L-Glutamic acid, 5-[2-(4-formylphenyl)hydrazide]

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  • Identifiers

    CAS number
    114847-20-0

    Molecular formula
    C12H15N3O4

    SMILES
    C1=CC(=CC=C1C=O)NNC(=O)CC[C@@H](C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 66.65%
    Savory 40.42%
    Meaty 29.43%
    Cooked 24.22%
    Sweet 22.58%
    Bitter 20.44%
    Milky 20.39%
    Fishy 19.6%
    Roasted 18.06%
    Burnt 17.97%

     

    Flavor
    Odorless 60.17%
    Bitter 52.63%
    Mild 33.49%
    Bland 27.04%
    Very mild 25.17%
    Yeast 22.57%
    Sweet-like 22.07%
    Faint 21.84%
    Nitrile 20.64%
    Orange flower 19.88%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.4

    pKa est.
    6.4 (neutral)

    Molecular weight
    265.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    734°C

    Flash point

    • 262.78 ˚C est.

  • Synonyms

    • DTXSID501235710
    • L-Glutamic acid, 5-[2-(4-formylphenyl)hydrazide]
    • (2S)-2-Amino-5-[2-(4-formylphenyl)hydrazinyl]-5-oxopentanoic acid
    • 114847-20-0
    • 114847-20-0

  • Applications

    Applications of L-Glutamic acid, 5-[2-(4-formylphenyl)hydrazide], CAS 114847-20-0 include use as synthetic intermediates and building blocks in pharmaceutical research for peptidomimetics and compound libraries; as scaffolds for functional ligands in metal coordination chemistry and catalysis; as hydrazide-based crosslinking and functionalization agents for polymers and coatings via hydrazone chemistry; as reagents for bioconjugation and fluorescent labeling through hydrazone formation with aldehydes; and as precursors for dye and organic-sensor components, leveraging the formylphenyl and hydrazide functionality.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.54
    methanol 3.75
    isopropanol 0.32
    water 10.1
    ethyl acetate 0.2
    n-propanol 0.39
    acetone 0.29
    n-butanol 0.39
    acetonitrile 0.18
    DMF 23.57
    toluene 0.07
    isobutanol 0.2
    1,4-dioxane 0.82
    methyl acetate 0.16
    THF 1.24
    2-butanone 0.38
    n-pentanol 0.25
    sec-butanol 0.33
    n-hexane 0.04
    ethylene glycol 7.3
    NMP 17.99
    cyclohexane 0.02
    DMSO 51.74
    n-butyl acetate 0.08
    n-octanol 0.11
    chloroform 0.04
    n-propyl acetate 0.12
    acetic acid 5.93
    dichloromethane 0.06
    cyclohexanone 0.92
    propylene glycol 5.31
    isopropyl acetate 0.14
    DMAc 34.34
    2-ethoxyethanol 5.32
    isopentanol 0.3
    n-heptane 0.04
    ethyl formate 0.44
    1,2-dichloroethane 0.06
    n-hexanol 0.2
    2-methoxyethanol 17.07
    isobutyl acetate 0.05
    tetrachloromethane 0.03
    n-pentyl acetate 0.1
    transcutol 8.9
    n-heptanol 0.23
    ethylbenzene 0.06
    MIBK 0.22
    2-propoxyethanol 2.7
    tert-butanol 0.41
    MTBE 0.11
    2-butoxyethanol 1.73
    propionic acid 0.99
    o-xylene 0.11
    formic acid 47.96
    diethyl ether 0.16
    m-xylene 0.07
    p-xylene 0.09
    chlorobenzene 0.03
    dimethyl carbonate 0.68
    n-octane 0.02
    formamide 44.76
    cyclopentanone 1.19
    2-pentanone 0.36
    anisole 0.21
    cyclopentyl methyl ether 0.37
    gamma-butyrolactone 1.76
    1-methoxy-2-propanol 6.77
    pyridine 0.62
    3-pentanone 0.36
    furfural 4.18
    n-dodecane 0.01
    diethylene glycol 9.13
    diisopropyl ether 0.05
    tert-amyl alcohol 0.41
    acetylacetone 0.78
    n-hexadecane 0.01
    acetophenone 0.41
    methyl propionate 0.41
    isopentyl acetate 0.1
    trichloroethylene 0.12
    n-nonanol 0.14
    cyclohexanol 0.43
    benzyl alcohol 0.5
    2-ethylhexanol 0.11
    isooctanol 0.17
    dipropyl ether 0.25
    1,2-dichlorobenzene 0.05
    ethyl lactate 0.83
    propylene carbonate 0.68
    n-methylformamide 7.01
    2-pentanol 0.23
    n-pentane 0.02
    1-propoxy-2-propanol 1.37
    1-methoxy-2-propyl acetate 0.5
    2-(2-methoxypropoxy) propanol 2.54
    mesitylene 0.06
    ε-caprolactone 0.86
    p-cymene 0.05
    epichlorohydrin 0.74
    1,1,1-trichloroethane 0.02
    2-aminoethanol 6.18
    morpholine-4-carbaldehyde 13.61
    sulfolane 8.6
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.31
    n-hexyl acetate 0.13
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.76
    sec-butyl acetate 0.08
    tert-butyl acetate 0.19
    decalin 0.02
    glycerin 29.08
    diglyme 6.32
    acrylic acid 2.44
    isopropyl myristate 0.07
    n-butyric acid 1.03
    acetyl acetate 0.19
    di(2-ethylhexyl) phthalate 0.25
    ethyl propionate 0.2
    nitromethane 5.57
    1,2-diethoxyethane 0.46
    benzonitrile 0.17
    trioctyl phosphate 0.15
    1-bromopropane 0.04
    gamma-valerolactone 5.61
    n-decanol 0.11
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.14
    propionitrile 0.14
    vinylene carbonate 0.7
    1,1,2-trichlorotrifluoroethane 5.28
    DMS 0.3
    cumene 0.05
    2-octanol 0.11
    2-hexanone 0.2
    octyl acetate 0.11
    limonene 0.06
    1,2-dimethoxyethane 4.05
    ethyl orthosilicate 0.24
    tributyl phosphate 0.18
    diacetone alcohol 1.51
    N,N-dimethylaniline 0.37
    acrylonitrile 0.35
    aniline 0.33
    1,3-propanediol 6.28
    bromobenzene 0.02
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.16
    2-methyl-cyclohexyl acetate 0.18
    tetrabutyl urea 0.49
    diisobutyl methanol 0.11
    2-phenylethanol 0.31
    styrene 0.06
    dioctyl adipate 0.19
    dimethyl sulfate 2.79
    ethyl butyrate 0.18
    methyl lactate 3.5
    butyl lactate 0.54
    diethyl carbonate 0.14
    propanediol butyl ether 2.39
    triethyl orthoformate 0.28
    p-tert-butyltoluene 0.05
    methyl 4-tert-butylbenzoate 0.86
    morpholine 1.83
    tert-butylamine 0.12
    n-dodecanol 0.09
    dimethoxymethane 3.77
    ethylene carbonate 0.44
    cyrene 4.67
    2-ethoxyethyl acetate 0.29
    2-ethylhexyl acetate 0.07
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.38
    dibutyl ether 0.13
    2,6-dimethyl-4-heptanol 0.11
    DEF 1.96
    dimethyl isosorbide 3.11
    tetrachloroethylene 0.19
    eugenol 1.38
    triacetin 0.55
    span 80 1.54
    1,4-butanediol 2.23
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.24
    methyl formate 3.2
    2-methyl-1-butanol 0.31
    n-decane 0.02
    butyronitrile 0.17
    3,7-dimethyl-1-octanol 0.1
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 0.52
    tetrahydropyran 0.28
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 5.75
    1-hexene 0.09
    2-isopropoxyethanol 1.5
    2,2,2-trifluoroethanol 3.78
    methyl butyrate 0.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction