Kojic acid dipalmitate

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  • Identifiers

    CAS number
    79725-98-7

    Molecular formula
    C38H66O6

    SMILES
    CCCCCCCCCCCCCCCC(=O)OCC1=CC(=O)C(=CO1)OC(=O)CCCCCCCCCCCCCCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fatty 71.84%
    Waxy 71.34%
    Oily 45.84%
    Odorless 34.3%
    Creamy 33.88%
    Dairy 28.32%
    Buttery 26.78%
    Milky 25.88%
    Sweet 23.28%
    Coconut 19.36%

     

    Flavor
    Waxy 50.43%
    Fatty 49.03%
    Oily 42.89%
    Mild 38.83%
    Bland 35.96%
    Creamy 31.7%
    Faint 31.07%
    Coconut 29.56%
    Fat 29.3%
    Odorless 26.47%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.4

    pKa est.
    9.91 (weak base)

    Molecular weight
    618.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    589°C

    Flash point

    • 259.89 ˚C est.

  • Synonyms

    • RefChem:1088064
    • 79725-98-7
    • Kojic acid dipalmitate
    • C38H66O6
    • pentadecyl 6-[(hexadecanoyloxy)methyl]-4-oxo-4H-pyran-3-carboxylate
    • orb3025423
    • SCHEMBL13671134
    • 5-(Palmitoyloxy)-2-[(palmitoyloxy)methyl]-4H-pyran-4-one
    • DTXSID301000694
    • AKOS016007920
    • FK06267
    • HY-W099579
    • AS-14788
    • CS-0152221
    • K0050
    • (5-hexadecanoyloxy-4-oxo-pyran-2-yl)methyl hexadecanoate
    • 6-[(Hexadecanoyloxy)methyl]-4-oxo-4H-pyran-3-yl hexadecanoate
    • 79725-98-7

  • Applications

    Kojic acid dipalmitate, CAS 79725-98-7, is a lipophilic derivative of kojic acid primarily used in cosmetics and personal care as a skin-brightening agent and tyrosinase inhibitor. In topical formulations, it often acts as a prodrug that releases kojic acid, enabling controlled delivery and improved dermal penetration in oil-based or emulsion systems such as serums, lotions, and creams. It is commonly used to enable lipophilic formulations and facilitate delivery of the active molecule, and is also viewed as an intermediate for the synthesis of kojic acid esters used in cosmetic ingredients. In pharmaceutical contexts, it may be considered for topical dermatology applications subject to regulatory approvals and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.11
    methanol 13.7
    isopropanol 10.3
    water 0.65
    ethyl acetate 108.52
    n-propanol 15.8
    acetone 93.48
    n-butanol 13.82
    acetonitrile 43.63
    DMF 132.38
    toluene 54.67
    isobutanol 13.5
    1,4-dioxane 85.04
    methyl acetate 105.56
    THF 211.25
    2-butanone 117.7
    n-pentanol 14.17
    sec-butanol 19.17
    n-hexane 5.27
    ethylene glycol 2.17
    NMP 488.33
    cyclohexane 15.12
    DMSO 157.6
    n-butyl acetate 63.22
    n-octanol 14.23
    chloroform 346.65
    n-propyl acetate 87.85
    acetic acid 75.03
    dichloromethane 422.54
    cyclohexanone 252.62
    propylene glycol 4.66
    isopropyl acetate 79.1
    DMAc 404.61
    2-ethoxyethanol 38.83
    isopentanol 14.42
    n-heptane 3.61
    ethyl formate 55.85
    1,2-dichloroethane 230.36
    n-hexanol 9.57
    2-methoxyethanol 37.69
    isobutyl acetate 46.6
    tetrachloromethane 77.46
    n-pentyl acetate 101.77
    transcutol 152.87
    n-heptanol 13.55
    ethylbenzene 29.82
    MIBK 52.47
    2-propoxyethanol 32.61
    tert-butanol 16.58
    MTBE 39.9
    2-butoxyethanol 45.31
    propionic acid 55.95
    o-xylene 45.22
    formic acid 21.44
    diethyl ether 33.63
    m-xylene 31.55
    p-xylene 45.51
    chlorobenzene 107.66
    dimethyl carbonate 65.49
    n-octane 2.75
    formamide 49.45
    cyclopentanone 299.43
    2-pentanone 83.47
    anisole 61.64
    cyclopentyl methyl ether 103.66
    gamma-butyrolactone 381.62
    1-methoxy-2-propanol 36.18
    pyridine 167.51
    3-pentanone 106.77
    furfural 258.32
    n-dodecane 1.59
    diethylene glycol 14.3
    diisopropyl ether 14.79
    tert-amyl alcohol 28.48
    acetylacetone 158.21
    n-hexadecane 1.92
    acetophenone 109.82
    methyl propionate 108.61
    isopentyl acetate 60.71
    trichloroethylene 481.55
    n-nonanol 15.52
    cyclohexanol 35.85
    benzyl alcohol 37.07
    2-ethylhexanol 12.12
    isooctanol 14.14
    dipropyl ether 26.53
    1,2-dichlorobenzene 136.36
    ethyl lactate 41.48
    propylene carbonate 196.44
    n-methylformamide 66.26
    2-pentanol 13.25
    n-pentane 3.85
    1-propoxy-2-propanol 34.48
    1-methoxy-2-propyl acetate 78.59
    2-(2-methoxypropoxy) propanol 48.23
    mesitylene 19.9
    ε-caprolactone 257.89
    p-cymene 17.46
    epichlorohydrin 317.75
    1,1,1-trichloroethane 281.02
    2-aminoethanol 7.1
    morpholine-4-carbaldehyde 206.83
    sulfolane 578.23
    2,2,4-trimethylpentane 4.47
    2-methyltetrahydrofuran 151.69
    n-hexyl acetate 84.4
    isooctane 1.64
    2-(2-butoxyethoxy)ethanol 55.01
    sec-butyl acetate 66.33
    tert-butyl acetate 94.12
    decalin 8.05
    glycerin 9.1
    diglyme 153.6
    acrylic acid 52.67
    isopropyl myristate 25.1
    n-butyric acid 79.72
    acetyl acetate 104.85
    di(2-ethylhexyl) phthalate 28.74
    ethyl propionate 92.69
    nitromethane 216.19
    1,2-diethoxyethane 73.16
    benzonitrile 58.74
    trioctyl phosphate 18.98
    1-bromopropane 85.75
    gamma-valerolactone 364.09
    n-decanol 9.58
    triethyl phosphate 48.3
    4-methyl-2-pentanol 9.27
    propionitrile 40.38
    vinylene carbonate 168.29
    1,1,2-trichlorotrifluoroethane 216.13
    DMS 95.92
    cumene 19.96
    2-octanol 13.34
    2-hexanone 73.91
    octyl acetate 34.05
    limonene 26.87
    1,2-dimethoxyethane 90.15
    ethyl orthosilicate 42.4
    tributyl phosphate 28.46
    diacetone alcohol 72.46
    N,N-dimethylaniline 47.17
    acrylonitrile 56.86
    aniline 51.94
    1,3-propanediol 11.62
    bromobenzene 124.18
    dibromomethane 213.45
    1,1,2,2-tetrachloroethane 432.47
    2-methyl-cyclohexyl acetate 60.42
    tetrabutyl urea 43.36
    diisobutyl methanol 9.06
    2-phenylethanol 26.84
    styrene 36.98
    dioctyl adipate 50.8
    dimethyl sulfate 175.04
    ethyl butyrate 68.32
    methyl lactate 46.98
    butyl lactate 67.21
    diethyl carbonate 47.62
    propanediol butyl ether 30.49
    triethyl orthoformate 54.55
    p-tert-butyltoluene 16.16
    methyl 4-tert-butylbenzoate 99.1
    morpholine 103.57
    tert-butylamine 11.21
    n-dodecanol 6.44
    dimethoxymethane 72.91
    ethylene carbonate 140.9
    cyrene 76.36
    2-ethoxyethyl acetate 138.83
    2-ethylhexyl acetate 53.8
    1,2,4-trichlorobenzene 188.38
    4-methylpyridine 144.07
    dibutyl ether 32.1
    2,6-dimethyl-4-heptanol 9.06
    DEF 126.07
    dimethyl isosorbide 124.86
    tetrachloroethylene 267.79
    eugenol 65.9
    triacetin 142.36
    span 80 40.42
    1,4-butanediol 6.99
    1,1-dichloroethane 179.15
    2-methyl-1-pentanol 18.34
    methyl formate 58.01
    2-methyl-1-butanol 18.22
    n-decane 3.63
    butyronitrile 31.99
    3,7-dimethyl-1-octanol 15.15
    1-chlorooctane 19.75
    1-chlorotetradecane 5.99
    n-nonane 3.3
    undecane 2.24
    tert-butylcyclohexane 5.36
    cyclooctane 5.23
    cyclopentanol 44.69
    tetrahydropyran 99.79
    tert-amyl methyl ether 47.01
    2,5,8-trioxanonane 81.0
    1-hexene 15.34
    2-isopropoxyethanol 32.23
    2,2,2-trifluoroethanol 61.31
    methyl butyrate 117.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction