C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 69.31%
    Sweet 40.83%
    Savory 28.44%
    Buttery 19.13%
    Meaty 19.12%
    Fishy 19.03%
    Milky 18.99%
    Bitter 18.18%
    Alcoholic 18.08%
    Oily 15.54%

     

    Flavor
    Odorless 73.48%
    Mild 31.36%
    Sweet-like 25.0%
    Bland 24.72%
    Very mild 24.13%
    Acidic 23.87%
    Sour 23.61%
    Yeast 23.06%
    Faint 21.38%
    Very slight 20.52%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.4

    pKa est.
    5.74 (weak acid)

    Molecular weight
    119.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    323°C

    Melting point expt.

    • 203 dec °C
    • 203 °C

    Flash point

    • 165.37 ˚C est.

    Solubility expt.

    • 1000000 mg/L (at 30 °C)
    • 1000.0 mg/mL

  • Synonyms

    • L-homoserine
    • 672-15-1
    • homoserine
    • (2S)-2-amino-4-hydroxybutanoic acid
    • 2-Amino-4-hydroxybutyric acid
    • 6KA95X0IVO
    • DTXSID5075159
    • CHEBI:15699
    • 2-amino-4-hydroxybutanoate
    • NSC-206251
    • (2S)-2-azaniumyl-4-hydroxybutanoate
    • CHEBI:30653
    • Homoserine L-
    • L Isomer OF homoserine
    • RefChem:924416
    • DTXCID1036046
    • 211-590-6
    • 932-027-7
    • 2-Amino-4-hydroxybutanoic acid
    • h-hoser-oh
    • (s)-2-amino-4-hydroxybutanoic acid
    • MFCD00063090
    • (S)-2-Amino-4-hydroxybutyric acid
    • (s)-homoserine
    • Homoserine (VAN)
    • 119736-88-8
    • (2S)-2-ammonio-4-hydroxybutanoate
    • NSC 206251
    • Butyric acid, 2-amino-4-hydroxy-, L-
    • Butanoic acid, 2-amino-4-hydroxy-, (S)-
    • UNII-6KA95X0IVO
    • Isothreonine
    • 2-amino-4-hydroxybutyrate
    • h-hse-oh
    • HSE
    • EINECS 211-590-6
    • (2S)-2-amino-4-hydroxy-butanoic acid
    • HOMOSERINE [MI]
    • HOMOSERINE, L-
    • Threonine EP Impurity A
    • bmse000040
    • 2-amino-4-hydroxy-Butyrate
    • SCHEMBL29649
    • CHEMBL11722
    • 2-amino-4-hydroxy-L-Butyrate
    • orb1302588
    • 2-amino-4-hydroxy-Butyric acid
    • (S)-2-Amino-4-hydroxybutanoate
    • L-2-Amino-4-hydroxybutyric acid
    • MSK2851
    • DTXSID201365201
    • (S)-2-amino-4-hydroxy-Butanoate
    • 2-amino-4-hydroxy-L-Butyric acid
    • STR06869
    • EBC-48150
    • s3118
    • (S)-2-amino-4-hydroxy-Butanoic acid
    • AKOS005146323
    • AKOS016015443
    • AC-5665
    • CS-W002292
    • DB04193
    • FH23855
    • HY-W002292
    • H-HSer-OH, H-Hse-OH, H-HoSer-OH
    • S-2-AMINO-4-HYDROXYBUTYRIC ACID
    • (S)-2-Amino-4-hydroxybutyric acid, Hse
    • BP-13218
    • L-Homoserine,labeledwith carbon-14(9ci)
    • SY005811
    • DB-031336
    • H1030
    • NS00079749
    • EN300-75344
    • C00263
    • Butyric acid, 2-amino-4-hydroxy-, L- (8CI)
    • 672H151
    • F040037
    • Q418214
    • Z1172369006
    • 09EC5004-E0F7-4325-B392-59A264DAF51F
    • 672-15-1

  • Applications

    L-Homoserine serves primarily as an upstream intermediate in the aspartate pathway for the microbial biosynthesis of essential amino acids, notably threonine and methionine, and is therefore encountered in industrial fermentation and amino‑acid production workflows. It is also used as a chemical building block in organic synthesis and peptide chemistry, where it provides a non-proteinogenic amino‑acid residue for designing surrogates and libraries. In addition, it is employed in metabolic engineering and biocatalysis research as a substrate or target in pathway optimization studies. It can function as a convenient chiral starting material for the preparation of specialty chemicals and pharmaceutical intermediates, and is used as a research standard and reagent in analytical and synthetic laboratories, with handling and usage subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.1
    methanol 0.29
    isopropanol 0.07
    water 128.74
    ethyl acetate 0.3
    n-propanol 0.07
    acetone 0.43
    n-butanol 0.06
    acetonitrile 0.16
    DMF 4.22
    toluene 0.09
    isobutanol 0.07
    1,4-dioxane 0.71
    methyl acetate 0.14
    THF 0.49
    2-butanone 0.16
    n-pentanol 0.06
    sec-butanol 0.08
    n-hexane 0.04
    ethylene glycol 7.34
    NMP 18.35
    cyclohexane 0.09
    DMSO 16.74
    n-butyl acetate 0.19
    n-octanol 0.15
    chloroform 0.1
    n-propyl acetate 0.1
    acetic acid 5.07
    dichloromethane 0.13
    cyclohexanone 0.94
    propylene glycol 2.12
    isopropyl acetate 0.25
    DMAc 7.14
    2-ethoxyethanol 0.99
    isopentanol 0.1
    n-heptane 0.11
    ethyl formate 0.43
    1,2-dichloroethane 0.13
    n-hexanol 0.22
    2-methoxyethanol 2.05
    isobutyl acetate 0.06
    tetrachloromethane 0.21
    n-pentyl acetate 0.16
    transcutol 2.08
    n-heptanol 0.26
    ethylbenzene 0.09
    MIBK 0.27
    2-propoxyethanol 1.49
    tert-butanol 0.29
    MTBE 0.1
    2-butoxyethanol 1.07
    propionic acid 0.86
    o-xylene 0.3
    formic acid 49.52
    diethyl ether 0.06
    m-xylene 0.24
    p-xylene 0.13
    chlorobenzene 0.07
    dimethyl carbonate 0.57
    n-octane 0.05
    formamide 13.11
    cyclopentanone 1.1
    2-pentanone 0.22
    anisole 0.16
    cyclopentyl methyl ether 0.42
    gamma-butyrolactone 2.1
    1-methoxy-2-propanol 1.21
    pyridine 0.27
    3-pentanone 0.25
    furfural 5.2
    n-dodecane 0.03
    diethylene glycol 7.01
    diisopropyl ether 0.09
    tert-amyl alcohol 0.33
    acetylacetone 1.29
    n-hexadecane 0.03
    acetophenone 0.45
    methyl propionate 0.35
    isopentyl acetate 0.22
    trichloroethylene 0.26
    n-nonanol 0.16
    cyclohexanol 0.31
    benzyl alcohol 0.31
    2-ethylhexanol 0.25
    isooctanol 0.25
    dipropyl ether 0.18
    1,2-dichlorobenzene 0.16
    ethyl lactate 0.66
    propylene carbonate 1.24
    n-methylformamide 1.61
    2-pentanol 0.07
    n-pentane 0.02
    1-propoxy-2-propanol 0.95
    1-methoxy-2-propyl acetate 0.72
    2-(2-methoxypropoxy) propanol 2.1
    mesitylene 0.29
    ε-caprolactone 1.07
    p-cymene 0.25
    epichlorohydrin 0.48
    1,1,1-trichloroethane 0.13
    2-aminoethanol 2.11
    morpholine-4-carbaldehyde 9.32
    sulfolane 13.61
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 0.3
    n-hexyl acetate 0.19
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 1.92
    sec-butyl acetate 0.1
    tert-butyl acetate 0.43
    decalin 0.07
    glycerin 18.61
    diglyme 3.16
    acrylic acid 2.34
    isopropyl myristate 0.12
    n-butyric acid 0.66
    acetyl acetate 0.54
    di(2-ethylhexyl) phthalate 0.47
    ethyl propionate 0.18
    nitromethane 3.68
    1,2-diethoxyethane 0.19
    benzonitrile 0.21
    trioctyl phosphate 0.34
    1-bromopropane 0.03
    gamma-valerolactone 3.36
    n-decanol 0.14
    triethyl phosphate 0.48
    4-methyl-2-pentanol 0.13
    propionitrile 0.07
    vinylene carbonate 1.14
    1,1,2-trichlorotrifluoroethane 6.39
    DMS 0.39
    cumene 0.13
    2-octanol 0.15
    2-hexanone 0.11
    octyl acetate 0.17
    limonene 0.31
    1,2-dimethoxyethane 0.98
    ethyl orthosilicate 0.44
    tributyl phosphate 0.32
    diacetone alcohol 1.88
    N,N-dimethylaniline 0.4
    acrylonitrile 0.19
    aniline 0.21
    1,3-propanediol 1.24
    bromobenzene 0.06
    dibromomethane 0.08
    1,1,2,2-tetrachloroethane 0.33
    2-methyl-cyclohexyl acetate 0.37
    tetrabutyl urea 0.64
    diisobutyl methanol 0.32
    2-phenylethanol 0.47
    styrene 0.06
    dioctyl adipate 0.24
    dimethyl sulfate 3.38
    ethyl butyrate 0.25
    methyl lactate 1.99
    butyl lactate 0.58
    diethyl carbonate 0.19
    propanediol butyl ether 1.51
    triethyl orthoformate 0.35
    p-tert-butyltoluene 0.27
    methyl 4-tert-butylbenzoate 1.36
    morpholine 0.54
    tert-butylamine 0.11
    n-dodecanol 0.12
    dimethoxymethane 0.92
    ethylene carbonate 0.72
    cyrene 5.08
    2-ethoxyethyl acetate 0.31
    2-ethylhexyl acetate 0.18
    1,2,4-trichlorobenzene 0.21
    4-methylpyridine 0.25
    dibutyl ether 0.08
    2,6-dimethyl-4-heptanol 0.32
    DEF 1.03
    dimethyl isosorbide 4.03
    tetrachloroethylene 0.56
    eugenol 1.67
    triacetin 0.66
    span 80 1.83
    1,4-butanediol 0.73
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.11
    methyl formate 1.73
    2-methyl-1-butanol 0.11
    n-decane 0.04
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.06
    1-chlorotetradecane 0.04
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.05
    cyclooctane 0.09
    cyclopentanol 0.42
    tetrahydropyran 0.14
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 4.06
    1-hexene 0.04
    2-isopropoxyethanol 0.58
    2,2,2-trifluoroethanol 8.65
    methyl butyrate 0.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction