Kobusone

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  • Identifiers

    CAS number
    24173-71-5

    Molecular formula
    C14H22O2

    SMILES
    C[C@@]12CC[C@@H]3[C@H](CC3(C)C)C(=O)CC[C@H]1O2

    Safety labels

  • Odor profile

    Fragrance
    Woody 81.96%
    Camphoreous 52.92%
    Herbal 51.54%
    Cedar 48.04%
    Fresh 45.56%
    Mint 43.28%
    Earthy 42.49%
    Amber 39.82%
    Spicy 38.56%
    Pine 38.24%

     

    Flavor
    Minty 42.06%
    Spicy 42.01%
    Woody 38.1%
    Herbal 37.69%
    Earthy 33.27%
    Camphor 32.78%
    Bitter 31.42%
    Fresh 30.24%
    Sweet 27.75%
    Spice 27.21%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    6.11 (neutral)

    Molecular weight
    222.32 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    328°C

    Flash point

    • 128.6 ˚C est.

  • Synonyms

    • Kobusone
    • (1R,4R,6R,10S)-4,12,12-Trimethyl-5-oxatricyclo[8.2.0.04,6]dodecan-9-one
    • (1R,4R,6R,10S)-4,12,12-trimethyl-5-oxatricyclo(8.2.0.04,6)dodecan-9-one
    • RefChem:1088063
    • 24173-71-5
    • (-)-Kobusone
    • Spectrum_001247
    • (-)-Kobusone; 6,7-Epoxy-12-norcaryophyllan-3-one
    • Spectrum2_000315
    • Spectrum3_000801
    • Spectrum4_000641
    • Spectrum5_001818
    • BSPBio_002261
    • KBioGR_000981
    • KBioSS_001727
    • SPECTRUM300048
    • SPBio_000310
    • CHEMBL3039087
    • SCHEMBL19361159
    • KBio2_001727
    • KBio2_004295
    • KBio2_006863
    • KBio3_001761
    • DTXSID001318080
    • GLXC-17250
    • HY-N3419
    • CCG-38591
    • AKOS032962384
    • FS-9642
    • SDCCGMLS-0066473.P001
    • NCGC00178735-01
    • DA-64758
    • CS-0024182
    • SR-05000002461
    • SR-05000002461-1
    • (1R,4R,6R,10S)-4,12,12-Trimethyl-5-oxatricyclo[8.2.0.0~4,6~]dodecan-9-one
    • 24173-71-5

  • Applications

    Kobusone (CAS 24173-71-5) is primarily used as an odorant/fragrance ingredient in the fragrance industry and cosmetics, helping to impart or adjust fragrance profiles in formulations. It may be used as a fragrance component in personal care products. It can be employed in household and cleaning products to impart or enhance fragrance. In industrial manufacturing, it can serve as an organic synthesis intermediate or as a solvent/carrier in specific formulations, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 76.81
    methanol 108.95
    isopropanol 50.69
    water 2.79
    ethyl acetate 80.7
    n-propanol 58.42
    acetone 90.66
    n-butanol 52.03
    acetonitrile 108.87
    DMF 123.03
    toluene 83.81
    isobutanol 42.68
    1,4-dioxane 188.35
    methyl acetate 95.99
    THF 195.58
    2-butanone 89.49
    n-pentanol 43.25
    sec-butanol 32.83
    n-hexane 2.86
    ethylene glycol 35.43
    NMP 121.91
    cyclohexane 8.99
    DMSO 98.12
    n-butyl acetate 87.42
    n-octanol 38.33
    chloroform 316.36
    n-propyl acetate 72.13
    acetic acid 105.33
    dichloromethane 231.52
    cyclohexanone 132.33
    propylene glycol 35.29
    isopropyl acetate 65.31
    DMAc 135.24
    2-ethoxyethanol 94.15
    isopentanol 49.18
    n-heptane 4.74
    ethyl formate 78.32
    1,2-dichloroethane 98.51
    n-hexanol 58.21
    2-methoxyethanol 130.97
    isobutyl acetate 65.54
    tetrachloromethane 39.13
    n-pentyl acetate 61.75
    transcutol 297.83
    n-heptanol 41.62
    ethylbenzene 46.7
    MIBK 62.7
    2-propoxyethanol 134.92
    tert-butanol 52.66
    MTBE 43.27
    2-butoxyethanol 94.43
    propionic acid 68.43
    o-xylene 53.9
    formic acid 63.15
    diethyl ether 44.93
    m-xylene 59.22
    p-xylene 71.06
    chlorobenzene 102.9
    dimethyl carbonate 50.55
    n-octane 2.76
    formamide 92.9
    cyclopentanone 147.78
    2-pentanone 68.3
    anisole 95.61
    cyclopentyl methyl ether 68.89
    gamma-butyrolactone 162.66
    1-methoxy-2-propanol 93.68
    pyridine 176.85
    3-pentanone 58.04
    furfural 195.82
    n-dodecane 3.73
    diethylene glycol 135.08
    diisopropyl ether 20.93
    tert-amyl alcohol 33.98
    acetylacetone 105.67
    n-hexadecane 4.37
    acetophenone 101.36
    methyl propionate 68.34
    isopentyl acetate 92.36
    trichloroethylene 226.56
    n-nonanol 39.17
    cyclohexanol 45.82
    benzyl alcohol 90.02
    2-ethylhexanol 42.16
    isooctanol 36.22
    dipropyl ether 40.35
    1,2-dichlorobenzene 95.36
    ethyl lactate 54.26
    propylene carbonate 117.85
    n-methylformamide 81.37
    2-pentanol 29.03
    n-pentane 3.48
    1-propoxy-2-propanol 93.13
    1-methoxy-2-propyl acetate 110.87
    2-(2-methoxypropoxy) propanol 100.43
    mesitylene 35.21
    ε-caprolactone 125.1
    p-cymene 37.29
    epichlorohydrin 172.9
    1,1,1-trichloroethane 102.01
    2-aminoethanol 52.66
    morpholine-4-carbaldehyde 180.18
    sulfolane 130.4
    2,2,4-trimethylpentane 3.52
    2-methyltetrahydrofuran 103.62
    n-hexyl acetate 79.34
    isooctane 3.5
    2-(2-butoxyethoxy)ethanol 122.96
    sec-butyl acetate 59.13
    tert-butyl acetate 68.23
    decalin 8.14
    glycerin 56.41
    diglyme 205.65
    acrylic acid 73.56
    isopropyl myristate 41.6
    n-butyric acid 83.15
    acetyl acetate 86.77
    di(2-ethylhexyl) phthalate 53.24
    ethyl propionate 60.01
    nitromethane 157.01
    1,2-diethoxyethane 93.0
    benzonitrile 128.37
    trioctyl phosphate 36.48
    1-bromopropane 50.74
    gamma-valerolactone 224.12
    n-decanol 30.79
    triethyl phosphate 45.73
    4-methyl-2-pentanol 30.16
    propionitrile 82.75
    vinylene carbonate 136.82
    1,1,2-trichlorotrifluoroethane 136.28
    DMS 82.89
    cumene 35.94
    2-octanol 26.12
    2-hexanone 70.17
    octyl acetate 49.04
    limonene 39.11
    1,2-dimethoxyethane 157.63
    ethyl orthosilicate 44.53
    tributyl phosphate 42.06
    diacetone alcohol 72.2
    N,N-dimethylaniline 63.91
    acrylonitrile 108.01
    aniline 83.29
    1,3-propanediol 73.7
    bromobenzene 105.27
    dibromomethane 133.83
    1,1,2,2-tetrachloroethane 160.13
    2-methyl-cyclohexyl acetate 77.8
    tetrabutyl urea 52.6
    diisobutyl methanol 30.43
    2-phenylethanol 98.83
    styrene 55.56
    dioctyl adipate 60.58
    dimethyl sulfate 63.46
    ethyl butyrate 70.69
    methyl lactate 56.95
    butyl lactate 65.24
    diethyl carbonate 61.39
    propanediol butyl ether 82.34
    triethyl orthoformate 60.64
    p-tert-butyltoluene 34.64
    methyl 4-tert-butylbenzoate 81.24
    morpholine 164.78
    tert-butylamine 33.25
    n-dodecanol 24.35
    dimethoxymethane 102.04
    ethylene carbonate 110.28
    cyrene 104.37
    2-ethoxyethyl acetate 97.95
    2-ethylhexyl acetate 75.75
    1,2,4-trichlorobenzene 112.6
    4-methylpyridine 152.17
    dibutyl ether 36.81
    2,6-dimethyl-4-heptanol 30.43
    DEF 70.62
    dimethyl isosorbide 160.88
    tetrachloroethylene 109.8
    eugenol 93.21
    triacetin 101.43
    span 80 83.0
    1,4-butanediol 39.96
    1,1-dichloroethane 97.21
    2-methyl-1-pentanol 42.94
    methyl formate 72.09
    2-methyl-1-butanol 39.07
    n-decane 5.45
    butyronitrile 79.23
    3,7-dimethyl-1-octanol 43.95
    1-chlorooctane 23.25
    1-chlorotetradecane 12.17
    n-nonane 4.26
    undecane 4.37
    tert-butylcyclohexane 6.95
    cyclooctane 4.08
    cyclopentanol 52.66
    tetrahydropyran 107.75
    tert-amyl methyl ether 32.29
    2,5,8-trioxanonane 150.43
    1-hexene 15.22
    2-isopropoxyethanol 73.45
    2,2,2-trifluoroethanol 55.13
    methyl butyrate 77.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction