L-Arginine, dihydroxymethylsilyl ester

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  • Identifiers

    CAS number
    190270-68-9

    Molecular formula
    C7H16N4O4Si

    SMILES
    C(C[C@@H](C(=O)O[Si]C(O)O)N)CN=C(N)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.56%
    Savory 37.05%
    Meaty 31.35%
    Fishy 27.43%
    Cooling 24.16%
    Cooked 19.3%
    Sweet 18.6%
    Cheesy 17.3%
    Roasted 16.24%
    Milky 15.8%

     

    Flavor
    Odorless 60.85%
    Bitter 39.55%
    Bland 32.84%
    Mild 31.53%
    Sweet-like 24.16%
    Faint 21.99%
    Very mild 20.85%
    Yeast 20.75%
    Nitrile 19.73%
    Bouillon 19.22%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.84 (neutral)

    Molecular weight
    248.31 g/mol

    Flash point

    • 172.14 ˚C est.

  • Synonyms

    • L-Arginine, dihydroxymethylsilyl ester
    • DTXSID501021719
    • 190270-68-9
    • 190270-68-9

  • Applications

    L-Arginine, dihydroxymethylsilyl ester (CAS 190270-68-9) is a protected derivative of L-Arginine used as an intermediate and building block in pharmaceutical and peptide synthesis; it often serves as a protecting group for the carboxyl function during peptide assembly. It also acts as a functional monomer or modifier for silicone-containing polymers and networks, including coatings and inks, and can function as a crosslinking precursor in silicone-based coatings and adhesives; additionally it serves as a building block for arginine-containing biomaterials or cosmetic ingredient development under appropriate formulation controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.1
    methanol 0.47
    isopropanol 0.06
    water 92.99
    ethyl acetate 0.06
    n-propanol 0.08
    acetone 0.08
    n-butanol 0.06
    acetonitrile 0.09
    DMF 3.07
    toluene 0.1
    isobutanol 0.05
    1,4-dioxane 0.14
    methyl acetate 0.05
    THF 0.24
    2-butanone 0.07
    n-pentanol 0.06
    sec-butanol 0.06
    n-hexane 0.05
    ethylene glycol 3.29
    NMP 10.13
    cyclohexane 0.14
    DMSO 24.61
    n-butyl acetate 0.08
    n-octanol 0.06
    chloroform 0.06
    n-propyl acetate 0.06
    acetic acid 3.03
    dichloromethane 0.09
    cyclohexanone 0.36
    propylene glycol 1.33
    isopropyl acetate 0.06
    DMAc 4.05
    2-ethoxyethanol 0.88
    isopentanol 0.06
    n-heptane 0.11
    ethyl formate 0.16
    1,2-dichloroethane 0.08
    n-hexanol 0.11
    2-methoxyethanol 1.75
    isobutyl acetate 0.03
    tetrachloromethane 0.05
    n-pentyl acetate 0.06
    transcutol 1.16
    n-heptanol 0.12
    ethylbenzene 0.07
    MIBK 0.07
    2-propoxyethanol 0.83
    tert-butanol 0.09
    MTBE 0.03
    2-butoxyethanol 0.53
    propionic acid 0.36
    o-xylene 0.19
    formic acid 36.51
    diethyl ether 0.05
    m-xylene 0.12
    p-xylene 0.1
    chlorobenzene 0.04
    dimethyl carbonate 0.27
    n-octane 0.05
    formamide 17.21
    cyclopentanone 0.41
    2-pentanone 0.09
    anisole 0.07
    cyclopentyl methyl ether 0.27
    gamma-butyrolactone 0.68
    1-methoxy-2-propanol 0.85
    pyridine 0.27
    3-pentanone 0.12
    furfural 2.12
    n-dodecane 0.02
    diethylene glycol 3.6
    diisopropyl ether 0.03
    tert-amyl alcohol 0.09
    acetylacetone 0.27
    n-hexadecane 0.02
    acetophenone 0.21
    methyl propionate 0.14
    isopentyl acetate 0.06
    trichloroethylene 0.12
    n-nonanol 0.07
    cyclohexanol 0.25
    benzyl alcohol 0.2
    2-ethylhexanol 0.09
    isooctanol 0.09
    dipropyl ether 0.17
    1,2-dichlorobenzene 0.06
    ethyl lactate 0.36
    propylene carbonate 0.42
    n-methylformamide 1.47
    2-pentanol 0.06
    n-pentane 0.04
    1-propoxy-2-propanol 0.51
    1-methoxy-2-propyl acetate 0.25
    2-(2-methoxypropoxy) propanol 0.72
    mesitylene 0.11
    ε-caprolactone 0.33
    p-cymene 0.1
    epichlorohydrin 0.21
    1,1,1-trichloroethane 0.03
    2-aminoethanol 1.73
    morpholine-4-carbaldehyde 3.55
    sulfolane 6.72
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.13
    n-hexyl acetate 0.05
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.83
    sec-butyl acetate 0.04
    tert-butyl acetate 0.09
    decalin 0.04
    glycerin 11.37
    diglyme 1.29
    acrylic acid 1.16
    isopropyl myristate 0.04
    n-butyric acid 0.3
    acetyl acetate 0.11
    di(2-ethylhexyl) phthalate 0.12
    ethyl propionate 0.09
    nitromethane 1.62
    1,2-diethoxyethane 0.11
    benzonitrile 0.11
    trioctyl phosphate 0.09
    1-bromopropane 0.04
    gamma-valerolactone 1.24
    n-decanol 0.06
    triethyl phosphate 0.17
    4-methyl-2-pentanol 0.05
    propionitrile 0.05
    vinylene carbonate 0.43
    1,1,2-trichlorotrifluoroethane 3.08
    DMS 0.13
    cumene 0.06
    2-octanol 0.07
    2-hexanone 0.06
    octyl acetate 0.05
    limonene 0.12
    1,2-dimethoxyethane 0.57
    ethyl orthosilicate 0.16
    tributyl phosphate 0.09
    diacetone alcohol 0.44
    N,N-dimethylaniline 0.2
    acrylonitrile 0.14
    aniline 0.24
    1,3-propanediol 0.81
    bromobenzene 0.03
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 0.15
    2-methyl-cyclohexyl acetate 0.12
    tetrabutyl urea 0.21
    diisobutyl methanol 0.07
    2-phenylethanol 0.2
    styrene 0.06
    dioctyl adipate 0.07
    dimethyl sulfate 1.47
    ethyl butyrate 0.12
    methyl lactate 1.08
    butyl lactate 0.27
    diethyl carbonate 0.09
    propanediol butyl ether 0.67
    triethyl orthoformate 0.18
    p-tert-butyltoluene 0.09
    methyl 4-tert-butylbenzoate 0.42
    morpholine 0.25
    tert-butylamine 0.05
    n-dodecanol 0.05
    dimethoxymethane 0.59
    ethylene carbonate 0.24
    cyrene 2.45
    2-ethoxyethyl acetate 0.11
    2-ethylhexyl acetate 0.05
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.19
    dibutyl ether 0.05
    2,6-dimethyl-4-heptanol 0.07
    DEF 0.44
    dimethyl isosorbide 1.37
    tetrachloroethylene 0.2
    eugenol 0.64
    triacetin 0.21
    span 80 0.65
    1,4-butanediol 0.47
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.05
    methyl formate 0.91
    2-methyl-1-butanol 0.06
    n-decane 0.03
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.04
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.08
    cyclopentanol 0.27
    tetrahydropyran 0.1
    tert-amyl methyl ether 0.06
    2,5,8-trioxanonane 1.5
    1-hexene 0.05
    2-isopropoxyethanol 0.32
    2,2,2-trifluoroethanol 2.93
    methyl butyrate 0.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction