L-Glutamic acid, 5-(dihydroxymethylsilyl) ester

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  • Identifiers

    CAS number
    190270-72-5

    Molecular formula
    C6H10NO6Si-

    SMILES
    C(CC(=O)O[Si]C(O)O)[C@@H](C(=O)[O-])N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 64.31%
    Savory 32.51%
    Sweet 32.0%
    Meaty 22.92%
    Milky 19.61%
    Buttery 18.15%
    Alcoholic 17.51%
    Sulfurous 17.18%
    Clean 17.08%
    Cooked 17.0%

     

    Flavor
    Odorless 70.34%
    Very mild 32.7%
    Bland 32.27%
    Mild 32.25%
    Sweet-like 25.63%
    Bitter 25.01%
    Yeast 22.6%
    Faint 19.61%
    Very slight 18.9%
    Stinky 18.55%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.29 (weak acid)

    Molecular weight
    220.23 g/mol

    Flash point

    • 176.21 ˚C est.

  • Synonyms

    • DTXSID501021814
    • L-Glutamic acid, 5-(dihydroxymethylsilyl) ester
    • 190270-72-5
    • 190270-72-5

  • Applications

    L-Glutamic acid, 5-(dihydroxymethylsilyl) ester (CAS 190270-72-5) is a protecting amino acid derivative used primarily in peptide synthesis and other complex organic syntheses to shield the gamma-carboxyl group, enabling selective downstream reactions; it is also employed as a starting material or intermediate in pharmaceutical manufacturing and polymer synthesis, particularly for producing protected polyglutamates and monomers for protected polymer sequences; owing to the stability of the silanol group, this derivative may be considered a precursor for amino acid derivatives in cosmetic and personal care formulations, and is evaluated for use in industrial chemical processes depending on local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.24
    methanol 8.27
    isopropanol 1.31
    water 74.31
    ethyl acetate 0.56
    n-propanol 1.04
    acetone 2.55
    n-butanol 0.83
    acetonitrile 0.54
    DMF 88.63
    toluene 0.45
    isobutanol 0.51
    1,4-dioxane 3.3
    methyl acetate 0.64
    THF 3.76
    2-butanone 0.76
    n-pentanol 0.63
    sec-butanol 0.84
    n-hexane 0.15
    ethylene glycol 31.73
    NMP 65.69
    cyclohexane 0.52
    DMSO 186.13
    n-butyl acetate 0.51
    n-octanol 0.76
    chloroform 0.1
    n-propyl acetate 0.44
    acetic acid 10.66
    dichloromethane 0.21
    cyclohexanone 2.27
    propylene glycol 13.03
    isopropyl acetate 0.53
    DMAc 59.06
    2-ethoxyethanol 14.8
    isopentanol 0.72
    n-heptane 0.41
    ethyl formate 1.24
    1,2-dichloroethane 0.32
    n-hexanol 0.92
    2-methoxyethanol 38.75
    isobutyl acetate 0.16
    tetrachloromethane 0.06
    n-pentyl acetate 0.58
    transcutol 19.48
    n-heptanol 1.07
    ethylbenzene 0.32
    MIBK 0.83
    2-propoxyethanol 8.38
    tert-butanol 2.64
    MTBE 0.61
    2-butoxyethanol 5.67
    propionic acid 1.75
    o-xylene 0.87
    formic acid 91.15
    diethyl ether 0.62
    m-xylene 0.56
    p-xylene 0.36
    chlorobenzene 0.13
    dimethyl carbonate 2.54
    n-octane 0.21
    formamide 86.04
    cyclopentanone 3.04
    2-pentanone 0.98
    anisole 0.88
    cyclopentyl methyl ether 1.82
    gamma-butyrolactone 4.71
    1-methoxy-2-propanol 18.48
    pyridine 1.57
    3-pentanone 0.85
    furfural 10.78
    n-dodecane 0.11
    diethylene glycol 28.49
    diisopropyl ether 0.32
    tert-amyl alcohol 1.83
    acetylacetone 3.38
    n-hexadecane 0.12
    acetophenone 1.66
    methyl propionate 1.27
    isopentyl acetate 0.44
    trichloroethylene 0.34
    n-nonanol 0.85
    cyclohexanol 1.69
    benzyl alcohol 1.79
    2-ethylhexanol 0.59
    isooctanol 0.73
    dipropyl ether 1.19
    1,2-dichlorobenzene 0.2
    ethyl lactate 2.67
    propylene carbonate 1.93
    n-methylformamide 19.21
    2-pentanol 0.67
    n-pentane 0.16
    1-propoxy-2-propanol 4.8
    1-methoxy-2-propyl acetate 2.06
    2-(2-methoxypropoxy) propanol 8.73
    mesitylene 0.55
    ε-caprolactone 2.25
    p-cymene 0.44
    epichlorohydrin 1.71
    1,1,1-trichloroethane 0.07
    2-aminoethanol 20.61
    morpholine-4-carbaldehyde 41.6
    sulfolane 27.31
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 1.32
    n-hexyl acetate 0.67
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 10.89
    sec-butyl acetate 0.26
    tert-butyl acetate 1.0
    decalin 0.15
    glycerin 57.52
    diglyme 17.7
    acrylic acid 4.61
    isopropyl myristate 0.43
    n-butyric acid 1.68
    acetyl acetate 0.69
    di(2-ethylhexyl) phthalate 1.04
    ethyl propionate 0.53
    nitromethane 13.47
    1,2-diethoxyethane 1.68
    benzonitrile 0.58
    trioctyl phosphate 0.8
    1-bromopropane 0.12
    gamma-valerolactone 12.31
    n-decanol 0.76
    triethyl phosphate 0.85
    4-methyl-2-pentanol 0.48
    propionitrile 0.28
    vinylene carbonate 1.82
    1,1,2-trichlorotrifluoroethane 9.61
    DMS 0.99
    cumene 0.27
    2-octanol 0.64
    2-hexanone 0.5
    octyl acetate 0.67
    limonene 0.64
    1,2-dimethoxyethane 12.46
    ethyl orthosilicate 0.78
    tributyl phosphate 0.68
    diacetone alcohol 5.73
    N,N-dimethylaniline 1.73
    acrylonitrile 0.76
    aniline 1.15
    1,3-propanediol 13.64
    bromobenzene 0.1
    dibromomethane 0.13
    1,1,2,2-tetrachloroethane 0.47
    2-methyl-cyclohexyl acetate 0.75
    tetrabutyl urea 2.11
    diisobutyl methanol 0.58
    2-phenylethanol 1.5
    styrene 0.29
    dioctyl adipate 0.95
    dimethyl sulfate 9.78
    ethyl butyrate 0.74
    methyl lactate 8.49
    butyl lactate 2.07
    diethyl carbonate 0.52
    propanediol butyl ether 7.95
    triethyl orthoformate 1.05
    p-tert-butyltoluene 0.46
    methyl 4-tert-butylbenzoate 3.56
    morpholine 5.15
    tert-butylamine 0.94
    n-dodecanol 0.65
    dimethoxymethane 15.55
    ethylene carbonate 1.16
    cyrene 14.04
    2-ethoxyethyl acetate 1.27
    2-ethylhexyl acetate 0.33
    1,2,4-trichlorobenzene 0.31
    4-methylpyridine 1.23
    dibutyl ether 0.54
    2,6-dimethyl-4-heptanol 0.58
    DEF 5.4
    dimethyl isosorbide 10.18
    tetrachloroethylene 0.49
    eugenol 5.47
    triacetin 2.29
    span 80 6.22
    1,4-butanediol 5.99
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.5
    methyl formate 11.53
    2-methyl-1-butanol 0.65
    n-decane 0.18
    butyronitrile 0.3
    3,7-dimethyl-1-octanol 0.54
    1-chlorooctane 0.24
    1-chlorotetradecane 0.16
    n-nonane 0.18
    undecane 0.14
    tert-butylcyclohexane 0.07
    cyclooctane 0.33
    cyclopentanol 1.78
    tetrahydropyran 0.98
    tert-amyl methyl ether 0.87
    2,5,8-trioxanonane 18.38
    1-hexene 0.18
    2-isopropoxyethanol 5.04
    2,2,2-trifluoroethanol 6.59
    methyl butyrate 0.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction